Not logged inDiscovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties
Soth, Michael J.; Le, Kang; Di Francesco, Maria Emilia; Hamilton, Matthew M.; Liu, Gang; Burke, Jason P.; Carroll, Chris L.; Kovacs, Jeffrey J.; Bardenhagen, Jennifer P.; Bristow, Christopher A.; Cardozo, Mario; Czako, Barbara; de Stanchina, Elisa; Feng, Ningping; Garvey, Jill R.; Gay, Jason P.; Do, Mary K. Geck; Greer, Jennifer; Han, Michelle; Harris, Angela; Herrera, Zachary; Huang, Sha; Giuliani, Virginia; Jiang, Yongying; Johnson, Sarah B.; Johnson, Troy A.; Kang, Zhijun; Leonard, Paul G.; Liu, Zhen; McAfoos, Timothy; Miller, Meredith; Morlacchi, Pietro; Mullinax, Robert A.; Palmer, Wylie S.; Pang, Jihai; Rogers, Norma; Rudin, Charles M.; Shepard, Hannah E.; Spencer, Nakia D.; Theroff, Jay; Wu, Qi; Xu, Alan; Yau, Ju Anne; Draetta, Giulio; Toniatti, Carlo; Heffernan, Timothy P.; Jones, Philip .png)
Share.png)
SaveFunctional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative PhosphorylationSun, Yuting; Bandi, Madhavi; Lofton, Timothy; Smith, Melinda; Bristow, Christopher A.; Carugo, Alessandro; Rogers, Norma; Leonard, Paul; Chang, Qing; Mullinax, Robert; Han, Jing; Shi, Xi; Seth, Sahil; Meyers, Brooke A.; Miller, Meredith; Miao, Lili; Ma, Xiaoyan; Feng, Ningping; Giuliani, Virginia; Do, Mary Geck; Czako, Barbara; Palmer, Wylie S.; Mseeh, Faika; Asara, John M.; Jiang, Yongying; Morlacchi, Pietro; Zhao, Shuping; Peoples, Michael; Tieu, Trang N.; Warmoes, Marc O.; Lorenzi, Philip L.; Muller, Florian L.; DePinho, Ronald A.; Draetta, Giulio F.; Toniatti, Carlo; Jones, Philip; Heffernan, Timothy P.; Marszalek, Joseph R. Share Save Functional genomics reveals dependency on 6-phosphogluconate dehydrogenase in OXPHOS-deficient tumorsSun, Yuting; Bandi, Madhavi; Lofton, Timothy; Smith, Melinda; Bristow, Christopher; Rogers, Norma; Edward, Chang; Do, Mary Geck; Jiang, Yongying; Morlacchi, Pietro; Muller, Florian; Mseeh, Faika; Czako, Barbara; Palmer, Wylie; Toniatti, Carlo; Jones, Philip; Draetta, Giulio; Heffernan, Timothy; Marszalek, Joseph Share Save Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discoveryZhan, Yanai; Kost-Alimova, Maria; Shi, Xi; Leo, Elisabetta; Bardenhagen, Jennifer P.; Shepard, Hannah E.; Appikonda, Srikanth; Vangamudi, Bhavatarini; Zhao, Shuping; Tieu, Trang N.; Jiang, Shiming; Heffernan, Timothy P.; Marszalek, Joseph R.; Toniatti, Carlo; Draetta, Giulio; Tyler, Jessica; Barton, Michelle; Jones, Philip; Palmer, Wylie S.; Do, Mary K. Geck; Andersen, Jannik N. Share Save The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNFMutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor StudiesVangamudi, Bhavatarini; Paul, Thomas A.; Shah, Parantu K.; Kost-Alimova, Maria; Nottebaum, Lisa; Shi, Xi; Zhan, Yanai; Leo, Elisabetta; Mahadeshwar, Harshad S.; Protopopov, Alexei; Futreal, Andrew; Tieu, Trang N.; Peoples, Mike; Heffernan, Timothy P.; Marszalek, Joseph R.; Toniatti, Carlo; Petrocchi, Alessia; Verhelle, Dominique; Owen, Dafydd R.; Draetta, Giulio; Jones, Philip; Palmer, Wylie S.; Sharma, Shikhar; Andersen, Jannik N. Share Save The SMARCA2/4 catalytic activity, but not the bromodomain, is a drug target in SWI/SNF mutant cancersVangamudi, Bhavatarini; Paui, Thomas; Shah, Parantu K.; Alimova, Maria K.; Nottebaum, Lisa; Shi, Xi; Zhan, Yanai; Leo, Elisabetta; Mahadeshwar, Harshad S.; Protopopov, Alexei; Futreal, Andrew; Tieu, Trang N.; Peoples, Mike; Petrocchi, Alessia; Marszalek, Joseph R.; Toniatti, Carlo; Heffernan, Timothy P.; Verhelle, Dominique; Draetta, Giulio; Owen, Dafydd; Jones, Philip; Palmer, Wylie; Sharma, Shikhar; Andersen, Jannik N. Share Save Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain InhibitorPalmer, Wylie S.; Poncet-Montange, Guillaume; Liu, Gang; Petrocchi, Alessia; Reyna, Naphtali; Subramanian, Govindan; Theroff, Jay; Yau, Anne; Kost-Alimova, Maria; Bardenhagen, Jennifer P.; Leo, Elisabetta; Shepard, Hannah E.; Tieu, Trang N.; Shi, Xi; Zhao, Yanai; Zhao, Shuping; Barton, Michelle C.; Draetta, Giulio; Toniatti, Carlo; Jones, Philip; Do, Mary Geck; Andersen, Jannik N. Share Save Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2Poncet-Montange, Guillaume; Zhan, Yanai; Bardenhagen, Jennifer P.; Petrocchi, Alessia; Leo, Elisabetta; Shi, Xi; Lee, Gilbert R.; Leonard, Paul G.; Do, Mary K. Geck; Cardozo, Mario G.; Andersen, Jannik N.; Palmer, Wylie S.; Jones, Philip; Ladbury, John E. Share Save Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent InhibitionSafina, Brian S.; Baker, Stewart; Baumgardner, Matt; Blaney, Paul M.; Chan, Bryan K.; Chen, Yung-Hsiang; Cartwright, Matthew W.; Castanedo, Georgette; Chabot, Christine; Cheguillaume, Arnaud J.; Goldsmith, Paul; Goldstein, David M.; Goyal, Bindu; Hancox, Timothy; Handa, Raj K.; Lyer, Pravin S.; Kaur, Jasmit; Kondru, Rama; Kenny, Jane R.; Krintel, Sussie L.; Li, Jun; Lesnick, John; Lucas, Matthew C.; Lewis, Cristina; Mukadam, Sophie; Murray, Jeremy; Nadin, Alan J.; Nonomiya, Jim; Padilla, Fernando; Palmer, Wylie S.; Pang, Jodie; Pegg, Neil; Price, Steve; Reif, Karin; Salphati, Laurent; Savy, Pascal A.; Seward, Eileen M.; Shuttleworth, Stephen; Sohal, Sukhjit; Sweeney, Zachary K.; Tay, Suzanne; Tivitmahaisoon, Parcharee; Waszkowycz, Bohdan; Wei, Binqing; Yue, Qin; Zhang, Chenghong; Sutherlin, Daniel P. Share Save Share Save Share Save N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha(1)-adrenoceptor antagonistsElworthy, TR; Ford, APDW; Bantle, GW; Morgans, DJ; Ozer, RS; Palmer, WS; Repke, DB; Romero, M; Sandoval, L; Sjogren, EB; Talamas, FX; Vazquez, A; Wu, H; Arredondo, NF; Blue, DR; DeSousa, A; Gross, LM; Kava, MS; Lesnick, JD; Vimont, RL; Williams, TJ; Zhu, QM; Pfister, JR; Clarke, DE Share Save Share Save 
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
