Emily M. Gesner - Publications, H-index & Citations

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Emily M. Gesner

university of alberta

11H-index

56Paper Count

1.1KCitation Count

Published Papers 12

Publication Date

Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2

ACS OMEGA

IF4.3

2021-08-09

OAAI

Melin, Lea; Gesner, Emily; Attwell, Sarah; Kharenko, Olesya A.; van der Horst, Edward H.; Hansen, Henrik C.; Gagnon, Alexandre

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BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program

CLINICAL CANCER RESEARCH

IF10.2

2021-06-18

OAAI

Kim, Dae-Hwan; Sun, Duanchen; Storck, William K.; Leng, Katherine Welker; Jenkins, Chelsea; Coleman, Daniel J.; Sampson, David; Guan, Xiangnan; Kumaraswamy, Anbarasu; Rodansky, Eva S.; Urrutia, Joshua A.; Schwartzman, Jacob A.; Zhang, Chao; Beltran, Himisha; Labrecque, Mark P.; Morrissey, Colm; Lucas, Jared M.; Coleman, Ilsa M.; Nelson, Peter S.; Corey, Eva; Handelman, Samuel K.; Sexton, Jonathan Z.; Aggarwal, Rahul; Abida, Wassim; Feng, Felix Y.; Small, Eric J.; Spratt, Daniel E.; Bankhead, Armand, III; Rao, Arvind; Gesner, Emily M.; Attwell, Sarah; Lakhotia, Sanjay; Campeau, Eric; Yates, Joel A.; Xia, Zheng; Alumkal, Joshi J.

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Preclinical characterization of ZEN-3694, a novel BET bromodomain inhibitor entering phase I studies for metastatic castration-resistant prostate cancer (mCRPC)

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Attwell, Sarah; Jahagirdar, Ravi; Norek, Karen; Calosing, Cyrus; Tsujikawa, Laura; Kharenko, Olesya A.; Patel, Reena G.; Gesner, Emily M.; Corey, Eva; Nguyen, Holly M.; Lakhotia, Sanjay; Hansen, Henrik C.; Campeau, Eric

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ZEN3365 is a novel BET bromodomain inhibitor for the treatment of hematologic malignancies and solid tumors

EUROPEAN JOURNAL OF CANCER

IF7.1

2014-11-01

PREAI

McLure, K. G.; Jahagirdar, R.; Kharenko, O. A.; Gesner, E. M.; Campeau, E.; Gilham, D.; Wu, J.; Tsujikawa, L.; Attwell, S.; Calosing, C.; Sharma, N.; Tobin, J.; Hansen, H. C.

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Role of pri-miRNA tertiary structure in miR-17∼92 miRNA biogenesis

RNA BIOLOGY

IF3.4

2014-10-27

OAAI

Chaulk, Steven G.; Thede, Gina L.; Kent, Oliver A.; Xu, Zhizhong; Gesner, Emily M.; Veldhoen, Richard A.; Khanna, Suneil K.; Goping, Ing Swie; MacMillan, Andrew M.; Mendell, Joshua T.; Young, Howard S.; Fahlman, Richard P.; Glover, J. N. Mark

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BET bromodomain inhibitors abrogate cell cycle progression and induces apoptosis in Myc-induced mouse lymphoma cells without affecting MYC transcription

CANCER RESEARCH

IF16.6

2014-10-01

PREAI

Bhadury, Joydeep; Nilsson, Lisa M.; Green, Lydia; Li, Zhoulei; Gesner, Emily M.; Muralidharan, Somsundar Veppil; Hansen, Henrik C.; Keller, Ulrich B.; Mclure, Kevin G.; Nilsson, Jonas A.

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BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2014-06-16

198

OAAI

Bhadury, Joydeep; Nilsson, Lisa M.; Muralidharan, Somsundar Veppil; Green, Lydia C.; Li, Zhoulei; Gesner, Emily M.; Hansen, Henrik C.; Keller, Ulrich B.; McLure, Kevin G.; Nilsson, Jonas A.

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RVX-2135 is a novel, orally bioavailable epigenetic BET inhibitor that synergizes with cytarabine and idarubicin to inhibit proliferation of acute myeloid leukemia cells.

CANCER RESEARCH

IF16.6

2013-04-01

PREAI

Campeau, Eric; Jahagirdar, Ravi; Wu, Jin; Gesner, Emily M.; Kharenko, Olesya; Yu, Raymond; Attwell, Sarah; Hansen, Henrik C.; Wagner, Gregory S.; McLure, Kevin G.; Young, Peter R.

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Cas5d processes pre-crRNA and is a member of a larger family of CRISPR RNA endonucleases

RNA

IF5

2012-09-24

OAAI

Garside, Erin L.; Schellenberg, Matthew J.; Gesner, Emily M.; Bonanno, Jeffrey B.; Sauder, J. Michael; Burley, Stephen K.; Almo, Steven C.; Mehta, Garima; Macmillan, Andrew M.

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Recognition and maturation of effector RNAs in a CRISPR interference pathway

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2011-05-15

167

PREAI

Gesner, Emily M.; Schellenberg, Matthew J.; Garside, Erin L.; George, Mark M.; MacMillan, Andrew M.

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Structural elucidation of a PRP8 core domain from the heart of the spliceosome

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1