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W

W. Nathaniel Brennen

Johns Hopkins University School of Medicine

27H-index
151Paper Count
3.1KCitation Count
Published Papers 38
Publication Date
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Cellular senescence in precancer lesions and early-stage cancers
errCancer Cell
IF44.5
err2025-11-06
err0
PREAI
errXen Ping Hoi; Mary M. Stangis; Sarah E. Glass; Jin-Hee Kim; Seung Woo Kang; W. Nathaniel Brennen; Ziyi Li; William M. Grady; Srinivasan Yegnasubramanian; Peter Kuhn; Costas A. Lyssiotis; Akiko Sagara; Martha J. Shrubsole; Humam Kadara; Ying Yuan; Robert J. Coffey; Ken S. Lau; Angelo M. De Marzo; Anirban Maitra; Jimin Min; Ming Yu; Keith S. Chan
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errSave
Overexpression of fibroblast activation protein (FAP) in the stroma of proliferative inflammatory atrophy (PIA) and primary adenocarcinoma of the prostate
errPathology
IF3
err2025-03-01
err0
errOAAI
errFernanda Caramella-Pereira; Qizhi Zheng; Jessica L. Hicks; Sujayita Roy; Tracy Jones; Martin Pomper; Lizamma Antony; Alan K. Meeker; Srinivasan Yegnasubramanian; Angelo M. De Marzo; W. Nathaniel Brennen
errShare
errSave
AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2024-06-19
err1
PREAI
errNouri, Mannan; Varkaris, Andreas; Ridinger, Maya; Dalrymple, Susan L.; Dennehy, Christopher M.; Isaacs, John T.; Einstein, David J.; Brennen, W. N.; Balk, Steven P.
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errSave
The Hallmarks of Precancer
errCANCER DISCOVERY
IF33.3
err2024-04-04
err4
errOAAI
errStangis, Mary M.; Chen, Zhengyi; Min, Jimin; Glass, Sarah E.; Jackson, Jordan O.; Radyk, Megan D.; Hoi, Xen Ping; Brennen, W. Nathaniel; Yu, Ming; Dinh, Huy Q.; Coffey, Robert J.; Shrubsole, Martha J.; Chan, Keith S.; Grady, William M.; Yegnasubramanian, Srinivasan; Lyssiotis, Costas A.; Maitra, Anirban; Halberg, Richard B.; Dey, Neelendu; Lau, Ken S.
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errSave
Prostate fibroblasts and prostate cancer associated fibroblasts exhibit different metabolic, matrix degradation and PD-L1 expression responses to hypoxia
errFRONTIERS IN MOLECULAR BIOSCIENCES
IF4
err2024-03-22
err1
errOAAI
errPacheco-Torres, Jesus; Sharma, Raj Kumar; Mironchik, Yelena; Wildes, Flonne; Brennen, W. Nathaniel; Artemov, Dmitri; Krishnamachary, Balaji; Bhujwalla, Zaver M.
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errSave
LSD1 inhibition transcriptionally reprograms neuroendocrine prostate cancer exposing unique therapeutic vulnerabilities
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errJasmine, Sumer M.; Mandl, Adel; Dalrymple, Susan L.; Kim, Sunghyun; Dias, Jennifer; Kleppe, Maria; Celatka, Cassandra; Tapper, Amy; Coleman, Ilsa; Nelson, Peter; Rienhoff, Hugh; Denmeade, Samuel R.; Brennen, W. Nathaniel
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errSave
Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer
errNATURE REVIEWS UROLOGY
IF14.6
err2023-10-31
err6
PREAI
errMori, Joakin O.; Elhussin, Isra; Brennen, W. Nathaniel; Graham, Mindy K.; Lotan, Tamara L.; Yates, Clayton C.; De Marzo, Angelo M.; Denmeade, Samuel R.; Yegnasubramanian, Srinivasan; Nelson, William G.; Denis, Gerald V.; Platz, Elizabeth A.; Meeker, Alan K.; Heaphy, Christopher M.
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errSave
Characterization of HOXB13 expression patterns in localized and metastatic castration-resistant prostate cancer
errJOURNAL OF PATHOLOGY
IF5.2
err2023-10-18
err9
errOAAI
errPatel, Radhika A.; Sayar, Erolcan; Coleman, Ilsa; Roudier, Martine P.; Hanratty, Brian; Low, Jin-Yih; Jaiswal, Neha; Ajkunic, Azra; Dumpit, Ruth; Ercan, Caner; Salama, Nina; O'Brien, Valerie P.; Isaacs, William B.; Epstein, Jonathan, I; De Marzo, Angelo M.; Trock, Bruce J.; Luo, Jun; Brennen, W. Nathaniel; Tretiakova, Maria; Vakar-Lopez, Funda; True, Lawrence D.; Goodrich, David W.; Corey, Eva; Morrissey, Colm; Nelson, Peter S.; Hurley, Paula J.; Gulati, Roman; Haffner, Michael C.
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errSave
Multiplex IHC assay to explore regional heterogeneity of FAP and inflammatory cell density in localized prostatic adenocarcinoma
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errPereira, Fernanda Caramella; Meeker, Alan K.; Pienta, Kenneth; Zheng, Qizhi; Jones, Tracy; Yegnasubramanian, Srinivasan; Hicks, Jessica L.; Roy, Sujayita; De Marzo, Angelo M.; Brennen, W. Nathaniel
errShare
errSave
IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry
errNATURE COMMUNICATIONS
IF15.7
err2023-03-23
err21
errOAAI
errLu, Peng; Oetjen, Karolyn A.; Bender, Diane E.; Ruzinova, Marianna B.; Fisher, Daniel A. C.; Shim, Kevin G.; Pachynski, Russell K.; Brennen, W. Nathaniel; Oh, Stephen T.; Link, Daniel C.; Thorek, Daniel L. J.
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errSave
Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2022-12-01
err27
errOAAI
errSena, Laura A.; Kumar, Rajendra; Sanin, David E.; Thompson, Elizabeth A.; Rosen, D. Marc; Dalrymple, Susan L.; Antony, Lizamma; Yang, Yuhan; Gomes-Alexandre, Carolina; Hicks, Jessica L.; Jones, Tracy; Bowers, Kiara A.; Eskra, Jillian N.; Meyers, Jennifer; Gupta, Anuj; Skaist, Alyza; Yegnasubramanian, Srinivasan; Luo, Jun; Brennen, W. Nathaniel; Kachhap, Sushant K.; Antonarakis, Emmanuel S.; De Marzo, Angelo M.; Isaacs, John T.; Markowski, Mark C.; Denmeade, Samuel R.
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errSave
Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype
errNEOPLASIA
IF7.7
err2022-10-01
err17
errOAAI
errde Groot, Amber E.; Myers, Kayla, V; Krueger, Timothy E. G.; Brennen, W. Nathaniel; Amend, Sarah R.; Pienta, Kenneth J.
errShare
errSave
There are gremlins in prostate cancer
errNATURE CANCER
IF28.5
err2022-05-27
err4
errOAAI
errSena, Laura A.; Brennen, W. Nathaniel; Isaacs, John T.
errShare
errSave
Mipsagargin: The Beginning-Not the End-of Thapsigargin Prodrug-Based Cancer Therapeutics
errMOLECULES
IF4.6
err2021-12-09
err18
errOAAI
errIsaacs, John T.; Brennen, William Nathaniel; Christensen, Soren Brogger; Denmeade, Samuel R.
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errSave
Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer
errCANCER RESEARCH
IF16.6
err2021-12-01
err34
errOAAI
errKumar, Rajendra; Mendonca, Janet; Owoyemi, Olutosin; Boyapati, Kavya; Thomas, Naiju; Kanacharoen, Suthicha; Coffey, Max; Topiwala, Deven; Gomes, Carolina; Ozbek, Busra; Jones, Tracy; Rosen, Marc; Dong, Liang; Wiens, Sadie; Brennen, W. Nathaniel; Isaacs, John T.; De Marzo, Angelo M.; Markowski, Mark C.; Antonarakis, Emmanuel S.; Qian, David Z.; Pienta, Kenneth J.; Pardoll, Drew M.; Carducci, Michael A.; Denmeade, Samuel R.; Kachhap, Sushant K.
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errSave
Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors (vol 39, pg 6935, 2020)
errONCOGENE
IF7.3
err2021-05-06
err0
errOAAI
errZhu, Yezi; Dalrymple, Susan L.; Coleman, Ilsa; Zheng, S. Lilly; Xu, Jianfeng; Hooper, Jody E.; Antonarakis, Emmanuel S.; De Marzo, Angelo M.; Meeker, Alan K.; Nelson, Peter S.; Isaacs, William B.; Denmeade, Samuel R.; Luo, Jun; Brennen, W. Nathaniel; Isaacs, John T.
errShare
errSave
Resistance to androgen receptor signaling inhibition does not necessitate development of neuroendocrine prostate cancer
errJCI INSIGHT
IF6.1
err2021-04-22
err34
errOAAI
errBrennen, W. Nathaniel; Zhu, Yezi; Coleman, Ilsa M.; Dalrymple, Susan L.; Antony, Lizamma; Patel, Radhika A.; Hanratty, Brian; Chikarmane, Roshan; Meeker, Alan K.; Zheng, S. Lilly; Hooper, Jody E.; Luo, Jun; De Marzo, Angelo M.; Corey, Eva; Xu, Jianfeng; Yegnasubramanian, Srinivasan; Haffner, Michael C.; Nelson, Peter S.; Nelson, William G.; Isaacs, William B.; Isaacs, John T.
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errSave
Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors (vol 39, pg 6935, 2020)
errONCOGENE
IF7.3
err2021-02-09
err0
errOAAI
errZhu, Yezi; Dalrymple, Susan L.; Coleman, Ilsa; Zheng, S. Lilly; Xu, Jianfeng; Hooper, Jody E.; Antonarakis, Emmanuel S.; De Marzo, Angelo M.; Meeker, Alan K.; Nelson, Peter S.; Isaacs, William B.; Denmeade, Samuel R.; Luo, Jun; Brennen, W. Nathaniel; Isaacs, John T.
errShare
errSave
Microparticle Encapsulation of a Prostate-targeted Biologic for the Treatment of Liver Metastases in a Preclinical Model of Castration-resistant Prostate Cancer
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2020-11-03
err2
errOAAI
errRogers, Oliver C.; Antony, Lizamma; Levy, Oren; Joshi, Nitin; Simons, Brian W.; Dalrymple, Susan; Rosen, Marc; Pickering, Andrew; Lan, Haoyue; Kuang, Heidi; Ranganath, Sudhir H.; Zheng, Lei; Karp, Jeffrey M.; Howard, S. Peter; Denmeade, Samuel R.; Isaacs, John T.; Brennen, W. Nathaniel
errShare
errSave
Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors
errONCOGENE
IF7.3
err2020-09-28
err75
errOAAI
errZhu, Yezi; Dalrymple, Susan L.; Coleman, Ilsa; Zheng, S. Lilly; Xu, Jianfeng; Hooper, Jody E.; Antonarakis, Emmanuel S.; De Marzo, Angelo M.; Meeker, Alan K.; Nelson, Peter S.; Isaacs, William B.; Denmeade, Samuel R.; Luo, Jun; Brennen, W. Nathaniel; Isaacs, John T.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
D
Drew M. Pardoll
H-index: 164 · Papers: 892
A
ArkingDan (Anirban Maitra)
H-index: 156 · Papers: 1.8K
J
Jonathan I. Epstein
H-index: 147 · Papers: 1.4K
K
Kenneth J. Pienta
H-index: 142 · Papers: 1.4K
C
Charles G. Drake
H-index: 133 · Papers: 1.2K
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