Not logged inTumour mutational burden and survival with molecularly matched therapy
de Bortoli, Till; Benary, Manuela; Horak, Peter; Lamping, Mario; Stintzing, Sebastian; Tinhofer, Ingeborg; Leyvraz, Serge; Schaefer, Reinhold; Klauschen, Frederick; Keller, Ulrich; Stenzinger, Albrecht; Froehling, Stefan; Kurzrock, Razelle; Keilholz, Ulrich; Rieke, Damian T.; Jelas, Ivan .png)
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SaveThe FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functionsAhmed, Syed Moiz; Ragunathan, Priya; Shin, Joon; Peter, Sabrina; Kleissle, Sabrina; Neuenschwander, Martin; Schaefer, Reinhold; Kries, Jens Peter V.; Grueber, Gerhard; Droge, Peter Share Save A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancerKendzia, Sandra; Franke, Susanne; Kroehler, Tarek; Golob-Schwarzl, Nicole; Schweiger, Caroline; Toeglhofer, Anna M.; Skofler, Christina; Uranitsch, Stefan; El-Heliebi, Amin; Fuchs, Julia; Punschart, Andreas; Stiegler, Philipp; Keil, Marlen; Hoffmann, Jens; Henderson, David; Lehrach, Hans; Yaspo, Marie-Laure; Reinhard, Christoph; Schaefer, Reinhold; Keilholz, Ulrich; Regenbrecht, Christian; Schicho, Rudolf; Fickert, Peter; Lax, Sigurd F.; Erdmann, Frank; Schulz, Marcel H.; Kiemer, Alexandra K.; Haybaeck, Johannes; Kessler, Sonja M. Share Save Share Save Biomarker-driven therapies for metastatic uveal melanoma: A prospective precision oncology feasibility studyLeyvraz, Serge; Konietschke, Frank; Peuker, Caroline; Schuette, Moritz; Kessler, Thomas; Ochsenreither, Sebastian; Ditzhaus, Marc; Spruenken, Erin D.; Doerpholz, Gina; Lamping, Mario; Rieke, Damian T.; Klinghammer, Konrad; Burock, Susen; Ulrich, Claas; Poch, Gabriela; Schaefer, Reinhold; Klauschen, Frederick; Joussen, Antonia; Yaspo, Marie-Laure; Keilholz, Ulrich Share Save Share Save SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer CellsKlotz-Noack, Kathleen; Klinger, Bertram; Rivera, Maria; Bublitz, Natalie; Uhlitz, Florian; Riemer, Pamela; Luethen, Mareen; Sell, Thomas; Kasack, Katharina; Gastl, Bastian; Ispasanie, Sylvia S. S.; Simon, Tincy; Janssen, Nicole; Schwab, Matthias; Zuber, Johannes; Horst, David; Bluethgen, Nils; Schaefer, Reinhold; Morkel, Markus; Sers, Christine Share Save Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastropheGastl, Bastian; Klotz-Noack, Kathleen; Klinger, Bertram; Ispasanie, Sylvia; Salib, Krenoula Hani Fouad; Zuber, Johannes; Mamlouk, Soulafa; Bublitz, Natalie; Bluethgen, Nils; Horst, David; Morkel, Markus; Schaefer, Reinhold; Sers, Christine Share Save Support of a molecular tumour board by an evidence-based decision management system for precision oncologyLamping, Mario; Benary, Manuela; Leyvraz, Serge; Messerschmidt, Clemens; Blanc, Eric; Kessler, Thomas; Schuette, Moritz; Lenze, Dido; Joehrens, Korinna; Burock, Susen; Klinghammer, Konrad; Ochsenreither, Sebastian; Sers, Christine; Schaefer, Reinhold; Tinhofer, Ingeborg; Beule, Dieter; Klauschen, Frederick; Yaspo, Marie-Laure; Keilholz, Ulrich; Rieke, Damian T. Share Save Discovery and Validation of Novel Biomarkers for Detection of Epithelial Ovarian CancerKulbe, Hagen; Otto, Raik; Darb-Esfahani, Silvia; Lammert, Hedwig; Abobaker, Salem; Welsch, Gabriele; Chekerov, Radoslav; Schaefer, Reinhold; Dragun, Duska; Hummel, Michael; Leser, Ulf; Sehouli, Jalid; Braicu, Elena Ioana Share Save Modulating chemoresistance: Uncovering the role of mutant SMAD4R361Hin colorectal cancer using PDO and PDX modelsPfohl, Ulrike; Silvestri, Alessandra; Schumacher, Dirk; Boehnke, Karsten; Haybaeck, Johannes; Bashir, Sanam; Kuehn, Ralf; Keil, Marlen; Schaefer, Reinhold; Walther, Wolfgang; Regenbrecht, Christian Share Save Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D culturesSchumacher, Dirk; Andrieux, Geoffroy; Boehnke, Karsten; Keil, Marlen; Silvestri, Alessandra; Silvestrov, Maxine; Keilholz, Ulrich; Haybaeck, Johannes; Erdmann, Gerrit; Sachse, Christoph; Templin, Markus; Hoffmann, Jens; Boerries, Melanie; Schaefer, Reinhold; Regenbrecht, Christian R. A. Share Save Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancerBormann, Felix; Stinzing, Sebastian; Tierling, Sascha; Morkel, Markus; Markelova, Maria Rivera; Walter, Jorn; Weichert, Wilko; Rossner, Florian; Kuhn, Natalia; Perner, Juliane; Dietz, Johanna; Ispasanie, Sylvia; Dietel, Manfred; Schaefer, Reinhold; Heinemann, Volker; Sers, Christine Share Save Share Save Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem CellsRegan, Joseph L.; Schumacher, Dirk; Staudte, Stephanie; Steffen, Andreas; Haybaeck, Johannes; Keilholz, Ulrich; Schweiger, Caroline; Golob-Schwarzl, Nicole; Mumberg, Dominik; Henderson, David; Lehrach, Hans; Regenbrecht, Christian R. A.; Schaefer, Reinhold; Lange, Martin Share Save Share Save Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitorsSchuette, Moritz; Risch, Thomas; Abdavi-Azar, Nilofar; Boehnke, Karsten; Schumacher, Dirk; Keil, Marlen; Yildirimman, Reha; Jandrasits, Christine; Borodina, Tatiana; Amstislavskiy, Vyacheslav; Worth, Catherine L.; Schweiger, Caroline; Liebs, Sandra; Lange, Martin; Warnatz, Hans-Joerg; Butcher, Lee M.; Barrett, James E.; Sultan, Marc; Wierling, Christoph; Golob-Schwarzl, Nicole; Lax, Sigurd; Uranitsch, Stefan; Becker, Michael; Welte, Yvonne; Regan, Joseph Lewis; Silvestrov, Maxine; Kehler, Inge; Fusi, Alberto; Kessler, Thomas; Herwig, Ralf; Landegren, Ulf; Wienke, Dirk; Nilsson, Mats; Velasco, Juan A.; Garin-Chesa, Pilar; Reinhard, Christoph; Beck, Stephan; Schaefer, Reinhold; Regenbrecht, Christian R. A.; Henderson, David; Lange, Bodo; Haybaeck, Johannes; Keilholz, Ulrich; Hoffmann, Jens; Lehrach, Hans; Yaspo, Marie-Laure Share Save DNA copy number changes define spatial patterns of heterogeneity in colorectal cancerMamlouk, Soulafa; Childs, Liam Harold; Aust, Daniela; Heim, Daniel; Melching, Friederike; Oliveira, Cristiano; Wolf, Thomas; Durek, Pawel; Schumacher, Dirk; Blaeker, Hendrik; von Winterfeld, Moritz; Gastl, Bastian; Moehr, Kerstin; Menne, Andrea; Zeugner, Silke; Redmer, Torben; Lenze, Dido; Tierling, Sascha; Moebs, Markus; Weichert, Wilko; Folprecht, Gunnar; Blanc, Eric; Beule, Dieter; Schaefer, Reinhold; Morkel, Markus; Klauschen, Frederick; Leser, Ulf; Sers, Christine Share Save Share Save Y-box protein-1/p18 as novel serum marker for ovarian cancer diagnosis: A study by the Tumor Bank Ovarian Cancer (TOC)Rohr, Irena; Braicu, Elena I.; En-Nia, Abdelaziz; Heinrich, Michaela; Richter, Rolf; Chekerov, Radoslav; Dechend, Ralf; Heidecke, Harald; Dragun, Duska; Schafer, Reinhold; Gorny, Xenia; Lindquist, Jonathan A.; Brandt, Sabine; Sehouli, Jalid; Mertens, Peter R. 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