Not logged inMaintenance durvalumab after fi rst-line chemotherapy in patients with HER2-negative advanced oesophago-gastric adenocarcinoma: results from the randomised PLATFORM study
Fong, C.; Patel, B.; Peckitt, C.; Bourmpaki, E.; Satchwell, L.; Cromarty, S.; Kidd, S.; von Loga, K.; Uhlik, M.; Begum, R.; Rana, T.; Waddell, T.; Darby, S.; Bradshaw, A.; Roques, T.; Morgan, C.; Rees, C.; Herbertson, R.; Das, P.; Thompson, C.; Hewish, M.; Petty, R.; Thistlethwaite, F.; Rao, S.; Starling, N.; Chau, I.; Cunningham, D. .png)
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SaveImmunological markers of pathological and clinical and outcomes in mismatch repair deficient (MMRd) colorectal cancer (CRC)Challoner, B. R.; Slater, S. C.; Sansano, H. B.; Aresu, M.; Bryant, A.; Chen, H-C.; Begum, R.; Rana, T.; Zhitkov, O.; Leamon, B.; Barber, L. J.; Peckitt, C.; Chau, I.; Starling, N.; Cunningham, D.; Gerlinger, M. Share Save Acquired resistance to first-line chemo- and EGFRab-therapy in mCRC: Biopsy analysis of the iSCORE trialLane, R.; Mencel, J.; Turkes, F.; Challoner, B. R.; McCafferty, N.; Ntellas, P.; Barber, L. J.; Rana, I.; Chen, H-C.; Begum, R.; Ficial, M.; Tran, A.; Terlizzo, M.; Rao, S.; Cunningham, D.; Chau, I.; Starling, N.; Gerlinger, M. Share Save MicroRNAs as biomarkers for trastuzumab-based therapy in HER2-positive advanced oesophago-gastric cancer patientsLote, Hazel; Mousoullou, Florentia; Vlachogiannis, George; Lampis, Andrea; Satchwell, Laura; Peckitt, Clare; Fong, Caroline; Begum, Ruwaida; Kidd, Shannon; Cromarty, Susan; Gordon, Anderley; Fribbens, Charlotte; Rao, Sheela; Starling, Naureen; Chau, Ian; Cunningham, David; Valeri, Nicola Share Save Genetic and immune landscape evolution in MMR-deficient colorectal cancerChalloner, Benjamin R.; Woolston, Andrew; Lau, David; Buzzetti, Marta; Fong, Caroline; Barber, Louise J.; Anandappa, Gayathri; Crux, Richard; Assiotis, Ioannis; Fenwick, Kerry; Begum, Ruwaida; Begum, Dipa; Lund, Tom; Sivamanoharan, Nanna; Sansano, Harold B.; Domingo-Arada, Melissa; Tran, Amina; Pandha, Hardev; Church, David; Eccles, Bryony; Ellis, Richard; Falk, Stephen; Hill, Mark; Krell, Daniel; Murugaesu, Nirupa; Nolan, Luke; Potter, Vanessa; Saunders, Mark; Shiu, Kai-Keen; Guettler, Sebastian; Alexander, James L.; Lazare-Iglesias, Hector; Kinross, James; Murphy, Jamie; von Loga, Katharina; Cunningham, David; Chau, Ian; Starling, Naureen; Ruiz-Banobre, Juan; Dhillon, Tony; Gerlinger, Marco Share Save Maintenance rucaparib after first-line platinum-based chemotherapy in advanced esophagogastric (OG) adenocarcinoma: Interim results from the PLATFORM trialGordon, A.; Fong, C. Y. K.; Davidson, M.; Cromarty, S.; Kidd, S.; Piadel, K.; Peckitt, C.; Satchwell, L.; Rajan, Z.; Begum, R.; Zhitkov, O.; Das, P.; Sothi, S.; Herbertson, R. A.; Darby, S.; Waddell, T. S.; Bradshaw, A.; Starling, N.; Chau, I.; Cunningham, D. Share Save PD1 and LAG3 inhibition as second plus line treatment after EGFR antibody-containing therapy in RAS/BRAF wildtype, MMRp metastatic colorectal cancerMencel, J.; Turkes, F.; Barber, L.; Challoner, B.; Buzzetti, M.; Tran, A.; Chen, H.; McCafferty, N.; Woolston, A.; Crux, R.; Rana, I.; Thomas, J.; Borja, V.; Begum, R.; Johnston, E.; Fotiadis, N.; Terlizzo, M.; Rao, S.; Chau, I.; Cunningham, D.; Gerlinger, M.; Starling, N. Share Save Clonal mutation burden and evolutionary dynamics analysis in metastatic gastro-esophageal adenocarcinoma (GEA) by error corrected whole-exome circulating tumor DNA sequencingMcCafferty, Neil; Fong, Caroline; Barber, Louise J.; Woolston, Andrew; Kleftogiannis, Dimitrios; Rana, Taqia; Cromarty, Susan; Kidd, Shannon; Begum, Ruwaida; Chau, Ian; Starling, Naureen; Cunningham, David; Gerlinger, Marco Share Save Circulating tumor DNA for recurrence prediction and efficacy analysis in the ICONIC trial of peri-operative FLOT and avelumab (PD-L1) in localized esophago-gastric adenocarcinomaGerlinger, Marco; Gordon, Anderley; Barber, Louise J.; Laliotis, Georgios; Athauda, Avani; Challoner, Benjamin; Woolston, Andrew; Mansukhani, Sonia; Dunstan, Matt; Petrou, Nikoletta; Khabra, Komel; Lazaro-Alcausi, Retchel; Crux, Richard; Borja, Victoria; Begum, Ruwaida; Rana, Isma; Palsuledesai, Charuta; Malhotra, Meenakshi; Liu, Minetta; Jurdi, Adham; Sharma, Shruti; Rao, Sheela; Kumar, Sacheen; Cunningham, David; Chau, Ian; Starling, Naureen; Chaudry, M. Asif Share Save ctDNA guided adjuvant chemotherapy versus standard of care adjuvant chemotherapy after curative surgery in patients with high risk stage II or stage III colorectal cancer: a multi-centre, prospective, randomised control trial (TRACC Part C)Slater, Susanna; Bryant, Annette; Chen, Hsiang-Chi; Begum, Ruwaida; Rana, Isma; Aresu, Maria; Peckitt, Clare; Zhitkov, Oleg; Lazaro-Alcausi, Retchel; Borja, Victoria; Powell, Rachel; Lowery, David; Hubank, Michael; Rich, Thereasa; Anandappa, Gayathri; Chau, Ian; Starling, Naureen; Cunningham, David Share Save Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancerChalloner, Benjamin R.; Woolston, Andrew; Lau, David; Buzzetti, Marta; Barber, Louise J.; Lund, Tom; Sansano, Harold B.; von Loga, Katharina; Lazare-Iglesias, Hector; Begum, Ruwaida; Crux, Richard; Cunningham, David; Chau, Ian; Starling, Naureen; Ruiz-Banobre, Juan; Dhillon, Tony; Gerlinger, Marco Share Save Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancerChalloner, Benjamin R.; Woolston, Andrew; Lau, David; Buzzetti, Marta; Barber, Louise J.; Lund, Tom; Sansano, Harold B.; von Loga, Katharina; Lazare-Iglesias, Hector; Begum, Ruwaida; Crux, Richard; Cunningham, David; Chau, Ian; Starling, Naureen; Ruiz-Banobre, Juan; Dhillon, Tony; Gerlinger, Marco Share Save Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damageCarotenuto, Pietro; Amato, Francesco; Lampis, Andrea; Rae, Colin; Hedayat, Somaieh; Previdi, Maria C.; Zito, Domenico; Raj, Maya; Guzzardo, Vincenza; Sclafani, Francesco; Lanese, Andrea; Parisi, Claudia; Vicentini, Caterina; Said-Huntingford, Ian; Hahne, Jens C.; Hallsworth, Albert; Kirkin, Vladimir; Young, Kate; Begum, Ruwaida; Wotherspoon, Andrew; Kouvelakis, Kyriakos; Azevedo, Sergio Xavier; Michalarea, Vasiliki; Upstill-Goddard, Rosie; Rao, Sheela; Watkins, David; Starling, Naureen; Sadanandam, Anguraj; Chang, David K.; Biankin, Andrew, V; Jamieson, Nigel B.; Scarpa, Aldo; Cunningham, David; Chau, Ian; Workman, Paul; Fassan, Matteo; Valeri, Nicola; Braconi, Chiara Share Save EMERGE: A phase II trial assessing the efficacy of domatinostat plus avelumab in patients with previously treated advanced mismatch repair proficient oesophagogastric and colorectal cancers - phase IIA dose findingCartwright, E.; Turkes, F.; Saffery, C.; Tran, A.; Smith, G.; Moreno, S. Esteban; Hatt, S.; Renn, A.; Johnston, E.; Kohoutova, D.; Begum, R.; Smyth, E.; Peckitt, C.; Fribbens, C.; Rao, S.; Watkins, D.; Chau, I.; Starling, N.; Cunningham, D. Share Save The Mutational Concordance of Fixed Formalin Paraffin Embedded and Fresh Frozen Gastro-Oesophageal Tumours Using Whole Exome SequencingChong, Irene Y.; Starling, Naureen; Rust, Alistair; Alexander, John; Aronson, Lauren; Llorca-Cardenosa, Marta; Chauhan, Ritika; Chaudry, Asif; Kumar, Sacheen; Fenwick, Kerry; Assiotis, Ioannis; Matthews, Nik; Begum, Ruwaida; Wotherspoon, Andrew; Terlizzo, Monica; Watkins, David; Chau, Ian; Lord, Christopher J.; Haider, Syed; Rao, Sheela; Cunningham, David Share Save Modulation of Biliary Cancer Chemo-Resistance Through MicroRNA-Mediated Rewiring of the Expansion of CD133+CellsCarotenuto, Pietro; Hedayat, Somaieh; Fassan, Matteo; Cardinale, Vincenzo; Lampis, Andrea; Guzzardo, Vincenza; Vicentini, Caterina; Scarpa, Aldo; Cascione, Luciano; Costantini, Daniele; Carpino, Guido; Alvaro, Domenico; Ghidini, Michele; Trevisani, Francesco; Te Poele, Robert; Salati, Massimiliano; Ventura, Sofia; Vlachogiannis, Georgios; Hahne, Jens C.; Boulter, Luke; Forbes, Stuart J.; Guest, Rachel V.; Cillo, Umberto; Said-Huntingford, Ian; Begum, Ruwaida; Smyth, Elizabeth; Michalarea, Vasiliki; Cunningham, David; Rimassa, Lorenza; Santoro, Armando; Roncalli, Massimo; Kirkin, Vladimir; Clarke, Paul; Workman, Paul; Valeri, Nicola; Braconi, Chiara Share Save Diagnostic Accuracy and Safety of Coaxial System in Oncology Patients Treated in a Specialist Cancer Center With Prospective Validation Within Clinical Trial DataKhan, Khurum; Gonzalez-Exposito, Reyes; Cunningham, David; Koh, Dow-Mu; Woolston, Andrew; Barber, Louise; Griffiths, Beatrice; Kouvelakis, Kyriakos; Calamai, Vanessa; Bali, Monia; Khan, Nasir; Bryant, Annette; Saffery, Claire; Dearman, Charles; Begum, Ruwaida; Rao, Sheela; Starling, Naureen; Watkins, David; Chau, Ian; Braconi, Chiara; Valeri, Nicola; Gerlinger, Marco; Fotiadis, Nicos Share Save MicroRNA deregulation of the serine synthesis pathway controls intrinsic and non-cell autonomous mechanism of resistance to Regorafenib in metastatic colorectal cancer (mCRC)Hedayat, Somaieh; Lampis, Andrea; Vlachogiannis, George; Khan, Khurum; Marchetti, Silvia; Fassan, Matteo; Ghidini, Michele; Begum, Ruwaida; Schirripa, Marta; Passalacqua, Rodolfo; Cunningham, David; Loupakis, Fotios; Valeri, Nicola Share Save MicroRNAs as biomarkers of resistance to HER2 inhibition in combination with chemotherapy in gastro-esophageal cancerLote, Hazel; Lampis, Andrea; Vlachogiannis, George; Hahne, Jens; Moorcraft, Sing-Yu; Davidson, Michael; Fong, Carolin; Begum, Ruwaida; Fassan, Matteo; Rao, Sheela; Watkins, David; Starling, Naureen; Chau, Ian; Cunningham, David; Valeri, Nicola Share Save A comparison of the transcriptomic profiles of matched tissue from primary colorectal cancer and corresponding secondary lung metastasesKhakoo, S.; Moorcraft, S.; Pacis, A.; Munter, M.; Lathrop, M.; Lefebvre, F.; Riazalhosseini, Y.; Shaikh, R.; Jones, T.; Begum, R.; Wotherspoon, A.; Saffery, C.; Kalaitzaki, E.; Anbunathan, H.; Rao, S.; Watkins, D.; Starling, N.; Cunningham, D.; Chau, I.; Bowcock, A. 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