Not logged inAcyl-CoA Synthetase 5 Knockout and Inhibitors Protect Against Diet-Induced Obesity in Mice by Activating the Ileal Brake
Powell, David R.; Van Sligtenhorst, Isaac; Main, Alan; Jin, Haihong; Carson, Kenneth G.; Shi, Zhi-Cai; Swaffield, Jonathan; Smith, Melinda; Harris, Angela; Gopinathan, Suma; Platt, Kenneth A.; Wade, Jeffrey; Zambrowicz, Brian; Mcdonald, Patricia; Orton, Darren; Kuttippurathu, Lakshmi; Mullens, Michael; Greer, Jennifer; Yang, Qi Melissa; Ding, Zhi-Ming .png)
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SaveDiscovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical PropertiesSoth, Michael J.; Le, Kang; Di Francesco, Maria Emilia; Hamilton, Matthew M.; Liu, Gang; Burke, Jason P.; Carroll, Chris L.; Kovacs, Jeffrey J.; Bardenhagen, Jennifer P.; Bristow, Christopher A.; Cardozo, Mario; Czako, Barbara; de Stanchina, Elisa; Feng, Ningping; Garvey, Jill R.; Gay, Jason P.; Do, Mary K. Geck; Greer, Jennifer; Han, Michelle; Harris, Angela; Herrera, Zachary; Huang, Sha; Giuliani, Virginia; Jiang, Yongying; Johnson, Sarah B.; Johnson, Troy A.; Kang, Zhijun; Leonard, Paul G.; Liu, Zhen; McAfoos, Timothy; Miller, Meredith; Morlacchi, Pietro; Mullinax, Robert A.; Palmer, Wylie S.; Pang, Jihai; Rogers, Norma; Rudin, Charles M.; Shepard, Hannah E.; Spencer, Nakia D.; Theroff, Jay; Wu, Qi; Xu, Alan; Yau, Ju Anne; Draetta, Giulio; Toniatti, Carlo; Heffernan, Timothy P.; Jones, Philip Share Save An inhibitor of oxidative phosphorylation exploits cancer vulnerabilityMolina, Jennifer R.; Sun, Yuting; Protopopova, Marina; Gera, Sonal; Bandi, Madhavi; Bristow, Christopher; McAfoos, Timothy; Morlacchi, Pietro; Ackroyd, Jeffrey; Agip, Ahmed-Noor A.; Al-Atrash, Gheath; Asara, John; Bardenhagen, Jennifer; Carrillo, Caroline C.; Carroll, Christopher; Chang, Edward; Ciurea, Stefan; Cross, Jason B.; Czako, Barbara; Deem, Angela; Daver, Naval; de Groot, John Frederick; Dong, Jian-Wen; Feng, Ningping; Gao, Guang; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Giuliani, Virginia; Han, Jing; Han, Lina; Henry, Verlene K.; Hirst, Judy; Huang, Sha; Jiang, Yongying; Kang, Zhijun; Khor, Tin; Konoplev, Sergej; Lin, Yu-Hsi; Liu, Gang; Lodi, Alessia; Lofton, Timothy; Ma, Helen; Mahendra, Mikhila; Matre, Polina; Mullinax, Robert; Peoples, Michael; Petrocchi, Alessia; Rodriguez-Canale, Jaime; Serreli, Riccardo; Shi, Thomas; Smith, Melinda; Tabe, Yoko; Theroff, Jay; Tiziani, Stefano; Xu, Quanyun; Zhang, Qi; Muller, Florian; DePinho, Ronald A.; Toniatti, Carlo; Draetta, Giulio F.; Heffernan, Timothy P.; Konopleva, Marina; Jones, Philip; Di Francesco, M. Emilia; Marszalek, Joseph R. Share Save IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumorsMolina, Jennifer; Bandi, Madhavi; Bardenhagen, Jennifer; Bristow, Christopher; Carroll, Christopher; Chang, Edward; Cross, Jason; Daver, Naval; Feng, Ningping; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Han, Jing; Hirst, Judy; Huang, Sha; Jiang, Yongying; Kang, Zhijun; Konopleva, Marina; Liu, Gang; Ma, Helen; Matre, Polina; McAfoos, Timothy; Meric-Bernstam, Funda; Morlacchi, Pietro; Muller, Florian; Protopopova, Marina; Smith, Melinda; Sonal, Sonal; Sun, Yuting; Theroff, Jay; Viale, Andrea; Xu, Quanyun; Toniatti, Carlo; Draetta, Giulio; Jones, Philip; Di Francesco, M. Emilia; Marszalek, Joseph R. Share Save LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in MicePowell, David R.; Smith, Melinda G.; Doree, Deon D.; Harris, Angela L.; Greer, Jennifer; DaCosta, Christopher M.; Thompson, Andrea; Jeter-Jones, Sabrina; Xiong, Wendy; Carson, Kenneth G.; Goodwin, Nicole C.; Harrison, Bryce A.; Rawlins, David B.; Strobel, Eric D.; Gopinathan, Suma; Wilson, Alan; Mseeh, Faika; Zambrowicz, Brian; Ding, Zhi-Ming Share Save Engaging the immune system with GSK3174998, a potent anti-OX40 agonist antibodyToniatti, Carlo; Yanamandra, Niranjan; Voo, Kui; Al-Shami, Amin; Boyer, Laura; Morley, Peter; Brett, Sara; Lofton, Tim; Greer, Jennifer; Feng, Ningping; Wistuba, Ignacio Ivan; Bhattacharya, Sabyasachi; Hopson, Christopher; Kilian, David; Jackson, Heather; Bojczuk, Paul; Mandal, Mili; Jing, Junping; French, Kevin; Srinivasan, Roopa; Hoos, Axel Share Save Title: IACS-010759 is a novel clinical candidate that targets AML cells by inducing a metabolic catastrophe through inhibition of oxidative phosphorylationMolina, Jennifer R.; Protopopova, Marina; Bandi, Madhavi; Bardenhagen, Jennifer; Bristow, Christopher; Carroll, Christopher; Chang, Edward; Feng, Ningping; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Huang, Sha; Jiang, Yongying; Konopleva, Marina; Matre, Polina; Han, Jing; Kang, Zhijun; Liu, Gang; McAfoos, Timothy; Morlacchi, Pietro; Smith, Melinda; Gera, Sonal; Theroff, Jay; Xu, Quanyun; Velez, Juliana; Toniatti, Carlo; Heffernan, Timothy; Draetta, Giulio; Di Francesco, M. Emilia; Jones, Philip; Marszalek, Joseph R. Share Save IACS-10759: A novel OXPHOS inhibitor that selectively kills tumors with metabolic vulnerabilitiesProtopopova, Marina; Bandi, Madhavi; Sun, Yuting; Bardenhagen, Jennifer; Bristow, Christopher; Carroll, Christopher; Chang, Edward; Feng, Ningping; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Konopleva, Marina; Matre, Polina; Kang, Zhijun; Liu, Gang; Muller, Florian; Lofton, Timothy; McAfoos, Timothy; Smith, Melinda; Theroff, Jay; Han, Jing; Wu, Yuanqing; Chin, Lynda; Draetta, Giulio; Jones, Philip; Toniatti, Carlo; Di Francesco, M. Emilia; Marszalek, Joseph R. Share Save Relapsed/refractory AML responds robustly to IACS-10759, a novel OXPHOS inhibitorProtopopova, Marina; Bandi, Madhavi; Bardenhagen, Jennifer; Bristow, Christophor; Carroll, Christopher; Chang, Edward; Feng, Ningping; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Konopleva, Marina; Matre, Polina; Kang, Zhijun; Liu, Gang; Muller, Florian; Lofton, Timothy; McAfoos, Timothy; Theroff, Jay; Sun, Yuting; Wu, Yuanqiang; Smith, Melinda; Chin, Lynda; Draetta, Giulio; Jones, Philip; Toniatti, Carlo; Di Francesco, M. Emilia; Marszalek, Joseph R. Share Save IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilitiesProtopopova, Marina; Bandi, Madhavi; Bardenhagen, Jennifer; Bristow, Christopher; Carroll, Christopher; Chang, Edward; Feng, Ningping; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Konopleva, Marina; Matre, Polina; Kang, Zhijun; Liu, Gang; Muller, Florian; Lofton, Timothy; McAfoos, Timothy; Sun, Yuting; Smith, Melinda; Theroff, Jay; Wu, Yuanqiang; Chin, Lynda; Draetta, Giulio; Jones, Philip; Toniatti, Carlo; Di Francesco, M. Emilia; Marszalek, Joseph R. Share Save Identification of OXPHOS inhibitors which selectively kill tumors with specific metabolic vulnerabilitiesMarszalek, Joseph R.; Bandi, Madhavi; Bardenhagen, Jennifer; Bristow, Christopher; Carroll, Christopher; Chang, Edward; Feng, Ninping; Czako, Barbara; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Johnson, Ryan M.; Konopleva, Marina; Kang, Zhijun; Liu, Gang; Lofton, Timothy; McAfoos, Timothy; Protopopova, Marina; Petrocchi, Alessia; Muller, Florian; Theroff, Jay; Wu, Yuanqing; Chin, Lynda; Draetta, Giulio; Jones, Philip; Toniatti, Carlo; Di Francesco, Emilia Share Save LX4211 Increases Serum Glucagon-Like Peptide 1 and Peptide YY Levels by Reducing Sodium/Glucose Cotransporter 1 (SGLT1)-Mediated Absorption of Intestinal GlucosePowell, David R.; Smith, Melinda; Greer, Jennifer; Harris, Angela; Zhao, Sharon; DaCosta, Christopher; Mseeh, Faika; Shadoan, Melanie K.; Sands, Arthur; Zambrowicz, Brian; Ding, Zhi-Ming Share Save 
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