Not logged in KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRASG12V mutations and KRAS wild-type amplifications Tedeschi, Antonio; Peng, David H.; Schischlik, Fiorella; Herdeis, Lorenz; Schaaf, Otmar; Santoro, Valeria; Gerlach, Daniel; Savarese, Fabio; Lipp, Jesse; Haslinger, Christian; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunber, Tobias; Gmachl, Michael; Rumpel, Klaus; Rees, Matthew; Ron, Melissa; Roth, Jennifer; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
KRASmulti inhibitor BI 3706674, an orally bioavailable, direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRASG12V-driven preclinical models Peng, David Hwa; Tedeschi, Antonio; Herdeis, Lorenz; Schaaf, Otmar; Savarese, Fabio; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunberg, Tobias; Schischlik, Firoella; Lipp, Jesse; Williams, Mariah; Chandler, Vaness; Deckard, Charles E.; Ramamoorthy, Vandhana; Daniele, Joseph R.; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, TImothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
Chromosome 3 dosage-loss informs on the unique biology underlying ultra high-risk uveal melanoma Rose, Johnathon Lynn; Srinivasan, Sanjana; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Terranova, Christopher; Gay, Jason; Daniele, Joseph R.; Dmitriy, Loza; Peoples, Michael; Soeung, Melinda; Ramamoorthy, Vandhana; Shah, Parth; Soni, Sanjay; Bristow, Christopher; Wang, Fangyang; Lopez, Anastasia; Deckard, Charles; Meyers, Brooke; Perelli, Luigi; Wani, Khalida; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joe; Lazar, Alexander J.; Futreal, Andrew; Draetta, Giulio F.; Woodman, Scott E.; Heffernan, Timothy; Genovese, Giannicola; Carugo, Alessandro; Giuliani, Virginia Share Save
BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRAS G12V-driven preclinical models Peng, David H.; Tedeschi, Antonio; Herdeis, Lorenz; Savarese, Fabio; Rocchetti, Francesca; Johannes, Popow; Huber, Heinrich J.; Melillo, Nicola; Dickinson, Jake; Mistry, Hitesh B.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broker, Joachim; Wunberg, Tobias; Schischlik, Fiorella; Lipp, Jesse; Ramamoorthy, Vandhana; Daniele, Joseph R.; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in preclinical models and validates wild-type amplified KRAS as a therapeutic target Tedeschi, Antonio; Herdeis, Lorenz; Santoro, Valeria; Savarese, Fabio; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broker, Joachim; Wunberg, Tobias; Gmachl, Michael; Klaus, Rumpel; Schischlik, Fiorella; Lipp, Jesse; Peng, David H.; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Vellano, Christopher R.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea Share Save
Advanced preclinical modeling reveals unique monosomy 3 associated biology in late-stage uveal melanoma Rose, Johnathon L.; Srinivasan, Sanjana; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Gay, Jason; Daniele, Joseph R.; Peoples, Michael; Soeung, Melinda; Ramamoorthy, Vandhana; Lopez, Anastasia; Deckard, Charles; Meyers, Brooke; Del Poggetto, Edoardo; Zamler, Daniel; Huang, Justin; Perelli, Luigi; Wani, Khalida; Bristow, Christopher; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joe; Lazar, Alexander J.; Futreal, Andrew; Draetta, Giulio F.; Woodman, Scott E.; Heffernan, Timothy; Genovese, Giannicola; Carugo, Alessandro; Giuliani, Virginia Share Save
The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma Lamhamedi-Cherradi, Salah-Eddine; Maitituoheti, Mayinuer; Menegaz, Brian A.; Krishnan, Sandhya; Vetter, Amelia M.; Camacho, Pamela; Wu, Chia-Chin; Beird, Hannah C.; Porter, Robert W.; Ingram, Davis R.; Ramamoorthy, Vandhana; Mohiuddin, Sana; McCall, David; Truong, Danh D.; Cuglievan, Branko; Futreal, P. Andrew; Velasco, Alejandra Ruiz; Anvar, Nazanin Esmaeili; Utama, Budi; Titus, Mark; Lazar, Alexander J.; Wang, Wei-Lien; Rodriguez-Aguayo, Cristian; Ratan, Ravin; Livingston, John A.; Rai, Kunal; MacLeod, A. Robert; Daw, Najat C.; Hayes-Jordan, Andrea; Ludwig, Joseph A. Share Save
Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib Sun, Yuting; Meyers, Brooke A.; Czako, Barbara; Leonard, Paul; Mseeh, Faika; Harris, Angela L.; Wu, Qi; Johnson, Sarah; Parker, Connor A.; Cross, Jason B.; Di Francesco, Maria Emilia; Bivona, Benjamin J.; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gao, Guang; Gera, Sonal; Giuliani, Virginia; Huang, Justin K.; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Liu, Chiu-Yi; Lopez, Anastasia M.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Miller, Meredith A.; Mullinax, Robert A.; Peoples, Michael; Ramamoorthy, Vandhana; Seth, Sahil; Spencer, Nakia D.; Suzuki, Erika; Williams, Christopher C.; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save
Discovery of IACS-13909, an allosteric SHP2 inhibitor that overcomes multiple mechanisms underlying osimertinib resistance Sun, Yuting; Meyers, Brooke A.; Johnson, Sarah B.; Harris, Angela L.; Czako, Barbara; Cross, Jason B.; Leonard, Paul G.; Mseeh, Faika; Di Francesco, Maria E.; Parker, Connor A.; Wu, Qi; Bristow, Christopher A.; Burke, Jason P.; Carrillo, Caroline C.; Carroll, Christopher L.; Chang, Qing; Feng, Ningping; Gera, Sonal; Guang, Gao; Huang, Justin Kwang-Lay; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J.; Ma, Xiaoyan; Mandal, Pijus K.; McAfoos, Timothy; Mullinax, Robert A.; Peoples, Michael D.; Ramamoorthy, Vandhana; Seth, Sahil; Suzuki, Erika; Williams, Christopher Conrad; Yu, Simon S.; Zuniga, Andy M.; Draetta, Giulio F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Kohl, Nancy E.; Jones, Philip Share Save
Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state Echeverria, Gloria V.; Ge, Zhongqi; Seth, Sahil; Zhang, Xiaomei; Jeter-Jones, Sabrina; Zhou, Xinhui; Cai, Shirong; Tu, Yizheng; McCoy, Aaron; Peoples, Michael; Sun, Yuting; Qiu, Huan; Chang, Qing; Bristow, Christopher; Carugo, Alessandro; Shao, Jiansu; Ma, Xiaoyan; Harris, Angela; Mundi, Prabhjot; Lau, Rosanna; Ramamoorthy, Vandhana; Wu, Yun; Alvarez, Mariano J.; Califano, Andrea; Moulder, Stacy L.; Symmans, William F.; Marszalek, Joseph R.; Heffernan, Timothy P.; Chang, Jeffrey T.; Piwnica-Worms, Helen Share Save
High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer Echeverria, Gloria V.; Powell, Emily; Seth, Sahil; Ge, Zhongqi; Carugo, Alessandro; Bristow, Christopher; Peoples, Michael; Robinson, Frederick; Qiu, Huan; Shao, Jiansu; Jeter-Jones, Sabrina L.; Zhang, Xiaomei; Ramamoorthy, Vandhana; Cai, Shirong; Wu, Wenhui; Draetta, Giulio; Moulder, Stacy L.; Symmans, William F.; Chang, Jeffrey T.; Heffernan, Timothy P.; Piwnica-Worms, Helen Share Save
Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival Subbiah, Vivek; Lamhamedi-Cherradi, Salah-Eddine; Cuglievan, Branko; Menegaz, Brian A.; Camacho, Pamela; Huh, Winston; Ramamoorthy, Vandhana; Anderson, Pete M.; Pollock, Raphael E.; Lev, Dina C.; Qiao, Wei; McAleer, Mary Frances; Benjamin, Robert S.; Patel, Shreyaskumar; Herzog, Cynthia E.; Daw, Najat C.; Feig, Barry W.; Lazar, Alexander J.; Hayes-Jordan, Andrea; Ludwig, Joseph A. Share Save
IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma Lamhamedi-Cherradi, Salah-Eddine; Menegaz, Brian A.; Ramamoorthy, Vandhana; Vishwamitra, Deeksha; Wang, Ying; Maywald, Rebecca L.; Buford, Adriana S.; Fokt, Izabela; Skora, Stanislaw; Wang, Jing; Naing, Aung; Lazar, Alexander J.; Rohren, Eric M.; Daw, Najat C.; Subbiah, Vivek; Benjamin, Robert S.; Ratan, Ravin; Priebe, Waldemar; Mikos, Antonios G.; Amin, Hesham M.; Ludwig, Joseph A. Share Save
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Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression Wang, Guocan; Lu, Xin; Dey, Prasenjit; Deng, Pingna; Wu, Chia Chin; Jiang, Shan; Fang, Zhuangna; Zhao, Kuo; Konaparthi, Ramakrishna; Hua, Sujun; Zhang, Jianhua; Li-Ning-Tapia, Elsa M.; Kapoor, Avnish; Wu, Chang-Jiun; Patel, Neelay Bhaskar; Guo, Zhenglin; Ramamoorthy, Vandhana; Tieu, Trang N.; Heffernan, Tim; Zhao, Di; Shang, Xiaoying; Khadka, Sunada; Hou, Pingping; Hu, Baoli; Jin, Eun-Jung; Yao, Wantong; Pan, Xiaolu; Ding, Zhihu; Shi, Yanxia; Li, Liren; Chang, Qing; Troncoso, Patricia; Logethetis, Christopher J.; McArthur, Mark J.; Chin, Lynda; Wang, Y. Alan; DePinho, Ronaldo A. Share Save
An Oral Formulation of YK-4-279: Preclinical Efficacy and Acquired Resistance Patterns in Ewing Sarcoma Lamhamedi-Cherradi, Salah-Eddine; Menegaz, Brian A.; Ramamoorthy, Vandhana; Aiyer, Ramani A.; Maywald, Rebecca L.; Buford, Adrianna S.; Doolittle, Dannette K.; Culotta, Kirk S.; O'Dorisio, James E.; Ludwig, Joseph A. Share Save
Modeling Ewing sarcoma tumors in vitro with 3D scaffolds Fong, Eliza Li Shan; Lamhamedi-Cherradi, Salah-Eddine; Burdett, Emily; Ramamoorthy, Vandhana; Lazar, Alexander J.; Kasper, F. Kurtis; Farach-Carson, Mary C.; Vishwamitra, Deeksha; Demicco, Elizabeth G.; Menegaz, Brian A.; Amin, Hesham M.; Mikos, Antonios G.; Ludwig, Joseph A. Share Save
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