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Functional assessment of RAD51 foci and replication fork dynamics in PARPi resistant BRCA1/2 mutated breast cancer Harvey-Jones, Elizabeth; Raghunandan, Maya; Robbez-Masson, Luisa; Alaguthurai, Thanussuyah; Llop-Guevara, Alba; Trendell, Jennifer; Rodriguez, Olga; Guzman, Marta; Weekes, Daniel; deRenty, Christelle; Knight, Eleanor; Marlow, Rebecca; Starling, Christopher; Liu, Ruifang; Ravindran, Nivedita; Roxanis, Ioannis; Lukashchuk, Natalia; Serra, Violeta; Pettitt, Stephen; Lord, Christopher; Tutt, Andrew N. J. Share Save
Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple-negative breast cancer Pascual-Reguant, Laura; Serra-Camprubi, Queralt; Datta, Debayan; Cianferoni, Damiano; Kourtis, Savvas; Ganez-Zapater, Antoni; Cannata, Chiara; Espinar, Lorena; Querol, Jessica; Garcia-Lopez, Laura; Musa-Afaneh, Sara; Guirola, Maria; Gkanogiannis, Anestis; Canturri, Andrea Miro; Guzman, Marta; Rodriguez, Olga; Herencia-Ropero, Andrea; Arribas, Joaquin; Serra, Violeta; Serrano, Luis; Tian, Tian, V; Peiro, Sandra; Sdelci, Sara Share Save
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer (September, 10.1038/s41467-022-32828-6, 2022) Palafox, Marta; Monserrat, Laia; Bellet, Meritxell; Villacampa, Guillermo; Gonzalez-Perez, Abel; Oliveira, Mafalda; Braso-Maristany, Fara; Ibrahimi, Nusaibah; Kannan, Srinivasaraghavan; Mina, Leonardo; Herrera-Abreu, Maria Teresa; Odena, Andreu; Sanchez-Guixe, Monica; Capelan, Marta; Azaro, Analia; Bruna, Alejandra; Rodriguez, Olga; Guzman, Marta; Grueso, Judit; Viaplana, Cristina; Hernandez, Javier; Su, Faye; Lin, Kui; Clarke, Robert B.; Caldas, Carlos; Arribas, Joaquin; Michiels, Stefan; Garcia-Sanz, Alicia; Turner, Nicholas C.; Prat, Aleix; Nuciforo, Paolo; Dienstmann, Rodrigo; Verma, Chandra S.; Lopez-Bigas, Nuria; Scaltriti, Maurizio; Arnedos, Monica; Saura, Cristina; Serra, Violeta Share Save
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer Palafox, Marta; Monserrat, Laia; Bellet, Meritxell; Villacampa, Guillermo; Gonzalez-Perez, Abel; Oliveira, Mafalda; Braso-Maristany, Fara; Ibrahimi, Nusaibah; Kannan, Srinivasaraghavan; Mina, Leonardo; Herrera-Abreu, Maria Teresa; Odena, Andreu; Sanchez-Guixe, Monica; Capelan, Marta; Azaro, Analia; Bruna, Alejandra; Rodriguez, Olga; Guzman, Marta; Grueso, Judit; Viaplana, Cristina; Hernandez, Javier; Su, Faye; Lin, Kui; Clarke, Robert B.; Caldas, Carlos; Arribas, Joaquin; Michiels, Stefan; Garcia-Sanz, Alicia; Turner, Nicholas C.; Prat, Aleix; Nuciforo, Paolo; Dienstmann, Rodrigo; Verma, Chandra S.; Lopez-Bigas, Nuria; Scaltriti, Maurizio; Arnedos, Monica; Saura, Cristina; Serra, Violeta Share Save
Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification Pellegrino, Benedetta; Herencia-Ropero, Andrea; Llop-Guevara, Alba; Pedretti, Flaminia; Moles-Fernandez, Alejandro; Viaplana, Cristina; Villacampa, Guillermo; Guzman, Marta; Rodriguez, Olga; Grueso, Judit; Jimenez, Jose; Arenas, Enrique J.; Degasperi, Andrea; Dias, Joao M. L.; Forment, Josep, V; O'Connor, Mark J.; Deas, Olivier; Cairo, Stefano; Zhou, Yinghui; Musolino, Antonino; Caldas, Carlos; Nik-Zainal, Serena; Clarke, Robert B.; Nuciforo, Paolo; Diez, Orland; Serres-Creixams, Xavier; Peg, Vicente; Espinosa-Bravo, Martin; Macarulla, Teresa; Oaknin, Ana; Mateo, Joaquin; Arribas, Joaquin; Dienstmann, Rodrigo; Bellet, Meritxell; Oliveira, Mafalda; Saura, Cristina; Gutierrez-Enriquez, Sara; Balmana, Judith; Serra, Violeta Share Save
Antitumor activity of patritumab deruxtecan (HER3-DXd), a HER3-directed antibody drug conjugate (ADC) across a diverse panel of breast cancer (BC) patient-derived xenografts (PDXs) Odena, Andreu; Monserrat, Laia; Braso-Maristany, Fara; Guzman, Marta; Grueso, Judit; Rodriguez, Olga; Scaltriti, Maurizio; Chandarlapaty, Sarat; Qiu, Yang; Koyama, Kumiko; Oliveira, Mafalda; Prat, Aleix; Serra, Violeta Share Save
PI3K activation promotes resistance to eribulin in HER2-negative breast cancer Gris-Oliver, Albert; Ibrahim, Yasir H.; Rivas, Martin A.; Garcia-Garcia, Celina; Sanchez-Guixe, Monica; Ruiz-Pace, Fiorella; Viaplana, Cristina; Perez-Garcia, Jose M.; Llombart-Cussac, Antonio; Grueso, Judit; Pares, Mireia; Guzman, Marta; Rodriguez, Olga; Anton, Pilar; Cozar, Patricia; Calvo, Maria Teresa; Bruna, Alejandra; Arribas, Joaquin; Caldas, Carlos; Dienstmann, Rodrigo; Nuciforo, Paolo; Oliveira, Mafalda; Cortes, Javier; Serra, Violeta Share Save
A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation Castroviejo-Bermejo, Marta; Cruz, Cristina; Llop-Guevara, Alba; Gutierrez-Enriquez, Sara; Ducy, Mandy; Hussein Ibrahim, Yasir; Gris-Oliver, Albert; Pellegrino, Benedetta; Bruna, Alejandra; Guzman, Marta; Rodriguez, Olga; Grueso, Judit; Bonache, Sandra; Moles-Fernandez, Alejandro; Villacampa, Guillermo; Viaplana, Cristina; Gomez, Patricia; Vidal, Marc; Peg, Vicente; Serres-Creixams, Xavier; Dellaire, Graham; Simard, Jacques; Nuciforo, Paolo; Rubio, Isabel T.; Dientsmann, Rodrigo; Barrett, J. Carl; Caldas, Carlos; Baselga, Jose; Saura, Cristina; Cortes, Javier; Deas, Olivier; Jonkers, Jos; Masson, Jean-Yves; Cairo, Stefano; Judde, Jean-Gabriel; O'Connor, Mark J.; Diez, Orland; Balmana, Judith; Serra, Violeta Share Save
Biomarkers of response to CDK4/6 inhibitor (CDK4/6i) in hormone receptor (HR) positive and HER2-positive breast cancer (BC) patient-derived xenografts (PDX) Palafox, Marta; Herrera-Abreu, Maria Teresa; Bellet, Meritxell; Oliveira, Mafalda; Bruna, Alejandra; Rodriguez, Olga; Guzman, Marta; Grueso, Judit; Vilaplana, Cristina; Arribas, Joaquin; di Tomaso, Emmanuelle; Su, Faye; Caldas, Carlos; Turner, Nicholas C.; Dienstmann, Rodrigo; Baselga, Jose; Scaltriti, Maurizio; Cortes, Javier; Saura, Cristina; Serra, Violeta Share Save
Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies Saei, Azad; Palafox, Marta; Benoukraf, Touati; Kumari, Nishi; Jaynes, Patrick William; Iyengar, Prasanna Vasudevan; Munoz-Couselo, Eva; Nuciforo, Paolo; Cortes, Javier; Notzel, Christopher; Kumarakulasinghe, Nesaretnam Barr; Richard, John Lalith Charles; Isa, Zul Fazreen Bin Adam; Pang, Brendan; Guzman, Marta; Siqin, Zhou; Yang, Henry; Tam, Wai Leong; Serra, Violeta; Eichhorn, Pieter Johan Adam Share Save
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer Cruz, C.; Castroviejo-Bermejo, M.; Gutierrez-Enriquez, S.; Llop-Guevara, A.; Ibrahim, Y. H.; Gris-Oliver, A.; Bonache, S.; Morancho, B.; Bruna, A.; Rueda, O. M.; Lai, Z.; Polanska, U. M.; Jones, G. N.; Kristel, P.; de Bustos, L.; Guzman, M.; Rodriguez, O.; Grueso, J.; Montalban, G.; Caratu, G.; Mancuso, F.; Fasani, R.; Jimenez, J.; Howat, W. J.; Dougherty, B.; Vivancos, A.; Nuciforo, P.; Serres-Creixams, X.; Rubio, I. T.; Oaknin, A.; Cadogan, E.; Barrett, J. C.; Caldas, C.; Baselga, J.; Saura, C.; Cortes, J.; Arribas, J.; Jonkers, J.; Diez, O.; O'Connor, M. J.; Balmana, J.; Serra, V Share Save
Identification of determinants of sensitivity to AKT inhibition using breast cancer (BC) patient-derived tumor xenografts (PDX) Gris-Oliver, Albert; Oliveira, Mafalda; Guzman, Marta; Rodriguez, Olga; Grueso, Judit; Scaltriti, Maurizio; Howat, William J.; Barrett, J. Carl; Cortes, Javier; Baselga, Jose; Schiavon, Gaia; Davies, Barry R.; Saura, Cristina; Serra, Violeta Share Save
Identification of CDK4/6-response biomarkers using estrogen receptor-positive breast cancer patient-derived xenografts (PDX) Serra, Violeta; Palafox, Marta; Herrera, Maria-Teresa; Rivas, Martin A.; Guzman, Marta; Rodriguez, Olga; Grueso, Judit; Bellet, Meritxell; Oliveira, Mafalda; Saura, Cristina; di Tomaso, Emmanuelle; Camponigro, Giordi; Turner, Nicholas C.; Cortes, Javier; Baselga, Jose Share Save
Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor-Positive Breast Cancer Herrera-Abreu, Maria Teresa; Palafox, Marta; Asghar, Uzma; Rivas, Martin A.; Cutts, Rosalind J.; Garcia-Murillas, Isaac; Pearson, Alex; Guzman, Marta; Rodriguez, Olga; Grueso, Judit; Bellet, Meritxell; Cortes, Javier; Elliott, Richard; Pancholi, Sunil; Baselga, Jose; Dowsett, Mitch; Martin, Lesley-Ann; Turner, Nicholas C.; Serra, Violeta Share Save
PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer Bosch, Ana; Li, Zhiqiang; Bergamaschi, Anna; Ellis, Haley; Toska, Eneda; Prat, Aleix; Tao, Jessica J.; Spratt, Daniel E.; Viola-Villegas, Nerissa T.; Castel, Pau; Minuesa, Gerard; Morse, Natasha; Rodon, Jordi; Ibrahim, Yasir; Cortes, Javier; Perez-Garcia, Jose; Galvan, Patricia; Grueso, Judit; Guzman, Marta; Katzenellenbogen, John A.; Kharas, Michael; Lewis, Jason S.; Dickler, Maura; Serra, Violeta; Rosen, Neal; Chandarlapaty, Sarat; Scaltriti, Maurizio; Baselga, Jose Share Save
Development of xenoimplants from germline BRCA1/2 mutant breast cancer (BC) for the identification of predictive biomarkers, mechanisms of resistance against poly(ADP-ribose) polymerase (PARP) inhibitors and evaluation of novel therapies Cruz, C.; Ibrahim, Y.; Morancho, B.; Anton, P.; Grueso, J.; Cozar, P.; Guzman, M.; Aviles, P. M.; Guillen, M. J.; Galmarini, C.; Arribas, J.; Baselga, J.; Balmana, J.; Serra, V. Share Save
PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition Ibrahim, Yasir H.; Garcia-Garcia, Celina; Serra, Violeta; He, Lei; Torres-Lockhart, Kristine; Prat, Aleix; Anton, Pilar; Cozar, Patricia; Guzman, Marta; Grueso, Judit; Rodriguez, Olga; Teresa Calvo, Maria; Aura, Claudia; Diez, Orland; Rubio, Isabel T.; Perez, Jose; Rodon, Jordi; Cortes, Javier; Ellisen, Leif W.; Scaltriti, Maurizio; Baselga, Jose Share Save
PI3K Inhibition Sensitizes Patient-derived Tumor Graft Models of Triple Negative Breast Cancer to PARP Inhibition Ibrahim, Y.; Garcia Garcia, C.; He, L.; Serra, V.; Anton, P.; Guzman, M.; Cozar, P.; Ellison, L.; Scaltriti, M.; Baslega, J. Share Save
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