Not logged inLow-Molecular Weight Cyclin E Confers a Vulnerability to PKMYT1 Inhibition in Triple-Negative Breast Cancer
Li, Mi; Lulla, Amriti R.; Wang, Yan; Tsavaschidis, Spyros; Wang, Fuchenchu; Karakas, Cansu; Nguyen, Tuyen D. T.; Bui, Tuyen N.; Pina, Marc A.; Chen, Mei-Kuang; Mastoraki, Sofia; Multani, Asha S.; Fowlkes, Natalie W.; Sahin, Aysegul; Marshall, C. Gary; Hunt, Kelly K.; Keyomarsi, Khandan .png)
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SaveThe DNA repair pathway as a therapeutic target to synergize with trastuzumab deruxtecan in HER2-targeted antibody-drug conjugate-resistant HER2-overexpressing breast cancerLee, Jangsoon; Kida, Kumiko; Koh, Jiwon; Liu, Huey; Manyam, Ganiraju C.; Gi, Young Jin; Rampa, Dileep R.; Multani, Asha S.; Wang, Jing; Jayachandran, Gitanjali; Lee, Dae-Won; Reuben, James M.; Sahin, Aysegul; Huo, Lei; Tripathy, Debu; Im, Seock-Ah; Ueno, Naoto T. Share Save Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA responseZhao, Mei; Wang, Tianxiao; Gleber-Netto, Frederico O.; Chen, Zhen; Mcgrail, Daniel J.; Gomez, Javier A.; Ju, Wutong; Gadhikar, Mayur A.; Ma, Wencai; Shen, Li; Wang, Qi; Tang, Ximing; Pathak, Sen; Raso, Maria Gabriela; Burks, Jared K.; Lin, Shiaw-Yih; Wang, Jing; Multani, Asha S.; Pickering, Curtis R.; Chen, Junjie; Myers, Jeffrey N.; Zhou, Ge Share Save Low molecular weight cyclin E deregulates DNA replication and damage repair to promote genomic instability in breast cancerLi, Mi; Tsavachidis, Spiridon; Wang, Fuchenchu; Bui, Tuyen; Nguyen, Tuyen D.; Luo, Linjie; Multani, Asha S.; Bondy, Melissa L.; Hunt, Kelly K.; Keyomarsi, Khandan Share Save Mutant p53 gains oncogenic functions through a cytosolic DNA responseZhao, Mei; Wang, Tianxiao; Gleber-Netto, Frederico O.; Chen, Zhen; McGrail, Daniel J.; Gomez, Javier A.; Ju, Wutong; Gadhikar, Mayur A.; Ma, Wencai; Shen, Li; Tang, Ximing; Pathak, Sen; Raso, Maria G.; Burks, Jared; Lin, Shiaw-Yih; Wang, Jing; Multani, Asha S.; Pickering, Curtis R.; Chen, Junjie; Myers, Jeffrey N.; Zhou, Ge Share Save Pot1b Deletion and Telomerase Haploinsufficiency in Mice Initiate an ATR- Dependent DNA Damage Response and Elicit Phenotypes Resembling Dyskeratosis CongenitaHe, Hua; Wang, Yang; Guo, Xiaolan; Ramchandani, Sonal; Ma, Jin; Shen, Mei-Feng; Garcia, Dennis A.; Deng, Yibin; Multani, Asha S.; You, Mingjian James; Chang, Sandy Share Save Share Save Chromosome size affects sequence divergence between species through the interplay of recombination and selectionTigano, Anna; Khan, Ruqayya; Omer, Arina D.; Weisz, David; Dudchenko, Olga; Multani, Asha S.; Pathak, Sen; Behringer, Richard R.; Aiden, Erez L.; Fisher, Heidi; MacManes, Matthew D. Share Save APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasisWormann, Sonja M.; Zhang, Amy; Thege, Fredrik, I; Cowan, Robert W.; Rupani, Dhwani N.; Wang, Runsheng; Manning, Sara L.; Gates, Chris; Wu, Weisheng; Levin-Klein, Rena; Rajapakshe, Kimal, I; Yu, Meifang; Multani, Asha S.; Kang, Ya'an; Taniguchi, Cullen M.; Schlacher, Katharina; Bellin, Melena D.; Katz, Matthew H. G.; Kim, Michael P.; Fleming, Jason B.; Gallinger, Steven; Maddipati, Ravikanth; Harris, Reuben S.; Notta, Faiyaz; Ross, Susan R.; Maitra, Anirban; Rhim, Andrew D. Share Save Telomere dysfunction instigates inflammation in inflammatory bowel diseaseChakravarti, Deepavali; Lee, Rumi; Multani, Asha S.; Santoni, Andrea; Keith, Zachery; Hsu, Wen-Hao; Chang, Kyle; Reyes, Laura; Rashid, Asif; Wu, Chang-Jiun; Li, Jun; Zhang, Jiexin; Shim, Hong Seok; Chandra, Krishna; Deng, Pingna; Spring, Denise J.; Nielsen, Ole Haagen; Riis, Lene Buhl; Mayigegowda, Kavya Kelagere; Blutt, Sarah E.; Zhang, Jianhua; Younes, Mamoun; DuPont, Andrew; Thirumurthi, Selvi; Vilar, Eduardo; Estes, Mary K.; Colla, Simona; Shroyer, Noah F.; DePinho, Ronald A. Share Save The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB SignalingChen, Baoqing; Dragomir, Mihnea P.; Fabris, Linda; Bayraktar, Recep; Knutsen, Erik; Liu, Xu; Tang, Changyan; Li, Yongfeng; Shimura, Tadanobu; Ivkovic, Tina Catela; De los Santos, Mireia Cruz; Anfossi, Simone; Shimizu, Masayoshi; Shah, Maitri Y.; Ling, Hui; Shen, Peng; Multani, Asha S.; Pardini, Barbara; Burks, Jared K.; Katayama, Hiroyuki; Reineke, Lucas C.; Huo, Longfei; Syed, Muddassir; Song, Shumei; Ferracin, Manuela; Oki, Eiji; Fromm, Bastian; Ivan, Cristina; Bhuvaneshwar, Krithika; Gusev, Yuriy; Mimori, Koshi; Menter, David; Sen, Subrata; Matsuyama, Takatoshi; Uetake, Hiroyuki; Vasilescu, Catalin; Kopetz, Scott; Parker-Thornburg, Jan; Taguchi, Ayumu; Hanash, Samir M.; Girnita, Leonard; Slaby, Ondrej; Goel, Ajay; Varani, Gabriele; Gagea, Mihai; Li, Chunlai; Ajani, Jaffer A.; Calin, George A. Share Save Telomere dysfunction is a driver of inflammatory bowel diseaseChakravarti, Deepavali; Multani, Asha; Dey, Prasenjit; Hu, Baoli; Zhao, Di; Chang, Kyle; Xizeng, Mao; Wang, Guocan; Terranova, Christoper; Liao, Wen-Ting; Spring, Denise; Hou, Pingping; Zhang, Jianhua; Okhuysen, Pablo; Vilar, Eduardo; Estes, Mary K.; Blutt, Sarah; Wang, Alan; DePinho, Ronald Share Save Share Save RETRACTION: Disruption of the NAD(P)H: Quinone Oxidoreductase 1 (NQO1) Gene in Mice Causes Myelogenous Hyperplasia (vol 62, pg 3030, 2002) (Retraction of Vol 62, Pg 3030, 2002)Long, Delwin J., II; Gaikwad, Amos; Multani, Asha; Pathak, Sen; Montgomery, Charles A.; Gonzalez, Frank J.; Jaiswal, Anil K. Share Save Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastomadeCarvalho, Ana C.; Kim, Hoon; Poisson, Laila M.; Winn, Mary E.; Mueller, Claudius; Cherba, David; Koeman, Julie; Seth, Sahil; Protopopov, Alexei; Felicella, Michelle; Zheng, Siyuan; Multani, Asha; Jiang, Yongying; Zhang, Jianhua; Nam, Do-Hyun; Petricoin, Emanuel F.; Chin, Lynda; Mikkelsen, Tom; Verhaak, Roel G. W. 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Share Save Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressuresGraham, Nicholas A.; Minasyan, Aspram; Lomova, Anastasia; Cass, Ashley; Balanis, Nikolas G.; Friedman, Michael; Chan, Shawna; Zhao, Sophie; Delgado, Adrian; Go, James; Beck, Lillie; Hurtz, Christian; Ng, Carina; Qiao, Rong; ten Hoeve, Johanna; Palaskas, Nicolaos; Wu, Hong; Muschen, Markus; Multani, Asha S.; Port, Elisa; Larson, Steven M.; Schultz, Nikolaus; Braas, Daniel; Christofk, Heather R.; Mellinghoff, Ingo K.; Graeber, Thomas G. Share Save Linking genomic reorganization to tumor initiation via the giant cell cycleNiu, N.; Zhang, J.; Zhang, N.; Mercado-Uribe, I.; Tao, F.; Han, Z.; Pathak, S.; Multani, A. S.; Kuang, J.; Yao, J.; Bast, R. C.; Sood, A. K.; Hung, M-C; Liu, J. Share Save Share Save 
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