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JAK inhibition decreases the autoimmune burden in Down syndrome Rachubinski, Angela L.; Wallace, Elizabeth; Gurnee, Emily; Enriquez-Estrada, Belinda A.; Worek, Kayleigh R.; Smith, Keith P.; Araya, Paula; Waugh, Katherine A.; Granrath, Ross E.; Britton, Eleanor; Lyford, Hannah R.; Donovan, Micah G.; Eduthan, Neetha Paul; Hill, Amanda A.; Martin, Barry; Sullivan, Kelly D.; Patel, Lina; Fidler, Deborah J.; Galbraith, Matthew D.; Dunnick, Cory A.; Norris, David A.; Espinosa, Joaquin M. Share Save
Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome Donovan, Micah G.; Rachubinski, Angela L.; Smith, Keith P.; Araya, Paula; Waugh, Katherine A.; Enriquez-Estrada, Belinda; Britton, Eleanor C.; Lyford, Hannah R.; Granrath, Ross E.; Schade, Kyndal A.; Kinning, Kohl T.; Eduthan, Neetha Paul; Sullivan, Kelly D.; Galbraith, Matthew D.; Espinosa, Joaquin M. Share Save
Variegated overexpression of chromosome 21 genes reveals molecular and immune subtypes of Down syndrome Donovan, Micah G.; Eduthan, Neetha P.; Smith, Keith P.; Britton, Eleanor C.; Lyford, Hannah R.; Araya, Paula; Granrath, Ross E.; Waugh, Katherine A.; Estrada, Belinda Enriquez; Rachubinski, Angela L.; Sullivan, Kelly D.; Galbraith, Matthew D.; Espinosa, Joaquin M. Share Save
Plasma neurofilament light chain concentrations are elevated in youth-onset type 2 diabetes and associated with neuropathy Fridman, Vera; Sillau, Stefan; Ritchie, Alanna; Bockhorst, Jacob; Coughlan, Christina; Araya, Paula; Espinosa, Joaquin M.; Smith, Keith; Lange, Ethan M.; Lange, Leslie A.; Ghormli, Laure El; Drews, Kimberly L.; Zeitler, Philip; Reusch, Jane E. B. Share Save
Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition Galbraith, Matthew D.; Rachubinski, Angela L.; Smith, Keith P.; Araya, Paula; Waugh, Katherine A.; Enriquez-Estrada, Belinda; Worek, Kayleigh; Granrath, Ross E.; Kinning, Kohl T.; Eduthan, Neetha Paul; Ludwig, Michael P.; Hsieh, Elena W. Y.; Sullivan, Kelly D.; Espinosa, Joaquin M. Share Save
Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation Tatavosian, Roubina; Donovan, Micah G.; Galbraith, Matthew D.; Duc, Huy N.; Szwarc, Maria M.; Joshi, Molishree U.; Frieman, Amy; Bilousova, Ganna; Cao, Yingqiong; Smith, Keith P.; Song, Kunhua; Rachubinski, Angela L.; Andrysik, Zdenek; Espinosa, Joaquin M. Share Save
IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome Araya, Paula; Kinning, Kohl T.; Coughlan, Christina; Smith, Keith P.; Granrath, Ross E.; Enriquez-Estrada, Belinda A.; Worek, Kayleigh; Sullivan, Kelly D.; Rachubinski, Angela L.; Wolter-Warmerdam, Kristine; Hickey, Francis; Galbraith, Matthew D.; Potter, Huntington; Espinosa, Joaquin M. Share Save
Specialized interferon action in COVID-19 Galbraith, Matthew D.; Kinning, Kohl T.; Sullivan, Kelly D.; Araya, Paula; Smith, Keith P.; Granrath, Ross E.; Shaw, Jessica R.; Baxter, Ryan; Jordan, Kimberly R.; Russell, Seth; Dzieciatkowska, Monika; Reisz, Julie A.; Gamboni, Fabia; Cendali, Francesca; Ghosh, Tusharkanti; Guo, Kejun; Wilson, Cara C.; Santiago, Mario L.; Monte, Andrew A.; Bennett, Tellen D.; Hansen, Kirk C.; Hsieh, Elena W. Y.; D'Alessandro, Angelo; Espinosa, Joaquin M. Share Save
The COVIDome Explorer researcher portal Sullivan, Kelly D.; Galbraith, Matthew D.; Kinning, Kohl T.; Bartsch, Kyle; Levinsky, Nik; Araya, Paula; Smith, Keith P.; Granrath, Ross E.; Shaw, Jessica R.; Baxter, Ryan; Jordan, Kimberly R.; Russell, Seth; Dzieciatkowska, Monika; Reisz, Julie A.; Gamboni, Fabia; Cendali, Francesca; Ghosh, Tusharkanti; Monte, Andrew A.; Bennett, Tellen D.; Miller, Michael G.; Hsieh, Elena W. Y.; D'Alessandro, Angelo; Hansen, Kirk C.; Espinosa, Joaquin M. Share Save
Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation Liggett, L. Alexander; Galbraith, Matthew D.; Smith, Keith P.; Sullivan, Kelly D.; Granrath, Ross E.; Enriquez-Estrada, Belinda; Kinning, Kohl T.; Shaw, Jessica R.; Rachubinski, Angela L.; Espinosa, Joaquin M.; DeGregori, James Share Save
Seroconversion stages COVID19 into distinct pathophysiological states Galbraith, Matthew D.; Kinning, Kohl T.; Sullivan, Kelly D.; Baxter, Ryan; Araya, Paula; Jordan, Kimberly R.; Russell, Seth; Smith, Keith P.; Granrath, Ross E.; Shaw, Jessica; Dzieciatkowska, Monika; Ghosh, Tusharkanti; Monte, Andrew A.; D'Alessandro, Angelo; Hansen, Kirk C.; Bennett, Tellen D.; Hsieh, Elena W. Y.; Espinosa, Joaquin M. Share Save
JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome Tuttle, Kathryn D.; Waugh, Katherine A.; Araya, Paula; Minter, Ross; Orlicky, David J.; Ludwig, Michael; Andrysik, Zdenek; Burchill, Matthew A.; Tamburini, Beth A. J.; Sempeck, Colin; Smith, Keith; Granrath, Ross; Tracy, Dayna; Baxter, Jessica; Espinosa, Joaquin M.; Sullivan, Kelly D. Share Save
Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity Araya, Paula; Waugh, Katherine A.; Sullivan, Kelly D.; Nunez, Nicolas G.; Roselli, Emiliano; Smith, Keith P.; Granrath, Ross E.; Rachubinski, Angela L.; Estrada, Belinda Enriquez; Butcher, Eric T.; Minter, Ross; Tuttle, Kathryn D.; Bruno, Tullia C.; Maccioni, Mariana; Espinosa, Joaquin M. Share Save
Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome Waugh, Katherine A.; Araya, Paula; Pandey, Ahwan; Jordan, Kimberly R.; Smith, Keith P.; Granrath, Ross E.; Khanal, Santosh; Butcher, Eric T.; Estrada, Belinda Enriquez; Rachubinski, Angela L.; McWilliams, Jennifer A.; Minter, Ross; Dimasi, Tiana; Colvin, Kelley L.; Baturin, Dmitry; Pham, Andrew T.; Galbraith, Matthew D.; Bartsch, Kyle W.; Yeager, Michael E.; Porter, Christopher C.; Sullivan, Kelly D.; Hsieh, Elena W.; Espinosa, Joaquin M. Share Save
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors Powers, Rani K.; Culp-Hi, Rachel; Ludwig, Michael P.; Smith, Keith P.; Waugh, Katherine A.; Minter, Ross; Tuttle, Kathryn D.; Lewis, Hannah C.; Rachubinski, Angela L.; Granrath, Ross E.; Carmona-Iragui, Maria; Wilkerson, Rebecca B.; Kahn, Darcy E.; Joshi, Molishree; Lleo, Alberto; Blesa, Rafael; Fortea, Juan; D'Alessandro, Angelo; Costello, James C.; Sullivan, Kelly D.; Espinosa, Joaquin M. Share Save
Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation Sullivan, Kelly D.; Evans, Donald; Pandey, Ahwan; Hraha, Thomas H.; Smith, Keith P.; Markham, Neil; Rachubinski, Angela L.; Wolter-Warmerdam, Kristine; Hickey, Francis; Espinosa, Joaquin M.; Blumenthal, Thomas Share Save
Novel Innate Immune Genes Regulating the Macrophage Response to Gram Positive Bacteria Alper, Scott; Warg, Laura A.; De Arras, Lesly; Flatley, Brenna R.; Davidson, Elizabeth J.; Adams, Jenni; Smith, Keith; Wohlford-Lenane, Christine L.; McCray, Paul B., Jr.; Pedersen, Brent S.; Schwartz, David A.; Yang, Ivana V. Share Save
Trisomy 21 consistently activates the interferon response Sullivan, Kelly D.; Lewis, Hannah C.; Hill, Amanda A.; Pandey, Ahwan; Jackson, Leisa P.; Cabral, Joseph M.; Smith, Keith P.; Liggett, L. Alexander; Gomez, Eliana B.; Galbraith, Matthew D.; DeGregori, James; Espinosa, Joaquin M. Share Save
Desmoplakin Variants Are Associated with Idiopathic Pulmonary Fibrosis Mathai, Susan K.; Pedersen, Brent S.; Smith, Keith; Russell, Pamela; Schwarz, Marvin I.; Brown, Kevin K.; Steele, Mark P.; Loyd, James E.; Crapo, James D.; Silverman, Edwin K.; Nickerson, Deborah; Fingerlin, Tasha E.; Yang, Ivana V.; Schwartz, David A. Share Save
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