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Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists Scott, James S.; Stead, Darren; Barlaam, Bernard; Breed, Jason; Carbajo, Rodrigo J.; Chiarparin, Elisabetta; Cureton, Natalie; Davey, Paul R. J.; Fisher, David I.; Gangl, Eric T.; Grebe, Tyler; Greenwood, Ryan D.; Hande, Sudhir; Hatoum-Mokdad, Holia; Hughes, Samantha J.; Hunt, Thomas A.; Johnson, Tony; Kavanagh, Stefan L.; Klinowska, Teresa C. M.; Larner, Carrie J. B.; Lawson, Mandy; Lister, Andrew S.; Longmire, David; Marden, Stacey; McGuire, Thomas M.; McMillan, Caroline; McMurray, Lindsay; Morrow, Christopher J.; Nissink, J. Willem M.; Moss, Thomas A.; O'Donovan, Daniel H.; Polanski, Radoslaw; Stokes, Stephen; Thakur, Kumar; Trueman, Dawn; Truman, Caroline; Tucker, Michael J.; Wang, Haixia; Whalley, Nicky; Wu, Dedong; Wu, Ye; Yang, Bin; Yang, Wenzhan Share Save
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology Goldberg, Frederick W.; Kettle, Jason G.; Lamont, Gillian M.; Buttar, David; Ting, Attilla K. T.; McGuire, Thomas M.; Cook, Calum R.; Beattie, David; Gutierrez, Pablo Morentin; Kavanagh, Stefan L.; Komen, Jasper C.; Kawatkar, Aarti; Clark, Roger; Hopcroft, Lorna; Hughes, Gareth; Critchlow, Susan E. Share Save
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An Enantioselective Suzuki-Miyaura Coupling To Form Axially Chiral Biphenols Pearce-Higgins, Robert; Hogenhout, Larissa N.; Docherty, Philip J.; Whalley, David M.; Chuentragool, Padon; Lee, Najung; Lam, Nelson Y. S.; McGuire, Thomas M.; Valette, Damien; Phipps, Robert J. Share Save
Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement Barlaam, Bernard; De Savi, Chris; Dishington, Allan; Drew, Lisa; Ferguson, Andrew D.; Ferguson, Douglas; Gu, Chungang; Hande, Sudhir; Hassall, Lorraine; Hawkins, Janet; Hird, Alexander W.; Holmes, Jane; Lamb, Michelle L.; Lister, Andrew S.; McGuire, Thomas M.; Moore, Jane E.; O'Connell, Nichole; Patel, Anil; Pike, Kurt G.; Sarkar, Ujjal; Shao, Wenlin; Stead, Darren; Varnes, Jeffrey G.; Vasbinder, Melissa M.; Wang, Lei; Wu, Liangwei; Xue, Lin; Yang, Bin; Yao, Tieguang Share Save
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Cu(OTf)2-Mediated Cross-Coupling of Nitriles and N-Heterocycles with Arylboronic Acids to Generate Nitrilium and Pyridinium Products** Bell, Nicola L.; Xu, Chao; Fyfe, James W. B.; Vantourout, Julien C.; Brals, Jeremy; Chabbra, Sonia; Bode, Bela E.; Cordes, David B.; Slawin, Alexandra M. Z.; McGuire, Thomas M.; Watson, Allan J. B. Share Save
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Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies Barlaam, Bernard; Casella, Robert; Cidado, Justin; Cook, Calum; De Savi, Chris; Dishington, Allan; Donald, Craig S.; Drew, Lisa; Ferguson, Andrew D.; Ferguson, Douglas; Glossop, Steve; Grebe, Tyler; Gu, Chungang; Hande, Sudhir; Hawkins, Janet; Hird, Alexander W.; Holmes, Jane; Horstick, James; Jiang, Yun; Lamb, Michelle L.; McGuire, Thomas M.; Moore, Jane E.; O'Connell, Nichole; Pike, Andy; Pike, Kurt G.; Proia, Theresa; Roberts, Bryan; San Martin, Maryann; Sarkar, Ujjal; Shao, Wenlin; Stead, Darren; Sumner, Neil; Thakur, Kumar; Vasbinder, Melissa M.; Varnes, Jeffrey G.; Wang, Jianyan; Wang, Lei; Wu, Dedong; Wu, Liangwei; Yang, Bin; Yao, Tieguang Share Save
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Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC) Ward, Richard A.; Anderton, Mark J.; Bethel, Paul; Breed, Jason; Cook, Calum; Davies, Emma J.; Dobson, Andrew; Dong, Zhiqiang; Fairley, Gary; Farrington, Paul; Feron, Lyman; Flemington, Vikki; Gibbons, Francis D.; Graham, Mark A.; Greenwood, Ryan; Hanson, Lyndsey; Hopcroft, Philip; Howells, Rachel; Hudson, Julian; James, Michael; Jones, Clifford D.; Jones, Christopher R.; Li, Yongchao; Lamont, Scott; Lewis, Richard; Lindsay, Nicola; McCabe, James; McGuire, Thomas; Rawlins, Philip; Roberts, Karen; Sandin, Linda; Simpson, Iain; Swallow, Steve; Tang, Jia; Tomkinson, Gary; Tonge, Michael; Wang, Zhenhua; Zhai, Baochang Share Save
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