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C

Caroline A. Heckman

helsinki institute of life science

42H-index
442Paper Count
7.4KCitation Count
Published Papers 121
Publication Date
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A myeloid-dormant metabolic transcriptome identifies a poor-prognosis subgroup in hyperdiploid multiple myeloma with targetable vulnerabilities
errBlood Cancer Journal
IF11.6
err2026-08-11
err0
errOAAI
errNaroa Barrena; Edurne San José-Enériz; Luis V. Valcárcel; Danel Olaverri-Mendizabal; Estibaliz Urizar-Compains; Leire Garate; Estíbaliz Miranda; Paula Rodriguez-Marquez; Romika Kumari; Patxi San Martín-Uriz; Juan Roberto Rodriguez-Madoz; Leonor Puchades-Carrasco; Caroline A. Heckman; Paula Rodriguez-Otero; Francisco J. Planes; Xabier Agirre; Felipe Prósper
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Distinct stem cell identities converge into shared erythroid stress in ERCC6L2 disease and Shwachman–Diamond syndrome
errHemaSphere
IF14.6
err2026-06-16
err0
errOAAI
errLaura Langohr; Ilse Kaaja; Suvi P. M. Douglas; Hanna Nebelung; Jessica Koski; Ina Ikonen; Lotta Katainen; Katri Maljanen; Marja Hakkarainen; Tuulia Räisänen; Riitta Niinimäki; Sakari Kakko; Timo Siitonen; Sadiksha Adhikari; Markus Vähä-Koskela; Caroline A. Heckman; Jenni Lahtela; Ulla Wartiovaara-Kautto; Esa Pitkänen; Outi Kilpivaara
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Solubility based mechanistic profiling of combinatorial drug therapy
errNature Communications
IF15.7
err2026-03-25
err0
errOAAI
errElham Gholizadeh; Ehsan Zangene; Uladzislau Vadadokhau; Danilo Ritz; Juho J. Miettinen; Rabah Soliymani; Marc Baumann; Mathias Wilhelm; Esko Kankuri; Paul A. Haynes; Caroline A. Heckman; Amir A. Saei; Mohieddin Jafari
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Succinate receptor 1 restricts hematopoiesis and prevents acute myeloid leukemia progression
errNature Communications
IF15.7
err2026-02-05
err0
errOAAI
errVincent Cuminetti; Emeline Boet; Marcel Heugel; Joanna Konieczny; Aurora Bernal; Manuel J. Gomez; Franco Grimolizzi; Nuria Vilaplana-Lopera; Marc Ferré; Alicia Villatoro; Deo P. Pandey; Carlos Torroja; Hagar Taman; Ruth H. Paulssen; Thomas Vogl; Caroline A. Heckman; Anders Vik; Giovanna Giovinazzo; Nick van Gastel; Paloma García; Fátima Sánchez-Cabo; Jean-Emmanuel Sarry; Lorena Arranz
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Drivers of clinical resistance to venetoclax and hypomethylating agents in acute myeloid leukemia and strategies for improving efficacy
errHemaSphere
IF14.6
err2026-01-11
err0
errOAAI
errIda Vänttinen; Joseph Saad; Tanja Ruokoranta; Sari Kytölä; Guangrong Qin; Bahar Tercan; Pia Ettala; Anu Partanen; Marja Pyörälä; Johanna Rimpiläinen; Timo Siitonen; Mikko Manninen; Peter J. M. Valk; Gerwin Huls; Vésteinn Thorsson; Caroline A. Heckman; Mika Kontro; Heikki Kuusanmäki
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Efficacy of melflufen in multiple myeloma with mutated or deleted TP53
errExperimental Hematology & Oncology
IF13.5
err2025-12-23
err0
errOAAI
errKlara Acs; Juho J. Miettinen; Philipp Sergeev; Tobias Heckel; Yumei Diao; Kristina Witt-Mulder; Marcus Thureson; Thorsten Bischler; Maiju-Emilia Huppunen; Minna Suvela; Jakob Obermüller; Umair Munawar; Ana Slipicevic; Ralf C. Bargou; Fredrik Lehmann; Stefan Svensson Gelius; Stefan Norin; Fredrik Schjesvold; Pieter Sonneveld; Thorsten Stühmer; Caroline A. Heckman
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Whole Exome Sequencing and Single-Cell DNA Sequencing for Assessment of Clonal Heterogeneity and Evolution in Acute Myeloid Leukemia
errComputational and Structural Biotechnology Journal
IF4.1
err2025-12-02
err0
errOAAI
errSadiksha Adhikari; Samuli Eldfors; Esa Pitkänen; Markus Vähä-Koskela; Caroline A. Heckman
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errSave
Targeting acute myeloid leukemia resistance with two novel combinations demonstrate superior efficacy in TP53, HLA-B, MUC4 and FLT3 mutations
errBiomedicine & Pharmacotherapy
IF7.5
err2025-10-13
err0
errOAAI
errElham Gholizadeh; Ehsan Zangene; Alun Parsons; Mika Kontro; Caroline A. Heckman; Mohieddin Jafari
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errSave
Digital twin models for predicting venetoclax and azacitidine-induced neutropenia in patients with acute myeloid leukemia
errnpj Digital Medicine
IF15.1
err2025-10-06
err0
errOAAI
errYue Zhang; Jonathan Martinez; Bahar Tercan; Heikki Kuusanmäki; Frank Emmert-Streib; Jerome G. Chandraseelan; Amer Farea; Olli Yli-Harja; Caroline A. Heckman; David L. Gibbs; Vesteinn Thorsson; Ilya Shmulevich; Mika Kontro; Guangrong Qin; Boris Aguilar
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errSave
Predictors of response and rational combinations for the novel MCL-1 inhibitor MIK665 in acute myeloid leukemia
errMOLECULAR ONCOLOGY
IF4.5
err2025-09-01
err1
errOAAI
errSaad, Joseph; Newman, Rhiannon; Khabusheva, Elmira; Aakko, Sofia; Durand, Eric; Tambe, Mahesh; Kuusanmaki, Heikki; Parsons, Alun; Miettinen, Juho J.; Javarappa, Komal Kumar; Olgac, Ezgi June; Ikonen, Nemo; Kontro, Mika; Porkka, Kimmo; Maacke, Heiko; Woo, Janghee; Halilovic, Ensar; Heckman, Caroline A.
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CLEVER-1 targeting antibody, bexmarilimab, supports HLA-DR expression and alters ex vivo responsiveness to azacitidine and venetoclax in myeloid malignancies
errSCIENTIFIC REPORTS
IF3.9
err2025-05-14
err0
errOAAI
errAakko, Sofia; Ylitalo, Arno; Kuusanmaki, Heikki; Rannikko, Jenna H.; Bjorkman, Mari; Mandelin, Jami; Heckman, Caroline A.; Kontro, Mika; Hollmen, Maija
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Integrative Analysis of Transcriptomic and Proteomic Data Identifies Patterns of Primary Resistance to Venetoclax-Azacitidine and Reveals Targetable Vulnerabilities in Acute Myeloid Leukemia (AML)
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errVanttinen, Ida; Saad, Joseph; Ruokoranta, Tanja; Kytola, Sari; Ettala, Pia-Sofia; Pyorala, Marja; Rimpilainen, Johanna; Siitonen, Timo; Heckman, Caroline A.; Kuusanmaki, Heikki; Kontro, Mika
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Investigating the Role of Neutrophil Extracellular Traps (NETs) in Multiple Myeloma Pathogenesis and Disease Evolution
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errDowling, Paul; Dunphy, Katie; Bazou, Despina; Miettinen, Juho J.; Heckman, Caroline A.; O'Gorman, Peter
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Distinct molecular profiles and shared drug vulnerabilities in pancreatic metastases of renal cell carcinoma
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-10-20
err0
errOAAI
errRoos-Mattila, Matilda; Kallio, Pauliina; Luck, Tamara J.; Polso, Minttu; Kumari, Romika; Mikkonen, Piia; Valimaki, Katja; Malmstedt, Minna; Ellonen, Pekka; Pellinen, Teijo; Heckman, Caroline A.; Mustonen, Harri; Puolakkainen, Pauli A.; Alitalo, Kari; Kallioniemi, Olli; Mirtti, Tuomas; Rannikko, Antti S.; Pietiainen, Vilja M.; Seppanen, Hanna E.
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Venetoclax triggers sublethal apoptotic signaling in venetoclax-resistant acute myeloid leukemia cells and induces vulnerability to PARP inhibition and azacitidine
errCELL DEATH & DISEASE
IF9.6
err2024-10-16
err0
errOAAI
errTambe, Mahesh; Unterberger, Sarah; Kriegbaum, Mette C.; Vanttinen, Ida; Olgac, Ezgi June; Vaha-Koskela, Markus; Kontro, Mika; Wennerberg, Krister; Heckman, Caroline A.
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Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones
errNATURE COMMUNICATIONS
IF15.7
err2024-10-03
err0
errOAAI
errIanevski, Aleksandr; Nader, Kristen; Driva, Kyriaki; Senkowski, Wojciech; Bulanova, Daria; Moyano-Galceran, Lidia; Ruokoranta, Tanja; Kuusanmaki, Heikki; Ikonen, Nemo; Sergeev, Philipp; Vaha-Koskela, Markus; Giri, Anil K.; Vaharautio, Anna; Kontro, Mika; Porkka, Kimmo; Pitkanen, Esa; Heckman, Caroline A.; Wennerberg, Krister; Aittokallio, Tero
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Genetic and functional analysis of Raynaud's syndrome implicates loci in vasculature and immunity
errCELL GENOMICS
IF9
err2024-09-01
err0
errOAAI
errTervi, Anniina; Ramste, Markus; Abner, Erik; Cheng, Paul; Lane, Jacqueline M.; Maher, Matthew; Valliere, Jesse; Lammi, Vilma; Strausz, Satu; Riikonen, Juha; Nguyen, Trieu; Martyn, Gabriella E.; Sheth, Maya U.; Xia, Fan; Docampo, Mauro Lago; Gu, Wenduo; Esko, Tonu; Saxena, Richa; Pirinen, Matti; Palotie, Aarno; Ripatti, Samuli; Sinnott-Armstrong, Nasa; Daly, Mark; Engreitz, Jesse M.; Rabinovitch, Marlene; Heckman, Caroline A.; Quertermous, Thomas; Jones, Samuel E.; Ollila, Hanna M.
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Targeting CD33+ Acute Myeloid Leukemia with GLK-33, a Lintuzumab-Auristatin Conjugate with a Wide Therapeutic Window
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2024-04-01
err1
PREAI
errSatomaa, Tero; Pynnoenen, Henna; Aitio, Olli; Hiltunen, Jukka O.; Pitkanen, Virve; Laehteenmaeki, Tuula; Kotiranta, Titta; Heiskanen, Annamari; Haenninen, Anna-Liisa; Niemela, Ritva; Helin, Jari; Kuusanmaki, Heikki; Vanttinen, Ida; Rathod, Ramji; Nieminen, Anni I.; Yatkin, Emrah; Heckman, Caroline A.; Kontro, Mika; Saarinen, Juhani
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Monosomy 7/del(7q) cause sensitivity to inhibitors of nicotinamide phosphoribosyltransferase in acute myeloid leukemia
errBLOOD ADVANCES
IF7.1
err2024-03-27
err0
errOAAI
errEldfors, Samuli; Saad, Joseph; Ikonen, Nemo; Malani, Disha; Vaha-Koskela, Markus; Gjertsen, Bjorn T.; Kontro, Mika; Porkka, Kimmo; Heckman, Caroline A.
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Label-free high dimensional single cell morphological profiling of different hematological malignancies by ghost cytometry
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errTsubouchi, Asako; Miettinen, Juho J.; Wagatsuma, Keisuke; Akai, Satoru; An, Yuri; Uematsu, Mika; Sergeev, Philipp; Tsallos, Dimitrios; Vaha-Koskela, Markus J.; Ota, Sadao; Heckman, Caroline A.
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Kari Alitalo
H-index: 187 · Papers: 1.1K
M
Michael R. Stratton
H-index: 179 · Papers: 644
A
Aarno Palotie
H-index: 171 · Papers: 1.2K
T
Tōnu Esko
H-index: 165 · Papers: 826
P
P. Andrew Futreal
H-index: 159 · Papers: 1.3K
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