Thomas A. Steitz - Publications, H-index & Citations

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Thomas A. Steitz

Yale University

120H-index

515Paper Count

5.1WCitation Count

Published Papers 89

Publication Date

Molecular dynamics analysis of Mg2+-dependent cleavage of a pistol ribozyme reveals a fail-safe secondary ion for catalysis

JOURNAL OF COMPUTATIONAL CHEMISTRY

IF4.8

2020-02-24

OAAI

Joseph, Newlyn N.; Roy, Raktim N.; Steitz, Thomas A.

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Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-01-09

OAAI

Kang, Dongwei; Zhang, Heng; Wang, Zhao; Zhao, Tong; Ginex, Tiziana; Luque, Francisco Javier; Yang, Yang; Wu, Gaochan; Feng, Da; Wei, Fenju; Zhang, Jian; De Clercq, Erik; Pannecouque, Christophe; Chen, Chin Ho; Lee, Kuo-Hsiung; Murugan, N. Arul; Steitz, Thomas A.; Zhan, Peng; Liu, Xinyong

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Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2018-12-24

OAAI

Lomakin, Ivan B.; Dmitriev, Sergey E.; Steitz, Thomas A.

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Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d] pyrimidine non-nucleoside inhibitors

ELIFE

IF0

2018-07-25

OAAI

Yang, Yang; Kang, Dongwei; Nguyen, Laura A.; Smithline, Zachary B.; Pannecouque, Christophe; Zhan, Peng; Liu, Xinyong; Steitz, Thomas A.

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Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

ANNUAL REVIEW OF BIOCHEMISTRY

IF0

2018-06-20

223

OAAI

Lin, Jinzhong; Zhou, Dejian; Steitz, Thomas A.; Polikanov, Yury S.; Gagnon, Matthieu G.

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Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1

CELL REPORTS

IF6.9

2017-07-01

OAAI

Lomakin, Ivan B.; Stolboushkina, Elena A.; Vaidya, Anand T.; Zhao, Chenguang; Garber, Maria B.; Dmitriev, Sergey E.; Steitz, Thomas A.

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Perspectives on the ribosome

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

IF4.7

2017-03-19

OAAI

Steitz, Thomas A.; Moore, Peter B.

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Crystal structure of Pistol, a class of self-cleaving ribozyme

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2017-01-17

OAAI

Nguyen, Laura A.; Wang, Jimin; Steitz, Thomas A.

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Structural insights into NusG regulating transcription elongation

NUCLEIC ACIDS RESEARCH

IF13.1

2016-11-29

OAAI

Liu, Bin; Steitz, Thomas A.

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Elongation factor 4 remodels the A-site tRNA on the ribosome

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2016-04-18

OAAI

Gagnon, Matthieu G.; Lin, Jinzhong; Steitz, Thomas A.

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Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome

NUCLEIC ACIDS RESEARCH

IF13.1

2016-04-13

OAAI

Melnikov, Sergey V.; Soll, Dieter; Steitz, Thomas A.; Polikanov, Yury S.

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Structures of E-coli σS-transcription initiation complexes provide new insights into polymerase mechanism

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2016-03-28

OAAI

Liu, Bin; Zuo, Yuhong; Steitz, Thomas A.

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Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition

NUCLEIC ACIDS RESEARCH

IF13.1

2016-01-24

151

OAAI

Gagnon, Matthieu G.; Roy, Raktim N.; Lomakin, Ivan B.; Florin, Tanja; Mankin, Alexander S.; Steitz, Thomas A.

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Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin II, Stratifin, and HSP27

JOURNAL OF INVESTIGATIVE DERMATOLOGY

IF5.7

2015-07-01

OAAI

Bunick, Christopher G.; Presland, Richard B.; Lawrence, Owen T.; Pearton, David J.; Milstone, Leonard M.; Steitz, Thomas A.

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Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A

MOLECULAR CELL

IF16.6

2015-06-01

OAAI

Polikanov, Yury S.; Starosta, Agata L.; Juette, Manuel F.; Altman, Roger B.; Terry, Daniel S.; Lu, Wanli; Burnett, Benjamin J.; Dinos, George; Reynolds, Kevin A.; Blanchard, Scott C.; Steitz, Thomas A.; Wilson, Daniel N.

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The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2015-05-18

159

OAAI

Roy, Raktim N.; Lomakin, Ivan B.; Gagnon, Matthieu G.; Steitz, Thomas A.

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Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble

MOLECULAR CELL

IF16.6

2015-05-01

216

OAAI

Zuo, Yuhong; Steitz, Thomas A.

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Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2015-03-16

219

OAAI

Polikanov, Yury S.; Melnikov, Sergey V.; Soell, Dieter; Steitz, Thomas A.

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Structural basis for transcription reactivation by RapA

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2015-02-02

OAAI

Liu, Bin; Zuo, Yuhong; Steitz, Thomas A.

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Polyspecific pyrrolysyl-tRNA synthetases from directed evolution

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2014-11-10

113

OAAI

Guo, Li-Tao; Wang, Yane-Shih; Nakamura, Akiyoshi; Eiler, Daniel; Kavran, Jennifer M.; Wong, Margaret; Kiessling, Laura L.; Steitz, Thomas A.; O'Donoghue, Patrick; Soell, Dieter

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Research Directions