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Aberrant basement membrane production by HSCs in MASLD is attenuated by the bile acid analog INT-767 Ramachandran, Prakash; Brice, Madara; Sutherland, Elena F.; Hoy, Anna M.; Papachristoforou, Eleni; Jia, Li; Turner, Frances; Kendall, Timothy J.; Marwick, John A.; Carragher, Neil O.; Oro, Denise; Feigh, Michael; Leeming, Diana J.; Nielsen, Mette J.; Karsdal, Morten A.; Hartmann, Nadine; Erickson, Mary; Adorini, Luciano; Roth, Jonathan D.; Fallowfield, Jonathan A. Share Save
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FXR agonists INT-787 and OCA increase RECK and inhibit liver steatosis and inflammation in diet-induced ob/ob mouse model of NASH Di Pasqua, Laura G.; Cagna, Marta; Palladini, Giuseppina; Croce, Anna C.; Cadamuro, Massimiliano; Fabris, Luca; Perlini, Stefano; Adorini, Luciano; Ferrigno, Andrea; Vairetti, Mariapia Share Save
An integrated analysis of fecal microbiome and metabolomic features distinguish non-cirrhotic NASH from healthy control populations Carr, Rotonya M.; Li, Yun; Chau, Lillian; Friedman, Elliot S.; Lee, Jung-Jin; Adorini, Luciano; Erickson, Mary; Zaru, Luna; Shringarpure, Reshma; Macconell, Leigh; Bittinger, Kyle; Li, Hongzhe; Wu, Gary D. Share Save
The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice Wang, Xiaoxin X.; Xie, Cen; Libby, Andrew E.; Ranjit, Suman; Levi, Jonathan; Myakala, Komuraiah; Bhasin, Kanchan; Jones, Bryce A.; Orlicky, David J.; Takahashi, Shogo; Dvornikov, Alexander; Kleiner, David E.; Hewitt, Stephen M.; Adorini, Luciano; Kopp, Jeffrey B.; Krausz, Kristopher W.; Rosenberg, Avi; McManaman, James L.; Robertson, Charles E.; Ir, Diana; Frank, Daniel N.; Luo, Yuhuan; Gonzalez, Frank J.; Gratton, Enrico; Levi, Moshe Share Save
Farnesoid X receptor activation by the novel agonist TC-100 (3?, 7?, 11?-Trihydroxy-6?-ethyl-5?-cholan-24-oic Acid) preserves the intestinal barrier integrity and promotes intestinal microbial reshaping in a mouse model of obstructed bile acid flow Marzano, M.; Fosso, Bruno; Colliva, C.; Notario, E.; Passeri, D.; Intranuovo, M.; Gioiello, A.; Adorini, L.; Pesole, G.; Pellicciari, R.; Moschetta, A.; Gadaleta, R. M. Share Save
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Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia Pataia, Vanessa; McIlvride, Saraid; Papacleovoulou, Georgia; Ovadia, Caroline; McDonald, Julie A. K.; Wahlstrom, Annika; Jansen, Eugene; Adorini, Luciano; Shapiro, David; Marchesi, Julian R.; Marschall, Hanns-Ulrich; Williamson, Catherine Share Save
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Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development Mouries, Juliette; Brescia, Paola; Silvestri, Alessandra; Spadoni, Ilaria; Sorribas, Marcel; Wiest, Reiner; Mileti, Erika; Galbiati, Marianna; Invernizzi, Pietro; Adorini, Luciano; Penna, Giuseppe; Rescigno, Maria Share Save
Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH Roth, Jonathan D.; Veidal, Sanne S.; Fensholdt, Louise K. D.; Rigbolt, Kristoffer T. G.; Papazyan, Romeo; Nielsen, Jens Christian; Feigh, Michael; Vrang, Niels; Young, Mark; Jelsing, Jacob; Adorini, Luciano; Hansen, Henrik H. Share Save
INOS-mediated decrease of matrix metalloproteinase activity by obeticholic acid in hepatic ischemia/reperfusion Di Pasqua, L. G.; Palladini, G.; Berardo, C.; Siciliano, V.; Adorini, L.; Richelmi, P.; Cadamuro, M.; Fabris, L.; Perlini, S.; Vairetti, M.; Ferrigno, A. Share Save
Therapeutic effects of the selective farnesoid X receptor agonist obeticholic acid in a monocrotaline-induced pulmonary hypertension rat model Comeglio, P.; Filippi, S.; Sarchielli, E.; Morelli, A.; Cellai, I.; Corno, C.; Adorini, L.; Vannelli, G. B.; Maggi, M.; Vignozzi, L. Share Save
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