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SaveIntegrative single-cell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B cell neoplasias
Guerrero-Murillo, Mercedes; Rill-Hinarejos, Aina; Trincado, Juan L.; Bataller, Alex; Ortiz-Maldonado, Valentin; Benitez-Ribas, Daniel; Espanol-Rego, Marta; Gonzalez-Navarro, Eazucena; Martinez-Cibrian, Nuria; Marchese, Domenica; Martin-Martin, Lourdes; Garcia-Sancho, Alejandro Martin; Rives, Susana; Heyn, Holger; Juan, Manel; Urbano-Ispizua, Alvaro; Delgado, Julio; Orfao, Alberto; Mereu, Elisabetta; Bueno, Clara; Menendez, Pablo Share Save Identification of novel small molecule-based strategies of COL7A1 upregulation and readthrough activity for the treatment of recessive dystrophic epidermolysis bullosaJover, Irene; Ramos, Maria C.; Escamez, Maria Jose; Lozoya, Estrella; Tormo, Jose R.; de Prado-Verdun, Diana; Mencia, Angeles; Pont, Merce; Puig, Carles; Larraufie, Marie-Helene; Gutierrez-Caballero, Cristina; Reyes, Fernando; Trincado, Juan Luis; Garcia-Gonzalez, Vicente; Cerrato, Rosario; Andres, Miriam; Crespo, Maribel; Vicente, Francisca; Godessart, Nuria; Genilloud, Olga; Larcher, Fernando; Nueda, Arsenio Share Save Integrative single-cell expression and functional studies unravels a sensitization to cytarabine-based chemotherapy through HIF pathway inhibition in AML leukemia stem cellsVelasco-Hernandez, Talia; Trincado, Juan L.; Vinyoles, Meritxell; Closa, Adria; Martinez-Moreno, Alba; Gutierrez-Aguera, Francisco; Molina, Oscar; Rodriguez-Cortez, Virginia C.; Ximeno-Parpal, Pau; Fernandez-Fuentes, Narcis; Petazzi, Paolo; Beneyto-Calabuig, Sergi; Velten, Lars; Romecin, Paola; Casquero, Raquel; Abollo-Jimenez, Fernando; de la Guardia, Rafael D.; Lorden, Patricia; Bataller, Alex; Lapillonne, Helene; Stam, Ronald W.; Vives, Susana; Torrebadell, Montserrat; Fuster, Jose L.; Bueno, Clara; Sarry, Jean-Emmanuel; Eyras, Eduardo; Heyn, Holger; Menendez, Pablo Share Save Converging and evolving immuno-genomic routes toward immune escape in breast cancerBlanco-Heredia, Juan; Souza, Carla Anjos; Trincado, Juan L.; Gonzalez-Cao, Maria; Goncalves-Ribeiro, Samuel; Gil, Sara Ruiz; Pravdyvets, Dmytro; Cedeno, Samandhy; Callari, Maurizio; Marra, Antonio; Gazzo, Andrea M.; Weigelt, Britta; Pareja, Fresia; Vougiouklakis, Theodore; Jungbluth, Achim A.; Rosell, Rafael; Brander, Christian; Tresserra, Francesc; Reis-Filho, Jorge S.; Tiezzi, Daniel Guimaraes; de la Iglesia, Nuria; Heyn, Holger; De Mattos-Arruda, Leticia Share Save Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progressionMolina, Oscar; Ortega-Sabater, Carmen; Thampi, Namitha; Fernandez-Fuentes, Narcis; Guerrero-Murillo, Mercedes; Martinez-Moreno, Alba; Vinyoles, Meritxell; Velasco-Hernandez, Talia; Bueno, Clara; Trincado, Juan L.; Granada, Isabel; Campos, Diana; Gimenez, Carles; Boer, Judith M.; den Boer, Monique L.; Calvo, Gabriel F.; Camos, Mireia; Fuster, Jose-Luis; Velasco, Pablo; Ballerini, Paola; Locatelli, Franco; Mullighan, Charles G.; Spierings, Diana C. J.; Foijer, Floris; Perez-Garcia, Victor M.; Menendez, Pablo Share Save GPRC5C drives branched-chain amino acid metabolism in leukemogenesisZhang, Yu Wei; Mess, Julian; Lalioti, Maria-Eleni; Romero-Mulero, Mari Carmen; Velasco-Hernandez, Talia; Obier, Nadine; Karantzelis, Nikolaos; Rettkowski, Jasmin; Schoenberger, Katharina; Karabacz, Noemie; Jaecklein, Karin; Morishima, Tatsuya; Trincado, Juan Luis; Romecin, Paola; Martinez, Alba; Takizawa, Hitoshi; Shoumariyeh, Khalid; Renders, Simon; Zeiser, Robert; Pahl, Heike L.; Beliveau, Francois; Hebert, Josee; Lehnertz, Bernhard; Sauvageau, Guy; Menendez, Pablo; Cabezas-Wallscheid, Nina Share Save Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectinFranco-Valls, Hector; Tusquets-Uxo, Elsa; Sala, Laura; Val, Maria; Pena, Raul; Iaconcig, Alessandra; Villarino, Alvaro; Jimenez-Arriola, Martin; Masso, Pere; Trincado, Juan L.; Eyras, Eduardo; Muro, Andres F.; Otero, Jorge; de Herreros, Antonio Garcia; Baulida, Josep Share Save β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemiaGarcia-Hernandez, Violeta; Arambilet, David; Guillen, Yolanda; Lobo-Jarne, Teresa; Maqueda, Maria; Gekas, Christos; Gonzalez, Jessica; Iglesias, Arnau; Vega-Garcia, Nerea; Sentis, Ines; Trincado, Juan L.; Marquez-Lopez, Ian; Heyn, Holger; Camos, Mireia; Espinosa, Lluis; Bigas, Anna Share Save Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high-hyperdiploid B-cell acute lymphoblastic leukemiaRamos-Muntada, Mireia; Trincado, Juan L.; Blanco, Joan; Bueno, Clara; Rodriguez-Cortez, Virginia C.; Bataller, Alex; Lopez-Millan, Belen; Schwab, Claire; Ortega, Margarita; Velasco, Pablo; Blanco, Maria L.; Nomdedeu, Josep; Ramirez-Orellana, Manuel; Minguela, Alfredo; Fuster, Jose L.; Cuatrecasas, Esther; Camos, Mireia; Ballerini, Paola; Escherich, Gabriele; Boer, Judith; DenBoer, Monique; Hernandez-Rivas, Jesus M.; Calasanz, Maria J.; Cazzaniga, Giovanni; Harrison, Christine J.; Menendez, Pablo; Molina, Oscar Share Save A single-cell tumor immune atlas for precision oncologyNieto, Paula; Elosua-Bayes, Marc; Trincado, Juan L.; Marchese, Domenica; Massoni-Badosa, Ramon; Salvany, Maria; Henriques, Ana; Nieto, Juan; Aguilar-Fernandez, Sergio; Mereu, Elisabetta; Moutinho, Catia; Ruiz, Sara; Lorden, Patricia; Chin, Vanessa T.; Kaczorowski, Dominik; Chan, Chia-Ling; Gallagher, Richard; Chou, Angela; Planas-Rigol, Ester; Rubio-Perez, Carlota; Gut, Ivo; Piulats, Josep M.; Seoane, Joan; Powell, Joseph E.; Batlle, Eduard; Heyn, Holger Share Save Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironmentRubio-Perez, Carlota; Planas-Rigol, Ester; Trincado, Juan L.; Bonfill-Teixidor, Ester; Arias, Alexandra; Marchese, Domenica; Moutinho, Catia; Serna, Garazi; Pedrosa, Leire; Iurlaro, Raffaella; Martinez-Ricarte, Francisco; Escudero, Laura; Cordero, Esteban; Cicuendez, Marta; Ruiz, Sara; Parra, Genis; Nuciforo, Paolo; Gonzalez, Josep; Pineda, Estela; Sahuquillo, Juan; Tabernero, Josep; Heyn, Holger; Seoane, Joan Share Save HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemiade Barrios, Oriol; Galaras, Alexandros; Trincado, Juan L.; Azagra, Alba; Collazo, Olga; Meler, Ainara; Agraz-Doblas, Antonio; Bueno, Clara; Ballerini, Paola; Cazzaniga, Giovanni; Stam, Ronald W.; Varela, Ignacio; De Lorenzo, Paola; Valsecchi, Maria Grazia; Hatzis, Pantelis; Menendez, Pablo; Parra, Maribel Share Save Share Save Share Save Share Save 
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