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SaveONC213: a novel strategy to resensitize resistant AML cells to venetoclax through induction of mitochondrial stress
Carter, Jenna L.; Su, Yongwei; Al-Antary, Eman T.; Zhao, Jianlei; Qiao, Xinan; Wang, Guan; Edwards, Holly; Polin, Lisa; Kushner, Juiwanna; Dzinic, Sijana H.; White, Kathryn; Buck, Steven A.; Huettemann, Maik; Allen, Joshua E.; Prabhu, Varun V.; Yang, Jay; Taub, Jeffrey W.; Ge, Yubin Share Save Share Save Share Save ONC201 COMBINED WITH THE ONCOLYTIC ADENOVIRUS DELTA-24-RGD AS A NEW THERAPEUTIC REGIME FOR PEDIATRIC HIGH-GRADE AND DIFFUSE MIDLINE GLIOMASde la Nava, Daniel; Ausejo-Mauleon, Iker; Nazarian, Javad; Mueller, Sabine; Allen, Joshua E.; Koschmann, Carl; Venneti, Sriram; Dun, Matthew D.; Gomez-Manzano, Candelaria; Fueyo, Juan; Patino-Garcia, Ana; Alonso, Marta M. Share Save Safety and pharmacokinetics of ONC201 (dordaviprone) administered two consecutive days per week in pediatric patients with H3 K27M-mutant gliomaOdia, Yazmin; Koschmann, Carl; Vitanza, Nicholas A.; de Blank, Peter; Aguilera, Dolly; Allen, Jeffrey; Daghistani, Doured; Hall, Matthew; Khatib, Ziad; Kline, Cassie; Macdonald, Tobey; Mueller, Sabine; Faison, Shamia L.; Allen, Joshua E.; Naderer, Odin J.; Ramage, Samuel C.; Tarapore, Rohinton S.; Mcgovern, Susan Lynne; Khatua, Soumen; Zaky, Wafik; Gardner, Sharon L. Share Save The oncolytic adenovirus Delta-24-RGD in combination with ONC201 induces a potent antitumor response in pediatric high-grade and diffuse midline glioma modelsde la Nava, Daniel; Ausejo-Mauleon, Iker; Laspidea, Virginia; Gonzalez-Huarriz, Marisol; Lacalle, Andrea; Casares, Noelia; Zalacain, Marta; Marrodan, Lucia; Garcia-Moure, Marc; Ochoa, Maria C.; Tallon-Cobos, Antonio Carlos; Hernandez-Osuna, Reyes; Marco-Sanz, Javier; Dhandapani, Laasya; Hervas-Corpion, Irati; Becher, Oren J.; Nazarian, Javad; Mueller, Sabine; Phoenix, Timothy N.; van der Lugt, Jasper; Hernaez, Mikel; Guruceaga, Elizabeth; Koschmann, Carl; Venneti, Sriram; Allen, Joshua E.; Dun, Matthew D.; Fueyo, Juan; Gomez-Manzano, Candelaria; Perez-Larraya, Jaime Gallego; Patino-Garcia, Ana; Labiano, Sara; Alonso, Marta M. Share Save ACTION: a randomized phase 3 study of ONC201 (dordaviprone) in patients with newly diagnosed H3 K27M-mutant diffuse gliomaArrillaga-Romany, Isabel; Lassman, Andrew; Mcgovern, Susan L.; Mueller, Sabine; Nabors, Burt; van den Bent, Martin; Vogelbaum, Michael A.; Allen, Joshua E.; Melemed, Allen S.; Tarapore, Rohinton S.; Wen, Patrick Y.; Cloughesy, Timothy Share Save Share Save Selective DRD2 antagonist and ClpP agonist ONC201 in a recurrent non-midline H3 K27M-mutant glioma cohortOdia, Yazmin; Hall, Matthew D.; Cloughesy, Timothy Francis; Wen, Patrick Y.; Arrillaga-Romany, Isabel; Daghistani, Doured; Mehta, Minesh P.; Tarapore, Rohinton S.; Ramage, Samuel C.; Allen, Joshua E. Share Save Patient-Level and Center-Level Factors Associated with Required Predonation Weight Loss among Obese Living Kidney DonorsPerry, Jackson; McLeod, M. Chandler; Reed, Rhiannon D.; Baker, Gavin A.; Stanford, Luke A.; Allen, Joshua; Jones, Bernarez; Robinson, Tayana; MacLennan, Paul A.; Kumar, Vineeta; Locke, Jayme E. Share Save The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid LeukemiaSu, Yongwei; Carter, Jenna L.; Li, Xinyu; Fukuda, Yu; Gray, Ashley; Lynch, John; Edwards, Holly; Ma, Jun; Schreiner, Patrick; Polin, Lisa; Kushner, Juiwanna; Dzinic, Sijana H.; Buck, Steven A.; Pruett-Miller, Shondra M.; Hege-Hurrish, Katie; Robinson, Camenzind; Qiao, Xinan; Liu, Shuang; Wu, Shuangshuang; Wang, Guan; Li, Jing; Allen, Joshua E.; Prabhu, Varun V.; Schimmer, Aaron D.; Joshi, Dhananjay; Kalhor-Monfared, Shiva; Watson, Iain D. G.; Marcellus, Richard; Isaac, Methvin B.; Al-awar, Rima; Taub, Jeffrey W.; Lin, Hai; Schuetz, John D.; Ge, Yubin Share Save Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic PathwaysVenneti, Sriram; Kawakibi, Abed Rahman; Ji, Sunjong; Waszak, Sebastian M.; Sweha, Stefan R.; Mota, Mateus; Pun, Matthew; Deogharkar, Akash; Chung, Chan; Tarapore, Rohinton S.; Ramage, Samuel; Chi, Andrew; Wen, Patrick Y.; Arrillaga-Romany, Isabel; Batchelor, Tracy T.; Butowski, Nicholas A.; Sumrall, Ashley; Shonka, Nicole; Harrison, Rebecca A.; De Groot, John; Mehta, Minesh; Hall, Matthew D.; Daghistani, Doured; Cloughesy, Timothy F.; Ellingson, Benjamin M.; Beccaria, Kevin; Varlet, Pascale; Kim, Michelle M.; Umemura, Yoshie; Garton, Hugh; Franson, Andrea; Schwartz, Jonathan; Jain, Rajan; Kachman, Maureen; Baum, Heidi; Burant, Charles F.; Mottl, Sophie L.; Cartaxo, Rodrigo T.; John, Vishal; Messinger, Dana; Qin, Tingting; Peterson, Erik; Sajjakulnukit, Peter; Ravi, Karthik; Waugh, Alyssa; Walling, Dustin; Ding, Yujie; Xia, Ziyun; Schwendeman, Anna; Hawes, Debra; Yang, Fusheng; Judkins, Alexander R.; Wahl, Daniel; Lyssiotis, Costas A.; de la Nava, Daniel; Alonso, Marta M.; Eze, Augustine; Spitzer, Jasper; Schmidt, Susanne V.; Duchatel, Ryan J.; Dun, Matthew D.; Cain, Jason E.; Jiang, Li; Stopka, Sylwia A.; Baquer, Gerard; Regan, Michael S.; Filbin, Mariella G.; Agar, Nathalie Y. R.; Zhao, Lili; Kumar-Sinha, Chandan; Mody, Rajen; Chinnaiyan, Arul; Kurokawa, Ryo; Pratt, Drew; Yadav, Viveka N.; Grill, Jacques; Kline, Cassie; Mueller, Sabine; Resnick, Adam; Nazarian, Javad; Allen, Joshua E.; Odia, Yazmin; Gardner, Sharon L.; Koschmann, Carl Share Save A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancerParaghamian, Sarah E.; Qiu, Jianqing; Hawkins, Gabrielle M.; Zhao, Ziyi; Sun, Wenchuan; Fan, Yali; Zhang, Xin; Suo, Hongyan; Hao, Tianran; Prabhu, Varun Vijay; Allen, Joshua E.; Zhou, Chunxiao; Bae-Jump, Victoria Share Save ACTION: A randomized phase 3 study of dordaviprone (ONC201) in patients with newly diagnosed H3 K27M-mutant diffuse gliomaArrillaga-Romany, Isabel; Lassman, Andrew; McGovern, Susan L.; Mueller, Sabine; Nabors, Louis B.; Van den Bent, Martin; Vogelbaum, Michael; Allen, Joshua E.; Melemed, Allen S.; Tarapore, Rohinton S.; Yang, Dewen; Wen, Patrick; Cloughsey, Timothy Share Save Share Save Depicting ONC201/Delta-24-RGD combination for the treatment of pHGGs and DMGs reveals a therapeutic benefit and a proinflammatory tumor microenvironment remodelationde la Nava, Daniel; Laspidea, Virginia; Ausejo-Mauleon, Iker; Garcia-Moure, Marc; Mueller, Sabine; Nazarian, Javad; Allen, Joshua E.; Becher, Oren; Fueyo, Juan; Gomez-Manzano, Candelaria; Patino-Garcia, Ana; Koschmann, Carl; Alonso, Marta M. Share Save Hypothetical generalized framework for a new imaging endpoint of therapeutic activity in early phase clinical trials in brain tumorsEllingson, Benjamin M.; Gerstner, Elizabeth R.; Lassman, Andrew B.; Chung, Caroline; Colman, Howard; Cole, Patricia E.; Leung, David; Allen, Joshua E.; Ahluwalia, Manmeet S.; Boxerman, Jerrold; Brown, Matthew; Goldin, Jonathan; Nduom, Edjah; Hassan, Islam; Gilbert, Mark R.; Mellinghoff, Ingo K.; Weller, Michael; Chang, Susan; Arons, David; Meehan, Clair; Selig, Wendy; Tanner, Kirk; Yung, W. K. Alfred; van den Bent, Martin; Wen, Patrick Y.; Cloughesy, Timothy F. Share Save Anti-Tumor and Anti-Invasive Effects of ONC201 on Ovarian Cancer Cells and a Transgenic Mouse Model of Serous Ovarian CancerFan, Yali; Wang, Jiandong; Fang, Ziwei; Pierce, Stuart R.; West, Lindsay; Staley, Allison; Tucker, Katherine; Yin, Yajie; Sun, Wenchuan; Kong, Weimin; Prabhu, Varun; Allen, Joshua E.; Zhou, Chunxiao; Bae-Jump, Victoria L. Share Save Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline gliomaCantor, Evan; Wierzbicki, Kyle; Tarapore, Rohinton S.; Ravi, Karthik; Thomas, Chase; Cartaxo, Rodrigo; Yadav, Viveka Nand; Ravindran, Ramya; Bruzek, Amy K.; Wadden, Jack; John, Vishal; Babila, Clarissa May; Cummings, Jessica R.; Kawakibi, Abed Rahman; Ji, Sunjong; Ramos, Johanna; Paul, Alyssa; Walling, Dustin; Leonard, Marcia; Robertson, Patricia; Franson, Andrea; Mody, Rajen; Garton, Hugh J. L.; Venetti, Sriram; Odia, Yazmin; Kline, Cassie; Vitanza, Nicholas A.; Khatua, Soumen; Mueller, Sabine; Allen, Joshua E.; Gardner, Sharon L.; Koschmann, Carl Share Save 
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