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Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope Liu, X. F.; Onda, M.; Schlomer, J.; Bassel, L.; Kozlov, S.; Tai, C. -H.; Zhou, Q.; Liu, W.; Tsao, H. -E.; Hassan, R.; Ho, M.; Pastan, I. Share Save
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A tri-specific killer engager against mesothelin targets NK cells towards lung cancer Kennedy, Philippa R.; Vallera, Daniel A.; Ettestad, Brianna; Hallstrom, Caroline; Kodal, Behiye; Todhunter, Deborah A.; Bendzick, Laura; Hinderlie, Peter; Walker, Joshua T.; Pulkrabek, Brittany; Pastan, Ira; Kratzke, Robert A.; Fujioka, Naomi; Miller, Jeffrey S.; Felices, Martin Share Save
Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models Parker, Scott; McDowall, Charlotte; Sanchez-Perez, Luis; Osorio, Cristina; Duncker, Patrick C.; Briley, Aaron; Swartz, Adam M.; Herndon, James E.; Yu, Yen-Rei A.; McLendon, Roger E.; Tedder, Thomas F.; Desjardins, Annick; Ashley, David M.; Gunn, Michael Dee; Enterline, David S.; Knorr, David A.; Pastan, Ira H.; Nair, Smita K.; Bigner, Darell D.; Chandramohan, Vidyalakshmi Share Save
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Podocytes are lost from glomeruli before completing apoptosis Yamamoto, Kazuyoshi; Okabe, Masahiro; Tanaka, Keiko; Yokoo, Takashi; Pastan, Ira; Araoka, Toshikazu; Osafune, Kenji; Udagawa, Tomohiro; Koizumi, Masahiro; Matsusaka, Taiji Share Save
Intraductal administration of transferrin receptor-targeted immunotoxin clears ductal carcinoma in situ in mouse models of breast cancer-a preclinical study Wang, Guannan; Kumar, Alok; Ding, Wanjun; Korangath, Preethi; Bera, Tapan; Wei, Junxia; Pai, Priya; Gabrielson, Kathleen; Pastan, Ira; Sukumar, Saraswati Share Save
Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin Liu, Xiufen; Onda, Masanori; Watson, Nathan; Hassan, Raffit; Ho, Mitchell; Bera, Tapan K.; Wei, Junxia; Chakraborty, Anirban; Beers, Richard; Zhou, Qi; Shajahan, Asif; Azadi, Parastoo; Zhan, Jingyu; Xia, Di; Pastan, Ira Share Save
Development of Highly Effective Anti-Mesothelin hYP218 Chimeric Antigen Receptor T Cells With Increased Tumor Infiltration and Persistence for Treating Solid Tumors Tomar, Sakshi; Zhang, Jingli; Khanal, Manakamana; Hong, Jessica; Venugopalan, Abhilash; Jiang, Qun; Sengupta, Manjistha; Miettinen, Markku; Li, Nan; Pastan, Ira; Ho, Mitchell; Hassan, Raffit Share Save
GPC1-Targeted Immunotoxins Inhibit Pancreatic Tumor Growth in Mice via Depletion of Short-lived GPC1 and Downregulation of Wnt Signaling Pan, Jiajia; Li, Nan; Renn, Alex; Zhu, Hu; Chen, Lu; Shen, Min; Hall, Matthew D.; Qian, Min; Pastan, Ira; Ho, Mitchell Share Save
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Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis Nishio, Takahiro; Koyama, Yukinori; Liu, Xiao; Rosenthal, Sara B.; Yamamoto, Gen; Fuji, Hiroaki; Baglieri, Jacopo; Li, Na; Brenner, Laura N.; Iwaisako, Keiko; Taura, Kojiro; Hagood, James S.; LaRusso, Nicholas F.; Bera, Tapan K.; Pastan, Ira; Brenner, David A.; Kisseleva, Tatiana Share Save
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Stabilization of hypoxia-inducible factor ameliorates glomerular injury sensitization after tubulointerstitial injury Zou, Jun; Yang, Jaewon; Zhu, Xiaoye; Zhong, Jianyong; Elshaer, Ahmed; Matsusaka, Taiji; Pastan, Ira; Haase, Volker H.; Yang, Hai-Chun; Fogo, Agnes B. Share Save
Moxetumomab pasudotox in heavily pre-treated patients with relapsed/refractory hairy cell leukemia (HCL): long-term follow-up from the pivotal trial Kreitman, Robert J.; Dearden, Claire; Zinzani, Pier Luigi; Delgado, Julio; Robak, Tadeusz; le Coutre, Philipp D.; Gjertsen, Bjorn T.; Troussard, Xavier; Roboz, Gail J.; Karlin, Lionel; Gladstone, Douglas E.; Kuptsova-Clarkson, Nataliya; Liu, Shiyao; Patel, Priti; Rotolo, Federico; Mitry, Emmanuel; Pastan, Ira; Giles, Francis Share Save
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Phase 1 study of the immunotoxin LMB-100 in patients with mesothelioma and other solid tumors expressing mesothelin Hassan, Raffit; Alewine, Christine; Mian, Idrees; Spreafico, Anna; Siu, Lillian L.; Gomez-Roca, Carlos; Delord, Jean-Pierre; Italiano, Antoine; Lassen, Ulrik; Soria, Jean-Charles; Bahleda, Rastilav; Thomas, Anish; Steinberg, Seth M.; Peer, Cody J.; Figg, William D.; Niederfellner, Gerhard; Naegelen, Valerie Meresse; Pastan, Ira Share Save
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