Not logged inA substrate binding model for the KEOPS tRNA modifying complex
Beenstock, Jonah; Ona, Samara Mishelle; Porat, Jennifer; Orlicky, Stephen; Wan, Leo C. K.; Ceccarelli, Derek F.; Maisonneuve, Pierre; Szilard, Rachel K.; Yin, Zhe; Setiaputra, Dheva; Mao, Daniel Y. L.; Khan, Morgan; Raval, Shaunak; Schriemer, David C.; Bayfield, Mark A.; Durocher, Daniel; Sicheri, Frank .png)
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SaveInhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiencyCanny, Marella D.; Moatti, Nathalie; Wan, Leo C. K.; Fradet-Turcotte, Amelie; Krasner, Danielle; Mateos-Gomez, Pedro A.; Zimmermann, Michal; Orthwein, Alexandre; Juang, Yu-Chi; Zhang, Wei; Noordermeer, Sylvie M.; Seclen, Eduardo; Wilson, Marcus D.; Vorobyov, Andrew; Munro, Meagan; Ernst, Andreas; Timothy F Ng; Cho, Tiffany; Cannon, Paula M.; Sidhu, Sachdev S.; Sicheri, Frank; Durocher, Daniel Share Save Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7Wan, Leo C. K.; Maisonneuve, Pierre; Szilard, Rachel K.; Lambert, Jean-Philippe; Ng, Timothy F.; Manczyk, Noah; Huang, Hao; Laister, Rob; Caudy, Amy A.; Gingras, Anne-Claude; Durocher, Daniel; Sicheri, Frank Share Save Share Save Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral ActivityHuang, Hao; Zeqiraj, Elton; Dong, Beihua; Jha, Babal Kant; Duffy, Nicole M.; Orlicky, Stephen; Thevakumaran, Neroshan; Talukdar, Manisha; Pillon, Monica C.; Ceccarelli, Derek F.; Wan, Leo C. K.; Juang, Yu-Chi; Mao, Daniel Y. L.; Gaughan, Christina; Brinton, Margo A.; Perelygin, Andrey A.; Kourinov, Igor; Guarne, Alba; Silverman, Robert H.; Sicheri, Frank Share Save Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular MachineMao, Daniel Y. L.; Neculai, Dante; Downey, Michael; Orlicky, Stephen; Haffani, Yosr Z.; Ceccarelli, Derek F.; Ho, Jenny S. L.; Szilard, Rachel K.; Zhang, Wei; Ho, Cynthia S.; Wan, Leo; Fares, Christophe; Rumpel, Sigrun; Kurinov, Igor; Arrowsmith, Cheryl H.; Durocher, Daniel; Sicheri, Frank Share Save 
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