J. Nicholas Cochran - Publications, H-index & Citations

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J. Nicholas Cochran

hudsonalpha institute for biotechnology

24H-index

107Paper Count

2.2KCitation Count

Published Papers 24

Publication Date

Blood-based AT(N) biomarkers for Alzheimer’s disease and frontotemporal lobar degeneration in Latin America

Nature Aging

IF19.4

2026-02-13

PREAI

Ariel Caviedes; Felipe Cabral-Miranda; Paulina Orellana; Hernán Hernández; Fernando Henríquez; Raul Gonzalez-Gomez; Matias Pizarro; Joaquin Migeot; Carolina Ochoa-Rosales; Carolina Gonzalez-Silva; Nickole Marin-Diaz; Carlos Coronel-Oliveros; Hernando Santamaría-García; Danilo Carmona; Adolfo M. García; Andrea Slachevsky; Andrew Singleton; Andy Yue Qi; Brian Lawlor; Bruce Miller; Catherine Dhooge; Caroline Pantazis; Chinedu T. Udeh-Momoh; David Aguillón; Diana L. Matallana; Eduardo R. Zimmer; Elisa de Paula França Resende; Francesca R. Farina; Francisca Cabello; Francisco Lopera; Henrik Zetterberg; José Alberto Avila-Funes; Juliana Acosta-Uribe; Katherine L. Possin; Kenneth S. Kosik; Kun Hu; Leonel T. Takada; Maira Okada de Oliveira; Marcelo Adrian Maito; Marc Suárez-Calvet; Maria E. Godoy; Maria Isabel Behrens; Mario A. Parra; Marta del Campo; Martin Bruno; Nancy Gelvez; Natalia Pozo-Castro; J. Nicholas Cochran; Nilton Custodio; Rodrigo Ortega; Rodrigo Santibanez; Rolando de la Cruz; Rosa Montesinos; Sarah McDonagh; Sara Bandres-Ciga; Shireen Javandel; Sonia M. D. Brucki; Stefanie D. Pina-Escudero; Victor Valcour; Ziyi Li; Jennifer S. Yokoyama; Agustin Ibañez; Claudia Duran-Aniotz

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Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer’s disease

Molecular Neurodegeneration

IF17.5

2025-12-01

OAAI

Olav M. Andersen; Matthijs W. J. de Waal; Giulia Monti; Niccolo Tesi; Anne Mette G. Jensen; Christa de Geus; Rosalina van Spaendonk; Maartje Vogel; Shahzad Ahmad; Najaf Amin; Philippe Amouyel; Gary W. Beecham; Céline Bellenguez; Claudine Berr; Joshua C. Bis; Anne Boland; Paola Bossù; Femke Bouwman; Jose Bras; Camille Charbonnier; Jordi Clarimon; Carlos Cruchaga; Antonio Daniele; Jean-François Dartigues; Stéphanie Debette; Jean-François Deleuze; Nicola Denning; Anita L. DeStefano; Oriol Dols-Icardo; Cornelia M. van Duijn; Lindsay A. Farrer; Maria Victoria Fernández; Wiesje M. van der Flier; Nick C. Fox; Daniela Galimberti; Emmanuelle Genin; Johan J. P. Gille; Benjamin Grenier-Boley; Detelina Grozeva; Yann Le Guen; Rita Guerreiro; Jonathan L. Haines; Clive Holmes; Holger Hummerich; M. Arfan Ikram; M. Kamran Ikram; Amit Kawalia; Robert Kraaij; Jean-Charles Lambert; Marc Lathrop; Afina W. Lemstra; Alberto Lleó; Richard M. Myers; Marcel M. A. M. Mannens; Rachel Marshall; Eden R. Martin; Carlo Masullo; Richard Mayeux; Simon Mead; Patrizia Mecocci; Alun Meggy; Merel O. Mol; Benedetta Nacmias; Adam C. Naj; Valerio Napolioni; J. Nicholas Cochran; Gaël Nicolas; Florence Pasquier; Pau Pastor; Margaret A. Pericak-Vance; Yolande A. L. Pijnenburg; Fabrizio Piras; Olivier Quenez; Alfredo Ramirez; Rachel Raybould; Richard Redon; Marcel J. T. Reinders; Anne-Claire Richard; Steffi G. Riedel-Heller; Fernando Rivadeneira; Jeroen G. J. van Rooij; Stéphane Rousseau; Natalie S. Ryan; Pascual Sanchez-Juan; Gerard D. Schellenberg; Philip Scheltens; Jonathan M. Schott; Sudha Seshadri; Daoud Sie; Rebecca Sims; Erik A. Sistermans; Sandro Sorbi; John C. van Swieten; Betty Tijms; André G. Uitterlinden; Pieter Jelle Visser; Michael Wagner; David Wallon; Li-San Wang; Julie Williams; Jennifer S. Yokoyama; Aline Zarea; Sven J. van der Lee; Johan G. Olsen; Marc Hulsman; Henne Holstege

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An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome

ALZHEIMERS & DEMENTIA

IF11.1

2024-06-26

OAAI

Snyder, Allison; Ryan, Veronica H.; Hawrot, James; Lawton, Sydney; Ramos, Daniel M.; Qi, Y. Andy; Johnson, Kory R.; Reed, Xylena; Johnson, Nicholas L.; Kollasch, Aaron W.; Duffy, Megan F.; VandeVrede, Lawren; Cochran, J. Nicholas; Miller, Bruce L.; Toro, Camilo; Bielekova, Bibiana; Marks, Debora S.; Yokoyama, Jennifer S.; Kwan, Justin Y.; Cookson, Mark R.; Ward, Michael E.

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Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements

AMERICAN JOURNAL OF HUMAN GENETICS

IF8.1

2024-02-01

OAAI

Rogers, Brianne B.; Anderson, Ashlyn G.; Lauzon, Shelby N.; Davis, M. Natalie; Hauser, Rebecca M.; Roberts, Sydney C.; Rodriguez-Nunez, Ivan; Trausch-Lowther, Katie; Barinaga, Erin A.; Hall, Paige I.; Knuesel, Matthew T.; Taylor, Jared W.; Mackiewicz, Mark; Roberts, Brian S.; Cooper, Sara J.; Rizzardi, Lindsay F.; Myers, Richard M.; Cochran, J. Nicholas

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Development of small-molecule Tau-SH3 interaction inhibitors that prevent amyloid-β toxicity and network hyperexcitability

NEUROTHERAPEUTICS

IF6.9

2024-01-01

OAAI

Roth, Jonathan R.; Rush, Travis; Thompson, Samantha J.; Aldaher, Adam R.; Dunn, Trae B.; Mesina, Jacob S.; Cochran, Nicholas; Boyle, Nicholas R.; Dean, Hunter B.; Yang, Zhengrong; Pathak, Vibha; Ruiz, Pedro; Wu, Mousheng; Day, Jeremy J.; Bostwick, J. Robert; Suto, Mark J.; Augelli-Szafran, Corinne E.; Roberson, Erik D.

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Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease?

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING

IF4.4

2023-09-28

OAAI

Mantyh, William G.; Cochran, J. Nicholas; Taylor, Jared W.; Broce, Iris J.; Geier, Ethan G.; Bonham, Luke W.; Anderson, Ashlyn G.; Sirkis, Daniel W.; La Joie, Renaud; Iaccarino, Leonardo; Chaudhary, Kiran; Edwards, Lauren; Strom, Amelia; Grant, Harli; Allen, Isabel E.; Miller, Zachary A.; Gorno-Tempini, Marilu L.; Kramer, Joel H.; Miller, Bruce L.; Desikan, Rahul S.; Rabinovici, Gil D.; Yokoyama, Jennifer S.

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Life-Limiting Peripheral Organ Dysfunction in Feline Sandhoff Disease Emerges after Effective CNS Gene Therapy

ANNALS OF NEUROLOGY

IF7.7

2023-08-16

OAAI

Johnson, Aime K.; McCurdy, Victoria J.; Gray-Edwards, Heather L.; Maguire, Anne S.; Cochran, J. Nicholas; Gross, Amanda L.; Skinner, Haleigh E.; Randle, Ashley N.; Shirley, Jamie L.; Brunson, Brandon L.; Bradbury, Allison M.; Leroy, Stanley G.; Hwang, Misako; Rockwell, Hannah E.; Cox, Nancy R.; Baker, Henry J.; Seyfried, Thomas N.; Sena-Esteves, Miguel; Martin, Douglas R.

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Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred

ALZHEIMERS & DEMENTIA

IF11.1

2023-03-23

PREAI

Cochran, Jesse Nicholas; Acosta-Uribe, Juliana; Esposito, Bianca T.; Madrigal, Lucia; Aguillon, David; Giraldo, Margarita M.; Taylor, Jared W.; Bradley, Joseph; Fulton-Howard, Brian; Andrews, Shea J.; Acosta-Baena, Natalia; Alzate, Diana; Garcia, Gloria P.; Piedrahita, Francisco; Lopez, Hugo E.; Anderson, Ashlyn G.; Rodriguez-Nunez, Ivan; Roberts, Kevin; Absher, Devin; Myers, Richard M.; Beecham, Gary W.; Reitz, Christiane; Rizzardi, Lindsay F.; Fernandez, Maria Victoria; Goate, Alison M.; Cruchaga, Carlos; Renton, Alan E.; Lopera, Francisco; Kosik, Kenneth S.

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Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer's disease-specific cis-regulatory elements

CELL GENOMICS

IF9

2023-03-01

OAAI

Anderson, Ashlyn G.; Rogers, Brianne B.; Loupe, Jacob M.; Rodriguez-Nunez, Ivan; Brazell, J. Nicholas; Roberts, Sydney C.; White, Lauren M.; Bunney, William E.; Bunney, Blynn G.; Watson, Stanley J.; Cochran, J. Nicholas; Myers, Richard M.; Rizzardi, Lindsay F.

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Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease

NATURE GENETICS

IF31.8

2022-11-21

OAAI

Holstege, Henne; Hulsman, Marc; Charbonnier, Camille; Grenier-Boley, Benjamin; Quenez, Olivier; Grozeva, Detelina; van Rooij, Jeroen G. J.; Sims, Rebecca; Ahmad, Shahzad; Amin, Najaf; Norsworthy, Penny J.; Dols-Icardo, Oriol; Hummerich, Holger; Kawalia, Amit; Amouyel, Philippe; Beecham, Gary W.; Berr, Claudine; Bis, Joshua C.; Boland, Anne; Bossu, Paola; Bouwman, Femke; Bras, Jose; Campion, Dominique; Cochran, J. Nicholas; Daniele, Antonio; Dartigues, Jean-Francois; Debette, Stephanie; Deleuze, Jean-Francois; Denning, Nicola; DeStefano, Anita L.; Farrer, Lindsay A.; Fernandez, Maria Victoria; Fox, Nick C.; Galimberti, Daniela; Genin, Emmanuelle; Gille, Johan J. P.; Le Guen, Yann; Guerreiro, Rita; Haines, Jonathan L.; Holmes, Clive; Ikram, M. Arfan; Ikram, M. Kamran; Jansen, Iris E.; Kraaij, Robert; Lathrop, Marc; Lemstra, Afina W.; Lleo, Alberto; Luckcuck, Lauren; Mannens, Marcel M. A. M.; Marshall, Rachel; Martin, Eden R.; Masullo, Carlo; Mayeux, Richard; Mecocci, Patrizia; Meggy, Alun; Mol, Merel O.; Morgan, Kevin; Myers, Richard M.; Nacmias, Benedetta; Naj, Adam C.; Napolioni, Valerio; Pasquier, Florence; Pastor, Pau; Pericak-Vance, Margaret A.; Raybould, Rachel; Redon, Richard; Reinders, Marcel J. T.; Richard, Anne-Claire; Riedel-Heller, Steffi G.; Rivadeneira, Fernando; Rousseau, Stephane; Ryan, Natalie S.; Saad, Salha; Sanchez-Juan, Pascual; Schellenberg, Gerard D.; Scheltens, Philip; Schott, Jonathan M.; Seripa, Davide; Seshadri, Sudha; Sie, Daoud; Sistermans, Erik A.; Sorbi, Sandro; van Spaendonk, Resie; Spalletta, Gianfranco; Tesi, Niccolo'; Tijms, Betty; Uitterlinden, Andre G.; van der Lee, Sven J.; Visser, Pieter Jelle; Wagner, Michael; Wallon, David; Wang, Li-San; Zarea, Aline; Clarimon, Jordi; van Swieten, John C.; Greicius, Michael D.; Yokoyama, Jennifer S.; Cruchaga, Carlos; Hardy, John; Ramirez, Alfredo; Mead, Simon; van der Flier, Wiesje M.; van Duijn, Cornelia M.; Williams, Julie; Nicolas, Gael; Bellenguez, Celine; Lambert, Jean-Charles

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Biomarkers for dementia in Latin American countries: Gaps and opportunities

ALZHEIMERS & DEMENTIA

IF11.1

2022-09-13

OAAI

Parra, Mario A.; Orellana, Paulina; Leon, Tomas; Victoria, Cabello G.; Henriquez, Fernando; Gomez, Rodrigo; Avalos, Constanza; Damian, Andres; Slachevsky, Andrea; Ibanez, Agustin; Zetterberg, Henrik; Tijms, Betty M.; Yokoyama, Jennifer S.; Pina-Escudero, Stefanie D.; Cochran, J. Nicholas; Matallana, Diana L.; Acosta, Daisy; Allegri, Ricardo; Arias-Suarez, Bianca P.; Barra, Bernardo; Behrens, Maria Isabel; Brucki, SoniaM. D.; Busatto, Geraldo; Caramelli, Paulo; Castro-Suarez, Sheila; Contreras, Valeria; Custodio, Nilton; Dansilio, Sergio; De la Cruz-Puebla, Myriam; de Souza, Leonardo Cruz; Diaz, Monica M.; Duque, Lissette; Farias, Gonzalo A.; Ferreira, Sergio T.; Guimet, Nahuel Magrath; Kmaid, Ana; Lira, David; Lopera, Francisco; Meza, Beatriz Mar; Miotto, Eliane C.; Nitrini, Ricardo; Nunez, Alberto; O'Neill, Santiago; Ochoa, John; Pintado-Caipa, Maritza; Resende, Elisa de Paula Franca; Risacher, Shannon; Rojas, Luz Angela; Sabaj, Valentina; Schilling, Lucas; Sellek, Allis F.; Sosa, Ana; Takada, Leonel T.; Teixeira, Antonio L.; Unaucho-Pilalumbo, Martha; Duran-Aniotz, Claudia

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PEA15 loss of function and defective cerebral development in the domestic cat

PLOS GENETICS

IF3.7

2020-12-08

OAAI

Graff, Emily C.; Cochran, J. Nicholas; Kaelin, Christopher B.; Day, Kenneth; Gray-Edwards, Heather L.; Watanabe, Rie; Koehler, Jey W.; Falgoust, Rebecca A.; Prokop, Jeremy W.; Myers, Richard M.; Cox, Nancy R.; Barsh, Gregory S.; Martin, Douglas R.

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The Role of Age-Related Clonal Hematopoiesis in Genetic Sequencing Studies Response

AMERICAN JOURNAL OF HUMAN GENETICS

IF8.1

2020-09-01

OAAI

Cochran, J. Nicholas; Myers, Richard M.; Yokoyama, Jennifer S.

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Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability

ELIFE

IF0

2020-07-13

OAAI

Voskobiynyk, Yuliya; Roth, Jonathan R.; Cochran, J. Nicholas; Rush, Travis; Carullo, Nancy V. N.; Mesina, Jacob S.; Waqas, Mohammad; Vollmer, Rachael M.; Day, Jeremy J.; McMahon, Lori L.; Roberson, Erik D.

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Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases

AMERICAN JOURNAL OF HUMAN GENETICS

IF8.1

2020-05-01

OAAI

Cochran, J. Nicholas; Geier, Ethan G.; Bonham, Luke W.; Newberry, J. Scott; Amaral, Michelle D.; Thompson, Michelle L.; Lasseigne, Brittany N.; Karydas, Anna M.; Roberson, Erik D.; Cooper, Gregory M.; Rabinovici, Gil D.; Miller, Bruce L.; Myers, Richard M.; Yokoyama, Jennifer S.

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A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity

NEUROBIOLOGY OF DISEASE

IF5.6

2020-02-01

OAAI

Rush, Travis; Roth, Jonathan R.; Thompson, Samantha J.; Aldaher, Adam R.; Cochran, J. Nicholas; Roberson, Erik D.

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Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr)

ALZHEIMERS & DEMENTIA

IF11.1

2019-02-08

OAAI

Ramirez Aguilar, Laura; Acosta-Uribe, Juliana; Giraldo, Margarita M.; Moreno, Sonia; Baena, Ana; Alzate, Diana; Cuastumal, Rosario; Aguillon, David; Madrigal, Lucia; Saldarriaga, Amanda; Navarro, Alexander; Garcia, Gloria P.; Aguirre-Acevedo, Daniel C.; Geier, Ethan G.; Cochran, J. Nicholas; Quiroz, Yakeel T.; Myers, Richard M.; Yokoyama, Jennifer S.; Kosik, Kenneth S.; Lopera, Francisco

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Aberrant Inclusion of a Poison Exon Causes Dravet Syndrome and Related SCN1A-Associated Genetic Epilepsies

AMERICAN JOURNAL OF HUMAN GENETICS

IF8.1

2018-12-01

101

OAAI

Carvill, Gemma L.; Engel, Krysta L.; Ramamurthy, Aishwarya; Cochran, J. Nicholas; Roovers, Jolien; Stamberger, Hannah; Lim, Nicholas; Schneider, Amy L.; Hollingsworth, Georgie; Holder, Dylan H.; Regan, Brigid M.; Lawlor, James; Lagae, Lieven; Ceulemans, Berten; Bebin, E. Martina; Nguyen, John; Barsh, Gregory S.; Weckhuysen, Sarah; Meisler, Miriam; Berkovic, Samuel E.; De Jonghe, Peter; Scheffer, Ingrid E.; Myers, Richard M.; Cooper, Gregory M.; Mefford, Heather C.

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Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia

ACTA NEUROPATHOLOGICA

IF9.3

2018-10-31

OAAI

Geier, Ethan G.; Bourdenx, Mathieu; Storm, Nadia J.; Cochran, J. Nicholas; Sirkis, Daniel W.; Hwang, Ji-Hye; Bonham, Luke W.; Ramos, Eliana Marisa; Diaz, Antonio; Van Berlo, Victoria; Dokuru, Deepika; Nana, Alissa L.; Karydas, Anna; Balestra, Maureen E.; Huang, Yadong; Russo, Silvia P.; Spina, Salvatore; Grinberg, Lea T.; Seeley, William W.; Myers, Richard M.; Miller, Bruce L.; Coppola, Giovanni; Lee, Suzee E.; Cuervo, Ana Maria; Yokoyama, Jennifer S.

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Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer's disease

NEUROBIOLOGY OF AGING

IF3.5

2017-01-01

OAAI

Love, Marissa Natelson; Clark, David G.; Cochran, J. Nicholas; Den Beste, Kyle A.; Geldmacher, David S.; Benzinger, Tammie L.; Gordon, Brian A.; Morris, John C.; Bateman, Randall J.; Roberson, Erik D.

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Research Directions