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Inhibition of acyl-CoA synthetase long-chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction Murphy, Connor S.; Fairfield, Heather; Demambro, Victoria E.; Fadel, Samaa; Gartner, Carlos A.; Karam, Michelle; Potts, Christian; Rodriguez, Princess; Qiang, Ya-Wei; Hamidi, Habib; Guan, Xiangnan; Vary, Calvin P. H.; Reagan, Michaela R. Share Save
Development of mutated β-catenin gene signature to identify CTNNB1 mutations from whole and spatial transcriptomic data in patients with HCC Lehrich, Brandon M.; Tao, Junyan; Liu, Silvia; Hirsch, Theo Z.; Yasaka, Tyler M.; Cao, Catherine; Delgado, Evan R.; Guan, Xiangnan; Lu, Shan; Pan, Long; Liu, Yuqing; Singh, Sucha; Poddar, Minakshi; Bell, Aaron; Singhi, Aatur D.; Zucman-Rossi, Jessica; Wang, Yulei; Monga, Satdarshan P. Share Save
Anti-TIGIT antibody tiragolumab improves PD-L1 blockade via myeloid and Treg cells Guan, Xiangnan; Hu, Ruozhen; Choi, Yoonha; Srivats, Shyam; Nabet, Barzin; Silva, John; Mcginnis, Lisa; Hendricks, Robert; Nutsch, Katherine; Banta, Karl; Duong, Ellen; Dunkle, Alexis; Chang, Patrick; Han, Joy; Mittman, Stephanie; Molden, Nandini; Daggumati, Pallavi Share Save
Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer Galsky, Matthew D.; Guan, Xiangnan; Rishipathak, Deepali; Rapaport, Aaron S.; Shehata, Hesham M.; Banchereau, Romain; Yuen, Kobe; Varfolomeev, Eugene; Hu, Ruozhen; Han, Chia -Jung; Li, Haocheng; Liang, Yuxin; Vucic, Domagoj; Wang, Li; Zhu, Jun; Yu, Haocheng; Herbst, Rebecca H.; Hajaj, Emma; Kiner, Evgeny; Bamias, Aristotelis; De Santis, Maria; Davis, Ian D.; Arranz, Jose Angel; Kikuchi, Eiji; Bernhard, Sandrine; Williams, Patrick; Lee, Chooi; Mellman, Ira; Sanjabi, Shomyseh; Johnston, Robert; Black, Peter C.; Grande, Enrique; Mariathasan, Sanjeev Share Save
Supervised learning of high-confidence phenotypic subpopulations from single-cell data (vol 5, pg 528, 2023) Ren, Tao; Chen, Canping; Danilov, Alexey V.; Liu, Susan; Guan, Xiangnan; Du, Shunyi; Wu, Xiwei; Sherman, Mara H.; Spellman, Paul T.; Coussens, Lisa M.; Adey, Andrew C.; Mills, Gordon B.; Wu, Ling-Yun; Xia, Zheng Share Save
Supervised learning of high-confidence phenotypic subpopulations from single-cell data Ren, Tao; Chen, Canping; Danilov, Alexey V.; Liu, Susan; Guan, Xiangnan; Du, Shunyi; Wu, Xiwei; Sherman, Mara H.; Spellman, Paul T.; Coussens, Lisa M.; Adey, Andrew C.; Mills, Gordon B.; Wu, Ling-Yun; Xia, Zheng Share Save
Anti-TIGIT antibody tiragolumab leverages myeloid cells and regulatory T cells to improve PD-L1 checkpoint blockade Patil, Namrata S.; Srivats, Shyam; Choi, Yoonha; Guan, Xiangnan; Nabet, Barzin; McGinnis, Lisa; Chiang, Eugene; Dunkle, Alexis; O'Gorman, Bill; Chang, Patrick S.; Hu, Ruozhen; Silva, John; Han, Joy; Au-Yeung, Amelia; Takahashi, Chikara; Molden, Nandini; Daggumati, Pallavi; Connolly, Wendy; Johnson, Melissa; Abreu, Delvys Rodriguez; Cho, Byoung Chul; Italiano, Antoine; Gil-Bazo, Ignacio; Felip, Enriqueta; Mellman, Ira; Meng, Raymond; Mariathasan, Sanjeev; Johnston, Robert; Shames, David S. Share Save
The ectonucleotidase CD39 identifies tumor-reactive CD8+T cells predictive of immune checkpoint blockade efficacy in human lung cancer Chow, Andrew; Uddin, Fathema Z.; Liu, Michael; Dobrin, Anton; Nabet, Barzin Y.; Mangarin, Levi; Lavin, Yonit; Rizvi, Hira; Tischfield, Sam E.; Quintanal-Villalonga, Alvaro; Chan, Joseph M.; Shah, Nisargbhai; Allaj, Viola; Manoj, Parvathy; Mattar, Marissa; Meneses, Maximiliano; Landau, Rebecca; Ward, Mariana; Kulick, Amanda; Kwong, Charlene; Wierzbicki, Matthew; Yavner, Jessica; Egger, Jacklynn; Chavan, Shweta S.; Farillas, Abigail; Holland, Aliya; Sridhar, Harsha; Ciampricotti, Metamia; Hirschhorn, Daniel; Guan, Xiangnan; Richards, Allison L.; Heller, Glenn; Mansilla-Soto, Jorge; Sadelain, Michel; Klebanoff, Christopher A.; Hellmann, Matthew D.; Sen, Triparna; de Stanchina, Elisa; Wolchok, Jedd D.; Merghoub, Taha; Rudin, Charles M. Share Save
ANTI-TIGIT ANTIBODY TIRAGOLUMAB LEVERAGES MYELOID CELLS AND REGULATORY T CELLS TO IMPROVE PD-L1 CHECKPOINT BLOCKADE Patil, Namrata; Meng, Raymond; Johnston, Robert; Chang, Patrick; Srivats, Shyam; Choi, Yoonha; Guan, Xiangnan; Nabet, Barzin; McGinnis, Lisa; Chiang, Eugene; Pham, Thinh; Dunkle, Alexis; O'Gorman, Bill; Mellman, Ira; Hu, Ruozhen; Silva, John; Han, Joy; Au-Yeung, Amelia; Takahashi, Chikara; Molden, Nandini; Daggumati, Pallavi; Connolly, Wendy; Johnson, Melissa; Rodriguez Abreu, Delvys; Cho, Byoung Chul; Italiano, Antoine; Gil Bazo, Ignacio; Felip, Enriqueta; Mariathasan, Sanjeev; Bais, Carlos; Shames, David Share Save
Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity Westbrook, Thomas C.; Guan, Xiangnan; Rodansky, Eva; Flores, Diana; Liu, Chia Jen; Udager, Aaron M.; Patel, Radhika A.; Haffner, Michael C.; Hu, Ya-Mei; Sun, Duanchen; Beer, Tomasz M.; Foye, Adam; Aggarwal, Rahul; Quigley, David A.; Youngren, Jack F.; Ryan, Charles J.; Gleave, Martin; Wang, Yuzhuo; Huang, Jiaoti; Coleman, Ilsa; Morrissey, Colm; Nelson, Peter S.; Evans, Christopher P.; Lara, Primo; Reiter, Robert E.; Witte, Owen; Rettig, Matthew; Wong, Christopher K.; Weinstein, Alana S.; Uzunangelov, Vlado; Stuart, Josh M.; Thomas, George, V; Feng, Felix Y.; Small, Eric J.; Yates, Joel A.; Xia, Zheng; Alumkal, Joshi J. Share Save
Single-cell analysis reveals clonally expanded tumor-associated CD57+ CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade Fehlings, Michael; Kim, Leesun; Guan, Xiangnan; Yuen, Kobe; Tafazzol, Alireza; Sanjabi, Shomyseh; Zill, Oliver A.; Rishipathak, Deepali; Wallace, Andrew; Nardin, Alessandra; Ma, Siming; Milojkovic, Ana; Newell, Evan W.; Mariathasan, Sanjeev; Yadav, Mahesh Share Save
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Pregnancy and weaning regulate human maternal liver size and function Bartlett, Alexandra Q.; Vesco, Kimberly K.; Purnell, Jonathan Q.; Francisco, Melanie; Goddard, Erica; Guan, Xiangnan; DeBarber, Andrea; Leo, Michael C.; Baetscher, Eric; Rooney, William; Naugler, Willscott; Guimaraes, Alexander R.; Catalano, Patrick; Xia, Zheng; Schedin, Pepper Share Save
Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data Sun, Duanchen; Guan, Xiangnan; Moran, Amy E.; Wu, Ling-Yun; Qian, David Z.; Schedin, Pepper; Dai, Mu-Shui; Danilov, Alexey, V; Alumkal, Joshi J.; Adey, Andrew C.; Spellman, Paul T.; Xia, Zheng Share Save
BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program Kim, Dae-Hwan; Sun, Duanchen; Storck, William K.; Leng, Katherine Welker; Jenkins, Chelsea; Coleman, Daniel J.; Sampson, David; Guan, Xiangnan; Kumaraswamy, Anbarasu; Rodansky, Eva S.; Urrutia, Joshua A.; Schwartzman, Jacob A.; Zhang, Chao; Beltran, Himisha; Labrecque, Mark P.; Morrissey, Colm; Lucas, Jared M.; Coleman, Ilsa M.; Nelson, Peter S.; Corey, Eva; Handelman, Samuel K.; Sexton, Jonathan Z.; Aggarwal, Rahul; Abida, Wassim; Feng, Felix Y.; Small, Eric J.; Spratt, Daniel E.; Bankhead, Armand, III; Rao, Arvind; Gesner, Emily M.; Attwell, Sarah; Lakhotia, Sanjay; Campeau, Eric; Yates, Joel A.; Xia, Zheng; Alumkal, Joshi J. Share Save
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Copy Number Loss of 17q22 Is Associated with Enzalutamide Resistance and Poor Prognosis in Metastatic Castration-Resistant Prostate Cancer Guan, Xiangnan; Sun, Duanchen; Lu, Eric; Urrutia, Joshua A.; Reiter, Robert Evan; Rettig, Matthew; Evans, Christopher P.; Lara, Primo, Jr.; Gleave, Martin; Beer, Tomasz M.; Thomas, George, V; Huang, Jiaoti; Aggarwal, Rahul R.; Quigley, David A.; Foye, Adam; Chen, William S.; Youngren, Jack; Weinstein, Alana S.; Stuart, Joshua M.; Feng, Felix Y.; Small, Eric J.; Xia, Zheng; Alumkal, Joshi J. Share Save
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