Not logged inIdentification of highly selective SIK 1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation
Babbe, Holger; Sundberg, Thomas B.; Tichenor, Mark; Seierstad, Mark; Bacani, Genesis; Berstler, James; Chai, Wenying; Chang, Leon; Chung, De Michael; Coe, Kevin; Collins, Bernard; Finley, Michael; Guletsky, Alexander; Lemke, Christopher T.; Mak, Puiying A.; Mathur, Ashok; Mercado-Marin, Eduardo, V; Metkar, Shailesh; Raymond, Donald D.; Rives, Marie -Laure; Rizzolio, Michele; Shaffer, Paul L.; Smith, Russell; Smith, Jacqueline; Steele, Ruth; Steffens, Helena; Suarez, Javier; Tian, Gaochao; Majewski, Nathan; Volak, Laurie P.; Wei, Jianmei; Desai, Prerak T.; Ong, Luvena L.; Koudriakova, Tatiana; Goldberg, Steven D.; Hirst, Gavin; Kaushik, Virendar K.; Ort, Tatiana; Seth, Nilufer; Graham, Daniel B.; Plevy, Scott; Venable, Jennifer D.; Xavier, Ramnik J.; Towne, Jennifer E. .png)
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SavePreclinical Serological Signatures are Associated With Complicated Crohn's Disease Phenotype at DiagnosisChoung, Rok Seon; Petralia, Francesca; Torres, Joana; Ungaro, Ryan C.; Porter, Chad; Sato, Takahiro; Telesco, Shannon; Strauss, Richard S.; Plevy, Scott; Princen, Fred; Riddle, Mark S.; Murray, Joseph A.; Colombel, Jean Frederic Share Save Share Save Neutralizing Anti-Granulocyte Macrophage-Colony Stimulating Factor Autoantibodies Recognize Post-Translational Glycosylations on Granulocyte Macrophage-Colony Stimulating Factor Years Before Diagnosis and Predict Complicated Crohn's DiseaseMortha, Arthur; Remark, Romain; Del Valle, Diane Marie; Chuang, Ling-Shiang; Chai, Zhi; Alves, Ines; Azevedo, Catarina; Gaifem, Joana; Martin, Jerome; Petralia, Francesca; Tuballes, Kevin; Barcessat, Vanessa; Tai, Siu Ling; Huang, Hsin-Hui; Laface, Ilaria; Jerez, Yeray Arteaga; Boschetti, Gilles; Villaverde, Nicole; Wang, Mona D.; Korie, Ujunwa M.; Murray, Joseph; Choung, Rok-Seon; Sato, Takahiro; Laird, Renee M.; Plevy, Scott; Rahman, Adeeb; Torres, Joana; Porter, Chad; Riddle, Mark S.; Kenigsberg, Ephraim; Pinho, Salome S.; Cho, Judy H.; Merad, Miriam; Colombel, Jean-Frederic; Gnjatic, Sacha Share Save Serum Biomarkers Identify Patients Who Will Develop Inflammatory Bowel Diseases Up to 5 Years Before DiagnosisTorres, Joana; Petralia, Francesca; Sato, Takahiro; Wang, Pei; Telesco, Shannon E.; Choung, Rok Seon; Strauss, Richard; Li, Xiao-Jun; Laird, Renee M.; Gutierrez, Ramiro L.; Porter, Chad K.; Plevy, Scott; Princen, Fred; Murray, Joseph A.; Riddle, Mark S.; Colombel, Jean-Frederic Share Save Share Save Share Save Dietary iron variably modulates assembly of the intestinal microbiota in colitis-resistant and colitis-susceptible miceEllermann, Melissa; Gharaibeh, Raad Z.; Maharshak, Nitsan; Perez-Chanona, Ernesto; Jobin, Christian; Carroll, Ian M.; Arthur, Janelle C.; Plevy, Scott E.; Fodor, Anthony A.; Brouwer, Cory R.; Sartor, R. Balfour Share Save Share Save A molecular measure of inflammation in IBD patients based on transcriptional profiles from 2495 intestinal biopsiesHuang, R.; Irizar, H.; Kosoy, R.; Song, W. -M.; Dinarzo, A.; Hao, K.; Rogers, J.; Atreja, A.; Mahajan, M.; Stojmirovic, A.; Perrigoue, J.; Brodmerkel, C.; Plevy, S.; Friedman, J.; Colombel, J. -F.; Dubinsky, M.; Sands, B.; Schadt, E.; Kasarskis, A.; Losic, B.; Argmann, C.; Suarez-Farinas, M. Share Save A colonic gene expression signature predicts non-response to anti-inflammatory therapies in inflammatory bowel diseaseSato, T.; Li, K.; Hayden, K.; Tomsho, L.; Baribaud, F.; Brodmerkel, C.; Greenbaum, L. E.; Friedman, J. R.; Curran, M.; Imai, Y.; Plevy, S.; Telesco, S. E. Share Save Gut microbiota density influences host physiology and is shaped by host and microbial factorsContijoch, Eduardo J.; Britton, Graham J.; Yang, Chao; Mogno, Ilaria; Li, Zhihua; Ng, Ruby; Llewellyn, Sean R.; Hira, Sheela; Johnson, Crystal; Rabinowitz, Keren M.; Barkan, Revital; Dotan, Iris; Hirten, Robert P.; Fu, Shih-Chen; Luo, Yuying; Yang, Nancy; Luong, Tramy; Labrias, Philippe R.; Lira, Sergio; Peter, Inga; Grinspan, Ari; Clemente, Jose C.; Kosoy, Roman; Kim-Schulze, Seunghee; Qin, Xiaochen; Castillo, Anabella; Hurley, Amanda; Atreja, Ashish; Rogers, Jason; Fasihuddin, Farah; Saliaj, Merjona; Nolan, Amy; Reyes-Mercedes, Pamela; Rodriguez, Carina; Aly, Sarah; Santa-Cruz, Kenneth; Peters, Lauren; Suarez-Farinas, Mayte; Huang, Ruiqi; Hao, Ke; Zhu, Jun; Zhang, Bin; Losic, Bojan; Irizar, Haritz; Song, Won-Min; Di Narzo, Antonio; Wang, Wenhui; Cohen, Benjamin L.; DiMaio, Christopher; Greenwald, David; Itzkowitz, Steven; Lucas, Aimee; Marion, James; Maser, Elana; Ungaro, Ryan; Naymagon, Steven; Novak, Joshua; Shah, Brijen; Ullman, Thomas; Rubin, Peter; George, James; Legnani, Peter; Telesco, Shannon E.; Friedman, Joshua R.; Brodmerkel, Carrie; Plevy, Scott; Cho, Judy H.; Colombel, Jean-Frederic; Schadt, Eric E.; Argmann, Carmen; Dubinsky, Marla; Kasarskis, Andrew; Sands, Bruce; Faith, Jeremiah J. Share Save Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse ModelGoettel, Jeremy A.; Kotlarz, Daniel; Emani, Rohini; Canavan, James B.; Konnikova, Liza; Illig, David; Frei, Sandra M.; Field, Michael; Kowalik, Matthew; Peng, Kaiyue; Gringauz, Jordan; Mitsialis, Vanessa; Wall, Sarah M.; Tsou, Amy; Griffith, Alexandra E.; Huang, Ying; Friedman, Joshua R.; Towne, Jennifer E.; Plevy, Scott E.; Hall, Aisling O'Hara; Snapper, Scott B. Share Save Gene Expression Signature for Prediction of Golimumab Response in a Phase 2a Open-Label Trial of Patients With Ulcerative ColitisTelesco, Shannon E.; Brodmerkel, Carrie; Zhang, Hongyan; Kim, Lilianne (Lee-Lian); Johanns, Jewel; Mazumder, Abhijit; Li, Katherine; Baribaud, Frederic; Curran, Mark; Strauss, Richard; Paxson, Bethany; Plevy, Scott; Davison, Timothy; Knight, Laura; Dibben, Sian; Schreiber, Stefan; Sandborn, William; Rutgeerts, Paul; Siegel, Corey A.; Reinisch, Walter; Greenbaum, Linda E. Share Save Share Save NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth (vol 18, pg 541, 2017)Chen, Liang; Wilson, Justin E.; Koenigsknecht, Mark J.; Chou, Wei-Chun; Montgomery, Stephanie A.; Truax, Agnieszka D.; Brickey, W. June; Packey, Christopher D.; Maharshak, Nitsan; Matsushima, Glenn K.; Plevy, Scott E.; Young, Vincent B.; Sartor, R. Balfour; Ting, Jenny P-Y Share Save NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth (vol 18, pg 541, 2017)Chen, Liang; Wilson, Justin E.; Koenigsknecht, Mark J.; Chou, Wei-Chun; Montgomery, Stephanie A.; Truax, Agnieszka D.; Brickey, W. June; Packey, Christopher D.; Maharshak, Nitsan; Matsushima, Glenn K.; Plevy, Scott E.; Young, Vincent B.; Sartor, R. Balfour; Ting, Jenny P-Y Share Save NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growthChen, Liang; Wilson, Justin E.; Koenigsknecht, Mark J.; Chou, Wei-Chun; Montgomery, Stephanie A.; Truax, Agnieszka D.; Brickey, W. June; Packey, Christopher D.; Maharshak, Nitsan; Matsushima, Glenn K.; Plevy, Scott E.; Young, Vincent B.; Sartor, R. Balfour; Ting, Jenny P-Y Share Save Share Save Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn's Disease After Ileocolonic ResectionRegueiro, Miguel; Feagan, Brian G.; Zou, Bin; Johanns, Jewel; Blank, Marion A.; Chevrier, Marc; Plevy, Scott; Popp, John; Cornillie, Freddy J.; Lukas, Milan; Danese, Silvio; Gionchetti, Paolo; Hanauer, Stephen B.; Reinisch, Walter; Sandborn, William J.; Sorrentino, Dario; Rutgeerts, Paul Share Save 
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