Not logged in Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor O'Brien, Darragh P.; Jones, Hannah B. L.; Shi, Yuqi; Guenther, Franziska; Vendrell, Iolanda; Viner, Rosa; Brennan, Paul E.; Mead, Emma; Zarganes-Tzitzikas, Tryfon; Davis, John B.; Pinto-Fernandez, Adan; England, Katherine S.; Murphy, Emma J.; Turnbull, Andrew P.; Kessler, Benedikt M. Share Save
Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides O'Brien, Darragh P.; Jones, Hannah B. L.; Guenther, Franziska; Murphy, Emma J.; England, Katherine S.; Vendrell, Iolanda; Anderson, Malcolm; Brennan, Paul E.; Davis, John B.; Turnbull, Andrew P.; Kessler, Benedikt M.; Pinto-Fernandez, Adan Share Save
Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson's disease models Williamson, Matthew G.; Madureira, Marta; McGuinness, William; Heon-Roberts, Rachel; Mock, Elliot D.; Naidoo, Kalina; Cramb, Kaitlyn M. L.; Caiazza, Maria-Claudia; Malpartida, Ana B.; Lavelle, Martha; Savory, Katrina; Humble, Stewart W.; Patterson, Ryan; Davis, John B.; Connor-Robson, Natalie; Ryan, Brent J.; Wade-Martins, Richard Share Save
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Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function Carling, Phillippa J.; Ryan, Brent J.; McGuinness, William; Kataria, Shikha; Humble, Stewart W.; Milde, Stefan; Duce, James A.; Kapadia, Nirav; Zuercher, William J.; Davis, John B.; Di Daniel, Elena; Wade-Martins, Richard Share Save
A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation (vol 11, 15319, 2021) Nizami, Sohaib; Millar, Val; Arunasalam, Kanisa; Zarganes-Tzitzikas, Tryfon; Brough, David; Tresadern, Gary; Brennan, Paul E.; Davis, John B.; Ebner, Daniel; Di Daniel, Elena Share Save
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A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation Nizami, Sohaib; Millar, Val; Arunasalam, Kanisa; Zarganes-Tzitzikas, Tryfon; Brough, David; Tresadern, Gary; Brennan, Paul E.; Davis, John B.; Ebner, Daniel; Di Daniel, Elena Share Save
TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages Hall-Roberts, Hazel; Agarwal, Devika; Obst, Juliane; Smith, Thomas B.; Monzon-Sandoval, Jimena; Di Daniel, Elena; Webber, Caleb; James, William S.; Mead, Emma; Davis, John B.; Cowley, Sally A. Share Save
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Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl- channel modulation Swanton, Tessa; Beswick, James A.; Hammadi, Halah; Morris, Lucy; Williams, Daniel; de Cesco, Stephane; El-Sharkawy, Lina; Yu, Shi; Green, Jack; Davis, John B.; Lawrence, Catherine B.; Brough, David; Freeman, Sally Share Save
Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology Horsburgh, Karen; Wardlaw, Joanna M.; van Agtmael, Tom; Allan, Stuart M.; Ashford, Mike L. J.; Bath, Philip M.; Brown, Rosalind; Berwick, Jason; Cader, M. Zameel; Carare, Roxana O.; Davis, John B.; Duncombe, Jessica; Farr, Tracy D.; Fowler, Jill H.; Goense, Jozien; Granata, Alessandra; Hall, Catherine N.; Hainsworth, Atticus H.; Harvey, Adam; Hawkes, Cheryl A.; Joutel, Anne; Kalaria, Rajesh N.; Kehoe, Patrick G.; Lawrence, Catherine B.; Lockhart, Andy; Love, Seth; Macleod, Malcolm R.; Macrae, I. Mhairi; Markus, Hugh S.; McCabe, Chris; McColl, Barry W.; Meakin, Paul J.; Miller, Alyson; Nedergaard, Maiken; O'Sullivan, Michael; Quinn, Terry J.; Rajani, Rikesh; Saksida, Lisa M.; Smith, Colin; Smith, Kenneth J.; Touyz, Rhian M.; Trueman, Rebecca C.; Wang, Tao; Williams, Anna; Williams, Steven C. R.; Work, Lorraine M. Share Save
A standardized clinical evaluation of phenotypic diversity in diabetic polyneuropathy Scholz, Joachim; Rathmell, James P.; David, William S.; Chad, David A.; Broderick, Alithia C.; Perros, Stephen G.; Shin, Naomi S.; Wells, Jenna L.; Davis, John B.; DiMaggio, Charles J.; Wang, Shuang; Tate, Simon N. Share Save
Down-regulation of the ATP-binding Cassette Transporter 2 (Abca2) Reduces Amyloid-β Production by Altering Nicastrin Maturation and Intracellular Localization Michaki, Vasiliki; Guix, Francesc X.; Vennekens, Krist'l; Munck, Sebastian; Dingwall, Colin; Davis, John B.; Townsend, Danyelle M.; Tew, Kenneth D.; Feiguin, Fabian; De Strooper, Bart; Dotti, Carlos G.; Wahle, Tina Share Save
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Xenon reduces activation of transient receptor potential vanilloid type 1 (TRPV1) in rat dorsal root ganglion cells and in human TRPV1-expressing HEK293 cells White, John P. M.; Calcott, Guy; Jenes, Agnes; Hossein, Mahmuda; Paule, Cleoper C.; Santha, Peter; Davis, John B.; Ma, Daqing; Rice, Andrew S. C.; Nagy, Istvan Share Save
Neurogenic responses mediated by vanilloid receptor-1 (TRPV1) are blocked by the high affinity antagonist, iodo-resiniferatoxin Rigoni, M; Trevisani, M; Gazzieri, D; Nadaletto, R; Tognetto, M; Creminon, C; Davis, JB; Campi, B; Amadesi, S; Geppetti, P; Harrison, S Share Save
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide Bisogno, T; Hanus, L; De Petrocellis, L; Tchilibon, S; Ponde, DE; Brandi, I; Moriello, AS; Davis, JB; Mechoulam, R; Di Marzo, V Share Save
GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models Medhurst, Andrew D.; Atkins, Alan R.; Beresford, Isabel J.; Brackenborough, Kim; Briggs, Michael A.; Calver, Andrew R.; Cilia, Jackie; Cluderay, Jane E.; Crook, Barry; Davis, John B.; Davis, Rebecca K.; Davis, Robert P.; Dawson, Lee A.; Foley, Andrew G.; Gartlon, Jane; Gonzalez, M. Isabel; Heslop, Teresa; Hirst, Warren D.; Jennings, Carol; Jones, Declan N. C.; Lacroix, Laurent P.; Martyn, Abbe; Ociepka, Sandrine; Ray, Alison; Regan, Ciaran M.; Roberts, Jennifer C.; Schogger, Joanne; Southam, Eric; Stean, Tania O.; Trail, Brenda K.; Upton, Neil; Wadsworth, Graham; Wald, Jeffrey A.; White, Trevor; Witherington, Jason; Woolley, Marie L.; Worby, Angela; Wilson, David M. Share Save
Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat- mediated activation of the receptor Gunthorpe, Martin J.; Hannan, Sara Luis; Smart, Darren; Jerman, Jeffrey C.; Arpino, Sandra; Smith, Graham D.; Brough, Stephen; Wright, Jim; Egerton, Julie; Lappin, Sarah C.; Holland, Vicky A.; Winborn, Kim; Thompson, Mervyn; Rami, Harshad K.; Randall, Andrew; Davis, John B. Share Save
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