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Nicholas K. Tonks

Cold Spring Harbor Laboratory

84H-index
202Paper Count
3.1WCitation Count
Published Papers 95
Publication Date
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Ganaxolone, an approved therapy for CDKL5-Deficiency Disorder, is an inhibitor of PTP1B
errJournal of Biological Chemistry
IF3.9
err2026-05-20
err0
errOAAI
errImanol Zubiete-Franco; Qingting Hu; Steven R. Alves; Raditya Utama; Nicholas K. Tonks
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Identification and Validation of an Inhibitor of the Protein Kinases PIM and DYRK
errJournal of Medicinal Chemistry
IF6.8
err2026-03-18
err0
errOAAI
errGyula Bencze; Prabhadevi Venkataramani; Elad Elkayam; Keith D. Rivera; Ankur Garg; Istvan Szabadakai; Laszlo Orfi; Leemor Joshua-Tor; Darryl J. Pappin; Nicholas K. Tonks
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The Dual-specificity Phosphatase JSP1 Regulates Neutrophil Adhesion via Integrin-SRC Signaling in Vascular Inflammation
errJournal of Biological Chemistry
IF3.9
err2026-03-16
err0
errOAAI
errLi Li; Nicholas K. Tonks
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errSave
Mechanisms, functions and therapeutic targeting of protein tyrosine phosphatases
errNature Reviews Molecular Cell Biology
IF90.2
err2025-09-30
err0
PREAI
errTony Tiganis; Nicholas K. Tonks
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errSave
Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err123
errOAAI
errLaMontagne, KR; Flint, AJ; Franza, BR; Pendergast, AM; Tonks, NK
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errSave
Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err218
errOAAI
errTiganis, T; Bennett, AM; Ravichandran, KS; Tonks, NK
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errSave
Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err177
errOAAI
errGalic, S; Klingler-Hoffmann, M; Fodero-Tavoletti, MT; Puryer, MA; Meng, TC; Tonks, NK; Tiganis, T
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errSave
Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err203
errOAAI
errGalic, S; Hauser, C; Kahn, BB; Haj, FG; Neel, BG; Tonks, NK; Tiganis, T
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errSave
Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow
errIUBMB LIFE
IF3.2
err2023-03-27
err0
PREAI
errTonks, Nicholas K. K.
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errSave
Structural and evolutionary relationships among protein tyrosine phosphatase domains
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err706
errOAAI
errAndersen, JN; Mortensen, OH; Peters, GH; Drake, PG; Iversen, LF; Olsen, OH; Jansen, PG; Andersen, HS; Tonks, NK; Moller, NPH
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errSave
Expression Profiling during Mammary Epithelial Cell Three-Dimensional Morphogenesis Identifies PTPRO as a Novel Regulator of Morphogenesis and ErbB2-Mediated Transformation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err39
errOAAI
errYu, Min; Lin, Guang; Arshadi, Niloofar; Kalatskaya, Irina; Xue, Bin; Haider, Syed; Nguyen, Francis; Boutros, Paul C.; Elson, Ari; Muthuswamy, Lakshmi B.; Tonks, Nicholas K.; Muthuswamy, Senthil K.
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errSave
PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils
errJCI INSIGHT
IF6.1
err2022-07-22
err24
errOAAI
errSong, Dongyan; Adrover, Jose M.; Felice, Christy; Christensen, Lisa N.; He, Xue-Yan; Merrill, Joseph R.; Wilkinson, John E.; Janowitz, Tobias; Lyons, Scott K.; Egeblad, Mikala; Tonks, Nicholas K.
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errSave
PTP1B Is an Intracellular Checkpoint that Limits T- cell and CAR T- cell Antitumor Immunity
errCANCER DISCOVERY
IF33.3
err2022-03-08
err67
errOAAI
errWiede, Florian; Lu, Kun-Hui; Du, Xin; Zeissig, Mara N.; Xu, Rachel; Goh, Pei Kee; Xirouchaki, Chrysovalantou E.; Hogarth, Samuel J.; Greatorex, Spencer; Sek, Kevin; Daly, Roger J.; Beavis, Paul A.; Darcy, Phillip K.; Tonks, Nicholas K.; Tiganis, Tony
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errSave
Connecting copper and cancer: from transition metal signalling to metalloplasia
errNATURE REVIEWS CANCER
IF66.8
err2021-11-11
err734
errOAAI
errGe, Eva J.; Bush, Ashley I.; Casini, Angela; Cobine, Paul A.; Cross, Justin R.; DeNicola, Gina M.; Dou, Q. Ping; Franz, Katherine J.; Gohil, Vishal M.; Gupta, Sanjeev; Kaler, Stephen G.; Lutsenko, Svetlana; Mittal, Vivek; Petris, Michael J.; Polishchuk, Roman; Ralle, Martina; Schilsky, Michael L.; Tonks, Nicholas K.; Vahdat, Linda T.; Van Aelst, Linda; Xi, Dan; Yuan, Peng; Brady, Donita C.; Chang, Christopher J.
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Mito-oncology agent: fermented extract suppresses the Warburg effect, restores oxidative mitochondrial activity, and inhibits in vivo tumor growth (vol 10, 14174, 2020)
errSCIENTIFIC REPORTS
IF3.9
err2021-01-29
err1
errOAAI
errBencze, Gyula; Bencze, Szilvia; Rivera, Keith D.; Watson, James D.; Hidvegi, Mate; Orfi, Laszlo; Tonks, Nicholas K.; Pappin, Darryl J.
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Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2020-05-01
err16
errOAAI
errFu, Panfeng; Ramchandran, Ramaswamy; Shaaya, Mark; Huang, Longshuang; Ebenezer, David L.; Jiang, Ying; Komarova, Yulia; Vogel, Stephen M.; Malik, Asrar B.; Minshall, Richard D.; Du, Guangwei; Tonks, Nicholas K.; Natarajan, Viswanathan
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Regulation of PTP1B activation through disruption of redox-complex formation
errNATURE CHEMICAL BIOLOGY
IF13.7
err2019-12-23
err22
errOAAI
errLondhe, Avinash D.; Bergeron, Alexandre; Curley, Stephanie M.; Zhang, Fuming; Rivera, Keith D.; Kannan, Akaash; Coulis, Gerald; Rizvi, Syed H. M.; Kim, Seung Jun; Pappin, Darryl J.; Tonks, Nicholas K.; Linhardt, Robert J.; Boivin, Benoit
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Spatial regulation of signaling by the coordinated action of the protein tyrosine kinases MET and FER
errCELLULAR SIGNALLING
IF3.7
err2018-10-01
err10
errOAAI
errZhang, Jiali; Wang, Zuo; Zhang, Siwei; Chen, Yanxun; Xiong, Xuexue; Li, Xiaojuan; Tonks, Nicholas K.; Fan, Gaofeng
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A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2018-02-01
err110
errOAAI
errKrishnan, Navasona; Konidaris, Konstantis F.; Gasser, Gilles; Tonks, Nicholas K.
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errSave
Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development
errNATURE COMMUNICATIONS
IF15.7
err2018-01-18
err49
errOAAI
errKrishnan, Navasona; Bonham, Christopher A.; Rus, Ioana A.; Shrestha, Om Kumar; Gauss, Carla M.; Haque, Aftabul; Tocilj, Ante; Joshua-Tor, Leemor; Tonks, Nicholas K.
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Research Directions

No research directions
Co-authors
Cooperation Journals
G
Gregory J. Hannon
H-index: 168 · Papers: 495
C
C. David Allis
H-index: 164 · Papers: 433
P
Pier Paolo Pandolfi
H-index: 160 · Papers: 818
P
Philip Cohen
H-index: 156 · Papers: 581
G
Guy A. Rouleau
H-index: 146 · Papers: 1.3K
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