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Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy Luo, J; McMullen, JR; Sobkiw, CL; Zhang, L; Dorfman, AL; Sherwood, MC; Logsdon, MN; Horner, JW; DePinho, RA; Izumo, S; Cantley, LC Share Save
Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy McMullen, JR; Shioi, T; Zhang, L; Tarnavski, O; Sherwood, MC; Dorfman, AL; Longnus, S; Pende, M; Martin, KA; Blenis, J; Thomas, G; Izumo, S Share Save
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Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes Shinozawa, Tadahiro; Nakamura, Koki; Shoji, Masanobu; Morita, Maya; Kimura, Maya; Furukawa, Hatsue; Ueda, Hiroki; Shiramoto, Masanari; Matsuguma, Kyoko; Kaji, Yoshikazu; Ikushima, Ippei; Yono, Makoto; Liou, Shyh-Yuh; Nagai, Hirofumi; Nakanishi, Atsushi; Yamamoto, Keiji; Izumo, Seigo Share Save
Transcription Factor GATA4 Is Activated but Not Required for Insulin-like Growth Factor 1 (IGF1)-induced Cardiac Hypertrophy Bisping, Egbert; Ikeda, Sadakatsu; Sedej, Miriam; Wakula, Paulina; McMullen, Julie R.; Tarnavski, Oleg; Sedej, Simon; Izumo, Seigo; Pu, William T.; Pieske, Burkert Share Save
Loss of PI3Kγ Enhances cAMP-Dependent MMP Remodeling of the Myocardial N-Cadherin Adhesion Complexes and Extracellular Matrix in Response to Early Biomechanical Stress Guo, Danny; Kassiri, Zamaneh; Basu, Ratnadeep; Chow, Fung L.; Kandalam, Vijay; Damilano, Federico; Liang, Wenbin; Izumo, Seigo; Hirsch, Emilio; Penninger, Josef M.; Backx, Peter H.; Oudit, Gavin Y. Share Save
PI3K(p110α) Protects Against Myocardial Infarction-Induced Heart Failure Identification of PI3K-Regulated miRNA and mRNA Lin, Ruby C. Y.; Weeks, Kate L.; Gao, Xiao-Ming; Williams, Rohan B. H.; Bernardo, Bianca C.; Kiriazis, Helen; Matthews, Vance B.; Woodcock, Elizabeth A.; Bouwman, Russell D.; Mollica, Janelle P.; Speirs, Helen J.; Dawes, Ian W.; Daly, Roger J.; Shioi, Tetsuo; Izumo, Seigo; Febbraio, Mark A.; Du, Xiao-Jun; McMullen, Julie R. Share Save
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Phosphatidylinositol 3-kinase γ is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning Ban, Kiwon; Cooper, Andrew J.; Samuel, Sara; Bhatti, Adil; Patel, Mikin; Izumo, Seigo; Penninger, Josef M.; Backx, Peter H.; Oudit, Gavin Y.; Tsushima, Robert G. Share Save
Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism Ha, Tuanzhu; Hua, Fang; Liu, Xiang; Ma, Jing; McMullen, Julie R.; Shioi, Tetsuo; Izumo, Seigo; Kelley, Jim; Gao, Xiag; Browder, William; Williams, David L.; Kao, Race L.; Li, Chuanfu Share Save
Resistin, an adipocytokine, offers protection against acute myocardial infarction Gao, Jinping; Chua, Chu Chang; Chen, Zhongyi; Wang, Hong; Xu, Xingshun; Hamdy, Ronald C.; McMullen, Julie R.; Shioi, Tetsuo; Izumo, Seigo; Chua, Balvin H. L. Share Save
A conserved role for phosphatidylinositol 3-kinase but not akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy O'Neill, Brian T.; Kim, Jaetaek; Wende, Adam R.; Theobald, Heather A.; Tuinei, Joseph; Buchanan, Jonathan; Guo, Aili; Zaha, Vlad G.; Davis, Don K.; Schell, John C.; Boudina, Sihem; Wayment, Benjamin; Litwin, Sheldon E.; Shioi, Tetsuo; Izumo, Seigo; Birnbaum, Morris J.; Abel, E. Dale Share Save
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis Zeisberg, Elisabeth M.; Tarnavski, Oleg; Zeisberg, Michael; Dorfman, Adam L.; McMullen, Julie R.; Gustafsson, Erika; Chandraker, Anil; Yuan, Xueli; Pu, William T.; Roberts, Anita B.; Neilson, Eric G.; Sayegh, Mohamed H.; Izumo, Seigo; Kalluri, Raghu Share Save
Protective effects of exercise and phosphoinositide 3-kinase(p110α) signaling in dilated and hypertrophic cardiomyopathy McMullen, Julie R.; Amirahmadi, Fatemeh; Woodcock, Elizabeth A.; Schinke-Braun, Martina; Bouwman, Russell D.; Hewitt, Kimberly A.; Mollica, Janelle P.; Zhang, Li; Zhang, Yunyu; Shioi, Tetsuo; Buerger, Antje; Izumo, Seigo; Jay, Patrick Y.; Jennings, Garry L. Share Save
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