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The metalloproteinase ADAM10 sheds angiotensin-converting enzyme (ACE) from the pulmonary endothelium as a soluble, functionally active convertase Webers, Maria; Yu, Yan; Eyll, Johanna; Vanderliek-Kox, Julia; Schun, Katharina; Michely, Anna; Schumertl, Tim; Garbers, Christoph; Dietrich, Jana; Jonigk, Danny D.; Krueger, Ingo; Kuehnel, Mark P.; Martin, Christian; Ludwig, Andreas; Duesterhoeft, Stefan Share Save
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Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity Blaesius, Katharina; Ludwig, Lena; Knapp, Sarah; Flasshove, Charlotte; Sonnabend, Friederike; Keller, Diandra; Tacken, Nikola; Gao, Xintong; Kahveci-Tuerkoez, Selcan; Grannemann, Caroline; Babendreyer, Aaron; Adrain, Colin; Huth, Sebastian; Baron, Jens Malte; Ludwig, Andreas; Duesterhoeft, Stefan Share Save
Gene-expression profiling of laser-dissected islets and studies in deficient mice reveal chemokines as differential driving force of type 1 diabetes Bender, Christine; Mueller, Peter; Tondello, Camilla; Horn, Jessica; Holdener, Martin; Lasch, Stanley; Bayer, Monika; Pfeilschifter, Josef M.; Tacke, Frank; Ludwig, Andreas; Hansmann, Martin -Leo; Doring, Claudia; Hintermann, Edith; Christen, Urs Share Save
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Mechanical activation of lung epithelial cells through the ion channel Piezo1 activates the metalloproteinases ADAM10 and ADAM17 and promotes growth factor and adhesion molecule release Grannemann, Caroline; Pabst, Alessa; Honert, Annika; Schieren, Jana; Martin, Christian; Hank, Sophia; Boell, Svenja; Blaesius, Katharina; Duesterhoeft, Stefan; Jahr, Holger; Merkel, Rudolf; Leube, Rudolf; Babendreyer, Aaron; Ludwig, Andreas Share Save
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A structural model of the iRhom-ADAM17 sheddase complex reveals functional insights into its trafficking and activity Kahveci-Tuerkoez, Selcan; Blaesius, Katharina; Wozniak, Justyna; Rinkens, Cindy; Seifert, Anke; Kasparek, Petr; Ohm, Henrike; Oltzen, Shixin; Nieszporek, Martin; Schwarz, Nicole; Babendreyer, Aaron; Preisinger, Christian; Sedlacek, Radislav; Ludwig, Andreas; Duesterhoeft, Stefan Share Save
Bioprinting-associated pulsatile hydrostatic pressure elicits a mild proinflammatory response in epi- and endothelial cells Nasehi, Ramin; Schieren, Jana; Grannemann, Caroline; Palkowitz, Alena L.; Babendreyer, Aaron; Schwarz, Nicole; Aveic, Sanja; Ludwig, Andreas; Leube, Rudolf E.; Fischer, Horst Share Save
L1 is sequentially processed by two differently activated metalloproteases and presenilin/γ-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth Maretzky, T; Schulte, M; Ludwig, A; Rose-John, S; Blobel, C; Hartmann, D; Altevogt, P; Saftig, P; Reiss, K Share Save
RETRACTED: Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum (Retracted article. See vol. 31, pg. 1330, 2011) Budagian, V; Bulanova, E; Orinska, Z; Duitman, E; Brandt, K; Ludwig, A; Hartmann, D; Lemke, G; Saftig, P; Bulfone-Paus, S Share Save
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Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis Xiao, Wenyuan; Pinilla-Baquero, Alejandro; Faulkner, John; Song, Xuehong; Prabhakar, Pradeep; Qiu, Hong; Moremen, Kelley W.; Ludwig, Andreas; Dempsey, Peter J.; Azadi, Parastoo; Wang, Lianchun Share Save
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Stretchable electrical cell-substrate impedance sensor platform for monitoring cell monolayers under strain Zhou, Chen; Bette, Sebastian; Babendreyer, Aaron; Hoffmann, Christina; Gerlach, Sven; Kremers, Tom; Ludwig, Andreas; Hoffmann, Bernd; Merkel, Rudolf; Uhlig, Stefan; Schnakenberg, Uwe Share Save
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The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release Dusterhoft, Stefan; Kahveci-Tuerkoez, Selcan; Wozniak, Justyna; Seifert, Anke; Kasparek, Petr; Ohm, Henrike; Liu, Shixin; Kopkanova, Jana; Lokau, Juliane; Garbers, Christoph; Preisinger, Christian; Sedlacek, Radislav; Freeman, Matthew; Ludwig, Andreas Share Save
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