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A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer Jung, Peter; Glaser, Stefan P.; Han, Jing; Popa, Alexandra; Pisarsky, Laura; Feng, Ningping; Geyer, Antonia; Haderk, Franziska; Alpar, Donat; Bristow, Christopher; Schmittner, Susanne; Traexler, Paula-Elena; Mahendra, Mikhila; Poehn, Birgit; Gandhi, Poojabahen; Fiorelli, Roberto; Awate, Sanket; Budano, Nicole; Martin, Florian; Albrecht, Christoph; Drobits-Handl, Barbara; Anand, Sathanandam S.; Kasturirangan, Srinath; Trapani, Francesca; Schweifer, Norbert; Marszalek, Joseph R.; Tontsch-Grunt, Ulrike; Pearson, Mark; Heffernan, Timothy P.; Kraut, Norbert; Vellano, Christopher P.; Garcia-Martinez, Juan Manuel Share Save
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance Thatikonda, Venu; Lyu, Hengyu; Jurado, Sabine; Kostyrko, Kaja; Bristow, Christopher A.; Albrecht, Christoph; Alpar, Donat; Arnhof, Heribert; Bergner, Oliver; Bosch, Karin; Feng, Ningping; Gao, Sisi; Gerlach, Daniel; Gmachl, Michael; Hinkel, Melanie; Lieb, Simone; Jeschko, Astrid; Machado, Annette A.; Madensky, Thomas; Marszalek, Ethan D.; Mahendra, Mikhila; Melo-Zainzinger, Gabriella; Molkentine, Jessica M.; Jaeger, Philipp A.; Peng, David H.; Schenk, Robyn L.; Sorokin, Alexey; Strauss, Sandra; Trapani, Francesca; Kopetz, Scott; Vellano, Christopher P.; Petronczki, Mark; Kraut, Norbert; Heffernan, Timothy P.; Marszalek, Joseph R.; Pearson, Mark; Waizenegger, Irene C.; Hofmann, Marco H. Share Save
Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer Dilly, Julien; Hoffman, Megan T.; Abbassi, Laleh; Li, Ziyue; Paradiso, Francesca; Parent, Brendan D.; Hennessey, Connor J.; Jordan, Alexander C.; Morgado, Micaela; Dasgupta, Shatavisha; Uribe, Giselle A.; Yang, Annan; Kapner, Kevin S.; Hambitzer, Felix P.; Qiang, Li; Feng, Hanrong; Geisberg, Jacob; Wang, Junning; Evans, Kyle E.; Lyu, Hengyu; Schalck, Aislyn; Feng, Ningping; Lopez, Anastasia M.; Bristow, Christopher A.; Kim, Michael P.; Rajapakshe, Kimal I.; Bahrambeigi, Vahid; Roth, Jennifer A.; Garg, Kavita; Guerrero, Paola A.; Stanger, Ben Z.; Cristea, Simona; Lowe, Scott W.; Baslan, Timour; Van Allen, Eliezer M.; Mancias, Joseph D.; Chan, Emily; Anderson, Abraham; Katlinskaya, Yuliya V.; Shalek, Alex K.; Hong, David S.; Pant, Shubham; Hallin, Jill; Anderes, Kenna; Olson, Peter; Heffernan, Timothy P.; Chugh, Seema; Christensen, James G.; Maitra, Anirban; Wolpin, Brian M.; Raghavan, Srivatsan; Nowak, Jonathan A.; Winter, Peter S.; Dougan, Stephanie K.; Aguirre, Andrew J. Share Save
Chromosome 3 copy number loss alone drives tumor evolution to aggressive disease in uveal melanoma Srinivasan, Sanjana; Rose, Johnathon; Minelli, Rosalba; Terranova, Christopher; Shah, Parth; Daniele, Joseph R.; Peoples, Michael; He, Meng; Liu, Chiu-Yi; Gay, Jason; Soeung, Melinda; Soni, Sanjay; Wang, Fangyang; Bristow, Christopher; Wani, Khalida; Perelli, Luigi; Loza, Dmitry; Feng, Ningping; Tarabichi, Maxime; Van Loo, Peter; Futreal, Andrew; Woodman, Scott; Lazar, Alexander; Vellano, Christopher P.; Marszalek, Joseph; Draetta, Giulio F.; Heffernan, Timothy; Carugo, Alessandro; Genovese, Giannicola; Giuliani, Virginia Share Save
IACS-16559, a CBP/P300 bromodomain inhibitor for the treatment of specific AML subsets Zanca, Ciro; Soth, Michael; Gao, Guang; Gay, Jason; Feng, Ningping; Bristow, Christopher; Le, Kang; Xu, Quanyun; Phuong Nguyen; Jiang, Yongying; Perry, Teresa; Mseeh, Faika; Leonard, Paul; Cross, Jason; Giuliani, Virginia; Marszalek, Joe; Jones, Philip; Heffernan, Tim Share Save
Chromosome 3 dosage-loss informs on the unique biology underlying ultra high-risk uveal melanoma Rose, Johnathon Lynn; Srinivasan, Sanjana; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Terranova, Christopher; Gay, Jason; Daniele, Joseph R.; Dmitriy, Loza; Peoples, Michael; Soeung, Melinda; Ramamoorthy, Vandhana; Shah, Parth; Soni, Sanjay; Bristow, Christopher; Wang, Fangyang; Lopez, Anastasia; Deckard, Charles; Meyers, Brooke; Perelli, Luigi; Wani, Khalida; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joe; Lazar, Alexander J.; Futreal, Andrew; Draetta, Giulio F.; Woodman, Scott E.; Heffernan, Timothy; Genovese, Giannicola; Carugo, Alessandro; Giuliani, Virginia Share Save
Anti-CSF1R antibody monotherapy inhibits minimal residual disease in a novel immunocompetent murine colorectal cancer metastasis model Mohamed, Alaa M.; Cho, Kyung Serk; Soeung, Melinda; Anderson, Amanda; Alshenaifi, Jumanah; Manyam, Ganiraju; Villareal, Oscar; Davis, Jennifer; Norton, Will; Gao, Sisi; Bristow, Christopher; Carbone, Federica; Napolitano, Stefania; Coker, Oluwadara; Khanduri, Isha; Huang, Justin; Maru, Dipen M.; Di Pilato, Mauro; Sun, Ryan; Wang, Linghua; Menter, David G.; Genovese, Giannicola; Draetta, Giulio; Fowlkes, Natalie; Kopetz, Scott Share Save
ASCL2+tumor cells modulate the response of colorectal cancer to MAPK targeting therapy Villarreal, Oscar E.; Lee, Hey Min; Ha Tran; Machado, Annette; Alshenaifi, Jumanah; Wong, Chi Wut; Coker, Olu; Minelli, Rosalba; Peoples, Michael; Martinez, Alejandro Hernandez; Fowlkes, Natalie; Kanikarla, Preeti; Lin, Kangyu; Bristow, Christopher; Viale, Andrea; Marszalek, Joseph R.; Shen, John Paul; Kopetz, Scott Share Save
Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer Perelli, Luigi; Carbone, Federica; Zhang, Li; Huang, Justin K. K.; Le, Courtney; Khan, Hania; Citron, Francesca; Del Poggetto, Edoardo; Gutschner, Tony; Tomihara, Hideo; Soeung, Melinda; Minelli, Rosalba; Srinivasan, Sanjana; Peoples, Michael; Lam, Truong Nguyen Anh; Lundgren, Sebastian; Xia, Ruohan; Zhu, Cihui; Mohamed, Alaa M. T.; Zhang, Jianhua; Sircar, Kanishka; Sgambato, Alessandro; Gao, JianJun; Jonasch, Eric; Draetta, Giulio F.; Futreal, Andrew; Bakouny, Ziad; Van Allen, Eliezer M.; Choueiri, Toni; Signoretti, Sabina; Msaouel, Pavlos; Litchfield, Kevin; Turajlic, Samra; Wang, Linghua; Chen, Ying Bei; Di Natale, Renzo G.; Hakimi, A. Ari; Giuliani, Virginia; Heffernan, Timothy P.; Viale, Andrea; Bristow, Christopher A.; Tannir, Nizar M.; Carugo, Alessandro; Genovese, Giannicola Share Save
Advanced preclinical modeling reveals unique monosomy 3 associated biology in late-stage uveal melanoma Rose, Johnathon L.; Srinivasan, Sanjana; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Gay, Jason; Daniele, Joseph R.; Peoples, Michael; Soeung, Melinda; Ramamoorthy, Vandhana; Lopez, Anastasia; Deckard, Charles; Meyers, Brooke; Del Poggetto, Edoardo; Zamler, Daniel; Huang, Justin; Perelli, Luigi; Wani, Khalida; Bristow, Christopher; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joe; Lazar, Alexander J.; Futreal, Andrew; Draetta, Giulio F.; Woodman, Scott E.; Heffernan, Timothy; Genovese, Giannicola; Carugo, Alessandro; Giuliani, Virginia Share Save
Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials Yap, Timothy A.; Daver, Naval; Mahendra, Mikhila; Zhang, Jixiang; Kamiya-Matsuoka, Carlos; Meric-Bernstam, Funda; Kantarjian, Hagop M.; Ravandi, Farhad; Collins, Meghan E.; Di Francesco, Maria Emilia; Dumbrava, Ecaterina E.; Fu, Siqing; Gao, Sisi; Gay, Jason P.; Gera, Sonal; Han, Jing; Hong, David S.; Jabbour, Elias J.; Ju, Zhenlin; Karp, Daniel D.; Lodi, Alessia; Molina, Jennifer R.; Baran, Natalia; Naing, Aung; Ohanian, Maro; Pant, Shubham; Pemmaraju, Naveen; Bose, Prithviraj; Piha-Paul, Sarina A.; Rodon, Jordi; Salguero, Carolina; Sasaki, Koji; Singh, Anand K.; Subbiah, Vivek; Tsimberidou, Apostolia M.; Xu, Quanyun A.; Yilmaz, Musa; Zhang, Qi; Li, Yuan; Bristow, Christopher A.; Bhattacharjee, Meenakshi B.; Tiziani, Stefano; Heffernan, Timothy P.; Vellano, Christopher P.; Jones, Philip; Heijnen, Cobi J.; Kavelaars, Annemieke; Marszalek, Joseph R.; Konopleva, Marina Share Save
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Shared Nearest Neighbors Approach and Interactive Browser for Network Analysis of a Comprehensive Non-Small-Cell Lung Cancer Data Set Schmidt, Stephanie T.; Akhave, Neal; Knightly, Ryan E.; Reuben, Alexandre; Vokes, Natalie; Zhang, Jianhua; Li, Jun; Fujimoto, Junya; Byers, Lauren A.; Sanchez-Espiridion, Beatriz; Diao, Lixia; Wang, Jing; Federico, Lorenzo; Forget, Marie-Andree; McGrail, Daniel J.; Weissferdt, Annikka; Lin, Shiaw-Yih; Lee, Younghee; Suzuki, Erika; Kovacs, Jeffrey J.; Behrens, Carmen; Wistuba, Ignacio I.; Futreal, Andrew; Vaporciyan, Ara; Sepesi, Boris; Heymach, John V.; Bernatchez, Chantale; Haymaker, Cara; Cascone, Tina; Zhang, Jianjun; Bristow, Christopher A.; Heffernan, Timothy P.; Negrao, Marcelo V.; Gibbons, Don L. Share Save
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A functional genomic approach to actionable gene fusions for precision oncology Li, Jun; Lu, Hengyu; Ng, Patrick Kwok-Shing; Pantazi, Angeliki; Ip, Carman Ka Man; Jeong, Kang Jin; Amador, Bianca; Tran, Richard; Tsang, Yiu Huen; Yang, Lixing; Song, Xingzhi; Dogruluk, Turgut; Ren, Xiaojia; Hadjipanayis, Angela; Bristow, Christopher A.; Lee, Semin; Kucherlapati, Melanie; Parfenov, Michael; Tang, Jiabin; Seth, Sahil; Mahadeshwar, Harshad S.; Mojumdar, Kamalika; Zeng, Dong; Zhang, Jianhua; Protopopov, Alexei; Seidman, Jonathan G.; Creighton, Chad J.; Lu, Yiling; Sahni, Nidhi; Shaw, Kenna R.; Meric-Bernstam, Funda; Futreal, Andrew; Chin, Lynda; Scott, Kenneth L.; Kucherlapati, Raju; Mills, Gordon B.; Liang, Han Share Save
A shared nearest neighbors approach for integrated, multi-platform networks and its application to the exploration of multiomics data from early-stage non-small cell lung cancers Schmidt, Stephanie T.; Akhave, Neal; Reuben, Alexandre; Cascone, Tina; Zhang, Jianhua; Li, Jun; Fujimoto, Junya; Byers, Lauren A.; Sanchez-Espiridion, Beatriz; Diao, Lixia; Wang, Jing; Federico, Lorenzo; Forget, Marie-Andree; McGrail, Daniel J.; Weissferdt, Annikka; Lin, Shiaw-Yih; Lee, Younghee; Vokes, Natalie; Behrens, Carmen; Wistuba, Ignacio I.; Futreal, Andrew; Vaporciyan, Ara; Sepesi, Boris; Heymach, John V.; Bernatchez, Chantale; Haymaker, Cara; Zhang, Jianjun; Bristow, Christopher A.; Heffernan, Timothy P.; Negrao, Marcelo V.; Gibbons, Don L. Share Save
Short-term treatment with multi-drug regimens combining BRAF/MEK-targeted therapy and immunotherapy results in durable responses in Braf-mutated melanoma White, Michael G.; Sloane, Robert Szczepaniak; Witt, Russell G.; Reuben, Alexandre; Gaudreau, Pierre Olivier; Andrews, Miles C.; Feng, Ningping; Johnson, Sarah; Class, Caleb A.; Bristow, Christopher; Wani, Khalida; Hudgens, Courtney; Nezi, Luigi; Manzo, Teresa; De Macedo, Mariana Pettaccia; Hu, Jianhua; Davis, Richard; Jiang, Hong; Prieto, Peter; Burton, Elizabeth; Hwu, Patrick; Tawbi, Hussein; Gershenwald, Jeffrey; Lazar, Alexander J.; Tetzlaff, Michael T.; Overwijk, Willem; Woodman, Scott E.; Cooper, Zachary A.; Marszalek, Joseph R.; Davies, Michael A.; Heffernan, Timothy P.; Wargo, Jennifer A. Share Save
Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer Evans, Kurt W.; Yuca, Erkan; Scott, Stephen S.; Zhao, Ming; Arango, Natalia Paez; Pico, Christian X. Cruz; Saridogan, Turcin; Shariati, Maryam; Class, Caleb A.; Bristow, Christopher A.; Vellano, Christopher P.; Zheng, Xiaofeng; Gonzalez-Angulo, Ana Maria; Su, Xiaoping; Tapia, Coya; Chen, Ken; Akcakanat, Argun; Lim, Bora; Tripathy, Debu; Yap, Timothy A.; Di Francesco, Maria Emilia; Draetta, Giulio F.; Jones, Philip; Heffernan, Timothy P.; Marszalek, Joseph R.; Meric-Bernstam, Funda Share Save
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