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An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns Deal, Milena; Kar, Asha; Lee, Seung Hyuk T.; Alvarez, Marcus; Rajkumar, Sandhya; Arasu, Uma Thanigai; Kaminska, Dorota; Mannisto, Ville; Heinonen, Sini; van der Kolk, Birgitta W.; Sailakivi, Ulla; Saarinen, Tuure; Juuti, Anne; Pihlajamaki, Jussi; Kaikkonen, Minna U.; Laakso, Markku; Pietilainen, Kirsi H.; Pajukanta, Paivi Share Save
Modification in mitochondrial function is associated with the FADS1 variant and its interaction with alpha-linolenic acid-enriched diet-An exploratory study Vaittinen, Maija; Ilha, Mariana; Sehgal, Ratika; Lankinen, Maria A.; Agren, Jyrki; Kakela, Pirjo; Virtanen, Kirsi A.; Laakso, Markku; Schwab, Ursula; Pihlajamaki, Jussi Share Save
Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes Wu, Ying-Chieh; Lehtonen, Sarka; Trontti, Kalevi; Kauppinen, Riitta; Kettunen, Pinja; Leinonen, Ville; Laakso, Markku; Kuusisto, Johanna; Hiltunen, Mikko; Hovatta, Iiris; Freude, Kristine; Dhungana, Hiramani; Koistinaho, Jari; Rolova, Taisia Share Save
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Single nucleus RNA-sequencing integrated into risk variant Lee, Seung Hyuk T.; Garske, Kristina M.; Arasu, Uma Thanigai; Kar, Asha; Miao, Zong; Alvarez, Marcus; Koka, Amogha; Darci-Maher, Nicholas; Benhammou, Jihane N.; Pan, David Z.; Ord, Tiit; Kaminska, Dorota; Mannisto, Ville; Heinonen, Sini; Wabitsch, Martin; Laakso, Markku; Agopian, Vatche G.; Pisegna, Joseph R.; Pietilainen, Kirsi H.; Pihlajamaki, Jussi; Kaikkonen, Minna U.; Pajukanta, Paeivi Share Save
Effects of Genetic Risk on Incident Type 2 Diabetes and Glycemia: The T2D-GENE Lifestyle Intervention Trial Lankinen, Maria Anneli; Nuotio, Petrus; Kauppinen, Susanna; Koivu, Noora; Tolonen, Ulla; Malkki-Keinanen, Katriina; Oravilahti, Anniina; Kuulasmaa, Teemu; Uusitupa, Matti; Schwab, Ursula; Laakso, Markku Share Save
ADA Presidents' Select Abstract: Discovering Stimulatory State-Specific Type 2 Diabetes GWAS Mechanisms with Single-Cell Multiomics on iPSC-Derived Fibro-adipogenic Progenitor Cell Villages Ventresca, Christa; Varshney, Arushi; Orchard, Peter; Tsan, Yao-Chang; Da Rocha, Andre Monteiro; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Scott, Laura; Koistinen, Heikki A.; Collins, Francis S.; Herron, Todd J.; Bielas, Stephanie; Parker, Stephen Share Save
Type 2 Diabetes GWAS Signal C2CD4A/B Insulin Resistance Mechanisms in Skeletal Muscle Epelle, Ibiere L.; Varshney, Arushi; Orchard, Peter; Zhang, Zhenhao; Feng, Fan; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Scott, Laura; Koistinen, Heikki A.; Collins, Francis S.; Liu, Jie; Parker, Stephen C. Share Save
Population-Scale Single-Nucleus Skeletal Muscle Chromatin Dynamics and Nucleosome Positioning in the Context of Type 2 Diabetes Wang, Xiaoou; Robertson, Cassie; Varshney, Arushi; Manickam, Nandini; Orchard, Peter; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Scott, Laura; Koistinen, Heikki A.; Collins, Francis S.; Parker, Stephen Share Save
Differential Cell-Type-Specific Gene Expression and Chromatin Accessibility by Type 2 Diabetes Status and Physical Activity Levels in Human Skeletal Muscle Ciotlos, Dan; Hanks, Sarah; Varshney, Arushi; Erdos, Michael; Manickam, Nandini; Stringham, Heather M.; Hill-Burns, Erin; Orchard, Peter; Narisu, Narisu; Bonnycastle, Lori L.; Sweeney, Michael D.; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Koistinen, Heikki A.; Collins, Francis S.; Parker, Stephen; Scott, Laura Share Save
Deep Learning Enhances Chromatin Accessibility Signals and Discovers Links with Genetic Variations in Skeletal Muscle Rare Cells Vu, Ha T. H.; Varshney, Arushi; Orchard, Peter; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Scott, Laura; Koistinen, Heikki A.; Collins, Francis S.; Parker, Stephen C. Share Save
Population-Scale Skeletal Muscle Single-Nucleus Multiomic Profiling Reveals Extensive Context-Specific Genetic Regulation Varshney, Arushi; Manickam, Nandini; Orchard, Peter; Tovar, Adelaide; Zhang, Zhenhao; Feng, Fan; Lakka, Timo A.; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Mohlke, Karen L.; Kitzman, Jacob; Koistinen, Heikki A.; Liu, Jie; Boehnke, Michael; Collins, Francis S.; Scott, Laura; Parker, Stephen C. Share Save
Widespread Age-Associated Changes in the Chromatin Architecture of Skeletal Muscle Cell Types Moo, Keagan G.; Albanus, Ricardo D'Oliveira; Varshney, Arushi; Orchard, Peter; Manickam, Nandini; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Scott, Laura; Koistinen, Heikki A.; Collins, Francis S.; Parker, Stephen Share Save
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