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A metabolic switch to the pentose-phosphate pathway induces radiation resistance in pancreatic cancer Shimoni-Sebag, Ariel; Abramovich, Ifat; Agranovich, Bella; Massri, Rami; Stossel, Chani; Atias, Dikla; Raites-Gurevich, Maria; Yizhak, Keren; Golan, Talia; Gottlieb, Eyal; Lawrence, Yaacov Richard Share Save
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy Chen, Jonathan H.; Nieman, Linda T.; Spurrell, Maxwell; Jorgji, Vjola; Elmelech, Liad; Richieri, Peter; Xu, Katherine H.; Madhu, Roopa; Parikh, Milan; Zamora, Izabella; Mehta, Arnav; Nabel, Christopher S.; Freeman, Samuel S.; Pirl, Joshua D.; Lu, Chenyue; Meador, Catherine B.; Barth, Jaimie L.; Sakhi, Mustafa; Tang, Alexander L.; Sarkizova, Siranush; Price, Colles; Fernandez, Nicolas F.; Emanuel, George; He, Jiang; Van Raay, Katrina; Reeves, Jason W.; Yizhak, Keren; Hofree, Matan; Shih, Angela; Sade-Feldman, Moshe; Boland, Genevieve M.; Pelka, Karin; Aryee, Martin J.; Mino-Kenudson, Mari; Gainor, Justin F.; Korsunsky, Ilya; Hacohen, Nir Share Save
The pentosephosphate pathway induces pancreatic cancer radioresistance, a preclinical study with clinical validation Shimoni-Sebag, Ariel; Abramovich, Ifat; Agranovich, Bella; Sirovsky, Yaarit; Stossel, Chani; Atias, Dikla; Raitses-Gurevich, Maria; Glick-Gorman, Yulia; Margalit, Ofer; Regev, David; Tal, Rotem; Tirosh, Itay; Golan, Talia; Yizhak, Keren; Gottlieb, Eyal; Lawrence, Yaacov R. Share Save
CIRCULATORY PLASMA PROTEOMIC BIOMARKERS PREDICT RESPONSE TO IMMUNOTHERAPY IN MELANOMA PATIENTS AND REVEAL BIOLOGICAL INSIGHTS INTO THE TUMOR MICROENVIRONMENT Mehta, Arnav; Rucevic, Marijana; Sprecher, Emmett; Hacohen, Nir; Boland, Genevieve; Parikh, Milan; Chen, Jiajia; Frederick, Dennie; Woods, Elliot; Bi, Lynn; Lieb, David; Hultin-Rosenberg, Lina; Guess, Jamey; Park, Ryan; Schneider, Alexis; Michaud, William; Miao, Benchun; Kasumova, Gyulnara; Kim, Michelle; Bai, Xue; Jenkins, Russell; Klempner, Samuel; Gonye, Anna; Yizhak, Keren; Sade-Feldman, Moshe; Liu, David; Sullivan, Ryan; Flaherty, Keith Share Save
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Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma Freeman, Samuel S.; Sade-Feldman, Moshe; Kim, Jaegil; Stewart, Chip; Gonye, Anna L. K.; Ravi, Arvind; Arniella, Monica B.; Gushterova, Irena; LaSalle, Thomas J.; Blaum, Emily M.; Yizhak, Keren; Frederick, Dennie T.; Sharova, Tatyana; Leshchiner, Ignaty; Elagina, Liudmila; Spiro, Oliver G.; Livitz, Dimitri; Rosebrock, Daniel; Aguet, Francois; Carrot-Zhang, Jian; Ha, Gavin; Lin, Ziao; Chen, Jonathan H.; Barzily-Rokni, Michal; Hammond, Marc R.; von Eckstaedt, Hans C. Vitzthum; Blackmon, Shauna M.; Jiao, Yunxin J.; Gabriel, Stacey; Lawrence, Donald P.; Duncan, Lyn M.; Stemmer-Rachamimov, Anat O.; Wargo, Jennifer A.; Flaherty, Keith T.; Sullivan, Ryan J.; Boland, Genevieve M.; Meyerson, Matthew; Getz, Gad; Hacohen, Nir Share Save
Combined signals from tumor and immune cells predict outcomes of checkpoint inhibition in melanoma Freeman, Samuel S.; Sade-Feldman, Moshe; Kim, Jaegil; Stewart, Chip; Ravi, Arvind; Arniella, Monica; Yizhak, Keren; Leshchiner, Ignaty; Elagina, Liudmila; Spiro, Oliver; Livitz, Dimitri; Rosebrock, Daniel; Aguet, Francois; Carrot-Zhang, Jian; Gonye, Anna; Ha, Gavin; Lin, Ziao; Chen, Jonathan H.; Frederick, Dennie T.; Barzily-Rokni, Michal; Hammond, Marc R.; Vitzthum, Hans; Blackmon, Shauna M.; Jiao, Yunxin J.; Lawrence, Donald P.; Duncan, Lyn M.; Stemmer-Rachamimov, Anat; Wargo, Jennifer A.; Flaherty, Keith T.; Boland, Genevieve M.; Sullivan, Ryan J.; Meyerson, Matthew; Getz, Gad; Hacohen, Nir Share Save
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance (vol 20, pg 1231, 2019) Verma, Vivek; Shrimali, Rajeev K.; Ahmad, Shamim; Dai, Winjie; Wang, Hua; Lu, Sumin; Nandre, Rahul; Gaur, Pankaj; Lopez, Jose; Sade-Feldman, Moshe; Yizhak, Keren; Bjorgaard, Stacey L.; Flaherty, Keith T.; Wargo, Jennifer A.; Boland, Genevieve M.; Sullivan, Ryan J.; Getz, Gad; Hammond, Scott A.; Tan, Ming; Qi, Jingjing; Wong, Phillip; Merghoub, Taha; Wolchok, Jedd; Hacohen, Nir; Janik, John E.; Mkrtichyan, Mikayel; Gupta, Seema; Khleif, Samir N. Share Save
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance Verma, Vivek; Shrimalim, Rajeev K.; Ahmadm, Shamim; Dai, Winjie; Wang, Hua; Lu, Sumin; Nandrelm, Rahul; Gaur, Pankaj; Lopez, Jose; Sade-Feldman, Moshe; Yizhak, Keren; Bjorgaard, Stacey L.; Flaherty, Keith T.; Wargo, Jennifer A.; Boland, Genevieve M.; Sullivan, Ryan J.; Getz, Gad; Hammond, Scott A.; Tan, Ming; Qi, Jingjing; Wong, Phillip; Merghoub, Taha; Wolchok, Jedd; Hacohen, Nir; Janik, John E.; Mkrtichyan, Mikayel; Gupta, Seema; Khleif, Samir N. Share Save
Effector B cells and tertiary lymphoid structures predict response to immune checkpoint blockade in solid tumors Reddy, Sangeetha M.; Helmink, Beth; Gao, Jianjun; Zhang, Shaojun; Yizhak, Keren; Sade-Feldman, Moshe; Basar, Rafet; Blando, Jorge; Han, Guangchun; Gopalakrishnan, Vancheswaran; Zhao, Hao; Liu, Wenbin; Tawbi, Hussein; Amaria, Rodabe; Davies, Michael; Gershenwald, Jeffrey; Burton, Elizabeth M.; Allison, James; Tetzlaff, Michael; Rezvani, Katy; Hacohen, Nir; Sharma, Padmanee; Wang, Linghua; Wargo, Jennifer Share Save
An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer Auslander, Noam; Cunningham, Chelsea E.; Toosi, Behzad M.; McEwen, Emily J.; Yizhak, Keren; Vizeacoumar, Frederick S.; Parameswaran, Sreejit; Gonen, Nir; Freywald, Tanya; Bhanumathy, Kalpana K.; Freywald, Andrew; Vizeacoumar, Franco J.; Ruppin, Eytan Share Save
Resistance to checkpoint blockade therapy through inactivation of antigen presentation Sade-Feldman, Moshe; Jiao, Yunxin J.; Chen, Jonathan H.; Rooney, Michael S.; Barzily-Rokni, Michal; Eliane, Jean-Pierre; Bjorgaard, Stacey L.; Hammond, Marc R.; Vitzthum, Hans; Blackmon, Shauna M.; Frederick, Dennie T.; Hazar-Rethinam, Mehlika; Nadres, Brandon A.; Van Seventer, Emily E.; Shukla, Sachet A.; Yizhak, Keren; Ray, John P.; Rosebrock, Daniel; Livitz, Dimitri; Adalsteinsson, Viktor; Getz, Gad; Duncan, Lyn M.; Li, Bo; Corcoran, Ryan B.; Lawrence, Donald P.; Stemmer-Rachamimov, Anat; Boland, Genevieve M.; Landau, Dan A.; Flaherty, Keith T.; Sullivan, Ryan J.; Hacohen, Nir Share Save
Identifying cancer-related processes in normal tissues via RNA-seq Yizhak, Keren; Kim, Jaegil; Aguet, Francois; Hess, Julian; Zhang, Hailei; Arich-Landkof, Eila; Shoresh, Noam; Segre, Ayelet; Stewart, Chip; Rosebrock, Dainel; Livitz, Dimitri; Haradhvala, Nicholas; Polak, Paz; Sullivan, Tim; Li, Xiao; Ardlie, Kristin; Getz, Gad Share Save
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