Not logged in.png)
Share.png)
SaveInsights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme
Sosinsky, Alona; Ambrose, John; Cross, William; Turnbull, Clare; Henderson, Shirley; Jones, Louise; Hamblin, Angela; Arumugam, Prabhu; Chan, Georgia; Chubb, Daniel; Noyvert, Boris; Mitchell, Jonathan; Walker, Susan; Bowman, Katy; Pasko, Dorota; Buongermino Pereira, Marianna; Volkova, Nadezda; Rueda-Martin, Antonio; Perez-Gil, Daniel; Lopez, Javier; Pullinger, John; Siddiq, Afshan; Zainy, Tala; Choudhury, Tasnim; Yavorska, Olena; Fowler, Tom; Bentley, David; Kingsley, Clare; Hing, Sandra; Deans, Zandra; Rendon, Augusto; Hill, Sue; Caulfield, Mark; Murugaesu, Nirupa Share Save Genetic and immune landscape evolution in MMR-deficient colorectal cancerChalloner, Benjamin R.; Woolston, Andrew; Lau, David; Buzzetti, Marta; Fong, Caroline; Barber, Louise J.; Anandappa, Gayathri; Crux, Richard; Assiotis, Ioannis; Fenwick, Kerry; Begum, Ruwaida; Begum, Dipa; Lund, Tom; Sivamanoharan, Nanna; Sansano, Harold B.; Domingo-Arada, Melissa; Tran, Amina; Pandha, Hardev; Church, David; Eccles, Bryony; Ellis, Richard; Falk, Stephen; Hill, Mark; Krell, Daniel; Murugaesu, Nirupa; Nolan, Luke; Potter, Vanessa; Saunders, Mark; Shiu, Kai-Keen; Guettler, Sebastian; Alexander, James L.; Lazare-Iglesias, Hector; Kinross, James; Murphy, Jamie; von Loga, Katharina; Cunningham, David; Chau, Ian; Starling, Naureen; Ruiz-Banobre, Juan; Dhillon, Tony; Gerlinger, Marco Share Save Beyond 100,000 genomes project: Whole genome sequencing for cancer patients within NHS Genomic Medicine ServiceSosinsky, A. A.; Walker, S.; Ambrose, J.; Coleran, R.; Yavorska, O.; Hamblin, A.; Murugaesu, N.; Talley, P.; Hing, S.; Starczynski, J.; Deans, S.; Hill, S. Share Save Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathySpielmann, Nadine; Miller, Gregor; Oprea, Tudor I.; Hsu, Chih-Wei; Fobo, Gisela; Frishman, Goar; Montrone, Corinna; Haseli Mashhadi, Hamed; Mason, Jeremy; Munoz Fuentes, Violeta; Leuchtenberger, Stefanie; Ruepp, Andreas; Wagner, Matias; Westphal, Dominik S.; Wolf, Cordula; Goerlach, Agnes; Sanz-Moreno, Adrian; Cho, Yi-Li; Teperino, Raffaele; Brandmaier, Stefan; Sharma, Sapna; Galter, Isabella Rikarda; Oestereicher, Manuela A.; Zapf, Lilly; Mayer-Kuckuk, Philipp; Rozman, Jan; Teboul, Lydia; Bunton-Stasyshyn, Rosie K. A.; Cater, Heather; Stewart, Michelle; Christou, Skevoulla; Westerberg, Henrik; Willett, Amelia M.; Wotton, Janine M.; Roper, Willson B.; Christiansen, Audrey E.; Ward, Christopher S.; Heaney, Jason D.; Reynolds, Corey L.; Prochazka, Jan; Bower, Lynette; Clary, David; Selloum, Mohammed; Bou About, Ghina; Wendling, Olivia; Jacobs, Hugues; Leblanc, Sophie; Meziane, Hamid; Sorg, Tania; Audain, Enrique; Gilly, Arthur; Rayner, Nigel W.; Aguilar-Pimentel, Juan A.; Becker, Lore; Garrett, Lillian; Hoelter, Sabine M.; Amarie, Oana V.; Calzada-Wack, Julia; Klein-Rodewald, Tanja; da Silva-Buttkus, Patricia; Lengger, Christoph; Stoeger, Claudia; Gerlini, Raffaele; Rathkolb, Birgit; Mayr, Daniela; Seavitt, John; Gaspero, Angelina; Green, Jennie R.; Garza, Arturo; Bohat, Ritu; Wong, Leeyean; Mcelwee, Melissa L.; Kalaga, Sowmya; Rasmussen, Tara L.; Lorenzo, Isabel; Lanza, Denise G.; Samaco, Rodney C.; Veeraragaven, Surabi; Gallegos, Juan J.; Kasparek, Petr; Petrezselyova, Silvia; King, Ruairidh; Johnson, Sara; Cleak, James; Szkoe-Kovacs, Zsombor; Codner, Gemma; Mackenzie, Matthew; Caulder, Adam; Kenyon, Janet; Gardiner, Wendy; Phelps, Hayley; Hancock, Rhys; Norris, Claire; Moore, Michayla A.; Seluke, Audrie M.; Urban, Rachel; Kane, Coleen; Goodwin, Leslie O.; Peterson, Kevin A.; Mckay, Matthew; Cook, Jenn J.; Lowy, Jacob P.; Mcfarland, Michael; Wood, Joshua A.; Willis, Brandon J.; Tolentino, Heather; Tolentino, Todd; Schuchbauer, Michael; Salazar, Jason; Johnson, Jennifer; Munson, Rebecca; Ayadi, Abdel; Pavlovic, Guillaume; Birling, Marie-Christine; Jacquot, Sylvie; Ali-Hadji, Dalila; Charles, Philippe; Andre, Philippe; Champy, Marie-France; Riet, Fabrice; Vukobradovic, Igor; Berberovic, Zorana; Qu, Dawei; Guo, Ruolin; D'Souza, Abigail; Huang, Ziyue; Camilleri, Susan; Ganguly, Milan; Adissu, Hibret; Eskandarian, Mohammed; Shang, Xueyuan; Duffin, Kyle; Xu, Catherine; Roberton, Kyle; Laurin, Valerie; Lan, Qing; Sleep, Gillian; Creighton, Amie; Lintott, Lauri; Gertsenstein, Marina; Pereira, Monica; Tondat, Sandra; Patel, Amit; Cruz, Maribelle; Bezginov, Alex; Miller, David; Hy, Wang; Yoshiki, Atsushi; Tanaka, Nobuhiko; Tamura, Masaru; Liu, Zhiwei; Ermakova, Olga; Ferrara, Anna; Fruscoloni, Paolo; Seisenberger, Claudia; Buerger, Antje; Giesert, Florian; Ambrose, J. C.; Gam, Arumu P.; Bevers, R.; Bleda, M.; Boardman-Pretty, F.; Boustred, C. R.; Brittain, H.; Caulfield, M. J.; Chan, G. C.; Fowler, T.; Giess, A.; Hamblin, A.; Henderson, S.; Hubbard, T. J. P.; Jackson, R.; Jones, L. J.; Kasperaviciute, D.; Kayikci, M.; Kousathanas, A.; Lahnstein, L.; Leigh, S. E. A.; Leong, I. U. S.; Lopez, F. J.; Maleady-Crowe, F.; Mcentagart, M.; Minneci, F.; Moutsianas, L.; Mueller, M.; Murugaesu, N.; Need, A. C.; O'Donovan, P.; Odhams, C. A.; Patch, C.; Perez-Gil, D.; Pereira, M. B.; Pullinger, J.; Rahim, T.; Rendon, A.; Rogers, T.; Savage, K.; Sawant, K.; Scott, R. H.; Siddiq, A.; Sieghart, A.; Smith, S. C.; Sosinsky, A.; Stuckey, A.; Tanguy, M.; Taylor-Tavares, A. L.; Thomas, E. R. A.; Thompson, S. R.; Tucci, A.; Welland, M. J.; Williams, E.; Witkowska, K.; Wood, S. M.; Hitz, Marc-Phillip; Zeggini, Eleftheria; Wolf, Eckhard; Sedlacek, Radislav; Murray, Steven A.; Svenson, Karen L.; Braun, Robert E.; White, Jaqueline K.; Kelsey, Lois; Gao, Xiang; Shiroishi, Toshihiko; Xu, Ying; Seong, Je Kyung; Mammano, Fabio; Tocchini-Valentini, Glauco P.; Beaudet, Arthur L.; Meehan, Terrence F.; Parkinson, Helen; Smedley, Damian; Mallon, Ann-Marie; Wells, Sara E.; Grallert, Harald; Wurst, Wolfgang; Marschall, Susan; Fuchs, Helmut; Brown, Steve D. M.; Flenniken, Ann M.; Nutter, Lauryl M. J.; Mckerlie, Colin; Herault, Yann; Lloyd, K. C. Kent; Dickinson, Mary E.; Gailus-Durner, Valerie; Hrabe de Angelis, Martin Share Save A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damageZou, Xueqing; Koh, Gene Ching Chiek; Nanda, Arjun Scott; Degasperi, Andrea; Urgo, Katie; Roumeliotis, Theodoros I.; Agu, Chukwuma A.; Badja, Cherif; Momen, Sophie; Young, Jamie; Amarante, Tauanne Dias; Side, Lucy; Brice, Glen; Perez-Alonso, Vanesa; Rueda, Daniel; Gomez, Celine; Bushell, Wendy; Harris, Rebecca; Choudhary, Jyoti S.; Ambrose, John C.; Arumugam, Prabhu; Baple, Emma L.; Bleda, Marta; Boardman-Pretty, Freya; Boissiere, Jeanne M.; Boustred, Christopher R.; Brittain, Helen; Caulfield, Mark J.; Chan, Georgia C.; Craig, Clare E. H.; Daugherty, Louise C.; de Burca, Anna; Devereau, Andrew; Elgar, Greg; Foulger, Rebecca E.; Fowler, Tom; Furio-Tari, Pedro; Giess, Adam; Hackett, Joanne M.; Halai, Dina; Hamblin, Angela; Henderson, Shirley; Holman, James E.; Hubbard, Tim J. P.; Ibanez, Kristina; Jackson, Rob; Jones, Louise J.; Kasperaviciute, Dalia; Kayikci, Melis; Kousathanas, Athanasios; Lahnstein, Lea; Lawson, Kay; Leigh, Sarah E. A.; Leong, Ivonne U. S.; Lopez, Javier F.; Maleady-Crowe, Fiona; Mason, Joanne; McDonagh, Ellen M.; Moutsianas, Loukas; Mueller, Michael; Murugaesu, Nirupa; Need, Anna C.; O'Donovan, Pter; Odhams, Chris A.; Orioli, Andrea; Patch, Christine; Pereira, Mariana Buongermino; Perez-Gil, Daniel; Polychronopoulos, Dimitris; Pullinger, John; Rahim, Tahrima; Rendon, Augusto; Riesgo-Ferreiro, Pablo; Rogers, Tim; Ryten, Mina; Savage, Kevin; Sawant, Kushmita; Scott, Richard H.; Siddiq, Afshan; Sieghart, Alexander; Smedley, Damian; Smith, Katherine R.; Smith, Samuel C.; Sosinsky, Alona; Spooner, William; Stevens, Helen E.; Stuckey, Alexander; Sultana, Razvan; Tanguy, Melanie; Thomas, Ellen R. A.; Thompson, Simon R.; Tregidgo, Carolyn; Tucci, Arianna; Walsh, Emma; Watters, Sarah A.; Welland, Matthew J.; Williams, Eleanor; Witkowska, Katarzyna; Wood, Suzanne M.; Zarowiecki, Magdalena; Jiricny, Josef; Skarnes, William C.; Nik-Zainal, Serena Share Save COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort studyLee, Lennard Y. W.; Cazier, Jean Baptiste; Angelis, Vasileios; Arnold, Roland; Bisht, Vartika; Campton, Naomi A.; Chackathayil, Julia; Cheng, Vinton W. T.; Curley, Helen M.; Fittall, Matthew W.; Freeman-Mills, Luke; Gennatas, Spyridon; Goel, Anshita; Hartley, Simon; Hughes, Daniel J.; Kerr, David; Lee, Alvin J. X.; Lee, Rebecca J.; McGrath, Sophie E.; Middleton, Christopher P.; Murugaesu, Nirupa; Newsom-Davis, Thomas; Okines, Alicia F. C.; Olsson-Brown, Anna C.; Palles, Claire; Pan, Yi; Pettengell, Ruth; Powles, Thomas; Protheroe, Emily A.; Purshouse, Karin; Sharma-Oates, Archana; Sivakumar, Shivan; Smith, Ashley J.; Starkey, Thomas; Turnbull, Chris D.; Varnai, Csilla; Yousaf, Nadia; Kerr, Rachel; Middleton, Gary Share Save Human and mouse essentiality screens as a resource for disease gene discoveryCacheiro, Pilar; Munoz-Fuentes, Violeta; Murray, Stephen A.; Dickinson, Mary E.; Bucan, Maja; Nutter, Lauryl M. J.; Peterson, Kevin A.; Haselimashhadi, Hamed; Flenniken, Ann M.; Morgan, Hugh; Westerberg, Henrik; Konopka, Tomasz; Hsu, Chih-Wei; Christiansen, Audrey; Lanza, Denise G.; Beaudet, Arthur L.; Heaney, Jason D.; Fuchs, Helmut; Gailus-Durner, Valerie; Sorg, Tania; Prochazka, Jan; Novosadova, Vendula; Lelliott, Christopher J.; Wardle-Jones, Hannah; Wells, Sara; Teboul, Lydia; Cater, Heather; Stewart, Michelle; Hough, Tertius; Wurst, Wolfgang; Sedlacek, Radislav; Adams, David J.; Seavitt, John R.; Tocchini-Valentini, Glauco; Mammano, Fabio; Braun, Robert E.; McKerlie, Colin; Herault, Yann; de Angelis, Martin Hrabe; Mallon, Ann-Marie; Lloyd, K. C. Kent; Brown, Steve D. M.; Parkinson, Helen; Meehan, Terrence F.; Smedley, Damian; Ambrose, J. C.; Arumugam, P.; Baple, E. L.; Bleda, M.; Boardman-Pretty, F.; Boissiere, J. M.; Boustred, C. R.; Brittain, H.; Caulfield, M. J.; Chan, G. C.; Craig, C. E. H.; Daugherty, L. C.; de Burca, A.; Devereau, A.; Elgar, G.; Foulger, R. E.; Fowler, T.; Furio-Tari, P.; Hackett, J. M.; Halai, D.; Hamblin, A.; Henderson, S.; Holman, J. E.; Hubbard, T. J. P.; Ibanez, K.; Jackson, R.; Jones, L. J.; Kasperaviciute, D.; Kayikci, M.; Lahnstein, L.; Lawson, K.; Leigh, S. E. A.; Leong, I. U. S.; Lopez, F. J.; Maleady-Crowe, F.; Mason, J.; McDonagh, E. M.; Moutsianas, L.; Mueller, M.; Murugaesu, N.; Need, A. C.; Odhams, C. A.; Patch, C.; Perez-Gil, D.; Polychronopoulos, D.; Pullinger, J.; Rahim, T.; Rendon, A.; Riesgo-Ferreiro, P.; Rogers, T.; Ryten, M.; Savage, K.; Sawant, K.; Scott, R. H.; Siddiq, A.; Sieghart, A.; Smith, K. R.; Sosinsky, A.; Spooner, W.; Stevens, H. E.; Stuckey, A.; Sultana, R.; Thomas, E. R. A.; Thompson, S. R.; Tregidgo, C.; Tucci, A.; Walsh, E.; Watters, S. A.; Welland, M. J.; Williams, E.; Witkowska, K.; Wood, S. M.; Zarowiecki, M.; Marschall, Susan; Lengger, Christoph; Maier, Holger; Seisenberger, Claudia; Buerger, Antje; Kuehn, Ralf; Schick, Joel; Hoerlein, Andreas; Oritz, Oskar; Giesert, Florian; Beig, Joachim; Kenyon, Janet; Codner, Gemma; Fray, Martin; Johnson, Sara J.; Cleak, James; Szoke-Kovacs, Zsombor; Lafont, David; Vancollie, Valerie E.; McLaren, Robbie S. B.; Hughes-Hallett, Lena; Rowley, Christine; Sanderson, Emma; Galli, Antonella; Tuck, Elizabeth; Green, Angela; Tudor, Catherine; Siragher, Emma; Dabrowska, Monika; Mazzeo, Cecilia Icoresi; Griffiths, Mark; Gannon, David; Doe, Brendan; Cockle, Nicola; Kirton, Andrea; Bottomley, Joanna; Ingle, Catherine; Ryder, Edward; Gleeson, Diane; Ramirez-Solis, Ramiro; Birling, Marie-Christine; Pavlovic, Guillaume; Ayadi, Abdel; Hamid, Meziane; About, Ghina Bou; Champy, Marie-France; Jacobs, Hugues; Wendling, Olivia; Leblanc, Sophie; Vasseur, Laurent; Chesler, Elissa J.; Kumar, Vivek; White, Jacqueline K.; Svenson, Karen L.; Wiegand, Jean-Paul; Anderson, Laura L.; Wilcox, Troy; Clark, James; Ryan, Jennifer; Denegre, James; Stearns, Tim; Philip, Vivek; Witmeyer, Catherine; Bates, Lindsay; Seavey, Zachary; Stanley, Pamela; Willet, Amelia; Roper, Willson; Creed, Julie; Moore, Michayla; Dorr, Alex; Fraungruber, Pamelia; Presby, Rose; Mckay, Matthew; Nguyen-Bresinsky, Dong; Goodwin, Leslie; Urban, Rachel; Kane, Coleen Share Save 100,000 genomes project: Integrating whole genome sequencing (WGS) data into clinical practiceSosinsky, A.; Ambrose, J.; Zarowiecki, M.; Mitchell, J.; Henderson, S.; Murugaesu, N.; Hamblin, A.; Turnbull, C.; Walker, S.; Perez-Gil, D.; Rueda-Martin, A.; Fowler, T.; Caulfield, M.; Rendon, A. Share Save 100,000 Genomes Project: Cancer programmeSosinsky, A.; Murugaesu, N.; Hamblin, A.; Ambrose, J.; Turnbull, C.; Henderson, S.; Rueda-Martin, A.; Fowler, T.; Caulfield, M.; Rendon, A. Share Save 100,000 Genomes Project: Cancer programSosinsky, Alona; Antoniou, Pavlos; Ambrose, John; Mijuskovic, Martina; Rueda-Martin, Antonio; Perez-Gil, Daniel; Serra, Enric; Henderson, Shirley; Hamblin, Angela; Schuh, Anna; Murugaesu, Nirupa; Turnbull, Clare; Rendon, Augusto; Caulfield, Mark Share Save The 100 000 Genomes Project: bringing whole genome sequencing to the NHSTurnbull, Clare; Scott, Richard H.; Thomas, Ellen; Jones, Louise; Murugaesu, Nirupa; Pretty, Freya Boardman; Halai, Dina; Baple, Emma; Craig, Clare; Hamblin, Angela; Henderson, Shirley; Patch, Christine; O'Neill, Amanda; Devereau, Andrew; Smith, Katherine; Martin, Antonio Rueda; Sosinsky, Alona; McDonagh, Ellen M.; Sultana, Razvan; Mueller, Michael; Smedley, Damian; Toms, Adam; Dinh, Lisa; Fowler, Tom; Bale, Mark; Hubbard, Tim; Rendon, Augusto; Hill, Sue; Caulfield, Mark J. Share Save Share Save Tracking the Genomic Evolution of Esophageal Adenocarcinoma through Neoadjuvant ChemotherapyMurugaesu, Nirupa; Wilson, Gareth A.; Birkbak, Nicolai J.; Watkins, Thomas B. K.; McGranahan, Nicholas; Kumar, Sacheen; Abbassi-Ghadi, Nima; Salm, Max; Mitter, Richard; Horswell, Stuart; Rowan, Andrew; Phillimore, Benjamin; Biggs, Jennifer; Begum, Sharmin; Matthews, Nik; Hochhauser, Daniel; Hanna, George B.; Swanton, Charles Share Save Intratumor heterogeneity in non-small cell lung cancer inferred by multi-region exome sequencingBruin, Elza D.; McGranahan, Nicholas; Yates, Lucy; Jamal-Hanjani, Mariam; Salm, Max; Mitter, Richard; Shafi, Seema; Murugaesu, Nirupa; Rowan, Andrew; Gerlinger, Marco; Wedge, David; Horswell, Stuart; Varela, Ignacio; Tom, Warren; Parikh, Chaitali; Harkins, Timothy; Lee, Clarence; Matthews, Nik; Stewart, Aengus; Campbell, Peter; Swanton, Charles Share Save Share Save An In Vivo Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis SuppressorMurugaesu, Nirupa; Iravani, Marjan; Van Weverwijk, Antoinette; Ivetic, Aleksandar; Johnson, Damian A.; Antonopoulos, Aristotelis; Fearns, Antony; Jamal-Hanjani, Mariam; Sims, David; Fenwick, Kerry; Mitsopoulos, Costas; Gao, Qiong; Orr, Nick; Zvelebil, Marketa; Haslam, Stuart M.; Dell, Anne; Yarwood, Helen; Lord, Christopher J.; Ashworth, Alan; Isacke, Clare M. Share Save Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressorIorns, Elizabeth; Ward, Toby M.; Dean, Sonja; Jegg, Anna; Thomas, Dafydd; Murugaesu, Nirupa; Sims, David; Mitsopoulos, Costas; Fenwick, Kerry; Kozarewa, Iwanka; Naceur-Lombarelli, Cristina; Zvelebil, Marketa; Isacke, Clare M.; Lord, Christopher J.; Ashworth, Alan; Hnatyszyn, H. James; Pegram, Mark; Lippman, Marc Share Save An in vivo functional screen to identify metastasis suppressor genesMurugaesu, Nirupa; Iravani, Marjan; Johnson, Damian; Antonopoulos, Aristotelis; Sims, David; Fenwick, Kerry; Mitsopoulos, Costas; Gao, Qiong; Orr, Nick; Zvelebil, Marketa; Haslam, Stuart; Dell, Anne; Lord, Christopher; Ashworth, Alan; Isacke, Clare Share Save High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencingSims, David; Mendes-Pereira, Ana M.; Frankum, Jessica; Burgess, Darren; Cerone, Maria-Antonietta; Lombardelli, Cristina; Mitsopoulos, Costas; Hakas, Jarle; Murugaesu, Nirupa; Isacke, Clare M.; Fenwick, Kerry; Assiotis, Ioannis; Kozarewa, Iwanka; Zvelebil, Marketa; Ashworth, Alan; Lord, Christopher J. Share Save 
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}