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William Wickner

Geisel School of Medicine at Dartmouth

93H-index
252Paper Count
2.6WCitation Count
Published Papers 89
Publication Date
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Functional assembly of the Qc-SNARE with Sec18 and Sec17 on membranes
errMolecular Biology of the Cell
IF2.7
err2026-01-01
err0
PREAI
errOrr, Amy; Lopes, Karina; O'Dwyer, Jerry; Wickner, William
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SNARE disassembly requires Sec18/NSF side loading
errNature Structural & Molecular Biology
IF10.1
err2025-07-02
err0
errOAAI
errYousuf A. Khan; K. Ian White; Richard A. Pfuetzner; Bharti Singal; Luis Esquivies; Garvey Mckenzie; Fang Liu; Katherine DeLong; Ucheor B. Choi; Elizabeth Montabana; Theresa Mclaughlin; William T. Wickner; Axel T. Brunger
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errSave
After their membrane assembly, Sec18 (NSF) and Sec17 (SNAP) promote membrane fusion
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2024-12-01
err0
PREAI
errSong, Hongki; Lopes, Karina; Orr, Amy; Wickner, William
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errSave
Sec18 binds the tethering/SM complex HOPS to engage the Qc-SNARE for membrane fusion
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2024-05-01
err1
errOAAI
errOrr, Amy; Wickner, William
errShare
errSave
MARCKS Effector Domain, a reversible lipid ligand, illuminates late stages of membrane fusion
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2023-11-01
err2
errOAAI
errOrr, Amy; Wickner, William
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errSave
Efficient fusion requires a membrane anchor on the vacuolar Qa-SNARE
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2023-08-01
err5
errOAAI
errWickner, William; Lopes, Karina; Song, Hongki; Rizo, Josep; Orr, Amy
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errSave
PI3P regulates multiple stages of membrane fusion
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2023-03-01
err3
errOAAI
errOrr, Amy; Wickner, William
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errSave
Sec18 supports membrane fusion by promoting Sec17 membrane association
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2022-11-01
err4
errOAAI
errOrr, Amy; Wickner, William
errShare
errSave
Fusion with wild-type SNARE domains is controlled by juxtamembrane domains, transmembrane anchors, and Sec17
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2022-05-01
err8
errOAAI
errOrr, Amy; Song, Hongki; Wickner, William
errShare
errSave
Phosphatidylinositol and phosphatidylinositol-3-phosphate activate HOPS to catalyze SNARE assembly, allowing small headgroup lipids to support the terminal steps of membrane fusion
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2021-11-01
err15
errOAAI
errTorng, Thomas; Wickner, William
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errSave
Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering
errELIFE
IF0
err2021-05-04
err21
errOAAI
errSong, Hongki; Torng, Thomas L.; Orr, Amy S.; Brunger, Axel T.; Wickner, William T.
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errSave
Asymmetric Rab activation of vacuolar HOPS to catalyze SNARE complex assembly
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2020-05-01
err20
errOAAI
errTorng, Thomas; Song, Hongki; Wickner, William
errShare
errSave
A Rab prenyl membrane-anchor allows effector recognition to be regulated by guanine nucleotide
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2020-03-25
err4
errOAAI
errLee, Miriam; Wickner, William; Song, Hongki
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errSave
HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE
errELIFE
IF0
err2020-01-21
err33
errOAAI
errSong, Hongki; Orr, Amy S.; Lee, Miriam; Harner, Max E.; Wickner, William T.
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errSave
Sec17 (α-SNAP) and Sec18 (NSF) restrict membrane fusion to R-SNAREs, Q-SNAREs, and SM proteins from identical compartments
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2019-11-04
err13
errOAAI
errJun, Youngsoo; Wickner, William
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errSave
Tethering guides fusion-competent trans-SNARE assembly
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2019-06-24
err20
errOAAI
errSong, Hongki; Wickner, William
errShare
errSave
Assembly of intermediates for rapid membrane fusion
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2018-01-01
err6
errOAAI
errHarner, Max; Wickner, William
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errSave
A short region upstream of the yeast vacuolar Qa-SNARE heptad-repeats promotes membrane fusion through enhanced SNARE complex assembly
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2017-08-15
err12
errOAAI
errSong, Hongki; Wickner, William
errShare
errSave
Sec17/Sec18 act twice, enhancing membrane fusion and then disassembling cis-SNARE complexes
errELIFE
IF0
err2017-07-18
err44
errOAAI
errSong, Hongki; Orr, Amy; Duan, Mengtong; Merz, Alexey J.; Wickner, William
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errSave
HOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex
errMOLECULAR BIOLOGY OF THE CELL
IF2.7
err2017-04-01
err38
errOAAI
errOrr, Amy; Song, Hongki; Rusin, Scott F.; Kettenbach, Arminja N.; Wickner, William
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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John R. Yates
H-index: 188 · Papers: 1.5K
D
David W. Russell
H-index: 144 · Papers: 860
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F. Ulrich Hartl
H-index: 133 · Papers: 498
R
Randy Schekman
H-index: 128 · Papers: 449
H
Hiroshi Nikaido
H-index: 118 · Papers: 391
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