David N. Palmer - Publications, H-index & Citations

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David N. Palmer

university of london

36H-index

129Paper Count

4.1KCitation Count

Published Papers 25

Publication Date

Magnetic Resonance Imaging as a Readout of CLN5 Gene Therapy Efficacy in Sheep

religion brain behavior

IF2.7

2025-04-03

OAAI

Murray, Samantha J.; Almuqbel, Mustafa M.; Felton, Simon A.; Palmer, Nickolas J.; Deane, Ashley R.; Myall, Daniel J.; Shoorangiz, Reza; Ella, Arsene; Keller, Matthieu; Palmer, David N.; Melzer, Tracy R.; Mitchell, Nadia L.

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Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC

JOURNAL OF TRANSLATIONAL MEDICINE

IF7.5

2023-07-05

OAAI

O'Leary, Claire; Forte, Gabriella; Mitchell, Nadia L.; Youshani, Amir Saam; Dyer, Adam; Wellby, Martin P.; Russell, Katharina N.; Murray, Samantha J.; Jolinon, Nelly; Jones, Simon A.; Stacey, Kevin; Davis, Daniel M.; Henckaerts, Els; Palmer, David N.; Kamaly-Asl, Ian; Bigger, Brian W.

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Progressive MRI brain volume changes in ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinosis

BRAIN COMMUNICATIONS

IF4.5

2023-01-02

OAAI

Murray, Samantha J.; Almuqbel, Mustafa M.; Felton, Simon A.; Palmer, Nickolas J.; Myall, Daniel J.; Shoorangiz, Reza; Ella, Arsene; Keller, Matthieu; Palmer, David N.; Melzer, Tracy R.; Mitchell, Nadia L.

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Modelling Neurological Diseases in Large Animals: Criteria for Model Selection and Clinical Assessment

CELLS

IF5.2

2022-08-25

OAAI

Eaton, Samantha L.; Murdoch, Fraser; Rzechorzek, Nina M.; Thompson, Gerard; Hartley, Claudia; Blacklock, Benjamin Thomas; Proudfoot, Chris; Lillico, Simon G.; Tennant, Peter; Ritchie, Adrian; Nixon, James; Brennan, Paul M.; Guido, Stefano; Mitchell, Nadia L.; Palmer, David N.; Whitelaw, C. Bruce A.; Cooper, Jonathan D.; Wishart, Thomas M.

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Intravitreal gene therapy protects against retinal dysfunction and degeneration in sheep with CLN5 Batten disease

EXPERIMENTAL EYE RESEARCH

IF2.7

2021-06-01

PREAI

Murray, Samantha J.; Russell, Katharina N.; Melzer, Tracy R.; Gray, Steven J.; Heap, Stephen J.; Palmer, David N.; Mitchell, Nadia L.

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Molecular Imaging of Pulmonary Tuberculosis in an Ex-Vivo Mouse Model Using Spectral Photon-Counting Computed Tomography and Micro-CT

IEEE ACCESS

IF3.6

2021-01-01

OAAI

Lowe, Chiara; Ortega-Gil, Ana; Moghiseh, Mahdieh; Anderson, Nigel G.; Munoz-Barrutia, Arrate; Vaquero, Juan Jose; Raja, Aamir Y.; Matanaghi, Aysouda; Chernoglazov, Alexander I.; Dapamede, Theodorus; Adebileje, Sikiru A.; Alexander, Steven; Amma, Maya R.; Anjomrouz, Marzieh; Asghariomabad, Fatemeh; Atharifard, Ali; Atlas, James; Baer, Kenzie; Bell, Stephen T.; Bheesette, Srinidhi; Butler, Philip H.; Carbonez, Pierre; Chambers, Claire; Chapagain, Krishna M.; Clark, Jennifer A.; Colgan, Frances; Crighton, Jonathan S.; Dahal, Shishir; Damet, Jerome; De Ruiter, Niels J. A.; Doesburg, Robert M. N.; Duncan, Neryda; Ghodsian, Nooshin; Gieseg, Steven P.; Goulter, Brian P.; Gurney, Sam; Healy, Joseph L.; Kanithi, Praveen Kumar; Kirkbride, Tracy; Lansley, Stuart P.; Mandalika, V. B. H.; Marfo, Emmanuel; Palmer, David; Panta, Raj K.; Prebble, Hannah M.; Renaud, Peter; Sayous, Yann; Schleich, Nanette; Searle, Emily; Sheeja, Jereena S.; Broeke, Lieza Vanden; Vivek, V. S.; Walker, E. Peter; Walsh, Michael F.; Wijesooriya, Manoj; Younger, W. Ross; Butler, Anthony P. H.

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The development of brain magnetic resonance approaches in large animal models for preclinical research

ANIMAL FRONTIERS

IF4.2

2019-06-25

OAAI

Ella, Arsene; Barriere, David A.; Adriaensen, Hans; Palmer, David N.; Melzer, Tracy R.; Mitchell, Nadia L.; Keller, Matthieu

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Improving brain delivery of adeno-associated viral gene therapy vectors for the treatment of MPS IIIC

MOLECULAR GENETICS AND METABOLISM

IF3.5

2019-02-01

PREAI

O'Leary, Claire; Forte, Gabriella; Mitchell, Nadia; Youshani, Amir Saam; Wellby, Martin; Russell, Katharina; Palmer, David; Henckaerts, Els; Asl, Ian Kamaly; Bigger, Brian

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Longitudinal In Vivo Monitoring of the CNS Demonstrates the Efficacy of Gene Therapy in a Sheep Model of CLN5 Batten Disease

MOLECULAR THERAPY

IF12

2018-10-01

OAAI

Mitchell, Nadia L.; Russell, Katharina N.; Wellby, Martin P.; Wicky, Hollie E.; Schoderboeck, Lucia; Barrell, Graham K.; Melzer, Tracy R.; Gray, Steven J.; Hughes, Stephanie M.; Palmer, David N.

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Conservation of Complete Trimethylation of Lysine-43 in the Rotor Ring of c-Subunits of Metazoan Adenosine Triphosphate (ATP) Synthases

MOLECULAR & CELLULAR PROTEOMICS

IF5.5

2015-04-01

OAAI

Walpole, Thomas B.; Palmer, David N.; Jiang, Huibing; Ding, Shujing; Fearnley, Ian M.; Walker, John E.

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Translational neurophysiology in sheep: measuring sleep and neurological dysfunction in CLN5 Batten disease affected sheep

BRAIN

IF11.7

2015-02-26

OAAI

Perentos, Nicholas; Martins, Amadeu Q.; Watson, Thomas C.; Bartsch, Ullrich; Mitchell, Nadia L.; Palmer, David N.; Jones, Matthew W.; Morton, A. Jennifer

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Inhibition of storage pathology in prenatal CLN5-deficient sheep neural cultures by lentiviral gene therapy

NEUROBIOLOGY OF DISEASE

IF5.6

2014-02-01

PREAI

Hughes, Stephanie M.; Hope, Katie M.; Xu, Janet Boyu; Mitchell, Nadia L.; Palmer, David N.

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Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression

JOURNAL OF NEUROINFLAMMATION

IF10.1

2013-07-30

OAAI

Kay, Graham W.; Palmer, David N.

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The specific loss of GnRH-positive neurons from the hypothalamus of sheep with CLN6 neuronal ceroid lipofuscinosis occurs without glial activation and has only minor effects on reproduction

NEUROBIOLOGY OF DISEASE

IF5.6

2011-03-01

PREAI

Kay, Graham W.; Jay, Nigel P.; Palmer, David N.

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Neuropeptide changes and neuroactive amino acids in CSF from humans and sheep with neuronal ceroid lipofuscinoses (NCLs, Batten disease)

NEUROCHEMISTRY INTERNATIONAL

IF4

2009-12-01

OAAI

Kay, Graham W.; Verbeek, Marcel M.; Furlong, Julie M.; Willemsen, Michel A. A. P.; Palmer, David N.

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Location and connectivity determine GABAergic interneuron survival in the brains of South Hampshire sheep with CLN6 neuronal ceroid lipofuscinosis

NEUROBIOLOGY OF DISEASE

IF5.6

2008-10-01

OAAI

Oswald, Manfred J.; Palmer, David N.; Kay, Graham W.; Barwell, Karen J.; Cooper, Jonathan D.

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A new large animal model of CLN5 neuronal ceroid lipofuscinosis in Borderdale sheep is caused by a nucleotide substitution at a consensus splice site (c.571+1G > A) leading to excision of exon 3

NEUROBIOLOGY OF DISEASE

IF5.6

2008-02-01

OAAI

Frugier, Tony; Mitchell, Nadia L.; Tammen, Imke; Houweling, Peter J.; Arthur, Donald G.; Kay, Graham W.; Van Diggelen, Otto P.; Jolly, Robert D.; Palmer, David N.

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Activation of non-neuronal cells within the prenatal developing brain of sheep with neuronal ceroid lipofuscinosis

BRAIN PATHOLOGY

IF6.2

2006-06-08

OAAI

Kay, Graham W.; Palmer, David N.; Rezaie, Payam; Cooper, Jonathan D.

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Lysine 43 is trimethylated in subunit c from bovine mitochondrial ATP synthase and in storage bodies associated with Batten disease

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2004-05-01