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D

Des R. Richardson

the university of sydney

101H-index
680Paper Count
4.2WCitation Count
Published Papers 231
Publication Date
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Implementing the design cues of dissociation dynamics and transmetalation in gallium(III) complexes to promote the anti-proliferative activity of ligands targeting intracellular iron(II) trafficking
errchem. sci.
IF0
err2026-02-10
err0
errOAAI
errMahendiran Dharmasivam †; Sadia Faiz †; Busra Kaya †; Tharushi P. Wijesinghe; Mediha Suleymanoglu; Mahan Gholam Azad; Vera Richardson; Ameer Fawad Zahoor; Danuta Kalinowski; William Lewis; Paul V. Bernhardt; Rukhsana Anjum; Des R. Richardson
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errSave
Artificial intelligence–assisted drug discovery in 2025: Faster, but is it better? The robots are coming, look out!
errPharmacological Reviews
IF17.3
err2025-12-02
err0
PREAI
errMahendiran Dharmasivam; Mahan Gholam Azad; Vera Richardson; Busra Kaya; Des R. Richardson
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errSave
Leading AI-Driven Drug Discovery Platforms: 2025 Landscape and Global Outlook
errPharmacological Reviews
IF17.3
err2025-11-10
err0
PREAI
errMahendiran Dharmasivam; Busra Kaya; Adedoyin Akinware; Mahan Gholam Azad; Des R. Richardson
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errSave
Thiosemicarbazones down-regulate N-Myc expression in neuroblastoma cells via transcriptional and post-transcriptional mechanisms
errPharmacological Research
IF10.5
err2025-09-19
err0
errOAAI
errZhao Deng; Mahan Gholam Azad; Des R. Richardson
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errSave
Metal-based Antibody, Nanobody, and Peptide Conjugates: Potential for Breast Cancer Therapy
errPharmacological Reviews
IF17.3
err2025-08-18
err0
PREAI
errBusra Kaya; Devina Laurencia; Maseeha Farha Ayoub; Mahan Gholam Azad; Mahendiran Dharmasivam; Des R. Richardson
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errSave
Advantages of Novel Anti-cancer Selenosemicarbazones: Preferential Reactivity of Their Fe(III), Cu(II), and Zn(II) Complexes with Key Physiological Reductants/Ligands Versus Isosteric Thiosemicarbazones
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-04-23
err1
PREAI
errDharmasivam, Mahendiran; Zhang, Stanley; Zhao, Xiao; Richardson, Vera; Wijesinghe, Tharushi P.; Suleymanoglu, Mediha; Azad, Mahan Gholam; Bernhardt, Paul V.; Kaya, Busra; Richardson, Des R.
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errSave
Structure-Activity Relationships of Novel Selenosemicarbazones: Potent Anti-Tumor Activity with Reduced Off-Target Effects
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-03-01
err0
PREAI
errDharmasivam, Mahendiran; Zhang, Stanley; Richardson, Des
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errSave
Innovative N-Acridine Thiosemicarbazones and Their Zn(II) Complexes Transmetallate with Cu(II): Redox Activity and Suppression of Detrimental Oxy-Myoglobin Oxidation
errINORGANIC CHEMISTRY
IF4.7
err2024-10-15
err1
PREAI
errKaya, Busra; Smith, Henry; Chen, Yanbing; Azad, Mahan Gholam; Russell, Tiffany M.; Richardson, Vera; Dharmasivam, Mahendiran; Richardson, Des R.
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errSave
Isosteric Replacement of Sulfur to Selenium in a Thiosemicarbazone: Promotion of Zn(II) Complex Dissociation and Transmetalation to Augment Anticancer Efficacy
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-07-05
err5
PREAI
errKaya, Busra; Gholam Azad, Mahan; Suleymanoglu, Mediha; Harmer, Jeffrey R.; Wijesinghe, Tharushi P.; Richardson, Vera; Zhao, Xiao; Bernhardt, Paul V.; Dharmasivam, Mahendiran; Richardson, Des R.
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errSave
Multi-modal mechanisms of the metastasis suppressor NDRG1: Inhibition of WNT/b-catenin signaling by stabilization of protein kinase Cα
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-07-01
err0
errOAAI
errAzad, Mahan Gholam; Hussaini, Mohammed; Russell, Tiffany M.; Richardson, Vera; Kaya, Busra; Dharmasivam, Mahendiran; Richardson, Des R.
errShare
errSave
Steric Blockade of Oxy-Myoglobin Oxidation by Thiosemicarbazones: Structure-Activity Relationships of the Novel PPP4pT Series (Vol 66, pg 15453, 2023)
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-04-10
err0
errOAAI
errWijesinghe, Tharushi P.; Kaya, Busra; Gonzalvez, Miguel A.; Harmer, Jeffrey R.; Gholam Azad, Mahan; Bernhardt, Paul V.; Dharmasivam, Mahendiran; Richardson, Des R.
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errSave
Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration
errMOLECULAR PHARMACOLOGY
IF3
err2024-02-01
err12
errOAAI
errRichardson, Miriam; Richardson, Des R.
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errSave
Targeting lysosomes by design: novel N-acridine thiosemicarbazones that enable direct detection of intracellular drug localization and overcome P-glycoprotein (Pgp)-mediated resistance
errCHEMICAL SCIENCE
IF7.4
err2024-01-01
err2
errOAAI
errKaya, Busra; Smith, Henry; Chen, Yanbing; Azad, Mahan Gholam; Russell, Tiffany M.; Richardson, Vera; Bernhardt, Paul V.; Dharmasivam, Mahendiran; Richardson, Des R.
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errSave
Differential transmetallation of complexes of the anti-cancer thiosemicarbazone, Dp4e4mT: effects on anti-proliferative efficacy, redox activity, oxy-myoglobin and oxy-hemoglobin oxidation
errCHEMICAL SCIENCE
IF7.4
err2024-01-01
err10
errOAAI
errDharmasivam, Mahendiran; Kaya, Busra; Wijesinghe, Tharushi P.; Richardson, Vera; Harmer, Jeffrey R.; Gonzalvez, Miguel A.; Lewis, William; Azad, Mahan Gholam; Bernhardt, Paul V.; Richardson, Des R.
errShare
errSave
Steric Blockade of Oxy-Myoglobin Oxidation by Thiosemicarbazones: Structure-Activity Relationships of the Novel PPP4pT Series
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-11-03
err7
PREAI
errWijesinghe, Tharushi P.; Kaya, Busra; Gonzalvez, Miguel A.; Harmer, Jeffrey R.; Gholam Azad, Mahan; Bernhardt, Paul V.; Dharmasivam, Mahendiran; Richardson, Des R.
errShare
errSave
The Myc Family and the Metastasis Suppressor NDRG1 Targeting Key Molecular Interactions with Innovative Therapeutics
errPHARMACOLOGICAL REVIEWS
IF17.3
err2023-09-01
err8
errOAAI
errDeng, Zhao; Richardson, Des R.
errShare
errSave
Potassium Channels in Parkinson's Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment
errPHARMACOLOGICAL REVIEWS
IF17.3
err2023-07-01
err16
errOAAI
errChen, Xiaoyi; Feng, Yunjiang; Quinn, Ronald J.; Pountney, Dean L.; Richardson, Des R.; Mellick, George D.; Ma, Linlin
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errSave
Innovative thiosemicarbazones that induce multi-modal mechanisms to down-regulate estrogen-, progesterone-, androgen- and prolactin-receptors in breast cancer
errPHARMACOLOGICAL RESEARCH
IF10.5
err2023-07-01
err7
errOAAI
errShehadeh-Tout, Faten; Milioli, Heloisa H.; Roslan, Suraya; Jansson, Patric J.; Dharmasivam, Mahendiran; Graham, Dinny; Anderson, Robin; Wijesinghe, Tharushi; Azad, Mahan Gholam; Richardson, Des R.; Kovacevic, Zaklina
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errSave
Designing Tailored Thiosemicarbazones with Bespoke Properties: The Styrene Moiety Imparts Potent and Selective Anti-Tumor Activity
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2023-06-01
err0
errOAAI
errRichardson, Des; Dharmasivam, Mahendiran; Kaya, Busra
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errSave
The role of the NDRG1 in the pathogenesis and treatment of breast cancer
errBIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
IF8.3
err2023-05-01
err11
errOAAI
errZhao, Xiao; Richardson, Des R.
errShare
errSave

Research Directions

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Co-authors
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