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ERα dysfunction caused by ESR1 mutations and therapeutic pressure promotes lineage plasticity in ER+ breast cancer Liang, Jackson; Yao, Xiaosai; Aouad, Patrick; Wang, Bu-Er; Crocker, Lisa; Chaudhuri, Subhra; Liang, Yuxin; Darmanis, Spyros; Giltnane, Jennifer; Moore, Heather M.; Aimi, Junko; Chang, Ching-Wei; Gates, Mary R.; Eng-Wong, Jennifer; Hafner, Marc; Metcalfe, Ciara Share Save
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Inhibition of GPX4 enhances CDK4/6 inhibitor and endocrine therapy activity in breast cancer Herrera-Abreu, M. T.; Guan, J.; Khalid, U.; Ning, J.; Costa, M. R.; Chan, J.; Li, Q.; Fortin, J-p.; Wong, W. R.; Perampalam, P.; Biton, A.; Sandoval, W.; Vijay, J.; Hafner, M.; Cutts, R.; Wilson, G.; Frankum, J.; Roumeliotis, T. I.; Alexander, J.; Hickman, O.; Brough, R.; Haider, S.; Choudhary, J.; Lord, C. J.; Swain, A.; Metcalfe, C.; Turner, N. C. Share Save
heredERA Breast Cancer: a phase III, randomized, open-label study evaluating the efficacy and safety of giredestrant plus the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection in patients with previously untreated HER2-positive, estrogen receptor-positive locally advanced or metastatic breast cancer Kuemmel, Sherko; Harper-Wynne, Catherine; Park, Yeon Hee; Franke, Fabio; de Laurentiis, Michelino; Schumacher-Wulf, Eva; Eiger, Daniel; Heeson, Sarah; Cardona, Andres; Ozyilkan, Ozgur; Morales-Vasquez, Flavia; Metcalfe, Ciara; Hafner, Marc; Restuccia, Eleonora; O'Shaughnessy, Joyce Share Save
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Clinical outcomes and exploratory gene expression analysis of OPPORTUNE: a phase II window-of-opportunity study to evaluate pictilisib plus anastrozole versus anastrozole alone in ER-positive breast cancer Chibly, Alejandro Martinez; Shia, Alice; Johnson, Radia; Hwang, Michael S.; Hafner, Marc; Metcalfe, Ciara; Shah, Kalpit; Slyper, Michal; Bolen, Chris; Pinder, Sarah E.; Thompson, Alastair M.; Gendreau, Steven; Schmid, Peter Share Save
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Exploratory gene expression analysis of coopERA Breast Cancer (BC): a study evaluating neoadjuvant giredestrant versus anastrozole alone and in combination with palbociclib in ER-positive, HER2-negative untreated early BC Chibly, Alejandro M.; Fernando, Tharu M.; Metcalfe, Ciara; Hafner, Marc; Owusu-Manu, Gilbert; Hurvitz, Sara; Bardia, Aditya; Fasching, Peter A.; Park, Yeon H.; Quiroga, Vanesa; Steinseifer, Jutta; Perez-Moreno, Pablo; Moore, Heather M. Share Save
Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis Kurtova, Antonina, V; Heinlein, Melanie; Haas, Simon; Velten, Lars; Dijkgraaf, Gerrit J. P.; Storm, Elaine E.; Kljavin, Noelyn M.; Boumahdi, Soufiane; Himmels, Patricia; Herault, Aurelie; Mancini, Andrew; Koeppen, Hartmut; Dail, Monique; Yan, Qingxiang; Zhang, Jianhuan; Koch, Ute; Radtke, Freddy; Modrusan, Zora; Metcalfe, Ciara; Piskol, Robert; de Sauvage, Frederic J. Share Save
Giredestrant reverses progesterone hypersensitivity driven by estrogen receptor mutations in breast cancer Liang, Jackson; Ingalla, Ellen Rei; Yao, Xiaosai; Wang, Bu-Er; Tai, Lisa; Giltnane, Jennifer; Liang, Yuxin; Daemen, Anneleen; Moore, Heather M.; Aimi, Junko; Chang, Ching -Wei; Gates, Mary R.; Eng-Wong, Jennifer; Tam, Lucinda; Bacarro, Natasha; Roose-Girma, Merone; Bellet, Meritxell; Hafner, Marc; Metcalfe, Ciara Share Save
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Compressive stress-mediated p38 activation required for ERα plus phenotype in breast cancer Munne, Pauliina M.; Martikainen, Lahja; Raty, Iiris; Bertula, Kia; Nonappa; Ruuska, Janika; Ala-Hongisto, Hanna; Peura, Aino; Hollmann, Babette; Euro, Lilya; Yavuz, Kerim; Patrikainen, Linda; Salmela, Maria; Pokki, Juho; Kivento, Mikko; Vaananen, Juho; Suomi, Tomi; Nevalaita, Liina; Mutka, Minna; Kovanen, Panu; Leidenius, Marjut; Meretoja, Tuomo; Hukkinen, Katja; Monni, Outi; Pouwels, Jeroen; Sahu, Biswajyoti; Mattson, Johanna; Joensuu, Heikki; Heikkila, Paivi; Elo, Laura L.; Metcalfe, Ciara; Junttila, Melissa R.; Ikkala, Olli; Klefstrom, Juha Share Save
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GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER plus Breast Cancer Liang, Jun; Zbieg, Jason R.; Blake, Robert A.; Chang, Jae H.; Daly, Stephen; DiPasquale, Antonio G.; Friedman, Lori S.; Gelzleichter, Thomas; Gill, Matthew; Giltnane, Jennifer M.; Goodacre, Simon; Guan, Jane; Hartman, Steven J.; Ingalla, Ellen Rei; Kategaya, Lorn; Kiefer, James R.; Kleinheinz, Tracy; Labadie, Sharada S.; Lai, Tommy; Li, Jun; Liao, Jiangpeng; Liu, Zhiguo; Mody, Vidhi; McLean, Neville; Metcalfe, Ciara; Nannini, Michelle A.; Oeh, Jason; O'Rourke, Martin G.; Ortwine, Daniel F.; Ran, Yingqing; Ray, Nicholas C.; Roussel, Fabien; Sambrone, Amy; Sampath, Deepak; Schutt, Leah K.; Vinogradova, Maia; Wai, John; Wang, Tao; Wertz, Ingrid E.; White, Jonathan R.; Yeap, Siew Kuen; Young, Amy; Zhang, Birong; Zheng, Xiaoping; Zhou, Wei; Zhong, Yu; Wang, Xiaojing Share Save
GDC-9545: A pure antiestrogen clinical candidate that immobilizes the estrogen receptor and profoundly alters chromatin accessibility in vivo Metcalfe, Ciara; Zhou, Wei; Guan, Jane; Blake, Robert A.; De Bruyn, Tom; Giltnane, Jennifer M.; Ingalla, Ellen; Kleinheinz, Tracy; Liang, Jun; Mody, Vidhi; Oeh, Jason; Ubhayakar, Savita; Wertz, Ingrid; Young, Amy; Zbieg, Jason; Wang, Xiaojing; Hafner, Marc Share Save
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