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T

Tomas Leek

astrazeneca

10H-index
23Paper Count
327Citation Count
Published Papers 16
Publication Date
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The complexities of oligonucleotide therapeutics: analytical challenges and opportunities within early drug discovery
errBIOANALYSIS
IF1.8
err2025-12-01
err0
PREAI
errJora, Manasses; Manz, Christian; Thunberg, Linda; Holtta, Mikko; Leek, Tomas; Czechtizky, Werngard
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Rapid and Flexible Analytical Characterization of Oligonucleotides in Early Drug Discovery
errJournal of Chromatography A
IF4
err2025-11-04
err0
errOAAI
errKathrin Stavenhagen; Manasses Jora; Carina Leandersson; Rebecca Rae; Julien Bourquin; Vahid Golghalyani; Werngard Czechtizky; Tomas Leek
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Towards automatically verifying chemical structures: the powerful combination of 1H NMR and IR spectroscopy
errChem. Sci.
IF7.4
err2025-10-09
err0
errOAAI
errJ. Benji Rowlands; Lina Jonsson; Jonathan Goodman; Peter Howe; Werngard Czechtizky; Tomas Leek; Richard James Lewis
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Correction to “Closing the Design–Make–Test–Analyze Loop: Interplay between Experiments and Predictions Drives PROTACs Bioavailability”
errJournal of Medicinal Chemistry
IF6.8
err2025-07-16
err0
PREAI
errZulma Santisteban Valencia; Jennifer Kingston; Filip Miljković; Hannah Rowbottom; Nadia Mann; Sophie Davies; Martin Ekblad; Silvio Di Castro; Karolina Kwapień; Erik Malmerberg; Stig D. Friis; Thomas Lundbäck; Tomas Leek; Johan Wernevik
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A comparative study of ion exchange vs. ion pair chromatography for preparative separation of oligonucleotides
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2025-04-01
err0
errOAAI
errEnmark, Martin; Unoson, Cecilia; Lesko, Marek; Stalberg, Olof; Stavenhagen, Kathrin; Jora, Manasses; Leek, Tomas; Thunberg, Linda; Borland, Kayla; Samuelsson, Jorgen; Fornstedt, Torgny
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Closing the Design-Make-Test-Analyze Loop: Interplay between Experiments and Predictions Drives PROTACs Bioavailability
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-11-08
err0
PREAI
errValencia, Zulma Santisteban; Kingston, Jennifer; Miljkovic, Filip; Rowbottom, Hannah; Mann, Nadia; Davies, Sophie; Ekblad, Martin; Di Castro, Silvio; Kwapien, Karolina; Malmerberg, Erik; Friis, Stig D.; Lundback, Thomas; Leek, Tomas; Wernevik, Johan
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Unravelling the Link between Oligonucleotide Structure and Diastereomer Separation in Hydrophilic Interaction Chromatography
errANALYTICAL CHEMISTRY
IF6.7
err2024-06-10
err12
errOAAI
errLardeux, Honorine; Stavenhagen, Kathrin; Paris, Clement; Dueholm, Rikke; Kurek, Camille; De Maria, Leonardo; Gnerlich, Felix; Leek, Tomas; Czechtizky, Werngard; Guillarme, Davy; Jora, Manasses
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Strategies for predictive modeling of overloaded oligonucleotide elution profiles in ion-pair chromatography
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2023-11-01
err4
errOAAI
errLesko, Marek; Kaczmarski, Krzysztof; Jora, Manasses; Stavenhagen, Kathrin; Leek, Tomas; Czechtizky, Werngard; Fornstedt, Torgny; Samuelsson, Jorgen
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Analyzing proteolytic stability and metabolic hotspots of therapeutic peptides in two rodent pulmonary fluids
errJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
IF3.1
err2023-02-01
err1
PREAI
errWesche, Frank; De Maria, Leonardo; Leek, Tomas; Narjes, Frank; Bird, James; Su, Wu; Czechtizky, Werngard
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Automated high-throughput in vitro assays to identify metabolic hotspots and protease stability of structurally diverse, pharmacologically active peptides for inhalation
errJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
IF3.1
err2022-03-01
err3
PREAI
errWesche, Frank; De Maria, Leonardo; Leek, Tomas; Narjes, Frank; Bird, James; Su, Wu; Czechtizky, Werngard
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errSave
How well does molecular simulation reproduce environment-specific conformations of the intrinsically disordered peptides PLP, TP2 and ONEG?
errCHEMICAL SCIENCE
IF7.4
err2022-01-01
err9
errOAAI
errReid, Lauren M.; Guzzetti, Ileana; Svensson, Tor; Carlsson, Anna-Carin; Su, Wu; Leek, Tomas; von Sydow, Lena; Czechtizky, Werngard; Miljak, Marija; Verma, Chandra; De Maria, Leonardo; Essex, Jonathan W.
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First inter-laboratory study of a Supercritical Fluid Chromatography method for the determination of pharmaceutical impurities
errJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
IF3.1
err2018-11-01
err44
errOAAI
errDispas, Amandine; Marini, Roland; Desfontaine, Vincent; Veuthey, Jean-Luc; Kotoni, Dorina; Losacco, Luca Gioacchino; Clarke, Adrian; Galea, Charlene Muscat; Mangelings, Debby; Jocher, Brandon M.; Regalado, Erik L.; Plachka, Katerina; Novakova, Lucie; Wuyts, Benjamin; Francois, Isabelle; Gray, Michael; Aubin, Andrew J.; Tarafder, Abhijit; Cazes, Maxime; Desvignes, Christophe; Villemet, Loic; Sarrut, Morgan; Raimbault, Adrien; Lemasson, Elise; Lesellier, Eric; West, Caroline; Leek, Tomas; Wong, Mengling; Dai, Lulu; Zhang, Kelly; Perrenoud, Alexandre Grand-Guillaume; Brunelli, Claudio; Hennig, Philippe; Bertin, Sophie; Mauge, Fabien; Da Costa, Nathalie; Farrell, William P.; Hill, Madeleine; Desphande, Niranjan; Grangrade, Manish; Sadaphule, Santosh; Yadav, Ravi; Rane, Sandesh; Shringare, Shankar; Iguiniz, Marion; Heinisch, Sabine; Lefevre, Julien; Corbel, Estelle; Roques, Nicolas; Vander Heyden, Yvan; Guillarme, Davy; Hubert, Philippe
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Investigation of robustness for supercritical fluid chromatography separation of peptides: Isocratic vs gradient mode
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2018-09-01
err29
errOAAI
errEnmark, Martin; Glenne, Emelie; Lesko, Marek; Weinmann, Annika Langborg; Leek, Tomas; Kaczmarski, Krzysztof; Klarqvist, Magnus; Samuelsson, Jorgen; Fornstedt, Torgny
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The importance of ion-pairing in peptide purification by reversed-phase liquid chromatography
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2017-05-01
err26
PREAI
errAsberg, Dennis; Weinmann, Annika Langborg; Leek, Tomas; Lewis, Richard J.; Klarqvist, Magnus; Lesko, Marek; Kaczmarski, Krzysztof; Samuelsson, Jorgen; Fornstedt, Torgny
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Mucin-based stationary phases as tool for the characterization of drug-mucus interaction
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2014-07-01
err18
PREAI
errGargano, Andrea F. G.; Laemmerhofer, Michael; Loenn, Hans; Schoenmakers, Peter J.; Leek, Tomas
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Mixed-mode chromatography with zwitterionic phosphopeptidomimetic selectors from Ugi multicomponent reaction
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2013-11-01
err34
PREAI
errGargano, Andrea F. G.; Leek, Tomas; Lindner, Wolfgang; Laemmerhofer, Michael
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Research Directions

No research directions
Co-authors
Cooperation Journals
R
Richard J. Lewis
H-index: 85 · Papers: 673
W
Wolfgang Lindner
H-index: 73 · Papers: 685
D
Davy Guillarme
H-index: 72 · Papers: 440
J
Jean‐Luc Veuthey
H-index: 69 · Papers: 454
Y
Yvan Vander Heyden
H-index: 68 · Papers: 954
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