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S

Sachdev S. Sidhu

anvil institute of systems biologics

84H-index
538Paper Count
2.4WCitation Count
Published Papers 188
Publication Date
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Dual targeting of inhibitory EGFR epitopes with synthetic antibodies in therapeutic-resistant cancers
errProtein Science
IF5.2
err2026-05-24
err0
PREAI
errJarrett J. Adams; Evan Mallette; Max London; Ryan J. Liang; Dewald van Dyk; Zvezdan Pavlovic; Isabelle Pot; C. Ronald Geyer; Heather A. Bruce; Levi L. Blazer; Craig A. Hokanson; Michael D. L. Suits; Alexander U. Singer; Sachdev S. Sidhu
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Using phage display for rational engineering of a higher-affinity humanized 3’ phosphohistidine-specific antibody
errCommunications Chemistry
IF6.2
err2025-11-27
err0
errOAAI
errGregory D. Martyn; Rajasree Kalagiri; Gianluca Veggiani; Robyn L. Stanfield; Indrani Choudhuri; Margaux Sala; Jill Meisenhelder; Chao Chen; Avik Biswas; Ronald M. Levy; Dmitry Lyumkis; Ian A. Wilson; Tony Hunter; Sachdev S. Sidhu
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errSave
USP10/GSK3β-mediated inhibition of PTEN drives resistance to PI3K inhibitors in breast cancer
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-11-17
err0
errOAAI
errKumari, Nishi; Wright, Sarah C. E.; Witham, Christopher M.; Monserrat, Laia; Palafox, Marta; Richard, John L. C.; Costa, Carlotta; Elkabets, Moshe; Agostino, Mark; Klemm, Theresa; Eccles, Melissa; Garnham, Alex; Wu, Ting; Nilsson, Jonas A.; Walz, Nikita; Venugopal, Veena; Cerra, Anthony; Vasilevski, Natali; Bridgeman, Stephanie; Bassi, Sona; Saei, Azad; Helal, Moutaz; Neundorf, Philipp; Riedel, Angela; Rosenfeldt, Mathias; Gill, Jespal; Pahor, Nikolett; Hartmann, Oliver; Chung, Jacky; Sidhu, Sachdev S.; Moderau, Nina; Jha, Sudhakar; Rodon, Jordi; Diefenbacher, Markus E.; Komander, David; Serra, Violeta; Eichhorn, Pieter Johan Adam
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Selective treatment of acute myeloid leukemia targeting the activated conformation of integrin beta2 with [225Ac]Macropa-PEG4-7065
errNuclear Medicine and Biology
IF3
err2025-11-10
err0
PREAI
errAnju Wadhwa; Haley Johnson; Kamal Mandal; Kondapa Bobba; Anil Bidkar; Athira Raveendran; Ellis Mayne; Sham Rampersaud; Amrik S. Kang; Megha Basak; Marina Lopez-Alvarez; Sanghee Lee; Veronica Steri; David Wilson; Henry VanBrocklin; Youngho Seo; Jarrett J. Adams; Sachdev S. Sidhu; Arun Wiita; Robert Flavell
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Anti-Robo1/2 monoclonal antibodies as a novel macrophage-based immunotherapy for glioblastoma
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errGeraldo, Luiz Henrique Medeiros; De Oliveira, Maria Luiza Lopes; Blazer, Levi; Sulman, Erik; Figueroa, Jose Ricardo McFaline; Sidhu, Sachdev; Lund, Amanda
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errSave
An asymmetric tetrabody is a potent and efficacious agonist of the erythropoietin receptor in vitro and in vivo
errProtein Science
IF5.2
err2025-09-17
err0
errOAAI
errJarrett J. Adams; Levi L. Blazer; Jacky Chung; Minoo Karimi; Taylor Davidson; Heather A. Bruce; Alexander U. Singer; Ning Yang; Lia Cardarelli; Isabelle Pot; Luigi Colombo; Lily Jun-shen Huang; Yue Ma; Stephen W. Michnick; Orson W. Moe; Sachdev S. Sidhu
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errSave
Synthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activation
errPROTEIN SCIENCE
IF5.2
err2025-05-24
err0
errOAAI
errAdams, Jarrett J.; Bruce, Heather A.; Subramania, Suryasree; Ploder, Lynda; Garcia, Julia; Pot, Isabelle; Blazer, Levi L.; Singer, Alexander U.; Sidhu, Sachdev S.
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errSave
Molecular characterization of a synthetic neutralizing antibody targeting p67 of Theileria parva
errPROTEIN SCIENCE
IF5.2
err2025-05-19
err0
errOAAI
errMiersch, Shane; Singer, Alex U.; Chen, Chao; Fellouse, Fred; Gopalsamy, Anupriya; Silva e Costa, Luciano; Lacasta, Anna; Chege, Hannah; Chege, Naomi; Nene, Vishvanath; Sidhu, Sachdev S.
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errSave
Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia
errMolecular Therapy
IF12
err2025-05-05
err0
errOAAI
errSyed Feroj Ahmed; Jayanthi Anand; Wei Zhang; Lori Buetow; Loveena Rishi; Louise Mitchell; Jonathan Bohlen; Sergio Lilla; Gary J. Sibbet; Colin Nixon; Amrita Patel; Karolina A. Majorek; Sara Zanivan; Jacinta C. Bustamante; Sachdev S. Sidhu; Karen Blyth; Danny T. Huang
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errSave
Suppressing Tymovirus replication in plants using a variant of ubiquitin
errPLOS PATHOGENS
IF4.9
err2025-01-27
err0
errOAAI
errDe Silva, Anuradha; Kim, Kihun; Weiland, John; Hwang, Jihyun; Chung, Jacky; Pereira, Higor S.; Patel, Trushar R.; Teyra, Joan; Patel, Ankoor; Mira, Mohammed M.; Khajehpour, Mazdak; Bolton, Melvin; Stasolla, Claudio; Sidhu, Sachdev S.; Mark, Brian L.
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errSave
Structural and biophysical characterisation of ubiquitin variants that inhibit the ubiquitin conjugating enzyme Ube2d2
errFEBS JOURNAL
IF4.2
err2024-10-29
err0
PREAI
errMcAlpine, Jeffery M. R. B.; Zhu, Gene; Pudjihartono, Nicholas; Teyra, Joan; Currie, Michael J.; Tillett, Zachary D.; Dobson, Renwick C. J.; Sidhu, Sachdev S.; Day, Catherine L.; Middleton, Adam J.
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errSave
NOVEL CNS SENSING SYNNOTCH-CAR T CELLS FOR TARGETING DIFFUSE MIDLINE GLIOMA
errNEURO-ONCOLOGY
IF13.4
err2024-06-18
err0
errOAAI
errLakshmanachetty, Senthilnath; Simic, Milos; Haegelin, Jeffrey; Watchmaker, Payal; Long, Haoyu; Deucker, Jason; Zhu, Robert; Sheperd, Chanelle; Yu, Wei; Ng, Ben; Wang, Yuan; Troyanskaya, Olga; Cardarelli, Lia; Sidhu, Sachdev; Lim, Wendell; Okada, Hideho
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errSave
Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification
errDEVELOPMENT
IF3.6
err2024-03-04
err3
errOAAI
errYang, Andy; Chidiac, Rony; Russo, Emma; Steenland, Hendrik; Pauli, Quinn; Bonin, Robert; Blazer, Levi L.; Adams, Jarrett J.; Sidhu, Sachdev S.; Goeva, Aleksandrina; Salahpour, Ali; Angers, Stephane
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Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands (vol 4, 7951, 2023)
errNATURE COMMUNICATIONS
IF15.7
err2023-12-01
err0
errOAAI
errLinossi, Edmond M.; Li, Kunlun; Veggiani, Gianluca; Tan, Cyrus; Dehkhoda, Farhad; Hockings, Colin; Calleja, Dale J.; Keating, Narelle; Feltham, Rebecca; Brooks, Andrew J.; Li, Shawn S.; Sidhu, Sachdev S.; Babon, Jeffrey J.; Kershaw, Nadia J.; Nicholson, Sandra E.
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errSave
Cell-based passive immunization for protection against SARS-CoV-2 infection
errSTEM CELL RESEARCH & THERAPY
IF7.3
err2023-11-06
err1
errOAAI
errSawula, Evan; Miersch, Shane; Jong, Eric D.; Li, Chengjin; Chou, Fang-Yu; Tang, Jean Kit; Saberianfar, Reza; Harding, Jeffrey; Sidhu, Sachdev S.; Nagy, Andras
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errSave
Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids
errCELL REPORTS
IF6.9
err2023-11-01
err2
errOAAI
errAlsaadi, Abdulkhaliq; Artibani, Mara; Hu, Zhiyuan; Wietek, Nina; Morotti, Matteo; Gonzalez, Laura Santana; Alazzam, Moiad; Jiang, Jason; Abdul, Beena; Majd, Hooman Soleymani; Blazer, Levi L.; Adams, Jarret; Silvestri, Francesca; Sidhu, Sachdev S.; Brugge, Joan S.; Ahmed, Ahmed Ashour
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Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target
errNATURE CANCER
IF28.5
err2023-10-30
err4
errOAAI
errMandal, Kamal; Wicaksono, Gianina; Yu, Clinton; Adams, Jarrett J.; Hoopmann, Michael R.; Temple, William C.; Izgutdina, Adila; Escobar, Bonell Patino; Gorelik, Maryna; Ihling, Christian H.; Nix, Matthew A.; Naik, Akul; Xie, William H.; Hubner, Juwita; Rollins, Lisa A.; Reid, Sandy M.; Ramos, Emilio; Kasap, Corynn; Steri, Veronica; Serrano, Juan Antonio Camara; Salangsang, Fernando; Phojanakong, Paul; McMillan, Melanie; Gavallos, Victor; Leavitt, Andrew D.; Logan, Aaron C.; Rooney, Cliona M.; Eyquem, Justin; Sinz, Andrea; Huang, Benjamin J.; Stieglitz, Elliot; Smith, Catherine C.; Moritz, Robert L.; Sidhu, Sachdev S.; Huang, Lan; Wiita, Arun P.
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errSave
Activity-based profiling of cullin-RING E3 networks by conformation-specific probes
errNATURE CHEMICAL BIOLOGY
IF13.7
err2023-08-31
err12
errOAAI
errHenneberg, Lukas T.; Singh, Jaspal; Duda, David M.; Baek, Kheewoong; Yanishevski, David; Murray, Peter J.; Mann, Matthias; Sidhu, Sachdev S.; Schulman, Brenda A.
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errSave
Nebulization of pharmacological solutions with an innovative medical device based on microvaporization
errHELIYON
IF3.6
err2023-03-01
err1
errOAAI
errBrandimarte, Bruno; Businco, Lino Di Rienzo; Cappello, Francesco; Fiore, Roberto; Bastone, Giuseppe; Gualdi, Gianfranco; Sollaku, Saadi; Casciani, Emanuele; Tortorella, Federica; Longo, Pasquale; Centanini, Eleonora; Pavaci, Silva; Sangiuolo, Federica; Patrizi, Maria Patrizia; Miersch, Shane; Sidhu, Sachdev S.; Sacchini, Virgilio; Novelli, Giuseppe
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Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site
errPLOS PATHOGENS
IF4.9
err2022-12-22
err16
errOAAI
errvan Vliet, Vera J. E.; Huynh, Nhan; Pala, Judith; Patel, Ankoor; Singer, Alex; Slater, Cole; Chung, Jacky; van Huizen, Mariska; Teyra, Joan; Miersch, Shane; Luu, Gia-Khanh; Ye, Wei; Sharma, Nitin; Ganaie, Safder S.; Russell, Raquel; Chen, Chao; Maynard, Mindy; Amarasinghe, Gaya K.; Mark, Brian L.; Kikkert, Marjolein; Sidhu, Sachdev S.
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Research Directions

No research directions
Co-authors
Cooperation Journals
M
Matthias Mann
H-index: 250 · Papers: 1.4K
H
Hans Clevers
H-index: 236 · Papers: 1.3K
E
Edward H. Sargent
H-index: 213 · Papers: 1.2K
S
Steven P. Gygi
H-index: 195 · Papers: 1.0K
M
Michael Diamond
H-index: 160 · Papers: 1.5K
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