Not logged inExpressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance
Cotton, Jennifer L.; Diez, Javier Estrada; Sagar, Vivek; Chen, Julie; Piquet, Michelle; Alford, John; Song, Youngchul; Li, Xiaoyan; Riester, Markus; Dimare, Matthew T.; Schumacher, Katja; Boulay, Gaylor; Sprouffske, Kathleen; Fan, Lin; Burks, Tyler; Mansur, Leandra; Wagner, Joel; Bhang, Hyo-eun C.; Iartchouk, Oleg; Reece-Hoyes, John; Morris, Erick J.; Hammerman, Peter S.; Ruddy, David A.; Korn, Joshua M.; Engelman, Jeffrey A.; Niederst, Matthew J. .png)
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SaveEchinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced SclerodermaPark, Gyu-Tae; Yoon, Jung-Won; Yoo, Sang-Bin; Song, Young-Chul; Song, Parkyong; Kim, Hyoung-Kyu; Han, Jin; Bae, Sung-Jin; Ha, Ki-Tae; Mishchenko, Natalia P.; Fedoreyev, Sergey A.; Stonik, Valentin A.; Kim, Moon-Bum; Kim, Jae-Ho Share Save Molecular barcoding and single cell approaches to investigate drug tolerance in EGFRmut NSCLCCotton, Jennifer L.; KrishnamurthyRadhakrishna, Viveksagar; Chen, Julie; Piquet, Michelle; Wagner, Joel; Boulay, Gaylor; Sprouffske, Kathleen; Song, Youngchul; Li, Xiaoyan; Schumacher, Katja; Thierry, Raphael; Kirkpatrick, Nathaniel D.; Ruddy, David A.; Korn, Joshua; Morris, Erick J.; Hammerman, Peter S.; Engelman, Jeffrey A.; Niederst, Matthew J. Share Save The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activationFerraro, Gino B.; Kodack, David P.; Askoxylakis, Vasileios; Sheng, Qing; Badeaux, Mark; Goel, Shom; Qi, Xiaolong; Shankaraiah, Ram; Cao, Alexander Z.; Ramjiawan, Rakesh R.; Bezwada, Divya; Patel, Bhushankumar; Song, Youngchul; Costa, Carlotta; Naxerova, Kamila; Wong, Christina; Kloepper, Jonas; Das, Rita; Tam, Angela; Tanboon, Jantima; Duda, Dan G.; Miller, Ryan C.; Siegel, Marni B.; Anders, Carey K.; Sanders, Melinda; Estrada, Valeria M.; Schlegel, Robert; Arteaga, Carlos L.; Brachtel, Elena; Huang, Alan; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K. Share Save Share Save Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancerFaber, Anthony C.; Farago, Anna F.; Costa, Carlotta; Dastur, Anahita; Gomez-Caraballo, Maria; Robbins, Rebecca; Wagner, Bethany L.; Rideout, William M., III; Jakubik, Charles T.; Ham, Jungoh; Edelman, Elena J.; Ebi, Hiromichi; Yeo, Alan T.; Hata, Aaron N.; Song, Youngchul; Patel, Neha U.; March, Ryan J.; Ah Ting Tam; Milano, Randy J.; Boisvert, Jessica L.; Hicks, Mark A.; Elmiligy, Sarah; Malstrom, Scott E.; Rivera, Miguel N.; Harada, Hisashi; Windle, Brad E.; Ramaswamy, Sridhar; Benes, Cyril H.; Jacks, Tyler; Engelman, Jeffrey A. Share Save Share Save Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS-mutant cancer modelsCorcoran, Ryan B.; Cheng, Katherine A.; Hata, Aaron N.; Faber, Anthony C.; Ebi, Hiromichi; Coffee, Erin M.; Greninger, Patricia; Brown, Ronald D.; Godfrey, Jason T.; Cohoon, Travis J.; Song, Youngchul; Lifshits, Eugene; Shioda, Toshi; Dias-Santagata, Dora; Singh, Anurag; Settleman, Jeffrey; Benes, Cyril H.; Mino-Kenudson, Mari; Wong, Kwok-Kin; Engelman, Jeffrey A. Share Save mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL Inhibition by Suppressing MCL-1Faber, Anthony C.; Coffee, Erin M.; Costa, Carlotta; Dastur, Anahita; Ebi, Hiromichi; Hata, Aaron N.; Yeo, Alan T.; Edelman, Elena J.; Song, Youngchul; Tam, Ah Ting; Boisvert, Jessica L.; Milano, Randy J.; Roper, Jatin; Kodack, David P.; Jain, Rakesh K.; Corcoran, Ryan B.; Rivera, Miguel N.; Ramaswamy, Sridhar; Hung, Kenneth E.; Benes, Cyril H.; Engelman, Jeffrey A. Share Save PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1Ebi, Hiromichi; Costa, Carlotta; Faber, Anthony C.; Nishtala, Madhuri; Kotani, Hiroshi; Juric, Dejan; Della Pelle, Patricia; Song, Youngchul; Yano, Seiji; Mino-Kenudson, Mari; Benes, Cyril H.; Engelman, Jeffrey A. Share Save PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.Ebi, Hiromichi; Costa, Carlotta; Faber, Anthony; Juric, Dejan; Della Pelle, Patricia; Song, Youngchui; Yano, Seiji; Mino-Kenudson, Mad; Benes, Cyril H.; Engelman, Jeffrey A. Share Save mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1Coffee, Erin M.; Faber, Anthony C.; Costa, Carlotta; Dastur, Anahita; Ebi, Hiromichi; Hata, Aaron N.; Yeo, Alan T.; Elena, J.; Song, Youngchul; Tam, Ah Ting; Boisvert, Jessica L.; Milano, Randy J.; Roper, Jatin; Kodack, David P.; Jain, Rakesh K.; Corcoran, Ryan B.; Rivera, Miguel N.; Ramaswamy, Sridhar; Hung, Kenneth E.; Benes, Cyril H.; Engelman, Jeffrey A. Share Save Share Save Share Save Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastasesKodack, David P.; Chung, Euiheon; Yamashita, Hiroshi; Incio, Joao; Duyverman, Annique M. M. J.; Song, Youngchul; Farrar, Christian T.; Huang, Yuhui; Ager, Eleanor; Kamoun, Walid; Goel, Shom; Snuderl, Matija; Lussiez, Alisha; Hiddingh, Lotte; Mahmood, Sidra; Tannous, Bakhos A.; Eichler, April F.; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K. Share Save Share Save Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancersEbi, Hiromichi; Corcoran, Ryan B.; Singh, Anurag; Chen, Zhao; Song, Youngchul; Lifshits, Eugene; Ryan, David P.; Meyerhardt, Jeffrey A.; Benes, Cyril; Settleman, Jeffrey; Wong, Kwok-Kin; Cantley, Lewis C.; Engelman, Jeffrey A. Share Save BIM Expression in Treatment-Naive Cancers Predicts Responsiveness to Kinase InhibitorsFaber, Anthony C.; Corcoran, Ryan B.; Ebi, Hiromichi; Sequist, Lecia V.; Waltman, Belinda A.; Chung, Euiheon; Incio, Joao; Digumarthy, Subba R.; Pollack, Sarah F.; Song, Youngchul; Muzikansky, Alona; Lifshits, Eugene; Roberge, Sylvie; Coffman, Erik J.; Benes, Cyril H.; Gomez, Henry L.; Baselga, Jose; Arteaga, Carlos L.; Rivera, Miguel N.; Dias-Santagata, Dora; Jain, Rakesh K.; Engelman, Jeffrey A. Share Save Using Tandem Mass Spectrometry in Targeted Mode to Identify Activators of Class IA PI3K in CancerYang, Xuemei; Turke, Alexa B.; Qi, Jie; Song, Youngchul; Rexer, Brent N.; Miller, Todd W.; Jaenne, Pasi A.; Arteaga, Carlos L.; Cantley, Lewis C.; Engelman, Jeffrey A.; Asara, John M. Share Save Receptor tyrosine kinases, not KRAS, activate PI3K in KRAS mutant colorectal cancersEbi, Hiromichi; Corcoran, Ryan B.; Singh, Anurag; Chen, Zhao; Song, Youngchul; Lifshits, Eugene; Ryan, David P.; Meyerhardt, Jeffrey A.; Benes, Cyril; Settleman, Jeffrey; Cantley, Lewis C.; Wong, Kwok-Kin; Engelman, Jeffrey A. Share Save 
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