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Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants

delete2025-06-27
delete0
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OA
AI
O
Or‐Yam Revach
A
Angelina M. Cicerchia
O
Ofir Shorer
C
Claire A. Palin
B
Boryana Petrova
S
Seth Anderson
B
Baolin Liu
J
Joshua Park
L
Lee Chen
A
Arnav Mehta
S
Samuel J. Wright
N
Niamh McNamee
A
Aya Tal-Mason
G
Giulia Cattaneo
P
Payal Tiwari
H
Hongyan Xie
J
Johanna M. Sweere
L
Li-Chun Cheng
N
Natalia Sigal
E
Elizabeth Enrico
M
Marisa Miljkovic
S
Shane A. Evans
N
Ngan Luu-Thuy Nguyen
M
Mark Whidden
R
Ramji Srinivasan
M
Matthew H. Spitzer
Y
Yi Sun
T
Tatyana Sharova
A
Aleigha Lawless
W
William A. Michaud
M
Martin Q. Rasmussen
J
Jacy Fang
J
Jeannette R. Brook
F
Feng Chen
X
Xinhui Wang
C
Cristina R. Ferrone
D
Donald P. Lawrence
R
Ryan J. Sullivan
D
David Liu
U
Uma M. Sachdeva
D
Debattama R. Sen
K
Keith T. Flaherty
R
Robert T. Manguso
L
Lloyd Bod
M
Manolis Kellis
G
Genevieve M. Boland
K
Keren Yizhak
J
Jiekun Yang
N
Naama Kanarek
M
Moshe Sade-Feldman
N
Nir Hacohen
R
Russell W. Jenkins *
DOI：10.1016/j.xcrm.2025.102210delete
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Abstract

Abstract

En 中文
• CD38hiCD8+ T cells are associated with ICB resistance in melanoma • CD38 expression is induced by chronic TCR stimulation and type I IFN signaling • Blocking CD38 restores NAD+ pools and mitochondrial function • Dual PD-1/CD38 blockade overcomes ICB resistance in patient-derived 3D tumor models
Keywords:
CD38
PD-1
immunotherapy
T cell exhaustion
organotypic tumor spheroids
ex vivo
3D microfluidic culture
cytokines
NAD+
AI Summary

AI Summary

Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Cell Reports Medicine cover
Cell Reports Medicine
IF:
10.6
Papers:
2.2K
Citations:
8.9K

Organization

M
Massachusetts General Hospital
Scholars:
3.4W
Papers: 2.6W
Citations: 8.6W
T
teiko bio
Scholars:
10
Papers: 1
Citations: 0
M
Massachusetts Institute of Technology
Scholars:
2.4K
Papers: 1.1K
Citations: 8
B
Broad Institute of MIT and Harvard
Scholars:
1.2K
Papers: 323
Citations: 0
H
Harvard Medical School
Scholars:
6.5W
Papers: 4.8W
Citations: 91
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