Not logged in Small molecule inhibitor of FEN1 nuclease utilizing a novel metal-binding pharmacophore synergizes with inhibitors of USP1, PARP, PARG and ATR Munguia, Jason; Agarwalla, Sanjay; Guo, Elaine; Martin, Dave; Fan, Junhua; Lonergan, Dave; Puerta, David; Zimmerman, Zachary; Taganov, Konstantin Share Save
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Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe Bhowmik, Shiva; Jones, David H.; Chiu, Hsien-Po; Park, In-Hee; Chiu, Hsiu-Ju; Axelrod, Herbert L.; Farr, Carol L.; Tien, Henry J.; Agarwalla, Sanjay; Lesley, Scott A. Share Save
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A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy Pethe, Kevin; Sequeira, Patricia C.; Agarwalla, Sanjay; Rhee, Kyu; Kuhen, Kelli; Phong, Wai Yee; Patel, Viral; Beer, David; Walker, John R.; Duraiswamy, Jeyaraj; Jiricek, Jan; Keller, Thomas H.; Chatterjee, Arnab; Tan, Mai Ping; Ujjini, Manjunatha; Rao, Srinivasa P. S.; Camacho, Luis; Bifani, Pablo; Mak, Puiying A.; Ma, Ida; Barnes, S. Whitney; Chen, Zhong; Plouffe, David; Thayalan, Pamela; Ng, Seow Hwee; Au, Melvin; Lee, Boon Heng; Tan, Bee Huat; Ravindran, Sindhu; Nanjundappa, Mahesh; Lin, Xiuhua; Goh, Anne; Lakshminarayana, Suresh B.; Shoen, Carolyn; Cynamon, Michael; Kreiswirth, Barry; Dartois, Veronique; Peters, Eric C.; Glynne, Richard; Brenner, Sydney; Dick, Thomas Share Save
Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 Å resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy3-keto-5-methylthiopentenyl-1-phosphate Xu, Qingping; Saikatendu, Kumar Singh; Krishna, S. Sri; McMullan, Daniel; Abdubek, Polat; Agarwalla, Sanjay; Ambing, Eileen; Astakhova, Tamara; Axelrod, Herbert L.; Carlton, Dennis; Chiu, Hsiu-Ju; Clayton, Thomas; DiDonato, Michael; Duan, Lian; Elsliger, Marc-Andr; Feuerhelm, Julie; Grzechnik, Slawomir K.; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Koesema, Eric; Miller, Mitchell D.; Morse, Andrew T.; Nigoghossian, Edward; Mach, Linda; Oommachen, Silvya; Paulsen, Jessica; Reyes, Ron; Rife, Christopher L.; Schwarzenbacher, Robert; van den Bedem, Henry; White, Aprilfawn; Wolf, Guenter; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A. Share Save
Crystal structure of homoserine O-succinyltransferase from Bacillus cereus at 2.4 Å resolution Zubieta, Chloe; Krishna, S. Sri; McMullan, Daniel; Miller, Mitchell D.; Abdubek, Polat; Agarwalla, Sanjay; Ambing, Eileen; Astakhova, Tamara; Axelrod, Herbert L.; Carlton, Dennis; Chiu, Hsiu-Ju; Clayton, Thomas; Deller, Marc; DiDonato, Michael; Duan, Lian; Elsliger, Marc-Andre; Grzechnik, Slawomir K.; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Koesema, Eric; Kumar, Abhinav; Marciano, David; Morse, Andrew T.; Nigoghossian, Edward; Oommachen, Silvya; Reyes, Ron; Rife, Christopher L.; van den Bedem, Henry; Weekes, Dana; White, Aprilfawn; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A. Share Save
Comparative structural analysis of a novel glutathione S-transferase (Atu5508) from Agrobacterium tumefaciens at 2.0 Å resolution Kosloff, Mickey; Han, Gye Won; Krishna, S. Sri; Schwarzenbacher, Robert; Fasnacht, Marc; Elsliger, Marc-Andre; Abdubek, Polat; Agarwalla, Sanjay; Ambing, Eileen; Astakhova, Tamara; Axelrod, Herbert L.; Canaves, Jaume M. .; Carlton, Dennis; Chiu, Hsiu-Ju; Clayton, Thomas; DiDonato, Michael; Duan, Lian; Feuerhelm, Julie; Grittini, Carina; Grzechnik, Slawomir K.; Hale, Joanna; Hampton, Eric; Haugen, Justin; Jaroszewski, Lukasz; Jin, Kevin K.; Johnson, Hope; Klock, Heath E.; Knuth, Mark W.; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Levin, Inna; McMullan, Daniel; Miller, Mitchell D.; Morse, Andrew T.; Moy, Kin; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Page, Rebecca; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Rife, Christopher L.; Sims, Eric; Spraggon, Glen; Sridhar, Vandana; Stevens, Raymond C.; van den Bedem, Henry; Velasquez, Jeff; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A. Share Save
Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 Å resolution reveals a fold similar to the Ran-binding protein Mog1p Xu, Qingping; Krishna, S. Sri; McMullan, Daniel; Schwarzenbacher, Robert; Miller, Mitchell D.; Abdubek, Polat; Agarwalla, Sanjay; Ambing, Eileen; Astakhova, Tamara; Axelrod, Herbert L.; Canaves, Jaume M.; Carlton, Dennis; Chiu, Hsiu-Ju; Clayton, Thomas; DiDonato, Michael; Duan, Lian; Elsliger, Marc-Andre; Feuerhelm, Julie; Grzechnik, Slawomir K.; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Morse, Andrew T.; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Rife, Christopher L.; Spraggon, Glen; Stevens, Raymond C.; van den Bedem, Henry; White, Aprilfawn; Wolf, Guenter; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A. Share Save
Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2.6 Å resolution reveals a new fold with a novel active site DiDonato, Michael; Krishna, S. Sri; Schwarzenbacher, Robert; McMullan, Daniel; Agarwalla, Sanjay; Brittain, Scott M.; Miller, Mitchell D.; Abdubek, Polat; Ambing, Eileen; Axelrod, Herbert L.; Canaves, Jaume M.; Chiu, Hsiu-Ju; Deacon, Ashley M.; Duan, Lian; Elsliger, Marc-Andre; Godzik, Adam; Grzechnik, Slawomir K.; Hale, Joanna; Hampton, Eric; Haugen, Justin; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A.; Levin, Inna; Morse, Andrew T.; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Rife, Christopher L.; Spraggon, Glen; Stevens, Raymond C.; van den Bedem, Henry; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Wilson, Ian A. Share Save
Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 Å resolution Mathews, Irimpan I.; Krishna, S. Sri; Schwarzenbacher, Robert; McMullan, Daniel; Jaroszewski, Lukasz; Miller, Mitchell D.; Abdubek, Polat; Agarwalla, Sanjay; Ambing, Eileen; Axelrod, Herbert L.; Canaves, Jaume M.; Carlton, Dennis; Chiu, Hsiu-Ju; Clayton, Thomas; DiDonato, Michael; Duan, Lian; Elsliger, Marc-Andre; Grzechnik, Slawomir K.; Hale, Joanna; Hampton, Eric; Haugen, Justin; Jin, Kevin K.; Klock, Heath E.; Koesema, Eric; Kovarik, John S.; Kreusch, Andreas; Kuhn, Peter; Levin, Inna; Morse, Andrew T.; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Rife, Christopher L.; Spraggon, Glen; Stevens, Raymond C.; van den Bedem, Henry; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A. Share Save
Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 A resolution Xu, Qingping; Schwarzenbacher, Robert; Krishna, S. Sri; McMullan, Daniel; Agarwalla, Sanjay; Quijano, Kevin; Abdubek, Polat; Ambing, Eileen; Axelrod, Herbert; Biorac, Tanya; Canaves, Jaume M.; Chiu, Hsiu-Ju; Elsliger, Marc-Andre; Grittini, Carina; Grzechnik, Slawomir K.; DiDonato, Michael; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Hornsby, Michael; Jaroszewski, Lukasz; Klock, Heath E.; Knuth, Mark W.; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Miller, Mitchell D.; Moy, Kin; Nigoghossian, Edward; Paulsen, Jessica; Reyes, Ron; Rife, Chris; Spraggon, Glen; Stevens, Raymond C.; Van den Bedem, Henry; Velasquez, Jeff; White, Aprilfawn; Wolf, Guenter; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A. Share Save
Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1.58 Å Resolution Han, Gye Won; Krishna, S. Sri; Schwarzenbacher, Robert; McMullan, Daniel; Ginalski, Krzysztof; Elsliger, Marc-Andre; Brittain, Scott M.; Abdubek, Polat; Agarwalla, Sanjay; Ambing, Eileen; Astakhova, Tamara; Axelrod, Herbert; Canaves, Jaume M.; Chin, Hsiu-Ju; DiDonato, Michael; Grzechnik, Slawomir K.; Hale, Joanna; Hampton, Eric; Haugen, Justin; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Miller, Mitchell D.; Morse, Andrew T.; Moy, Kin; Nigoghossian, Edward; Oommachen, Sylvia; Ouyang, Jie; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Rife, Chris; Spraggon, Glen; Stevens, Raymond C.; van den Bedem, Henry; Velasquez, Jeff; Wang, Xianhong; West, Bill; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A. Share Save
Crystal structure of TM1367 from Thermotoga maritima at 1.90 Å resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold Jin, Kevin Kai; Krishna, S. Sri; Schwarzenbacher, Robert; McMullan, Daniel; Abdubek, Polat; Agarwalla, Sanjay; Ambing, Eileen; Axelrod, Herbert; Canaves, Jaume M.; Chiu, Hsiu-Ju; Deacon, Ashley M.; DiDonato, Michael; Elsliger, Marc-Andre; Feuerhelm, Julie; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K.; Hale, Joanna; Hampton, Eric; Haugen, Justin; Hornsby, Michael; Jaroszewski, Lukasz; Klock, Heath E.; Knuth, Mark W.; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A.; Miller, Mitchell D.; Moy, Kin; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Rife, Chris; Stevens, Raymond C.; Spraggon, Glen; van den Bedem, Henry; Velasquez, Jeff; White, Aprilfawn; Wolf, Guenter; Han, Gye Won; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Wilson, Ian A. Share Save
Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 A resolution DiDonato, M; Krishna, SS; Schwarzenbacher, R; McMullan, D; Jaroszewski, L; Miller, MD; Abdubek, M; Agarwalla, S; Ambing, E; Axelrod, H; Biorac, T; Chiu, HJ; Deacon, AM; Elsliger, MA; Feuerhelm, J; Godzik, A; Grittini, C; Grzechnik, SK; Hale, J; Hampton, E; Haugen, J; Hornsby, M; Klock, HE; Knuth, MW; Koesema, E; Kreusch, A; Kuhn, P; Lesley, SA; Moy, K; Nigoghossian, E; Okach, L; Paulsen, J; Quijano, K; Reyes, R; Rife, C; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; White, A; Wolf, G; Xu, QP; Hodgson, KO; Wooley, J; Wilson, IA Share Save
Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 Å resolution reveals a new fold Xu, QP; Schwarzenbacher, R; McMullan, D; Abdubek, P; Agarwalla, S; Ambing, E; Axelrod, H; Biorac, T; Canaves, JM; Chin, HJ; Deacon, AM; DiDonato, M; Elsliger, MA; Godzik, A; Grittini, C; Grzechnik, SK; Hale, J; Hampton, E; Han, GW; Haugen, J; Hornsby, M; Jaroszewski, L; Klock, HE; Koesema, E; Kreusch, A; Kuhn, P; Lesley, SA; Miller, MD; Moy, K; Nigoghossian, E; Paulsen, J; Quijano, K; Reyes, R; Rife, C; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; White, A; Wolf, G; Hodgson, KO; Wooley, J; Wilson, IA Share Save
Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2.20 Å resolution Jaroszewski, L; Schwarzenbacher, R; McMullan, D; Abdubek, P; Agarwalla, S; Ambing, E; Axelrod, H; Biorac, T; Canaves, JM; Chiu, HJ; Deacon, AM; DiDonato, M; Elsliger, MA; Godzik, A; Grittini, C; Grzechnik, SK; Hale, J; Hampton, E; Han, GW; Haugen, J; Hornsby, M; Klock, HE; Koesema, E; Kreusch, A; Kuhn, P; Lesley, SA; Miller, MD; Moy, K; Nigoghossian, E; Paulsen, J; Quijano, K; Reyes, R; Rife, C; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; White, A; Wolf, G; Xu, QP; Hodgson, KO; Wooley, J; Wilson, IA Share Save
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