Lai‐Xi Wang - Publications, H-index & Citations

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Lai‐Xi Wang

university of maryland

60H-index

303Paper Count

1.2WCitation Count

Published Papers 141

Publication Date

Antibody glyco-optimization and site-specific conjugation enhance the immune-stimulating activity of antibody-TLR ligand conjugates

Journal of Biological Chemistry

IF3.9

2026-06-19

OAAI

Xianyang Wang; Yaoxian Lou; Helena Yun; Margaryta Gomozkova; Guangming Li; Lishan Su; Lai-Xi Wang

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A Zebrafish Galectin-1 Isoform Is Expressed in Skin and Gills and Binds to Bacteria, Bacterial Adhesin Receptors, and Epidermal Mucus Glycans

International Journal of Molecular Sciences

IF4.9

2026-04-27

OAAI

Chiguang Feng; Kelsey Abernathy; Sheng Wang; Guanghui Zong; Nilli Zmora; Allison Shupp; Muddassar Iqbal; Lai-Xi Wang; Gerardo R. Vasta

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N-Azidoacetylglucosamine (GlcNAz)-Derived Sugar Oxazolines as a New Class of Substrates for Chemoenzymatic Site-Specific Antibody Bioconjugation

JACS Au

IF8.7

2026-02-23

OAAI

Guanghui Zong; Margaryta Gomozkova; Tala Azzam; Eric J. Sundberg; Lai-Xi Wang

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Probing the Broad-Spectrum Virus-Neutralizing Epitopes Using the High-Density Oligomannose-Conjugates and Carbohydrate Microarrays

BIOCONJUGATE CHEMISTRY

IF3.9

2025-10-01

PREAI

Toonstra, Christian; Wu, Lisa; Wang, Lai-Xi; Wang, Denong

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Galectin-3 disrupts tight junctions of airway epithelial cell monolayers by inducing expression and release of matrix metalloproteinases upon influenza A infection

GLYCOBIOLOGY

IF3.3

2024-11-21

PREAI

Iqbal, Muddassar; Feng, Chiguang; Zong, Guanghui; Wang, Lai-Xi; Vasta, Gerardo R.

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Chemoenzymatic Synthesis of Sulfated N-Glycans Recognized by Siglecs and Other Glycan-Binding Proteins

JACS AU

IF8.7

2024-07-26

OAAI

Huang, Kun; Bashian, Eleanor E.; Zong, Guanghui; Nycholat, Corwin M.; McBride, Ryan; Gomozkova, Margaryta; Wang, Shengyang; Huang, Chin; Chapla, Digantkumar G.; Schmidt, Edward N.; Macauley, Matthew; Moremen, Kelley W.; Paulson, James C.; Wang, Lai-Xi

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Evaluation of Two Chemoenzymatic Glycan Remodeling Approaches to Generate Site-Specific Antibody-Drug Conjugates

ANTIBODIES

IF2.7

2023-11-03

OAAI

Yang, Qiang; Chen, He; Ou, Chong; Zheng, Zhihao; Zhang, Xiao; Liu, Yunpeng; Zong, Guanghui; Wang, Lai-Xi

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Ghost Fragment Ions in Structure and Site-Specific Glycoproteomics Analysis

ANALYTICAL CHEMISTRY

IF6.7

2023-06-29

OAAI

Campos, Diana; Girgis, Michael; Yang, Qiang; Zong, Guanghui; Goldman, Radoslav; Wang, Lai-Xi; Sanda, Miloslav

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Synthetic Site-Specific Antibody-Ligand Conjugates Promote Asialoglycoprotein Receptor-Mediated Degradation of Extracellular Human PCSK9

ACS CHEMICAL BIOLOGY

IF3.8

2023-06-27

OAAI

Donahue, Thomas C.; Ou, Chong; Yang, Qiang; Flinko, Robin; Zhang, Xiao; Zong, Guanghui; Lewis, George K.; Wang, Lai-Xi

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Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-03-27

OAAI

Chen, Xinhai; Gula, Haley; Pius, Tonu; Ou, Chong; Gomozkova, Margaryta; Wang, Lai-Xi; Schneewind, Olaf; Missiakas, Dominique

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LC-MS/MS-PRM Quantification of IgG Glycoforms Using Stable Isotope Labeled IgG1 Fc Glycopeptide Standard

JOURNAL OF PROTEOME RESEARCH

IF3.6

2023-02-10

OAAI

Sanda, Miloslav; Yang Qiang; Zong Guanghui; Chen He; Zheng Zhihao; Dhani, Harmeet; Khan, Khalid; Kroemer, Alexander; Wang Lai-Xi; Goldman, Radoslav

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Catanionic Vesicles as a Facile Scaffold to Display Natural N-Glycan Ligands for Probing Multivalent Carbohydrate-Lectin Interactions

BIOCONJUGATE CHEMISTRY

IF3.9

2023-01-16

OAAI

Donahue, Thomas C.; Zong, Guanghui; Ou, Chong; DeShong, Philip; Wang, Lai -Xi

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Mechanism of high-mannose N-glycan breakdown and metabolism by Bifidobacterium longum

NATURE CHEMICAL BIOLOGY

IF13.7

2022-11-28

PREAI

Cordeiro, Rosa L.; Santos, Camila R.; Domingues, Mariane N.; Lima, Tatiani B.; Pirolla, Renan A. S.; Morais, Mariana A. B.; Colombari, Felippe M.; Miyamoto, Renan Y.; Persinoti, Gabriela F.; Borges, Antonio C.; de Farias, Marcelo A.; Stoffel, Fabiane; Li, Chao; Gozzo, Fabio C.; van Heel, Marin; Guerin, Marcelo E.; Sundberg, Eric J.; Wang, Lai-Xi; Portugal, Rodrigo V.; Giuseppe, Priscila O.; Murakami, Mario T.

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Synthetic nanobodies as tools to distinguish IgG Fc glycoforms

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-11-21

OAAI

Kao, Kevin S.; Gupta, Aaron; Zong, Guanghui; Li, Chao; Kerschbaumer, Isabell; Borghi, Sara; Achkar, Jacqueline M.; Bournazos, Stylianos; Wang, Lai-Xi; Ravetch, Jeffrey V.

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Synthesis, binding affinity, and inhibitory capacity of cyclodextrin-based multivalent glycan ligands for human galectin-3

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2022-10-01

OAAI

Ou, Chong; Li, Chao; Feng, Chiguang; Tong, Xin; Vasta, Gerardo R.; Wang, Lai-Xi

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An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant replication in rhesus macaques

PNAS NEXUS

IF3.8

2022-06-17

OAAI

Sui, Yongjun; Li, Jianping; Andersen, Hanne; Zhang, Roushu; Prabhu, Sunaina K.; Hoang, Tanya; Venzon, David; Cook, Anthony; Brown, Renita; Teow, Elyse; Velasco, Jason; Pessaint, Laurent; Moore, Ian N.; Lagenaur, Laurel; Talton, Jim; Breed, Matthew W.; Kramer, Josh; Bock, Kevin W.; Minai, Mahnaz; Nagata, Bianca M.; Choo-Wosoba, Hyoyoung; Lewis, Mark G.; Wang, Lai-Xi; Berzofsky, Jay A.

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Synthesis and Immunological Study of N-Glycan-Bacteriophage Qβ Conjugates Reveal Dominant Antibody Responses to the Conserved Chitobiose Core

BIOCONJUGATE CHEMISTRY

IF3.9

2022-06-10

OAAI

Donahue, Thomas C.; Zong, Guanghui; O'Brien, Nicholas A.; Ou, Chong; Gildersleeve, Jeffrey C.; Wang, Lai-Xi

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Synthesis and Evaluation of Three Azide-Modified Disaccharide Oxazolines as Enzyme Substrates for Single-Step Fc Glycan-Mediated Antibody-Drug Conjugation

BIOCONJUGATE CHEMISTRY

IF3.9

2022-05-11

OAAI

Zhang, Xiao; Ou, Chong; Liu, Huiying; Wang, Lai-Xi

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Site-Specific Chemoenzymatic Conjugation of High-Affinity M6P Glycan Ligands to Antibodies for Targeted Protein Degradation

ACS CHEMICAL BIOLOGY

IF3.8

2022-03-22

OAAI

Zhang, Xiao; Liu, Huiying; He, Jia; Ou, Chong; Donahue, Thomas C.; Muthana, Musleh M.; Su, Lishan; Wang, Lai-Xi

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Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE

NATURE COMMUNICATIONS

IF15.7

2022-03-03

OAAI

Garcia-Alija, Mikel; Du, Jonathan J.; Ordonez, Izaskun; Diz-Vallenilla, Asier; Moraleda-Montoya, Alicia; Sultana, Nazneen; Huynh, Chau G.; Li, Chao; Donahue, Thomas Connor; Wang, Lai-Xi; Trastoy, Beatriz; Sundberg, Eric J.; Guerin, Marcelo E.

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Research Directions