Not logged in Convergent evolution of BRCA2 reversion mutations under therapeutic pressure by PARP inhibition and platinum chemotherapy Walmsley, Charlotte S.; Jonsson, Philip; Cheng, Michael L.; Mcbride, Sean; Kaeser, Christopher; Vargas, Herbert Alberto; Laudone, Vincent; Taylor, Barry S.; Kappagantula, Rajya; Baez, Priscilla; Richards, Allison L.; Noronha, Anne Marie; Perera, Dilmi; Berger, Michael; Solit, David B.; Iacobuzio-Donahue, Christine A.; Scher, Howard I.; Donoghue, Mark T. A.; Abida, Wassim; Schram, Alison M. Share Save
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LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in preclinical PI3Kα H1047R-mutant breast cancer models Puca, Loredana; Dowless, Michele S.; Perez-Ferreiro, Carmen M.; Ortiz-Ruiz, Maria Jesus; Donoho, Gregory P.; Capen, Andrew; Huber, Lysiane; Bogner, Sarah M.; Fei, Dongling; Manro, Jason R.; Yu, Chun Ping; Xu, Wei Guo; Wang, Rui; Chen, Shuang; Hicks, Mark A.; Zolfaghari, Parisa; Faber, Andrew; Gilmour, Raymond; Ramstetter, Monica D.; Chang, Matthew T.; Lallena, Maria Jose; Gong, Xuequian; Hyman, David M.; Smyth, Lillian M.; Brandhuber, Barbara J.; Taylor, Barry S.; Klippel, Anke Share Save
ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1 Su, Wenjing; Mukherjee, Radha; Yaeger, Rona; Son, Jieun; Xu, Jianing; Na, Na; Timaul, Neilawattie Merna; Hechtman, Jaclyn; Paroder, Viktoriya; Lin, Mika; Mattar, Marissa; Qiu, Juan; Chang, Qing; Zhao, Huiyong; Zhang, Jonathan; Little, Megan; Adachi, Yuta; Han, Sae-Won; Taylor, Barry S.; Ebi, Hiromichi; Abdel-Wahab, Omar; de Stanchina, Elisa; Rudin, Charles M.; Janne, Pasi A.; McCormick, Frank; Yao, Zhan; Rosen, Neal Share Save
Germline Pathogenic Variants Impact Clinicopathology of Advanced Lung Cancer Mukherjee, Semanti; Bandlamudi, Chaitanya; Hellmann, Matthew D.; Kemel, Yelena; Drill, Esther; Rizvi, Hira; Tkachuk, Kaitlyn; Khurram, Aliya; Walsh, Michael F.; Zauderer, Marjorie G.; Mandelker, Diana; Topka, Sabine; Zehir, Ahmet; Srinivasan, Preethi; Selvan, Myvizhi Esai; Carlo, Maria I.; Cadoo, Karen A.; Latham, Alicia; Hamilton, Jada G.; Liu, Ying L.; Lipkin, Steven M.; Belhadj, Sami; Bond, Gareth L.; Gumus, Zeynep H.; Klein, Robert J.; Ladanyi, Marc; Solit, David B.; Robson, Mark E.; Jones, David R.; Kris, Mark G.; Vijai, Joseph; Stadler, Zsofia K.; Amos, Christopher I.; Taylor, Barry S.; Berger, Michael F.; Rudin, Charles M.; Offit, Kenneth Share Save
AKT mutant allele-specific activation dictates pharmacologic sensitivities Bhattarai, Tripti Shrestha; Shamu, Tambudzai; Gorelick, Alexander N.; Chang, Matthew T.; Chakravarty, Debyani; Gavrila, Elena, I; Donoghue, Mark T. A.; Gao, JianJong; Patel, Swati; Gao, Sizhi Paul; Reynolds, Margaret H.; Phillips, Sarah M.; Soumerai, Tara; Abida, Wassim; Hyman, David M.; Schram, Alison M.; Solit, David B.; Smyth, Lillian M.; Taylor, Barry S. Share Save
The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers (vol 13, 1450, 2022) Rosen, Ezra Y.; Won, Helen H.; Zheng, Youyun; Cocco, Emiliano; Selcuklu, Duygu; Gong, Yixiao; Friedman, Noah D.; de Bruijn, Ino; Sumer, Onur; Bielski, Craig M.; Savin, Casey; Bourque, Caitlin; Falcon, Christina; Clarke, Nikeysha; Jing, Xiaohong; Meng, Fanli; Zimel, Catherine; Shifman, Sophie; Kittane, Srushti; Wu, Fan; Ladanyi, Marc; Ebata, Kevin; Kherani, Jennifer; Brandhuber, Barbara J.; Fagin, James; Sherman, Eric J.; Rekhtman, Natasha; Berger, Michael F.; Scaltriti, Maurizio; Hyman, David M.; Taylor, Barry S.; Drilon, Alexander Share Save
Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity Araujo, Nathalia; Sledziona, James; Noothi, Sunil K.; Burikhanov, Ravshan; Hebbar, Nikhil; Ganguly, Saptadwipa; Shrestha-Bhattarai, Tripti; Zhu, Beibei; Katz, Wendy S.; Zhang, Yi; Taylor, Barry S.; Liu, Jinze; Chen, Li; Weiss, Heidi L.; He, Daheng; Wang, Chi; Morris, Andrew J.; Cassis, Lisa A.; Nikolova-Karakashian, Mariana; Nagareddy, Prabhakar R.; Melander, Olle; Evers, B. Mark; Kern, Philip A.; Rangnekar, Vivek M. Share Save
The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers Rosen, Ezra Y.; Won, Helen H.; Zheng, Youyun; Cocco, Emiliano; Selcuklu, Duygu; Gong, Yixiao; Friedman, Noah D.; de Bruijn, Ino; Sumer, Onur; Bielski, Craig M.; Savin, Casey; Bourque, Caitlin; Falcon, Christina; Clarke, Nikeysha; Jing, Xiaohong; Meng, Fanli; Zimel, Catherine; Shifman, Sophie; Kittane, Srusthi; Wu, Fan; Ladanyi, Marc; Ebata, Kevin; Kherani, Jennifer; Brandhuber, Barbara J.; Fagin, James; Sherman, Eric J.; Rekhtman, Natasha; Berger, Michael F.; Scaltriti, Maurizio; Hyman, David M.; Taylor, Barry S.; Drilon, Alexander Share Save
The context-specific role of germline pathogenicity in tumorigenesis Srinivasan, Preethi; Bandlamudi, Chaitanya; Jonsson, Philip; Kemel, Yelena; Chavan, Shweta S.; Richards, Allison L.; Penson, Alexander, V; Bielski, Craig M.; Fong, Christopher; Syed, Aijazuddin; Jayakumaran, Gowtham; Prasad, Meera; Hwee, Jason; Sumer, Selcuk Onur; de Bruijn, Ino; Li, Xiang; Gao, JianJiong; Schultz, Nikolaus; Cambria, Roy; Galle, Jesse; Mukherjee, Semanti; Vijai, Joseph; Cadoo, Karen A.; Carlo, Maria, I; Walsh, Michael F.; Mandelker, Diana; Ceyhan-Birsoy, Ozge; Shia, Jinru; Zehir, Ahmet; Ladanyi, Marc; Hyman, David M.; Zhang, Liying; Offit, Kenneth; Robson, Mark E.; Solit, David B.; Stadler, Zsofia K.; Berger, Michael F.; Taylor, Barry S. Share Save
A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers Cercek, Andrea; Chatila, Walid K.; Yaeger, Rona; Walch, Henry; Fernandes, Gustavo Dos Santos; Krishnan, Asha; Palmaira, Lerie; Maio, Anna; Kemel, Yelena; Srinivasan, Preethi; Bandlamudi, Chaitanya; Salo-Mullen, Erin; Tejada, Prince R.; Belanfanti, Kimeisha; Galle, Jesse; Joseph, Vijai; Segal, Neil; Varghese, Anna; Reidy-Lagunes, Diane; Shia, Jinru; Vakiani, Efsevia; Mondaca, Sebastian; Mendelsohn, Robin; Lumish, Melissa A.; Steinruecke, Felix; Kemeny, Nancy; Connell, Louise; Ganesh, Karuna; Markowitz, Arnold; Nash, Garrett; Guillem, Jose; Smith, J. Joshua; Paty, Phillip B.; Zhang, Liying; Mandelker, Diana; Birsoy, Ozge; Robson, Mark; Offit, Kenneth; Taylor, Barry; Berger, Michael; Solit, David; Weiser, Martin; Saltz, Leonard B.; Aguilar, Julio Garcia; Schultz, Nikolaus; Diaz, Luis A., Jr.; Stadler, Zsofia K. Share Save
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TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors Cocco, Emiliano; Lee, Ji Eun; Kannan, Srinivasaraghavan; Schram, Alison M.; Won, Helen H.; Shifman, Sophie; Kulick, Amanda; Baldino, Laura; Toska, Eneda; Arruabarrena-Aristorena, Amaia; Kittane, Srushti; Wu, Fan; Cai, Yanyan; Arena, Sabrina; Mussolin, Benedetta; Kannan, Ram; Vasan, Neil; Gorelick, Alexander N.; Berger, Michael F.; Novoplansky, Ofra; Jagadeeshan, Sankar; Liao, Yi; Rix, Uwe; Misale, Sandra; Taylor, Barry S.; Bardelli, Alberto; Hechtman, Jaclyn F.; Hyman, David M.; Elkabets, Moshe; de Stanchina, Elisa; Verma, Chandra S.; Ventura, Andrea; Drilon, Alexander; Scaltriti, Maurizio Share Save
AKT1 E17K Inhibits Cancer Cell Migration by Abrogating β-Catenin Signaling Gao, Sizhi Paul; Kiliti, Amber J.; Zhang, Kai; Vasani, Naresh; Mao, Ninghui; Jordan, Emmet; Wise, Hannah C.; Bhattarai, Tripti Shrestha; Hu, Wenhuo; Dorso, Madeline; Rodrigues, James A.; Kim, Kwanghee; Hanrahan, Aphrothiti J.; Razavi, Pedram; Carver, Brett; Chandarlapaty, Sarat; Reis-Filho, Jorge S.; Taylor, Barry S.; Solit, David B. Share Save
Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor Taylor, Justin; Donoghue, Mark T. A.; Ho, Caleb; Petrova-Drus, Kseniya; Al-Ahmadie, Hikmat A.; Funt, Samuel A.; Zhang, Yanming; Aypar, Umut; Rao, Pavitra; Chavan, Shweta S.; Haddadin, Michael; Tamari, Roni; Giralt, Sergio; Tallman, Martin S.; Rampal, Raajit K.; Baez, Priscilla; Kappagantula, Rajya; Kosuri, Satyajit; Dogan, Ahmet; Tickoo, Satish K.; Reuter, Victor E.; Bosl, George J.; Iacobuzio-Donahue, Christine A.; Solit, David B.; Taylor, Barry S.; Feldman, Darren R.; Abdel-Wahab, Omar Share Save
Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer Hanrahan, Aphrothiti J.; Sylvester, Brooke E.; Chang, Matthew T.; Elzein, Arijh; Gao, Jianjiong; Han, Weiwei; Liu, Ye; Xu, Dong; Gao, Sizhi P.; Gorelick, Alexander N.; Jones, Alexis M.; Kiliti, Amber J.; Nissan, Moriah H.; Nimura, Clare A.; Poteshman, Abigail N.; Yao, Zhan; Gao, Yijun; Hu, Wenhuo; Wise, Hannah C.; Gavrila, Elena, I; Shoushtari, Alexander N.; Tiwari, Shakuntala; Viale, Agnes; Abdel-Wahab, Omar; Merghoub, Taha; Berger, Michael F.; Rosen, Neal; Taylor, Barry S.; Solit, David B. Share Save
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors Vasan, Neil; Razavi, Pedram; Johnson, Jared L.; Shao, Hong; Shah, Hardik; Antoine, Alesia; Ladewig, Erik; Gorelick, Alexander; Lin, Ting-Yu; Toska, Eneda; Xu, Guotai; Kazmi, Abiha; Chang, Matthew T.; Taylor, Barry S.; Dickler, Maura N.; Jhaveri, Komal; Chandarlapaty, Sarat; Rabadan, Raul; Reznik, Ed; Smith, Melissa L.; Sebra, Robert; Schimmoller, Frauke; Wilson, Timothy R.; Friedman, Lori S.; Cantley, Lewis C.; Scaltriti, Maurizio; Baselga, Jose Share Save
Germline mutation prevalence in young adults with cancer Stadler, Zsofia K.; Maio, Anna; Padunan, Angelika; Kemel, Yelena; Salo-Mullen, Erin; Sheehan, Margaret; Belanfanti, Kimeisha; Tejada, Prince R.; Birsoy, Ozge; Mandelker, Diana; Zhang, Liying; Galle, Jesse; Feldman, Darren; Boucai, Laura; Bender, Julia Glade; Piotrowski, Anna; Aghajanian, Carol; Cadoo, Karen A.; Carlo, Maria, I; Walsh, Michael; Janjigian, Yelena; O'Reilly, Eileen; DeAngelis, Lisa M.; Solit, David B.; Taylor, Barry; Cercek, Andrea; Tap, William; Robson, Mark E.; Berger, Michael F.; Offit, Kenneth; Diaz, Luis A. Share Save
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