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SavePharmacological inhibition of PMS2 increases tumor mutational burden, induces microsatellite instability and elicits immune mediated rejection in vivo
Piumatti, Eleonora; Hervieu, Alexia; Riou, Philippe; Blagg, Julian; Peall, Adam; Weeks, Sam; Rodriguez-Plata, Maria T.; Rospo, Giuseppe; Arunachalam, Sasi; Meier, Bettina; Tongue, Paige; McLaren, Tessa; Parmar, Kalpesh; Patel, Pradip; Clark, David; Langley, Gareth; Nichols, Charles; Rousseau, Benoit; Winship, Paul; Baker, Matthew; Drysdale, Martin; Germano, Giovanni; Bardelli, Alberto Share Save Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cellsSogari, Alberto; Rovera, Emanuele; Grasso, Gaia; Mariella, Elisa; Reilly, Nicole Megan; Lamba, Simona; Mauri, Gianluca; Durinikova, Erika; Vitiello, Pietro Paolo; Lorenzato, Annalisa; Avolio, Marco; Piumatti, Eleonora; Bonoldi, Emanuela; Aquilano, Maria Costanza; Arena, Sabrina; Sartore-Bianchi, Andrea; Siena, Salvatore; Trusolino, Livio; Donalisio, Manuela; Russo, Mariangela; Di Nicolantonio, Federica; Lembo, David; Bardelli, Alberto Share Save Tolerance to colibactin correlates with response to chemotherapeutic agents in colorectal cancerSogari, Alberto; Rovera, Emanuele; Reilly, Nicole Megan; Lamba, Simona; Durinikova, Erika; Lorenzato, Annalisa; Avolio, Marco; Piumatti, Eleonora; Russo, Mariangela; Arena, Sabrina; Trusolino, Livio; Donalisio, Manuela; Di Nicolantonio, Federica; Lembo, David; Bardelli, Alberto Share Save NP1867, a potent, selective, covalent small molecule inhibitor of DNA Mismatch Repair (MMR) protein PMS2, functionally inhibits MMR in cells and elicits COSMIC mutational signatures consistent with MMR-deficient patient samplesBlagg, Julian; Riou, Philippe; Hervieu, Alexia; Piumatti, Eleonora; Rospo, Giuseppe; Arunachalam, Sasi; Meier, Bettina; Weeks, Sam; Rodriguez, Maria; Parmar, Kalpesh; Patel, Pradip; Peall, Adam; Tongue, Paige; McLaren, Tess; Workman, Robert; Bago, Ruzica; Robjohns, Stuart; Beaumont, Rebecca; Briggs, Mike; Langley, Gareth; Nichols, Charles; Clark, David; Winship, Paul; Rousseau, Benoit; Baker, Matthew; Drysdale, Martin; Germano, Giovanni; Bardelli, Alberto Share Save Share Save 
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