William C. Wetsel - Publications, H-index & Citations

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William C. Wetsel

Duke University Medical Center

72H-index

313Paper Count

1.9WCitation Count

Published Papers 99

Publication Date

A suite of engineered mice for interrogating psychedelic drug actions

Nature Neuroscience

IF20

2026-08-06

OAAI

Yi-Ting Chiu; Ariel Y. Deutch; Wei Wang; Gavin P. Schmitz; Karen Lu Huang; D. Dewran Kocak; Pierre Llorach; Kasey R. Bowyer; Bei Liu; Noah Sciaky; Kunjie Hua; Chongguang Chen; Sarah E. Mott; Jesse Niehaus; Jeffrey F. DiBerto; Justin English; Jessica J. Walsh; Grégory Scherrer; Melissa A. Herman; Zhuhao Wu; William C. Wetsel; Bryan L. Roth

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A cholinergic hub in the nucleus accumbens gates opioid-reward learning

Nature

IF48.5

2026-08-05

PREAI

S. Aryana Yousefzadeh; Haidun Yan; Seung-Hwa Kwak; Yunju Oh; Pyeonghwa Jeong; Vladimir Pogorelov; J. Russell Ravenel; Shaun S. X. Lim; James M. Roach; Brenda C. Shields; Ramona M. Rodriguiz; William C. Wetsel; Jiyong Hong; Michael R. Tadross

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Structure-guided Discovery of Non-catechol Dopamine D1 Receptor Ligands with Biased Agonism and Antagonism

Journal of Biological Chemistry

IF3.9

2026-04-27

OAAI

Yang Zhou; William C. Wetsel; Alem W. Kahsai; Steven H. Olson; Lawrence S. Barak

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Perinatal exposure to perfluoroalkyl substances impairs maternal care and induces depressive-like behavior in mice

TOXICOLOGICAL SCIENCES

IF4.1

2025-11-01

PREAI

Rawtani, Harshal; Mellouk, Namya; Jackson, Julia; Lee, Chia-ying; Rodriguiz, Ramona M.; Wetsel, William C.; Feng, Liping

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Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain

Cell

IF42.5

2025-05-19

PREAI

Ran Guo; Ouyang Chen; Yang Zhou; Sangsu Bang; Sharat Chandra; Yize Li; Gang Chen; Rou-Gang Xie; Wei He; Jing Xu; Richard Zhou; Shaoyong Song; Kelsey L. Person; Madelyn N. Moore; Abigail R. Alwin; Ivan Spasojevic; Michael R. Jackson; Steven H. Olson; Marc G. Caron; Lauren M. Slosky; William C. Wetsel; Lawrence S. Barak; Ru-Rong Ji

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Two doses of Qβ virus like particle vaccines elicit protective antibodies against heroin and fentanyl

NPJ VACCINES

IF6.5

2025-03-28

OAAI

Romano, Isabella G.; Johnson-Weaver, Brandi; Core, Susan B.; Jamus, Andzoa N.; Brackeen, Marcus; Blough, Bruce; Dey, Subhakar; Huang, Yumei; Staats, Herman; Wetsel, William C.; Chackerian, Bryce; Frietze, Kathryn M.

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Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions

NATURE COMMUNICATIONS

IF15.7

2024-08-09

OAAI

Gao, Yudong; Shonai, Daichi; Trn, Matthew; Zhao, Jieqing; Soderblom, Erik J.; Garcia-Moreno, S. Alexandra; Gersbach, Charles A.; Wetsel, William C.; Dawson, Geraldine; Velmeshev, Dmitry; Jiang, Yong-hui; Sloofman, Laura G.; Buxbaum, Joseph D.; Soderling, Scott H.

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Presynaptic Rac1 in the hippocampus selectively regulates working memory

ELIFE

IF0

2024-07-24

OAAI

Kim, Jaebin; Bustamante, Edwin; Sotonyi, Peter; Maxwell, Nicholas; Parameswaran, Pooja; Kent, Julie K.; Wetsel, William C.; Soderblom, Erik J.; Racz, Bence; Soderling, Scott H.

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The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2023-10-10

OAAI

Pogorelov, Vladimir M.; Rodriguiz, Ramona M.; Roth, Bryan L.; Wetsel, William C.

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Rescue of glutaric aciduria type I in mice by liver- directed therapies

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2023-04-19

OAAI

Barzi, Mercedes; Johnson, Collin G.; Chen, Tong; Rodriguiz, Ramona M.; Hemmingsen, Madeline; Gonzalez, Trevor J.; Rosales, Alan; Beasley, James; Peck, Cheryl K.; Ma, Yunhan; Stiles, Ashlee R.; Wood, Timothy C.; Maeso-Diaz, Raquel; Diehl, Anna Mae; Young, Sarah P.; Everitt, Jeffrey I.; Wetsel, William C.; Lagor, William R.; Bissig-Choisat, Beatrice; Asokan, Aravind; El-Gharbawy, Areeg; Bissig, Karl-Dimiter

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Abi2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

139

OAAI

Grove, M; Demyanenko, G; Echarri, A; Zipfel, PA; Quiroz, ME; Rodriguiz, RM; Playford, M; Martensen, SA; Robinson, MR; Wetsel, WC; Maness, PF; Pendergast, AM

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Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Quan, H; Athirakul, K; Wetsel, WC; Torres, GE; Stevens, R; Chen, YT; Coffman, TM; Caron, MG

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Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice

COMMUNICATIONS BIOLOGY

IF5.1

2023-03-09

OAAI

Wang, Zhuoran; Li, Qiang; Kolls, Brad J. J.; Mace, Brian; Yu, Shu; Li, Xuan; Liu, Wei; Chaparro, Eduardo; Shen, Yuntian; Dang, Lihong; del Aguila, Angela; Bernstock, Joshua D. D.; Johnson, Kory R. R.; Yao, Junjie; Wetsel, William C. C.; Moore, Scott D. D.; Turner, Dennis A. A.; Yang, Wei

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RESCUE OF GLUTARIC ACIDURIA TYPE I MICE BY LIVER DIRECTED THERAPIES

MOLECULAR GENETICS AND METABOLISM

IF3.5

2023-03-01

PREAI

Barzi, Mercedes; Johnson, Collin; Chen, Tong; Rodriguiz, Ramona; Hemmingsen, Madeline; Gonzalez, Trevor J.; Rosales, Alan; Beasley, James; Ma, Yunhan; Stiles, Ashlee R.; Wood, Timothy C.; Maeso-Diaz, Raquel; Diehl, Ana Mae; Young, Sarah P.; Everitt, Jeffrey I.; Wetsel, William C.; Bissig-Choisat, Beatrice; Asokan, Aravind; El-Gharbawy, Areeg; Bissig, Karl-Dimiter

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Protective effects of omega-3 fatty acids in a blood-brain barrier-on- chip model and on postoperative delirium-like behaviour in mice

BRITISH JOURNAL OF ANAESTHESIA

IF9.2

2023-02-01

OAAI

Yang, Ting; Velagapudi, Ravikanth; Kong, Cuicui; Ko, Unghyeon; Kumar, Vardhman; Brown, Paris; Franklin, Nathan O.; Zhang, Xiaobei; Caceres, Ana I.; Min, Hyunjung; Filiano, Anthony J.; Rodriguiz, Ramona M.; Wetsel, William C.; Varghese, Shyni; Terrando, Niccolo

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Establishment of multi-stage intravenous self-administration paradigms in mice

SCIENTIFIC REPORTS

IF3.9

2022-12-11

OAAI

Slosky, Lauren M. M.; Pires, Andrea; Bai, Yushi; Clark, Nicholas B. B.; Hauser, Elizabeth R. R.; Gross, Joshua D. D.; Porkka, Fiona; Zhou, Yang; Chen, Xiaoxiao; Pogorelov, Vladimir M. M.; Toth, Krisztian; Wetsel, William C. C.; Barak, Lawrence S. S.; Caron, Marc G. G.

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Conserved YKL-40 changes in mice and humans after postoperative delirium

brain behavior and immunity

IF0

2022-12-01

OAAI

David-Bercholz, Jennifer; Acker, Leah; Caceres, Ana I.; Wu, Pau Yen; Goenka, Saanvi; Franklin, Nathan O.; Rodriguiz, Ramona M.; Wetsel, William C.; Devinney, Michael; Wright, Mary Cooter; Zetterberg, Henrik; Yang, Ting; Berger, Miles; Terrando, Niccolo

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Characterization and Chemical Optimization of the D2 Dopamine Receptor-Selective Antagonist, ML321, Identifies Lead Compounds for the Clinical Treatment of Neuropsychiatric Disorders

FASEB JOURNAL

IF4.2

2022-05-13

PREAI

Nilson, Ashley N.; Garcia, Andres Dulcey; Free, R. B.; Boldizsar, Noelia; Pearlstein, Hannah; Rocereta, Julia A.; Rodriguiz, Ramona M.; Lane, J. R.; Lee, Kuo H.; Shi, Lei; Wetsel, William C.; Marugan, Juan J.; Sibley, David R.

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Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome

FRONTIERS IN IMMUNOLOGY

IF5.9

2022-05-06

OAAI

Zhang, Zhiquan; Ma, Qing; Velagapudi, Ravikanth; Barclay, William E.; Rodriguiz, Ramona M.; Wetsel, William C.; Yang, Ting; Shinohara, Mari L.; Terrando, Niccolo

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Discovery of a functionally selective ghrelin receptor (GHSR1a) ligand for modulating brain dopamine

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-03-03

OAAI

Gross, J. D.; Kim, D. W.; Zhou, Y.; Jansen, D.; Slosky, L. M.; Clark, N. B.; Ray, C. R.; Hu, X.; Southall, N.; Wang, A.; Xu, X.; Barnaeva, E.; Wetsel, W. C.; Ferrer, M.; Marugan, J. J.; Caron, M. G.; Barak, L. S.; Toth, K.

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Research Directions