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Preemptive optimization of a clinical antibody for broad neutralization of SARS-CoV-2 variants and robustness against viral escape Zhu, Fangqiang; Rajan, Saravanan; Hayes, Conor F.; Kwong, Ka Yin; Goncalves, Andre R.; Zemla, Adam T.; Lau, Edmond Y.; Zhang, Yi; Cai, Yingyun; Goforth, John W.; Landajuela, Mikel; Gilchuk, Pavlo; Kierny, Michael; Dippel, Andrew; Amofah, Bismark; Kaplan, Gilad; Peano, Vanessa Cadevilla; Morehouse, Christopher; Sparklin, Ben; Gopalakrishnan, Vancheswaran; Tuffy, Kevin M.; Nguyen, Amy; Beloor, Jagadish; Kijak, Gustavo; Liu, Chang; Dijokaite-Guraliuc, Aiste; Mongkolsapaya, Juthathip; Screaton, Gavin R.; Petersen, Brenden K.; Desautels, Thomas A.; Bennett, Drew; Segelke, Brent W.; Arrildt, Kathryn T.; Kaul, Samantha; Grzesiak, Emilia A.; da Silva, Felipe Leno; Bates, Thomas W.; Earnhart, Christopher G.; Hopkins, Svetlana; Sundaram, Shivshankar; Esser, Mark T.; Francica, Joseph R.; Faissol, Daniel M.; LLNL Generative Unconstrained Intelligent Drug Engn GUIDE Consortium Share Save
The molecular reach of antibodies crucially underpins their viral neutralisation capacity (vol 16, 338, 2025) Huhn, Anna; Nissley, Daniel; Wilson, Daniel B.; Kutuzov, Mikhail A.; Donat, Robert; Tan, Tiong Kit; Zhang, Ying; Barton, Michael I.; Liu, Chang; Dejnirattisai, Wanwisa; Supasa, Piyada; Mongkolsapaya, Juthathip; Townsend, Alain; James, William; Screaton, Gavin; van der Merwe, P. Anton; Isaacson, Samuel A. Share Save
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Oligomerization- driven avidity correlates with SARS- CoV-2 cellular binding and inhibition Asor, Roi; Olerinyova, Anna; Burnap, Sean A.; Kushwah, Manish S.; Soltermann, Fabian; Rudden, Lucas S. P.; Hensen, Mario; Vasiljevic, Snezana; Brun, Juliane; Hill, Michelle; Chang, Liu; Dejnirattisai, Wanwisa; Supasa, Piyada; Mongkolsapaya, Juthathip; Zhou, Daming; Stuart, David I.; Screaton, Gavin R.; Degiacomi, Matteo T.; Zitzmann, Nicole; Benesch, Justin L. P.; Struwe, Weston B.; Kukura, Philipp Share Save
AZD3152 neutralizes SARS-CoV-2 historical and contemporary variants and is protective in hamsters and well tolerated in adults Cai, Yingyun; Diallo, Seme; Rosenthal, Kim; Ren, Kuishu; Flores, Daniel J.; Dippel, Andrew; Oganesyan, Vaheh; van Dyk, Nydia; Chen, Xiaoru; Cantu, Erin; Choudhary, Rakesh; Sulikowski, Michal; Adissu, Hibret; Chawla, Bhavna; Kar, Swagata; Liu, Chang; Dijokaite-Guraliuc, Aiste; Mongkolsapaya, Juthathip; Rajan, Saravanan; Loo, Yueh-Ming; Beavon, Rohini; Webber, Chris; Chang, Lee-Jah; Thomas, Steven; Clegg, Lindsay; Zhang, Huixia; Screaton, Gavin R.; Philbin, Nora; Harre, Mark; Selim, Abdulhafez; Martinez-Alier, Nuria; Uriel, Alison; Cohen, Taylor S.; Perez, John L.; Esser, Mark T.; Blair, Wade; Francica, Joseph R. Share Save
Comparative analysis of SARS-CoV-2 neutralization titers reveals consistency between human and animal model serum and across assays Muehlemann, Barbara; Wilks, Samuel H.; Baracco, Lauren; Bekliz, Meriem; Carreno, Juan Manuel; Corman, Victor M.; Davis-Gardner, Meredith E.; Dejnirattisai, Wanwisa; Diamond, Michael S.; Douek, Daniel C.; Drosten, Christian; Eckerle, Isabella; Edara, Venkata-Viswanadh; Ellis, Madison; Fouchier, Ron A. M.; Frieman, Matthew; Godbole, Sucheta; Haagmans, Bart; Halfmann, Peter J.; Henry, Amy R.; Jones, Terry C.; Katzelnick, Leah C.; Kawaoka, Yoshihiro; Kimpel, Janine; Krammer, Florian; Lai, Lilin; Liu, Chang; Lusvarghi, Sabrina; Meyer, Benjamin; Mongkolsapaya, Juthathip; Montefiori, David C.; Mykytyn, Anna; Netzl, Antonia; Pollett, Simon; Roessler, Annika; Screaton, Gavin R.; Shen, Xiaoying; Sigal, Alex; Simon, Viviana; Subramanian, Rahul; Supasa, Piyada; Suthar, Mehul S.; Tuereli, Sina; Wang, Wei; Weiss, Carol D.; Smith, Derek J. Share Save
A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity Liu, Chang; Zhou, Daming; Dijokaite-Guraliuc, Aiste; Supasa, Piyada; Duyvesteyn, Helen M. E.; Ginn, Helen M.; Selvaraj, Muneeswaran; Mentzer, Alexander J.; Das, Raksha; de Silva, Thushan I.; Ritter, Thomas G.; Plowright, Megan; Newman, Thomas A. H.; Stafford, Lizzie; Kronsteiner, Barbara; Temperton, Nigel; Lui, Yuan; Fellermeyer, Martin; Goulder, Philip; Klenerman, Paul; Dunachie, Susanna J.; Barton, Michael I.; Kutuzov, Mikhail A.; Dushek, Omer; Fry, Elizabeth E.; Mongkolsapaya, Juthathip; Ren, Jingshan; Stuart, David I.; Screaton, Gavin R. Share Save
Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection Liu, Chang; Das, Raksha; Dijokaite-Guraliuc, Aiste; Zhou, Daming; Mentzer, Alexander J.; Supasa, Piyada; Selvaraj, Muneeswaran; Duyvesteyn, Helen M. E.; Ritter, Thomas G.; Temperton, Nigel; Klenerman, Paul; Dunachie, Susanna J.; Paterson, Neil G.; Williams, Mark A.; Hall, David R.; Fry, Elizabeth E.; Mongkolsapaya, Juthathip; Ren, Jingshan; Stuart, David I.; Screaton, Gavin R. Share Save
The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA.2.86 Zhou, Daming; Supasa, Piyada; Liu, Chang; Dijokaite-Guraliuc, Aiste; Duyvesteyn, Helen M. E.; Selvaraj, Muneeswaran; Mentzer, Alexander J.; Das, Raksha; Dejnirattisai, Wanwisa; Temperton, Nigel; Klenerman, Paul; Dunachie, Susanna J.; Fry, Elizabeth E.; Mongkolsapaya, Juthathip; Ren, Jingshan; Stuart, David I.; Screaton, Gavin R. Share Save
Heterologous prime-boost immunization induces protection against dengue virus infection in cynomolgus macaques Keelapang, Poonsook; Ketloy, Chutitorn; Puttikhunt, Chunya; Sriburi, Rungtawan; Prompetchara, Eakachai; Sae-Lim, Malinee; Siridechadilok, Bunpote; Duangchinda, Thaneeya; Noisakran, Sansanee; Charoensri, Nicha; Suriyaphol, Prapat; Suparattanagool, Piyanan; Utaipat, Utaiwan; Masrinoul, Promsin; Avirutnan, Panisadee; Mongkolsapaya, Juthathip; Screaton, Gavin; Auewarakul, Prasert; Malaivijitnond, Suchinda; Yoksan, Sutee; Malasit, Prida; Ruxrungtham, Kiat; Pulmanausahakul, Rojjanaporn; Sittisombut, Nopporn Share Save
Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history Hornsby, Hailey R.; Nicols, Alexander R.; Longet, Stephanie; Liu, Chang; Tomic, Adriana; Angyal, Adrienn; Kronsteiner, Barbara K.; Tyerman, Jessica K.; Tipton, Tom; Zhang, Peijun; Gallis, Marta; Supasa, Piyada; Selvaraj, Muneeswaran; Abraham, Priyanka; Neale, Isabel; Ali, Mohammad A.; Barratt, Natalie M.; Nell, Jeremy; Gustafsson, Lotta; Strickland, Scarlett; Grouneva, Irina; Rostron, Timothy C.; Moore, Shona M.; Hering, Luisa L.; Dobson, Susan L.; Bibi, Sagida; Mongkolsapaya, Juthathip; Lambe, Teresa; Wootton, Dan; Hall, Victoria; Hopkins, Susan; Dong, Tao; Barnes, Eleanor; Screaton, Gavin; Richter, Alex; Turtle, Lance; Rowland-Jones, Sarah L.; Carroll, Miles; Duncan, Christopher J. A.; Klenerman, Paul; Dunachie, Susanna J.; Payne, Rebecca P.; de Silva, Thushan, I Share Save
Blockade-of-Binding Activities toward Envelope-Associated, Type-Specific Epitopes as a Correlative Marker for Dengue Virus-Neutralizing Antibody Keelapang, Poonsook; Kraivong, Romchat; Pulmanausahakul, Rojjanaporn; Sriburi, Rungtawan; Prompetchara, Eakachai; Kaewmaneephong, Jutamart; Charoensri, Nicha; Pakchotanon, Pattarakul; Duangchinda, Thaneeya; Suparattanagool, Piyanan; Luangaram, Prasit; Masrinoul, Promsin; Mongkolsapaya, Juthathip; Screaton, Gavin; Ruxrungtham, Kiat; Auewarakul, Prasert; Yoksan, Sutee; Malasit, Prida; Puttikhunt, Chunya; Ketloy, Chutitorn; Sittisombut, Nopporn Share Save
Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS- CoV-2 Thursz, Mark; Sadiq, Fouzia; Tree, Julia A.; Karayiannis, Peter; Beasley, David W. C.; Dejnirattisai, Wanwissa; Mongkolsapaya, Juthathip; Screaton, Gavin; Wand, Matthew; Elmore, Michael J.; Carroll, Miles W.; Matthews, Ian; Thomas, Howard Share Save
Accelerating drug target inhibitor discovery with a deep generative foundation model Chenthamarakshan, Vijil; Hoffman, Samuel C.; Owen, C. David; Lukacik, Petra; Strain-Damerell, Claire; Fearon, Daren; Malla, Tika R.; Tumber, Anthony; Schofield, Christopher J.; Duyvesteyn, Helen M. E.; Dejnirattisai, Wanwisa; Carrique, Loic; Walter, Thomas S.; Screaton, Gavin R.; Matviiuk, Tetiana; Mojsilovic, Aleksandra; Crain, Jason; Walsh, Martin A.; Stuart, David I.; Das, Payel Share Save
Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy Ragonnet-Cronin, Manon; Nutalai, Rungtiwa; Huo, Jiandong; Dijokaite-Guraliuc, Aiste; Das, Raksha; Tuekprakhon, Aekkachai; Supasa, Piyada; Liu, Chang; Selvaraj, Muneeswaran; Groves, Natalie; Hartman, Hassan; Ellaby, Nicholas; Sutton, J. Mark; Bahar, Mohammad W.; Zhou, Daming; Fry, Elizabeth; Ren, Jingshan; Brown, Colin; Klenerman, Paul; Dunachie, Susanna J.; Mongkolsapaya, Juthathip; Hopkins, Susan; Chand, Meera; Stuart, David I.; Screaton, Gavin R.; Rokadiya, Sakib Share Save
Persistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study-A single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines Shaw, Robert H.; Greenland, Melanie; Stuart, Arabella S. V.; Aley, Parvinder K.; Andrews, Nick J.; Cameron, J. Claire; Charlton, Sue; Clutterbuck, Elizabeth A.; Collins, Andrea M.; Darton, Tom; Dinesh, Tanya; Duncan, Christopher J. A.; Faust, Saul N.; Ferreira, Daniela M.; Finn, Adam; Goodman, Anna L.; Green, Christopher A.; Hallis, Bassam; Heath, Paul T.; Hill, Helen; Lambe, Teresa; Libri, Vincenzo; Lillie, Patrick J.; Morey, Ella; Mujadidi, Yama F.; Payne, Ruth; Plested, Emma L.; Provstgaard-Morys, Samuel; Ramasamy, Maheshi N.; Ramsay, Mary; Read, Robert C.; Robinson, Hannah; Screaton, Gavin R.; Singh, Nisha; Turner, David P. J.; Turner, Paul J.; White, Rachel; Nguyen-Van-Tam, Jonathan S.; Liu, Xinxue; Snape, Matthew D. Share Save
Evaluation of T cell responses to naturally processed variant SARS-CoV-2 spike antigens in individuals following infection or vaccination Yin, Zixi; Chen, Ji-Li; Lu, Yongxu; Wang, Beibei; Godfrey, Leila; Mentzer, Alexander J.; Yao, Xuan; Liu, Guihai; Wellington, Dannielle; Zhao, Yiqi; Wing, Peter A. C.; Dejnirattisa, Wanwisa; Supasa, Piyada; Liu, Chang; Hublitz, Philip; Beveridge, Ryan; Waugh, Craig; Clark, Sally-Ann; Clark, Kevin; Sopp, Paul; Rostron, Timothy; Mongkolsapaya, Juthathip; Screaton, Gavin R.; Ogg, Graham; Ewer, Katie; Pollard, Andrew J.; Gilbert, Sarah; Knight, Julian C.; Lambe, Teresa; Smith, Geoffrey L.; Dong, Tao; Peng, Yanchun Share Save
Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens Moore, Shona C.; Kronsteiner, Barbara; Longet, Stephanie; Adele, Sandra; Deeks, Alexandra S.; Liu, Chang; Dejnirattisai, Wanwisa; Reyes, Laura Silva; Meardon, Naomi; Faustini, Sian; Al-Taei, Saly; Tipton, Tom; Hering, Luisa M.; Angyal, Adrienn; Brown, Rebecca; Nicols, Alexander R.; Dobson, Susan L.; Supasa, Piyada; Tuekprakhon, Aekkachai; Cross, Andrew; Tyerman, Jessica K.; Hornsby, Hailey; Grouneva, Irina; Plowright, Megan; Zhang, Peijun; Newman, Thomas A. H.; Nell, Jeremy M.; Abraham, Priyanka; Ali, Mohammad; Malone, Tom; Neale, Isabel; Phillips, Eloise; Wilson, Joseph D.; Murray, Sam M.; Zewdie, Martha; Shields, Adrian; Horner, Emily C.; Booth, Lucy H.; Stafford, Lizzie; Bibi, Sagida; Wootton, Daniel G.; Mentzer, Alexander J.; Conlon, Christopher P.; Jeffery, Katie; Matthews, Philippa C.; Pollard, Andrew J.; Brown, Anthony; Rowland-Jones, Sarah L.; Mongkolsapaya, Juthathip; Payne, Rebecca P.; Dold, Christina; Lambe, Teresa; Thaventhiran, James E. D.; Screaton, Gavin; Barnes, Eleanor; Hopkins, Susan; Hall, Victoria; Ducan, Christopher J. A.; Richter, Alex; Carroll, Miles; de Silva, Thushan I.; Klenerman, Paul; Dunachie, Susann; Turtle, Lance; PITCH Consortium Share Save
A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75 Huo Jiandong; Dijokaite-Guraliuc, Aiste; Liu Chang; Zhou Daming; Ginn, Helen M.; Das, Raksha; Supasa, Piyada; Selvaraj, Muneeswaran; Nutalai, Rungtiwa; Tuekprakhon, Aekkachai; Duyvesteyn, Helen M. E.; Mentzer, Alexander J.; Skelly, Donal; Ritter, Thomas G.; Amini, Ali; Bibi, Sagida; Adele, Sandra; Johnson, Sile Ann; Paterson, Neil G.; Williams, Mark A.; Hall, David R.; Plowright, Megan; Newman, Thomas A. H.; Hornsby, Hailey; de Silva, Thushan, I; Temperton, Nigel; Klenerman, Paul; Barnes, Eleanor; Dunachie, Susanna J.; Pollard, Andrew J.; Lambe, Teresa; Goulder, Philip; Fry, Elizabeth E.; Mongkolsapaya, Juthathip; Ren, Jingshan; Stuart, David I.; Screaton, Gavin R. Share Save
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