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CDK12/13 inactivation triggers STING-mediated antitumor immunity in preclinical models Bao, Yi; Chang, Yu; Tien, Jean Ching-Yi; Cruz, Gabriel; Yang, Fan; Mannan, Rahul; Mahapatra, Somnath; Paturu, Radha; Cao, Xuhong; Su, Fengyun; Wang, Rui; Zhang, Yuping; Gondal, Mahnoor; Choi, Jae eun; Gurkan, Jonathan K.; Miner, Stephanie J.; Robinson, Dan R.; Wu, Yi-Mi; Zhou, Licheng; Wang, Zhen; Kryczek, Ilona; Wang, Xiaoju; Cieslik, Marcin; Qiao, Yuanyuan; Tsodikov, Alexander; Zou, Weiping; Ding, Ke; Chinnaiyan, Arul M. Share Save
Genomic Insights and Cell of Origin Concepts Reveal Distal Nephron Origin for SDH-B Deficient Renal Cell Carcinoma Mannan, Rahul; Zhang, Yuping; Paturu, Radha; Hu, Jing; Mahapatra, Somnath; Chinnaiyan, Anya; Wang, Xiaoming (Mindy); Cao, Xuhong; Su, Fengyun; Wang, Rui; Picken, Maria; Palapattu, Ganesh; Hafez, Khaled; Vaishampayan, Ulka; Gupta, Sounak; Sangoi, Ankur; Argani, Pedram; Chinnaiyan, Arul; Dhanasekaran, Saravana; Mehra, Rohit Share Save
Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma Chugh, Seema; Tien, Jean C.; Hon, Jennifer; Kenum, Carson; Mannan, Rahul; Cheng, Yunhui; Li, Chi Chiang; Taher, Zainab I.; Delekta, Andrew D.; Bawa, Pushpinder Singh; Apel, Ingrid J.; Miner, Stephanie J.; Cao, Xuhong; Mehra, Rohit; Dhanasekaran, Saravana M.; Qiao, Yuanyuan; Mody, Rajen; Chinnaiyan, Arul M. Share Save
Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment (vol 22, pg 111, 2020) Kregel, Steven; Wang, Chao; Han, Xin; Xiao, Lanbo; Fernandez-Salas, Ester; Bawa, Pushpinder; McCollum, Brooke L.; Wilder-Romans, Kari; Apel, Ingrid J.; Cao, Xuhong; Speers, Corey; Wang, Shaomeng; Chinnaiyan, Arul M. Share Save
Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition Chang, Yu; Wang, Xiaoju; Yang, Jianzhang; Tien, Jean Ching-Yi; Mannan, Rahul; Cruz, Gabriel; Zhang, Yuping; Vo, Josh N.; Magnuson, Brian; Mahapatra, Somnath; Cho, Hanbyul; Dhanasekaran, Saravana Mohan; Wang, Cynthia; Wang, Zhen; Zhou, Licheng; Zhou, Kaijie; Zhou, Yang; Zhang, Pujuan; Huang, Weixue; Xiao, Lanbo; Liu, Weihuang Raymond; Hamadeh, Rudana; Su, Fengyun; Wang, Rui; Miner, Stephanie J.; Cao, Xuhong; Cheng, Yunhui; Mehra, Rohit; Ding, Ke; Chinnaiyan, Arul M. Share Save
CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13 Tien, Jean Ching-Yi; Luo, Jie; Chang, Yu; Zhang, Yuping; Cheng, Yunhui; Wang, Xiaoju; Yang, Jianzhang; Mannan, Rahul; Mahapatra, Somnath; Shah, Palak; Wang, Xiao-Ming; Todd, Abigail J.; Eyunni, Sanjana; Cheng, Caleb; Rebernick, Ryan J.; Xiao, Lanbo; Bao, Yi; Neiswender, James; Brough, Rachel; Pettitt, Stephen J.; Cao, Xuhong; Miner, Stephanie J.; Zhou, Licheng; Wu, Yi-Mi; Labanca, Estefania; Wang, Yuzhuo; Parolia, Abhijit; Cieslik, Marcin; Robinson, Dan R.; Wang, Zhen; Feng, Felix Y.; Chou, Jonathan; Lord, Christopher J.; Ding, Ke; Chinnaiyan, Arul M. Share Save
NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis Parolia, Abhijit; Eyunni, Sanjana; Verma, Brijesh Kumar; Young, Eleanor; Liu, Yihan; Liu, Lianchao; George, James; Aras, Shweta; Das, Chandan Kanta; Mannan, Rahul; Rasool, Reyaz Ur; Mitchell-Velasquez, Erick; Mahapatra, Somnath; Luo, Jie; Carson, Sandra E.; Xiao, Lanbo; Gajjala, Prathibha R.; Venkatesh, Sharan; Jaber, Mustapha; Wang, Xiaoju; He, Tongchen; Qiao, Yuanyuan; Pang, Matthew; Zhang, Yuping; Tien, Jean Ching-Yi; Louw, Micheala; Alhusayan, Mohammed; Cao, Xuhong; Su, Fengyun; Tavana, Omid; Hou, Caiyun; Wang, Zhen; Ding, Ke; Chinnaiyan, Arul M.; Asangani, Irfan A. Share Save
Expression of L1 Cell Adhesion Molecule, a Nephronal Principal Cell Marker, in Nephrogenic Adenoma Mannan, Rahul; Wang, Xiaoming; Mahapatra, Somnath; Wang, Susanna; Chinnaiyan, Anya K.; Skala, Stephanie L.; Zhang, Yuping; McMurry, Lisa M.; Zelenka-Wang, Sylvia; Cao, Xuhong; Sangoi, Ankur R.; Dadhania, Vipulkumar; Picken, Maria M.; Menon, Santosh; Al-Ahmadie, Hikmat; Chinnaiyan, Arul M.; Dhanasekaran, Saravana M.; Mehra, Rohit Share Save
PIKfyve, expressed by CD11c-positive cells, controls tumor immunity Choi, Jae Eun; Qiao, Yuanyuan; Kryczek, Ilona; Yu, Jiali; Gurkan, Jonathan; Bao, Yi; Gondal, Mahnoor; Tien, Jean Ching-Yi; Maj, Tomasz; Yazdani, Sahr; Parolia, Abhijit; Xia, Houjun; Zhou, Jiajia; Wei, Shuang; Grove, Sara; Vatan, Linda; Lin, Heng; Li, Gaopeng; Zheng, Yang; Zhang, Yuping; Cao, Xuhong; Su, Fengyun; Wang, Rui; He, Tongchen; Cieslik, Marcin; Green, Michael D.; Zou, Weiping; Chinnaiyan, Arul M. Share Save
CDK12 loss promotes prostate cancer development while exposing vulnerabilities to paralog-based synthetic lethality Tien, Jean C.; Chang, Yu; Zhang, Yuping; Chou, Jonathan; Cheng, Yunhui; Wang, Xiaoju; Yang, Jianzhang; Mannan, Rahul; Shah, Palak; Wang, Xiao-Ming; Todd, Abbey; Eyunni, Sanjana; Cheng, Caleb; Cao, Xuhong; Bao, Yi; Neiswender, James; Brough, Rachel; Pettitt, Stephen; Labanca, Estefania; Wang, Yuzhuo; Cieslik, Marcin; Lord, Christopher J.; Ding, Ke; Chinnaiyan, Arul M. Share Save
Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment (vol 22, pg 111, 2020) Kregel, Steven; Wang, Chao; Han, Xin; Xiao, Lanbo; Fernandez-Salas, Ester; Bawa, Pushpinder; Mccollum, Brooke L.; Wilder-Romans, Kari; Apel, Ingrid J.; Cao, Xuhong; Speers, Corey; Wang, Shaomeng; Chinnaiyan, Arul M. Share Save
Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma (vol 21, pg 322, 2019) Choi, Jae Eun; Verhaegen, Monique E.; Yazdani, Sahr; Malik, Rohit; Harms, Paul W.; Mangelberger, Doris; Tien, Jean; Cao, Xuhong; Wang, Yuping; Cieslik, Marcin; Gurkan, Jonathan; Yazdani, Mishaal; Jing, Xiaojun; Juckette, Kristin; Su, Fengyun; Wang, Rui; Zhou, Bing; Apel, Ingrid J.; Wang, Shaomeng; Dlugosz, Andrzej A.; Chinnaiyan, Arul M. Share Save
Targeting the SWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies Xiao, Lanbo; He, Tongchen; Klingbeil, Olaf; Eleanor, Young; Wu, Xiaoli; Qiao, Yuanyuan; Parolia, Abhijit; Eyunni, Sanjana; Mannan, Rahul; Mahapatra, Somnath; Kim, NamHoon; Zheng, Heng; Su, Fengyun; Cao, Xuhong; Samajdar, Susanta; Ramachandra, Murali; Vakoc, Christopher R.; Chinnaiyan, Arul M. Share Save
FOXA1 alterations distinctively drive prostate tumorigenesis or therapy resistance in mice Eyunni, Sanjana; Parolia, Abhijit; Young, Eleanor; George, James Matthew; Mannan, Rahul; Carson, Sandra E.; Zhang, Yuping; Tien, Jean; Jaber, Mustapha; Luo, Jie; Pang, Matthew; Mehra, Rohit; Cao, Xuhong; Su, Fengyun; Wang, Rui; Cieslik, Marcin; Lee, Dong Kee; Xu, Jianming; Chinnaiyan, Arul M. Share Save
Targeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy Borker, Parth; Bao, Yi; Qiao, Yuanyuan; Chinnaiyan, Arul; Choi, Jae Eun; Zhang, Yuping; Mannan, Rahul; Cheng, Caleb; He, Tongchen; Zheng, Yang; Yu, Jiali; Gondal, Mahnoor; Cruz, Gabriel; Grove, Sara Sara; Cao, Xuhong; Su, Fengyun; Wang, Rui; Chang, Yu; Kryczek, Ilona; Cieslik, Marcin; Green, Michael D.; Zou, Weiping Share Save
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