Christopher M. Dobson - Publications, H-index & Citations

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Christopher M. Dobson

University of Cambridge

162H-index

1.1KPaper Count

11.8WCitation Count

Published Papers 381

Publication Date

Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-04-03

OAAI

Chen, Serene W.; Barritt, Joseph D.; Cascella, Roberta; Bigi, Alessandra; Cecchi, Cristina; Banchelli, Martina; Gallo, Angelo; Jarvis, James A.; Chiti, Fabrizio; Dobson, Christopher M.; Fusco, Giuliana; De Simone, Alfonso

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Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-05-15

OAAI

Miller, Alyssa; Wei, Jiapeng; Meehan, Sarah; Dobson, Christopher M.; Welland, Mark E.; Klenerman, David; Vendruscolo, Michele; Ruggeri, Francesco Simone; Knowles, Tuomas P. J.

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Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum

BIOSENSORS & BIOELECTRONICS

IF10.5

2023-05-01

OAAI

Schneider, Matthias M.; Scheidt, Tom; Priddey, Ashley J.; Xu, Catherine K.; Hu, Mengsha; Meisl, Georg; Devenish, Sean R. A.; Dobson, Christopher M.; Kosmoliaptsis, Vasilis; Knowles, Tuomas P. J.

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The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2022-09-07

OAAI

Fusco, Giuliana; Bemporad, Francesco; Chiti, Fabrizio; Dobson, Christopher M. M.; De Simone, Alfonso

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The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity

MOLECULES

IF4.6

2022-02-15

OAAI

Xu, Catherine K.; Castellana-Cruz, Marta; Chen, Serene W.; Du, Zhen; Meisl, Georg; Levin, Aviad; Mannini, Benedetta; Itzhaki, Laura S.; Knowles, Tuomas P. J.; Dobson, Christopher M.; Cremades, Nunilo; Kumita, Janet R.

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The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends

NATURE COMMUNICATIONS

IF15.7

2021-10-14

OAAI

Schneider, Matthias M.; Gautam, Saurabh; Herling, Therese W.; Andrzejewska, Ewa; Krainer, Georg; Miller, Alyssa M.; Trinkaus, Victoria A.; Peter, Quentin A. E.; Ruggeri, Francesco Simone; Vendruscolo, Michele; Bracher, Andreas; Dobson, Christopher M.; Hartl, F. Ulrich; Knowles, Tuomas P. J.

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The Amyloid Fibril-Forming β-Sheet Regions of Amyloid β and α-Synuclein Preferentially Interact with the Molecular Chaperone 14-3-3ζ

MOLECULES

IF4.6

2021-10-11

OAAI

Williams, Danielle M.; Thorn, David C.; Dobson, Christopher M.; Meehan, Sarah; Jackson, Sophie E.; Woodcock, Joanna M.; Carver, John A.

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Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2021-10-04

OAAI

Hakala, Tuuli A.; Yates, Emma, V; Challa, Pavan K.; Toprakcioglu, Zenon; Nadendla, Karthik; Matak-Vinkovic, Dijana; Dobson, Christopher M.; Martinez, Rodrigo; Corzana, Francisco; Knowles, Tuomas P. J.; Bernardes, Goncalo J. L.

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Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response (vol 4, 843, 2021)

COMMUNICATIONS BIOLOGY

IF5.1

2021-07-26

OAAI

Joshi, Priyanka; Perni, Michele; Limbocker, Ryan; Mannini, Benedetta; Casford, Sam; Chia, Sean; Habchi, Johnny; Labbadia, Johnathan; Dobson, Christopher M.; Vendruscolo, Michele

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Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans

SCIENTIFIC REPORTS

IF3.9

2021-07-13

OAAI

Perni, Michele; Mannini, Benedetta; Xu, Catherine K.; Kumita, Janet R.; Dobson, Christopher M.; Chiti, Fabrizio; Vendruscolo, Michele

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Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response

COMMUNICATIONS BIOLOGY

IF5.1

2021-07-07

OAAI

Joshi, Priyanka; Perni, Michele; Limbocker, Ryan; Mannini, Benedetta; Casford, Sam; Chia, Sean; Habchi, Johnny; Labbadia, Johnathan; Dobson, Christopher M.; Vendruscolo, Michele

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Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

FRONTIERS IN NEUROSCIENCE

IF3.2

2021-06-18

OAAI

Limbocker, Ryan; Staats, Roxine; Chia, Sean; Ruggeri, Francesco S.; Mannini, Benedetta; Xu, Catherine K.; Perni, Michele; Cascella, Roberta; Bigi, Alessandra; Sasser, Liam R.; Block, Natalie R.; Wright, Aidan K.; Kreiser, Ryan P.; Custy, Edward T.; Meisl, Georg; Errico, Silvia; Habchi, Johnny; Flagmeier, Patrick; Kartanas, Tadas; Hollows, Jared E.; Nguyen, Lam T.; LeForte, Kathleen; Barbut, Denise; Kumita, Janet R.; Cecchi, Cristina; Zasloff, Michael; Knowles, Tuomas P. J.; Dobson, Christopher M.; Chiti, Fabrizio; Vendruscolo, Michele

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Characterisation of the structural, dynamic and aggregation properties of the W64R amyloidogenic variant of human lysozyme

BIOPHYSICAL CHEMISTRY

IF2.2

2021-04-01

OAAI

Vettore, Nicola; Moray, Joel; Brans, Alain; Herman, Raphael; Charlier, Paulette; Kumita, Janet R.; Kerff, Frederic; Dobson, Christopher M.; Dumoulin, Mireille

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Scaling analysis reveals the mechanism and rates of prion replication in vivo

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2021-03-25

OAAI

Meisl, Georg; Kurt, Timothy; Condado-Morales, Itzel; Bett, Cyrus; Sorce, Silvia; Nuvolone, Mario; Michaels, Thomas C. T.; Heinzer, Daniel; Avar, Merve; Cohen, Samuel I. A.; Hornemann, Simone; Aguzzi, Adriano; Dobson, Christopher M.; Sigurdson, Christina J.; Knowles, Tuomas P. J.

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The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

NATURE COMMUNICATIONS

IF15.7

2021-03-22

146

OAAI

Cascella, Roberta; Chen, Serene W.; Bigi, Alessandra; Camino, Jose D.; Xu, Catherine K.; Dobson, Christopher M.; Chiti, Fabrizio; Cremades, Nunilo; Cecchi, Cristina

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Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors

ACS CHEMICAL NEUROSCIENCE

IF3.9

2021-02-04

OAAI

Fani, Giulia; Mannini, Benedetta; Vecchi, Giulia; Cascella, Roberta; Cecchi, Cristina; Dobson, Christopher M.; Vendruscolo, Michele; Chiti, Fabrizio

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A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers (vol 4, 19, 2021)

COMMUNICATIONS BIOLOGY

IF5.1

2021-01-26

OAAI

Cataldi, Rodrigo; Chia, Sean; Pisani, Katarina; Ruggeri, Francesco S.; Xu, Catherine K.; Sneideris, Tomas; Perni, Michele; Sarwat, Sunehera; Joshi, Priyanka; Kumita, Janet R.; Linse, Sara; Habchi, Johnny; Knowles, Tuomas P. J.; Mannini, Benedetta; Dobson, Christopher M.; Vendruscolo, Michele

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A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers

COMMUNICATIONS BIOLOGY

IF5.1

2021-01-04

OAAI

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Machine learning-aided protein identification from multidimensional signatures

LAB ON A CHIP

IF5.4

2021-01-01

OAAI

Zhang, Yuewen; Wright, Maya A.; Saar, Kadi L.; Challa, Pavankumar; Morgunov, Alexey S.; Peter, Quentin A. E.; Devenish, Sean; Dobson, Christopher M.; Knowles, Tuomas P. J.

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Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis

CELL CHEMICAL BIOLOGY

IF7.2

2021-01-01

OAAI

Lindstedt, Philip R.; Aprile, Francesco A.; Sormanni, Pietro; Rakoto, Robertinah; Dobson, Christopher M.; Bernardes, Goncalo J. L.; Vendruscolo, Michele

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Research Directions