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Matthew D. Hirschey

duke university

53H-index
151Paper Count
1.8WCitation Count
Published Papers 69
Publication Date
Caenorhabditis elegans fed native gut microbiota have altered bioenergetic pathway utilization impacting mitochondrial function and susceptibility to pollutants
err2026-03-13
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errChristina Bergemann; Laura Jameson; Isabel Kenny-Ganzert; Javier Huayta; Pol Castellano-Escuder; Arunabh Sarkar; Olga Ilkayeva; David Sherwood; matthew Hirschey; Joel Meyer
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In vivo imaging of metabolic heterogeneity across three endpoints relevant to aggressive breast cancer
err2026-02-10
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errVictoria W D’Agostino; Michelle Kwan; Adelle Yong; Kira Grossman; Enakshi D Sunassee; Megan C Madonna; Matthew Hirschey; Gregory M Palmer; Nirmala Ramanujam
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Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia
err2025-12-05
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errAmy E. Stewart; Derek K. Zachman; Pol Castellano-Escuder; Lois M. Kelly; Ben Zolyomi; Michael D. I. Aiduk; Christopher D. Delaney; Ian C. Lock; Claudie Bosc; John Bradley; Shane T. Killarney; J. Darren Stuart; Paul A. Grimsrud; Olga R. Ilkayeva; Christopher B. Newgard; Navdeep S. Chandel; Alexandre Puissant; Kris C. Wood; Matthew D. Hirschey
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Targeting androgen receptor signaling to enhance cancer immunotherapy
err2025-12-03
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errDavid A. Bader; Binita Chakraborty; Donald P. McDonnell; Matthew D. Hirschey
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Fatty acid desaturases link cell metabolism pathways to promote proliferation of Epstein-Barr virus-infected B cells
err2025-05-22
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errBonglack, Emmanuela N.; Hill, Kaeden K.; Barry, Ashley P.; Bartlett, Alexandria; Castellano-Escuder, Pol; Hirschey, Matthew D.; Luftig, Micah A.
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Optical imaging reveals chemotherapy-induced metabolic reprogramming of residual disease and recurrence
err2024-04-05
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errSunassee, Enakshi D.; Deutsch, Riley J.; D'Agostino, Victoria W.; Castellano-Escuder, Pol; Siebeneck, Elizabeth A.; Ilkayeva, Olga; Crouch, Brian T.; Madonna, Megan C.; Everitt, Jeffrey; Alvarez, James V.; Palmer, Gregory M.; Hirschey, Matthew D.; Ramanujam, Nirmala
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NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease
err2023-08-01
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errMyakala, Komuraiah; Wang, Xiaoxin X.; Shults, Nataliia, V; Krawczyk, Ewa; Jones, Bryce A.; Yang, Xiaoping; Rosenberg, Avi Z.; Ginley, Brandon; Sarder, Pinaki; Brodsky, Leonid; Jang, Yura; Na, Chan Hyun; Qi, Yue; Zhang, Xu; Guha, Udayan; Wu, Ci; Bansal, Shivani; Ma, Junfeng; Cheema, Amrita; Albanese, Chris; Hirschey, Matthew D.; Yoshida, Teruhiko; Kopp, Jeffrey B.; Panov, Julia; Levi, Moshe
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Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
err2023-03-27
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errLombard, David B.; Alt, Frederick W.; Cheng, Hwei-Ling; Bunkenborg, Jakob; Streeper, Ryan S.; Mostoslavsky, Raul; Kim, Jennifer; Yancopoulos, George; Valenzuela, David; Murphy, Andrew; Yang, Yinhua; Chen, Yaohui; Hirschey, Matthew D.; Bronson, Roderick T.; Haigis, Marcia; Guarente, Leonard P.; Farese, Robert V., Jr.; Weissman, Sherman; Verdin, Eric; Schwer, Bjoern
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Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control
err2023-03-03
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errMills, Christine A.; Wang, Xianxi; Bhatt, Dhaval P.; Grimsrud, Paul A.; Matson, Jacob Peter; Lahiri, Debojyoti; Burke, Daniel J.; Cook, Jeanette Gowen; Hirschey, Matthew D.; Emanuele, Michael J.
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In vivo metabolic imaging identifies lipid vulnerability in a preclinical model of Her2+/Neu breast cancer residual disease and recurrence
err2022-09-26
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errMadonna, Megan C.; Duer, Joy E.; McKinney, Brock J.; Sunassee, Enakshi D.; Crouch, Brian T.; Ilkayeva, Olga; Hirschey, Matthew D.; Alvarez, James, V; Ramanujam, Nirmala
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Statin therapy inhibits fatty acid synthase via dynamic protein modifications
err2022-05-10
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errTrub, Alec G.; Wagner, Gregory R.; Anderson, Kristin A.; Crown, Scott B.; Zhang, Guo-Fang; Thompson, J. Will; Ilkayeva, Olga R.; Stevens, Robert D.; Grimsrud, Paul A.; Kulkarni, Rhushikesh A.; Backos, Donald S.; Meier, Jordan L.; Hirschey, Matthew D.
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Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice
err2022-04-01
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errBhatt, Dhaval P.; Mills, C. Allie; Anderson, Kristin A.; Henriques, Barbara J.; Lucas, Tania G.; Francisco, Sara; Liu, Juan; Ilkayeva, Olga R.; Adams, Alexander E.; Kulkarni, Shreyas R.; Backos, Donald S.; Major, Michael B.; Grimsrud, Paul A.; Gomes, Claudio M.; Hirschey, Matthew D.
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Discovering the landscape of protein modifications
err2021-05-01
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errKeenan, Keith E.; Zachman, Derek K.; Hirschey, Matthew D.
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A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism
err2021-01-01
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errEnriquez-Hesles, Elisa; Smith, Daniel L., Jr.; Maqani, Nazif; Wierman, Margaret B.; Sutcliffe, Matthew D.; Fine, Ryan D.; Kalita, Agata; Santos, Sean M.; Muehlbauer, Michael J.; Bain, James R.; Janes, Kevin A.; Hartman, John L.; Hirschey, Matthew D.; Smith, Jeffrey S.
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Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone
err2021-01-01
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errGonzalez-Hunt, Claudia P.; Luz, Anthony L.; Ryde, Ian T.; Turner, Elena A.; Ilkayeva, Olga R.; Bhatt, Dhaval P.; Hirschey, Matthew D.; Meyer, Joel N.
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NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism
err2020-04-20
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errFox, Douglas B.; Garcia, Nina Marie G.; McKinney, Brock J.; Lupo, Ryan; Noteware, Laura C.; Newcomb, Rachel; Liu, Juan; Locasale, Jason W.; Hirschey, Matthew D.; Alvarez, James V.
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Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease
err2019-12-10
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errAssiri, Mohammed A.; Ali, Hadi R.; Marentette, John O.; Yun, Youngho; Liu, Juan; Hirschey, Matthew D.; Saba, Laura M.; Harris, Peter S.; Fritz, Kristofer S.
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SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα
err2019-12-01
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errNaiman, Shoshana; Huynh, Frank K.; Gil, Reuven; Glick, Yair; Shahar, Yael; Touitou, Noga; Nahum, Liat; Avivi, Matan Y.; Roichman, Asael; Kanfi, Yariv; Gertler, Asaf A.; Doniger, Tirza; Ilkayeva, Olga R.; Abramovich, Ifat; Yaron, Orly; Lerrer, Batia; Gottlieb, Eyal; Harris, Robert A.; Gerber, Doron; Hirschey, Matthew D.; Cohen, Haim Y.
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Cellular energetics and mitochondrial uncoupling in canine aging
err2019-04-01
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errNicholatos, Justin W.; Robinette, Timothy M.; Tata, Saurabh V. P.; Yordy, Jennifer D.; Francisco, Adam B.; Platov, Michael; Yeh, Tiffany K.; Ilkayeva, Olga R.; Huynh, Frank K.; Dokukin, Maxim; Volkov, Dmytro; Weinstein, Michael A.; Boyko, Adam R.; Miller, Richard A.; Sokolov, Igor; Hirschey, Matthew D.; Libert, Sergiy
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Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism
err2019-01-15
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errAli, Hadi R.; Assiri, Mohammed A.; Harris, Peter S.; Michel, Cole R.; Yun, Youngho; Marentette, John O.; Huynh, Frank K.; Orlicky, David J.; Shearn, Colin T.; Saba, Laura M.; Reisdorph, Richard; Reisdorph, Nichole; Hirschey, Matthew D.; Fritz, Kristofer S.
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