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S

Sarah Howlett

University College London

31H-index
72Paper Count
6.7KCitation Count
Published Papers 22
Publication Date
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Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers
errCell
IF42.5
err2025-08-26
err0
errOAAI
errEmily Grist; Peter Dutey-Magni; Marina A. Parry; Larissa Mendes; Ashwin Sachdeva; James A. Proudfoot; Anis A. Hamid; Mazlina Ismail; Sarah Howlett; Stefanie Friedrich; Lia DePaula Oliveira; Laura Murphy; Christopher Brawley; Oluwademilade Dairo; Sharanpreet Lall; Yang Liu; Daniel Wetterskog; Anna Wingate; Karolina Nowakowska; Leila Zakka; Claire L. Amos; Nafisah B. Atako; Victoria Wang; Hannah L. Rush; Robert J. Jones; Hing Leung; William R. Cross; Silke Gillessen; Chris C. Parker; Teresa Marafioti; Alfonso Urbanucci; Matthew Fittall; Edward M. Schaeffer; Daniel E. Spratt; David Waugh; Thomas Powles; Matthew R. Sydes; Felix Y. Feng; Daniel M. Berney; Mahesh K.B. Parmar; Noel W. Clarke; Elai Davicioni; Tamara L. Lotan; Christopher J. Sweeney; Louise C. Brown; Nicholas D. James; Gerhardt Attard
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errSave
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age
errNature Immunology
IF27.6
err2025-08-13
err0
errOAAI
errSteven B. Wells; Daniel B. Rainbow; Michal Mark; Peter A. Szabo; Can Ergen; Daniel P. Caron; Ana Raquel Maceiras; Elior Rahmani; Eli Benuck; Valeh Valiollah Pour Amiri; David Chen; Allon Wagner; Sarah K. Howlett; Lorna B. Jarvis; Karen L. Ellis; Masaru Kubota; Rei Matsumoto; Krishnaa Mahbubani; Kouresh Saeb-Parsy; Cecilia Dominguez Conde; Laura Richardson; Chuan Xu; Shuang Li; Lira Mamanova; Liam Bolt; Alicja Wilk; Sarah A. Teichmann; Donna L. Farber; Peter A. Sims; Joanne L. Jones; Nir Yosef
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errSave
The STAMPEDE2 niraparib-abiraterone acetate plus prednisolone trial: A phase III, randomised, open-label trial in patients with metastatic prostate cancer (mPC) with a deleterious alteration in a homologous recombination repair (HRR) gene starting androgen deprivation therapy (ADT)
errANNALS OF ONCOLOGY
IF65.4
err2024-09-01
err0
PREAI
errHowlett, S.; Kayani, M.; Brown, L. C.; Amos, C. L.; Dutey-Magni, P.; Yogeswaran, Y.; O'Shea, L.; Hogan, C.; Wingate, A.; Lall, S.; Eeles, R.; Hubank, M.; Williams, P.; Cross, W.; Sachdeva, A.; Clarke, N.; Parmar, M. K.; James, N. D.; Grist, E.; Attard, G.
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errSave
FlowAtlas: an interactive tool for high-dimensional immunophenotyping analysis bridging FlowJo with computational tools in Julia
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2024-07-17
err0
errOAAI
errCoppard, Valerie; Szep, Grisha; Georgieva, Zoya; Howlett, Sarah K.; Jarvis, Lorna B.; Rainbow, Daniel B.; Suchanek, Ondrej; Needham, Edward J.; Mousa, Hani S.; Menon, David K.; Feyertag, Felix; Mahbubani, Krishnaa T.; Saeb-Parsy, Kourosh; Jones, Joanne L.
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errSave
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
errCOMMUNICATIONS BIOLOGY
IF5.1
err2021-10-14
err30
errOAAI
errJarvis, Lorna B.; Rainbow, Daniel B.; Coppard, Valerie; Howlett, Sarah K.; Georgieva, Zoya; Davies, Jessica L.; Mullay, Harpreet Kaur; Hester, Joanna; Ashmore, Tom; Van den Bosch, Aletta; Grist, James T.; Coles, Alasdair J.; Mousa, Hani S.; Pluchino, Stefano; Mahbubani, Krishnaa T.; Griffin, Julian L.; Saeb-Parsy, Kourosh; Issa, Fadi; Peruzzotti-Jametti, Luca; Wicker, Linda S.; Jones, Joanne L.
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errSave
Immunological considerations and challenges for regenerative cellular therapies
errCOMMUNICATIONS BIOLOGY
IF5.1
err2021-06-25
err75
errOAAI
errPetrus-Reurer, Sandra; Romano, Marco; Howlett, Sarah; Jones, Joanne Louise; Lombardi, Giovanna; Saeb-Parsy, Kourosh
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errSave
Does Concurrent Use of CDK4/6 Inhibitors During Palliative Radiotherapy Increase Toxicity in Patients With Metastatic Breast Cancer?
errCLINICAL ONCOLOGY
IF3
err2021-01-01
err13
PREAI
errHowlett, S.; Harvey-Jones, E.; Smith, D.; Ahmad, S.; Goldsmith, C.; Sawyer, E.; Castell, F.; Swampillai, A.; Mullassery, V.
errShare
errSave
Distinct microbial and immune niches of the human colon
errNATURE IMMUNOLOGY
IF27.6
err2020-02-17
err181
errOAAI
errJames, Kylie R.; Gomes, Tomas; Elmentaite, Rasa; Kumar, Nitin; Gulliver, Emily L.; King, Hamish W.; Stares, Mark D.; Bareham, Bethany R.; Ferdinand, John R.; Petrova, Velislava N.; Polanski, Krzysztof; Forster, Samuel C.; Jarvis, Lorna B.; Suchanek, Ondrej; Howlett, Sarah; James, Louisa K.; Jones, Joanne L.; Meyer, Kerstin B.; Clatworthy, Menna R.; Saeb-Parsy, Kourosh; Lawley, Trevor D.; Teichmann, Sarah A.
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errSave
Keratinocyte growth factor impairs human thymic recovery from lymphopenia
errJCI INSIGHT
IF6.1
err2019-06-20
err18
errOAAI
errColes, Alasdair J.; Azzopardi, Laura; Kousin-Ezewu, Onajite; Mullay, Harpreet Kaur; Thompson, Sara A. J.; Jarvis, Lorna; Davies, Jessica; Howlett, Sarah; Rainbow, Daniel; Babar, Judith; Sadler, Timothy J.; Brown, J. William L.; Needham, Edward; May, Karen; Georgieva, Zoya G.; Handel, Adam E.; Maio, Stefano; Deadman, Mary; Rota, Ioanna; Hollander, Georg; Dawson, Sarah; Jayne, David; Seggewiss-Bernhardt, Ruth; Douek, Daniel C.; Isaacs, John D.; Jones, Joanne L.
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errSave
A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease
errJOURNAL OF AUTOIMMUNITY
IF7
err2018-12-01
err126
errOAAI
errPeterson, Laurence B.; Bell, Charles J. M.; Howlett, Sarah K.; Pekalski, Marcin L.; Brady, Kevin; Hinton, Heather; Sauter, Denise; Todd, John A.; Umana, Pablo; Ast, Oliver; Waldhauer, Inja; Freimoser-Grundschober, Anne; Moessner, Ekkehard; Klein, Christian; Hosse, Ralf J.; Wicker, Linda S.
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errSave
Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice
errJOURNAL OF IMMUNOLOGY
IF3.4
err2015-11-15
err13
errOAAI
errFraser, Heather I.; Howlett, Sarah; Clark, Jan; Rainbow, Daniel B.; Stanford, Stephanie M.; Wu, Dennis J.; Hsieh, Yi-Wen; Maine, Christian J.; Christensen, Mikkel; Kuchroo, Vijay; Sherman, Linda A.; Podolin, Patricia L.; Todd, John A.; Steward, Charles A.; Peterson, Laurence B.; Bottini, Nunzio; Wicker, Linda S.
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errSave
Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells
errJOURNAL OF AUTOIMMUNITY
IF7
err2015-01-01
err92
errOAAI
errBell, Charles J. M.; Sun, Yongliang; Nowak, Urszula M.; Clark, Jan; Howlett, Sarah; Pekalski, Marcin L.; Yang, Xin; Ast, Oliver; Waldhauer, Inja; Freimoser-Grundschober, Anne; Moessner, Ekkehard; Umana, Pablo; Klein, Christian; Hosse, Ralf J.; Wicker, Linda S.; Peterson, Laurence B.
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errSave
Evidence that Cd101 Is an Autoimmune Diabetes Gene in Nonobese Diabetic Mice
errJOURNAL OF IMMUNOLOGY
IF3.4
err2011-07-01
err32
errOAAI
errRainbow, Daniel B.; Moule, Carolyn; Fraser, Heather I.; Clark, Jan; Howlett, Sarah K.; Burren, Oliver; Christensen, Mikkel; Moody, Val; Steward, Charles A.; Mohammed, Javid P.; Fusakio, Michael E.; Masteller, Emma L.; Finger, Erik B.; Houchins, J. P.; Naf, Dieter; Koentgen, Frank; Ridgway, William M.; Todd, John A.; Bluestone, Jeffrey A.; Peterson, Laurence B.; Mattner, Jochen; Wicker, Linda S.
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errSave
Nonobese Diabetic Congenic Strain Analysis of Autoimmune Diabetes Reveals Genetic Complexity of the Idd18 Locus and Identifies Vav3 as a Candidate Gene
errJOURNAL OF IMMUNOLOGY
IF3.4
err2010-05-01
err28
errOAAI
errFraser, Heather I.; Dendrou, Calliope A.; Healy, Barry; Rainbow, Daniel B.; Howlett, Sarah; Smink, Luc J.; Gregory, Simon; Steward, Charles A.; Todd, John A.; Peterson, Laurence B.; Wicker, Linda S.
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errSave
Expression of Diabetes-Associated Genes by Dendritic Cells and CD4 T Cells Drives the Loss of Tolerance in Nonobese Diabetic Mice
errJOURNAL OF IMMUNOLOGY
IF3.4
err2009-08-01
err42
errOAAI
errHamilton-Williams, Emma E.; Martinez, Xavier; Clark, Jan; Howlett, Sarah; Hunter, Kara M.; Rainbow, Daniel B.; Wen, Li; Shlomchik, Mark J.; Katz, Jonathan D.; Beilhack, Georg F.; Wicker, Linda S.; Sherman, Linda A.
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errSave
NKG2D-RAE-1 Receptor-Ligand Variation Does Not Account for the NK Cell Defect in Nonobese Diabetic Mice
errJOURNAL OF IMMUNOLOGY
IF3.4
err2008-11-15
err14
errOAAI
errMaier, Lisa M.; Howlett, Sarah K.; Rainbow, Kara M.; Clark, Jan; Howson, Joanna M. M.; Todd, John A.; Wicker, Linda S.
errShare
errSave
Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species
errBIOCHEMICAL SOCIETY TRANSACTIONS
IF4.3
err2008-05-21
err29
errOAAI
errRainbow, Dan B.; Esposito, Laura; Howlett, Sarah K.; Hunter, Kara M.; Todd, John A.; Peterson, Laurence B.; Wicker, Linda S.
errShare
errSave
Genome-wide microarray expression analysis of CD4+ T cells from nonobese diabetic congenic mice identifies Cd55 (Daf1) and Acadl as candidate genes for type I diabetes
errJOURNAL OF IMMUNOLOGY
IF3.4
err2008-01-15
err25
errOAAI
errIrie, Junichiro; Reck, Brian; Wu, Yuehong; Wicker, Linda S.; Howlett, Sarah; Rainbow, Daniel; Feingold, Eleanor; Ridgway, William M.
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errSave
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
errNATURE GENETICS
IF31.8
err2007-02-04
err367
errOAAI
errYamanouchi, Jun; Rainbow, Dan; Serra, Pau; Howlett, Sarah; Hunter, Kara; Garner, Valerie E. S.; Gonzalez-Munoz, Andrea; Clark, Jan; Veijola, Riitta; Cubbon, Rose; Chen, Show-Ling; Rosa, Raymond; Cumiskey, Anne Marie; Serreze, David V.; Gregory, Simon; Rogers, Jane; Lyons, Paul A.; Healy, Barry; Smink, Luc J.; Todd, John A.; Peterson, Laurence B.; Wicker, Linda S.; Santamaria, Pere
errShare
errSave
Type 1 diabetes genes and pathways shared by humans and NOD mice
errJOURNAL OF AUTOIMMUNITY
IF7
err2005-01-01
err158
PREAI
errWicker, LS; Clark, J; Fraser, HI; Garner, VES; Gonzalez-Munoz, A; Healy, B; Howlett, S; Hunter, K; Rainbow, D; Rosa, RL; Smink, LJ; Todd, JA; Peterson, LB
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
J
Jeffrey A. Bluestone
H-index: 158 · Papers: 670
V
Vijay K. Kuchroo
H-index: 157 · Papers: 682
J
John A. Todd
H-index: 142 · Papers: 1.1K
S
Sarah A. Teichmann
H-index: 141 · Papers: 677
D
Daniel C. Douek
H-index: 137 · Papers: 595
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