Not logged in Camizestrant-induced heart rate reduction is mediated via a sinoatrial node pacemaker channel mechanism Hall, Andrew; El-Haou, Said; Villar, Inmaculada C.; Molla, David; Kwan, Maggie; Purbrick, Stuart; Henry, David; Kirk, Jason; Hawthorne, Glen; Canzolino, Serena; Harding, Joanna; Harmer, Alexander; Bucchi, Annalisa; Roberts, Liz; Pointon, Amy; Protze, Stephanie; Baruscotti, Mirko; Wright, Lindsay Share Save
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Computational approaches identify a transcriptomic fingerprint of drug-induced structural cardiotoxicity Au Yeung, Victoria P. W.; Obrezanova, Olga; Zhou, Jiarui; Yang, Hongbin; Bowen, Tara J.; Ivanov, Delyan; Saffadi, Izzy; Carter, Alfie S.; Subramanian, Vigneshwari; Dillmann, Inken; Hall, Andrew; Corrigan, Adam; Viant, Mark R.; Pointon, Amy Share Save
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Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes Raniga, Kavita; Nasir, Aishah; Vo, Nguyen T. N.; Vaidyanathan, Ravi; Dickerson, Sarah; Hilcove, Simon; Mosqueira, Diogo; Mirams, Gary R.; Clements, Peter; Hicks, Ryan; Pointon, Amy; Stebbeds, Will; Francis, Jo; Denning, Chris Share Save
Prediction of inotropic effect based on calcium transients in human iPSC-derived cardiomyocytes and machine learning Yang, Hongbin; Obrezanova, Olga; Pointon, Amy; Stebbeds, Will; Francis, Jo; Beattie, Kylie A.; Clements, Peter; Harvey, James S.; Smith, Graham F.; Bender, Andreas Share Save
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Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning Yang, Hongbin; Stebbeds, Will; Francis, Jo; Pointon, Amy; Obrezanova, Olga; Beattie, Kylie A.; Clements, Peter; Harvey, James S.; Smith, Graham F.; Bender, Andreas Share Save
In silico approaches in organ toxicity hazard assessment: Current status and future needs for predicting heart, kidney and lung toxicities Bassan, Arianna; Alves, Vinicius M.; Amberg, Alexander; Anger, Lennart T.; Beilke, Lisa; Bender, Andreas; Bernal, Autumn; Cronin, Mark T. D.; Hsieh, Jui-Hua; Johnson, Candice; Kemper, Raymond; Mumtaz, Moiz; Neilson, Louise; Pavan, Manuela; Pointon, Amy; Pletz, Julia; Ruiz, Patricia; Russo, Daniel P.; Sabnis, Yogesh; Sandhu, Reena; Schaefer, Markus; Stavitskaya, Lidiya; Szabo, David T.; Valentin, Jean-Pierre; Woolley, David; Zwickl, Craig; Myatt, Glenn J. Share Save
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Cardiovascular microphysiological systems (CVMPS) for safety studies - a pharma perspective Pointon, Amy; Maher, Jonathan; Davis, Myrtle; Baker, Thomas; Cichocki, Joseph; Ramsden, Diane; Hale, Christopher; Kolaja, Kyle L.; Levesque, Paul; Sura, Radhakrishna; Stresser, David M.; Gintant, Gary Share Save
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective Vargas, Hugo M.; Rolf, Michael G.; Wisialowski, Todd A.; Achanzar, William; Bahinski, Anthony; Bass, Alan; Benson, Charles T.; Chaudhary, Khuram W.; Couvreur, Nicolas; Dota, Corina; Engwall, Michael J.; Michael Foley, C.; Gallacher, David; Greiter-Wilke, Andrea; Guillon, Jean-Michel; Guth, Brian; Himmel, Herbert M.; Hegele-Hartung, Christa; Ito, Maki; Jenkinson, Stephen; Chiba, Katsuyoshi; Lagrutta, Armando; Levesque, Paul; Martel, Eric; Okai, Yoshiko; Peri, Ravikumar; Pointon, Amy; Qu, Yusheng; Teisman, Ard; Traebert, Martin; Yoshinaga, Takashi; Gintant, Gary A.; Leishman, Derek J.; Valentin, Jean-Pierre Share Save
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Drug-induced myocardial dysfunction - recommendations for assessment in clinical and pre-clinical studies Ebrahimi, Ahmad; Raichlen, Joel S.; Pointon, Amy; Gottfridsson, Christer; Munley, Jiefen; Hockings, Paul; Cartwright, James; Buss, Nicholas; Wikstrom, Johannes; Gan, Li-Ming; Whittaker, Andrew; Khalil, Ali; George, Richard T.; Garkaviy, Pavlo; Brott, David Share Save
On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships McAleer, Christopher W.; Pointon, Amy; Long, Christopher J.; Brighton, Rocky L.; Wilkin, Benjamin D.; Bridges, L. Richard; Sriram, Narasimham Narasimhan; Fabre, Kristin; McDougall, Robin; Muse, Victorine P.; Mettetal, Jerome T.; Srivastava, Abhishek; Williams, Dominic; Schnepper, Mark T.; Roles, Jeff L.; Shuler, Michael L.; Hickman, James J.; Ewart, Lorna Share Save
Information-Derived Mechanistic Hypotheses for Structural Cardiotoxicity Svensson, Fredrik; Zoufir, Azedine; Mahmoud, Samar; Afzal, Avid M.; Smit, Ines; Giblin, Kathryn A.; Clements, Peter J.; Mettetal, Jerome T.; Pointon, Amy; Harvey, James S.; Greene, Nigel; Williams, Richard V.; Bender, Andreas Share Save
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