Mark P. Labrecque - Publications, H-index & Citations

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Mark P. Labrecque

revolution medicines

14H-index

139Paper Count

1.1KCitation Count

Published Papers 17

Publication Date

Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer

Nature Medicine

IF50

2026-08-11

OAAI

Ida Aronchik; Sumit Kar; Yongxian Zhuang; Ethan Ahler; Lick Pui Lai; Vidya Seshadri; Yu Chi Yang; Ashenafi Bulle; Marie Menard; Biswadeep Nayak; Mark P. Labrecque; Julien Dilly; Eejung Kim; Lingyan Jiang; Jason Yano; Urszula N. Wasko; Ciara Helland; Sean Bredeson; Brett Garrick; Yevgeniy Gindin; Brad Sickler; Xing Wei; Kyle Seamon; Jingjing Jiang; Kian-Huat Lim; Matthew Holderfield; Elsa Quintana; Aparna Hegde; Zeena Salman; Alexander Starodub; Alexander Spira; Wungki Park; David S. Hong; Minal Barve; Meredith Pelster; David Sommerhalder; Salman R. Punekar; Ignacio Garrido-Laguna; Brian M. Wolpin; Anirban Maitra; W. Clay Gustafson; Steve Kelsey; Jacqueline A. M. Smith; Kevin K. Lin; Andrew J. Aguirre; Mallika Singh

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TEAD inhibition overcomes YAP/TAZ-driven resistance to RAS(ON) inhibitors

MOLECULAR CANCER THERAPEUTICS

IF5.5

2024-06-10

PREAI

Vemulapalli, Vidyasiri; Dinh, Phuong; Ayala, Mariela Moreno; Zhang, Zheng; Labrecque, Mark; Aronchik, Ida; Jiang, Jingjing; Singh, Mallika; Quintana, Elsa; Weller, Caroline; Wildes, David

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Mutant-selective KRASG12D(ON) inhibitor suppresses proliferation in vitro and tumor growth in vivo of KrasG12D GEMM-derived PDAC organoids

CANCER RESEARCH

IF16.6

2024-01-16

PREAI

Labrecque, Mark P.; Jiang, Lingyan; Nasholm, Nicole; Nayak, Biswadeep; Yu, Xinxing; Song, Avian; Weller, Caroline; Evans, James W.; Zafra, Maria Paz; Parsons, Marie; Menard, Marie; Dow, Lukas E.; Jiang, Jingjing; Aronchik, Ida; Singh, Mallika

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The heterogeneity of prostate cancers lacking AR activity will require diverse treatment approaches

ENDOCRINE-RELATED CANCER

IF4.6

2021-08-01

OAAI

Labrecque, Mark P.; Alumkal, Joshi J.; Coleman, Ilsa M.; Nelson, Peter S.; Morrissey, Colm

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RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer

CANCER RESEARCH

IF16.6

2021-07-26

OAAI

Labrecque, Mark P.; Brown, Lisha G.; Coleman, Ilsa M.; Lakely, Bryce; Brady, Nicholas J.; Lee, John K.; Nguyen, Holly M.; Li, Dapei; Hanratty, Brian; Haffner, Michael C.; Rickman, David S.; True, Lawrence D.; Lin, Daniel W.; Lam, Hung-Ming; Alumkal, Joshi J.; Corey, Eva; Nelson, Peter S.; Morrissey, Colm

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BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program

CLINICAL CANCER RESEARCH

IF10.2

2021-06-18

OAAI

Kim, Dae-Hwan; Sun, Duanchen; Storck, William K.; Leng, Katherine Welker; Jenkins, Chelsea; Coleman, Daniel J.; Sampson, David; Guan, Xiangnan; Kumaraswamy, Anbarasu; Rodansky, Eva S.; Urrutia, Joshua A.; Schwartzman, Jacob A.; Zhang, Chao; Beltran, Himisha; Labrecque, Mark P.; Morrissey, Colm; Lucas, Jared M.; Coleman, Ilsa M.; Nelson, Peter S.; Corey, Eva; Handelman, Samuel K.; Sexton, Jonathan Z.; Aggarwal, Rahul; Abida, Wassim; Feng, Felix Y.; Small, Eric J.; Spratt, Daniel E.; Bankhead, Armand, III; Rao, Arvind; Gesner, Emily M.; Attwell, Sarah; Lakhotia, Sanjay; Campeau, Eric; Yates, Joel A.; Xia, Zheng; Alumkal, Joshi J.

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Regulation of CEACAM5 and Therapeutic Efficacy of an Anti-CEACAM5-SN38 Antibody-drug Conjugate in Neuroendocrine Prostate Cancer

CLINICAL CANCER RESEARCH

IF10.2

2021-02-01

OAAI

DeLucia, Diana C.; Cardillo, Thomas M.; Ang, Lisa; Labrecque, Mark P.; Zhang, Ailin; Hopkins, James E.; De Sarkar, Navonil; Coleman, Ilsa; da Costa, Rui M. Gil; Corey, Eva; True, Lawrence D.; Haffner, Michael C.; Schweizer, Michael T.; Morrissey, Colm; Nelson, Peter S.; Lee, John K.

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Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived Xenografts

EUROPEAN UROLOGY

IF25.2

2020-02-01

OAAI

Lam, Hung-Ming; Nguyen, Holly M.; Labrecque, Mark P.; Brown, Lisha G.; Coleman, Ilsa M.; Gulati, Roman; Lakely, Bryce; Sondheim, Daniel; Chatterjee, Payel; Marck, Brett T.; Matsumoto, Alvin M.; Mostaghel, Elahe A.; Schweizer, Michael T.; Nelson, Peter S.; Corey, Eva

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Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2019-09-16

260

OAAI

Labrecque, Mark P.; Coleman, Ilsa M.; Brown, Lisha G.; True, Lawrence D.; Kollath, Lori; Lakely, Bryce; Nguyen, Holly M.; Yang, Yu C.; da Costa, Rui M. Gil; Kaipainen, Arja; Coleman, Roger; Higano, Celestia S.; Yu, Evan Y.; Cheng, Heather H.; Mostaghel, Elahe A.; Montgomery, Bruce; Schweizer, Michael T.; Hsieh, Andrew C.; Lin, Daniel W.; Corey, Eva; Nelson, Peter S.; Morrissey, Colm

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Pre-mRNA splicing factors promote cellular plasticity in castration-resistant prostate cancer

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Labrecque, Mark P.; Coleman, Ilsa M.; Brown, Lisha G.; Lakely, Bryce; Kollath, Lori; Lin, Daniel W.; True, Lawrence D.; Corey, Eva; Nelson, Peter S.; Morrissey, Colm

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Supraphysiological testosterone inhibits tumor growth and is associated with inhibition of ARV7 signaling and DNA damage response in preclinical models of enzalutamide-resistant prostate cancer

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Lam, Hung-Ming; Labrecque, Mark P.; Nguyen, Holly M.; Brown, Lisha G.; Coleman, Ilsa M.; Gulati, Roman; Lakely, Bryce; Sondheim, Daniel; Merck, Brett; Matsumoto, Alvin M.; Mostaghel, Elahe A.; Schweizer, Michael T.; Nelson, Peter S.; Corey, Eva

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Expression of human inducible nitric oxide synthase in response to cytokines is regulated by hypoxia-inducible factor-1

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2019-01-01

PREAI

Lee, Martin; Wang, Christine; Jin, Steven W.; Labrecque, Mark P.; Beischlag, Timothy V.; Brockman, Mark A.; Choy, Jonathan C.

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Defining the molecular phenotypes of metastatic castration-resistant prostate cancer sensitive to FGF pathway inhibition

CANCER RESEARCH

IF16.6

2018-07-01

PREAI

Labrecque, Mark P.; Brown, Lisha G.; Coleman, Ilsa M.; True, Lawrence D.; Kollath, Lori; Lakely, Bryce; Yang, Yu C.; Nguyen, Holly M.; Corey, Eva; Nelson, Peter S.; Morrissey, Colm

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Retinoblastoma protein (Rb) links hypoxia to altered mechanical properties in cancer cells as measured by an optical tweezer

SCIENTIFIC REPORTS

IF3.9

2017-08-10

OAAI

Khakshour, S.; Labrecque, M. P.; Esmaeilsabzali, H.; Lee, F. J. S.; Cox, M. E.; Park, E. J.; Beischlag, T. V.

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The retinoblastoma protein regulates hypoxia-inducible factor-1α-mediated transcriptional programs, tumor cell invasiveness, tumor growth and metastasis in human breast cancer cells

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Takhar, Mandeep K.; Labrecque, Mark P.; Tam, Kevin J.; Haegert, Anne; Bell, Robert H.; Altamirano-Dimas, Manuel; Collins, Colin C.; Prefontaine, Gratien G.; Cox, Michael E.; Bennewith, Kevin L.; Beischlag, Timothy V.

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Loss of retinoblastoma protein dysregulates HIF1-mediated genetic programs, and promotes tumor cell invasiveness and neuroendocrine differentiation in prostate cancer cells

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Labrecque, Mark; Takhar, Mandeep; Nason, Rebecca J.; Santacruz, Stephanie; Tam, Kevin; Massah, Shabnam; Haegert, Anne; Bell, Robert; Altamirano-Dimas, Manuel; Collins, Colin; Lee, Frank; Prefontaine, Gratien; Cox, Michael; Beischlag, Timothy

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Estrogen Receptor Expression Is Required for Low-Dose Resveratrol-Mediated Repression of Aryl Hydrocarbon Receptor Activity

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2010-11-01

OAAI

Perdew, Gary H.; Hollingshead, Brett D.; DiNatale, Brett C.; Morales, J. Luis; Labrecque, Mark P.; Takhar, Mandeep K.; Tam, Kevin J.; Beischlag, Timothy V.

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Research Directions