Not logged in A Phase Ia/b study of MEK1/2 inhibitor binimetinib with MET inhibitor crizotinib in patients with RAS mutant advanced colorectal cancer (MErCuRIC) Aroldi, Francesca; Elez, Elena; Andre, Thierry; Perkins, Geraldine; Prenen, Hans; Popovici, Vlad; Gallagher, Peter; Houlden, Jennifer; Collins, Linda; Roberts, Corran; Rolfo, Christian; Di Nicolantonio, Federica; Grayson, Margaret; Boyd, Ruth; Bettens, Karolien; Delfavero, Jurgen; Coyle, Victoria; Lawler, Mark; Khawaja, Hajrah; Laurent-Puig, Pierre; Salto-Tellez, Manuel; Maughan, Tim S.; Tabernero, Josep; Adams, Richard; Jones, Robert; Hennessy, Bryan T.; Bardelli, Alberto; Peeters, Marc; Middleton, Mark R.; Wilson, Richard H.; Van Schaeybroeck, Sandra Share Save
Detection of NRAS, KRAS and BRAF mutations in FFPE derived DNA with a novel targeted resequencing-based diagnostics assay Marques, C.; Bettens, K.; Goossens, D.; Heyrman, L.; Heusdens, C.; Kupers, S.; Berwouts, S.; Van Barel, D.; Rotthier, A.; Del-Favero, J. Share Save
A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer's disease Verheijen, Jan; Van den Bossche, Tobi; van der Zee, Julie; Engelborghs, Sebastiaan; Sanchez-Valle, Raquel; Llado, Albert; Graff, Caroline; Thonberg, Hakan; Pastor, Pau; Ortega-Cubero, Sara; Pastor, Maria A.; Benussi, Luisa; Ghidoni, Roberta; Binetti, Giuliano; Clarimon, Jordi; Lleo, Alberto; Fortea, Juan; de Mendonca, Alexandre; Martins, Madalena; Grau-Rivera, Oriol; Gelpi, Ellen; Bettens, Karolien; Mateiu, Ligia; Dillen, Lubina; Cras, Patrick; De Deyn, Peter P.; Van Broeckhoven, Christine; Sleegers, Kristel Share Save
Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations Bettens, Karolien; Vermeulen, Steven; Van Cauwenberghe, Caroline; Heeman, Bavo; Asselbergh, Bob; Robberecht, Caroline; Engelborghs, Sebastiaan; Vandenbulcke, Mathieu; Vandenberghe, Rik; De Deyn, Peter Paul; Cruts, Marc; Van Broeckhoven, Christine; Sleegers, Kristel Share Save
A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42 Sleegers, Kristel; Bettens, Karolien; De Roeck, Arne; Van Cauwenberghe, Caroline; Cuyvers, Elise; Verheijen, Jan; Struyfs, Hanne; Van Dongen, Jasper; Vermeulen, Steven; Engelborghs, Sebastiaan; Vandenbulcke, Mathieu; Vandenberghe, Rik; De Deyn, Peter Paul; Van Broeckhoven, Christine Share Save
Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: a European early-onset dementia consortium study Cuyvers, Elise; van der Zee, Julie; Bettens, Karolien; Engelborghs, Sebastiaan; Vandenbulcke, Mathieu; Robberecht, Caroline; Dillen, Lubina; Merlin, Celine; Geerts, Nathalie; Graff, Caroline; Thonberg, Hakan; Chiang, Huei-Hsin; Pastor, Pau; Ortega-Cubero, Sara; Pastor, Maria A.; Diehl-Schmid, Janine; Alexopoulos, Panagiotis; Benussi, Luisa; Ghidoni, Roberta; Binetti, Giuliano; Nacmias, Benedetta; Sorbi, Sandro; Sanchez-Valle, Raquel; Llado, Albert; Gelpi, Ellen; Almeida, Maria Rosario; Santana, Isabel; Clarimon, Jordi; Lleo, Alberto; Fortea, Juan; de Mendonca, Alexandre; Martins, Madalena; Borroni, Barbara; Padovani, Alessandro; Matej, Radoslav; Rohan, Zdenek; Ruiz, Agustin; Frisoni, Giovanni B.; Fabrizi, Gian Maria; Vandenberghe, Rik; De Deyn, Peter P.; Van Broeckhoven, Christine; Sleegers, Kristel Share Save
Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia Cuyvers, Elise; Bettens, Karolien; Philtjens, Stephanie; Van Langenhove, Tim; Gijselinck, Ilse; van der Zee, Julie; Engelborghs, Sebastiaan; Vandenbulcke, Mathieu; Van Dongen, Jasper; Geerts, Nathalie; Maes, Githa; Mattheijssens, Maria; Peeters, Karin; Cras, Patrick; Vandenberghe, Rik; De Deyn, Peter P.; Van Broeckhoven, Christine; Cruts, Marc; Sleegers, Kristel Share Save
Complement receptor 1 coding variant p.Ser1610Thr in Alzheimer's disease and related endophenotypes Van Cauwenberghe, Caroline; Bettens, Karolien; Engelborghs, Sebastiaan; Vandenbulcke, Mathieu; Van Dongen, Jasper; Vermeulen, Steven; Vandenberghe, Rik; De Deyn, Peter P.; Van Broeckhoven, Christine; Sleegers, Kristel Share Save
C9orf72 G4C2 repeat expansions in Alzheimer's disease and mild cognitive impairment Cacace, Rita; Van Cauwenberghe, Caroline; Bettens, Karolien; Gijselinck, Ilse; van der Zee, Julie; Engelborghs, Sebastiaan; Vandenbulcke, Mathieu; Van Dongen, Jasper; Baumer, Veerle; Dillen, Lubina; Mattheijssens, Maria; Peeters, Karin; Cruts, Marc; Vandenberghe, Rik; De Deyn, Peter P.; Van Broeckhoven, Christine; Sleegers, Kristel Share Save
Polymorphism of brain derived neurotrophic factor influences β amyloid load in cognitively intact apolipoprotein E ε4 carriers Adamczuk, Katarzyna; De Weer, An-Sofie; Nelissen, Natalie; Chen, Kewei; Sleegers, Kristel; Bettens, Karolien; Van Broeckhoven, Christine; Vandenbulcke, Mathieu; Thiyyagura, Pradeep; Dupont, Patrick; Van Laere, Koen; Reiman, Eric M.; Vandenberghe, Rik Share Save
Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease Lambert, J-C; Grenier-Boley, B.; Harold, D.; Zelenika, D.; Chouraki, V.; Kamatani, Y.; Sleegers, K.; Ikram, M. A.; Hiltunen, M.; Reitz, C.; Mateo, I.; Feulner, T.; Bullido, M.; Galimberti, D.; Concari, L.; Alvarez, V.; Sims, R.; Gerrish, A.; Chapman, J.; Deniz-Naranjo, C.; Solfrizzi, V.; Sorbi, S.; Arosio, B.; Spalletta, G.; Siciliano, G.; Epelbaum, J.; Hannequin, D.; Dartigues, J-F; Tzourio, C.; Berr, C.; Schrijvers, E. M. C.; Rogers, R.; Tosto, G.; Pasquier, F.; Bettens, K.; Van Cauwenberghe, C.; Fratiglioni, L.; Graff, C.; Delepine, M.; Ferri, R.; Reynolds, C. A.; Lannfelt, L.; Ingelsson, M.; Prince, J. A.; Chillotti, C.; Pilotto, A.; Seripa, D.; Boland, A.; Mancuso, M.; Bossu, P.; Annoni, G.; Nacmias, B.; Bosco, P.; Panza, F.; Sanchez-Garcia, F.; Del Zompo, M.; Coto, E.; Owen, M.; O'Donovan, M.; Valdivieso, F.; Caffara, P.; Scarpini, E.; Combarros, O.; Buee, L.; Campion, D.; Soininen, H.; Breteler, M.; Riemenschneider, M.; Van Broeckhoven, C.; Alperovitch, A.; Lathrop, M.; Tregouet, D-A; Williams, J.; Amouyel, P. Share Save
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk Bettens, Karolien; Brouwers, Nathalie; Engelborghs, Sebastiaan; Lambert, Jean-Charles; Rogaeva, Ekaterina; Vandenberghe, Rik; Le Bastard, Nathalie; Pasquier, Florence; Vermeulen, Steven; Van Dongen, Jasper; Mattheijssens, Maria; Peeters, Karin; Mayeux, Richard; St George-Hyslop, Peter; Amouyel, Philippe; De Deyn, Peter P.; Sleegers, Kristel; Van Broeckhoven, Christine Share Save
APOE and Alzheimer disease: a major gene with semi-dominant inheritance Genin, E.; Hannequin, D.; Wallon, D.; Sleegers, K.; Hiltunen, M.; Combarros, O.; Bullido, M. J.; Engelborghs, S.; De Deyn, P.; Berr, C.; Pasquier, F.; Dubois, B.; Tognoni, G.; Fievet, N.; Brouwers, N.; Bettens, K.; Arosio, B.; Coto, E.; Del Zompo, M.; Mateo, I.; Epelbaum, J.; Frank-Garcia, A.; Helisalmi, S.; Porcellini, E.; Pilotto, A.; Forti, P.; Ferri, R.; Scarpini, E.; Siciliano, G.; Solfrizzi, V.; Sorbi, S.; Spalletta, G.; Valdivieso, F.; Vepsalainen, S.; Alvarez, V.; Bosco, P.; Mancuso, M.; Panza, F.; Nacmias, B.; Bossu, P.; Hanon, O.; Piccardi, P.; Annoni, G.; Seripa, D.; Galimberti, D.; Licastro, F.; Soininen, H.; Dartigues, J-F; Kamboh, M. I.; Van Broeckhoven, C.; Lambert, J. C.; Amouyel, P.; Campion, D. Share Save
Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites Brouwers, N.; Van Cauwenberghe, C.; Engelborghs, S.; Lambert, J-C; Bettens, K.; Le Bastard, N.; Pasquier, F.; Montoya, A. Gil; Peeters, K.; Mattheijssens, M.; Vandenberghe, R.; De Deyn, P. P.; Cruts, M.; Amouyel, P.; Sleegers, K.; Van Broeckhoven, C. Share Save
The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study Lambert, Jean-Charles; Sleegers, Kristel; Gonzalez-Perez, Antonio; Ingelsson, Martin; Beecham, Gary W.; Hiltunen, Mikko; Combarros, Onofre; Bullido, Maria J.; Brouwers, Nathalie; Bettens, Karolien; Berr, Claudine; Pasquier, Florence; Richard, Florence; DeKosky, Steven T.; Hannequin, Didier; Haines, Jonathan L.; Tognoni, Gloria; Fievet, Nathalie; Dartigues, Jean-Francois; Tzourio, Christophe; Engelborghs, Sebastiaan; Arosio, Beatrice; Coto, Elicer; De Deyn, Peter; Del Zompo, Maria; Mateo, Ignacio; Boada, Merce; Antunez, Carmen; Lopez-Arrieta, Jesus; Epelbaum, Jacques; Schjcide, Brit-Marcn Michaud; Frank-Garcia, Ana; Gicdraitis, Vilmentas; Helisalmi, Seppo; Porcellini, Elisa; Pilotto, Alberto; Forti, Paola; Ferri, Raffaele; Delepine, Marc; Zelenika, Diana; Lathrop, Mark; Scarpini, Elio; Siciliano, Gabriele; Solfrizzi, Vincenzo; Sorbi, Sandro; Spalletta, Gianfranco; Ravaglia, Giovanni; Valdivieso, Fernando; Vepsalainen, Saila; Alvarez, Victoria; Bosco, Paolo; Mancuso, Michelangelo; Panza, Francesco; Nacmias, Benedetta; Bossu, Paola; Hanon, Olivier; Piccardi, Paola; Annoni, Giorgio; Mann, David; Marambaud, Philippe; Seripa, Davide; Galimberti, Daniela; Tanzi, Rudolph E.; Bertram, Lars; Lendon, Corinne; Lannfelt, Lars; Licastro, Federico; Campion, Dominique; Pericak-Vance, Margaret A.; Soininen, Hilkka; Van Broeckhoven, Christine; Alperovitch, Annick; Ruiz, Agustin; Kamboh, M. Ilyas; Amouyel, Philippe Share Save
Contribution of TARDBP to Alzheimer's Disease Genetic Etiology Brouwers, Nathalie; Bettens, Karolien; Gijselinck, Ilse; Engelborghs, Sebastiaan; Pickut, Barbara A.; Van Miegroet, Helen; Montoya, Ana Gil; Mattheijssens, Maria; Peeters, Karin; De Deyn, Peter P.; Cruts, Marc; Sleegers, Kristel; Van Broeckhoven, Christine Share Save
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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (vol 41, pg 1088, 2009) Harold, Denise; Abraham, Richard; Hollingworth, Paul; Sims, Rebecca; Gerrish, Amy; Hamshere, Marian L.; Pahwa, Jaspreet Singh; Moskvina, Valentina; Dowzell, Kimberley; Williams, Amy; Jones, Nicola; Thomas, Charlene; Stretton, Alexandra; Morgan, Angharad R.; Lovestone, Simon; Powell, John; Proitsi, Petroula; Lupton, Michelle K.; Brayne, Carol; Rubinsztein, David C.; Gill, Michael; Lawlor, Brian; Lynch, Aoibhinn; Morgan, Kevin; Brown, Kristelle S.; Passmore, Peter A.; Craig, David; McGuinness, Bernadette; Todd, Stephen; Holmes, Clive; Mann, David; Smith, A. David; Love, Seth; Kehoe, Patrick G.; Hardy, John; Mead, Simon; Fox, Nick; Rossor, Martin; Collinge, John; Maier, Wolfgang; Jessen, Frank; Schuermann, Britta; van den Bussche, Hendrik; Heuser, Isabella; Kornhuber, Johannes; Wiltfang, Jens; Dichgans, Martin; Froelich, Lutz; Hampel, Harald; Huell, Michael; Rujescu, Dan; Goate, Alison M.; Kauwe, John S. K.; Cruchaga, Carlos; Nowotny, Petra; Morris, John C.; Mayo, Kevin; Sleegers, Kristel; Bettens, Karolien; Engelborghs, Sebastiaan; De Deyn, Peter P.; Van Broeckhoven, Christine; Livingston, Gill; Bass, Nicholas J.; Gurling, Hugh; McQuillin, Andrew; Gwilliam, Rhian; Deloukas, Panagiotis; Al-Chalabi, Ammar; Shaw, Christopher E.; Tsolaki, Magda; Singleton, Andrew B.; Guerreiro, Rita; Muehleisen, Thomas W.; Noethen, Markus M.; Moebus, Susanne; Joeckel, Karl-Heinz; Klopp, Norman; Wichmann, H-Erich; Carrasquillo, Minerva M.; Pankratz, V. Shane; Younkin, Steven G.; Holmans, Peter A.; O'Donovan, Michael; Owen, Michael J.; Williams, Julie Share Save
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